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Stephen A. Lerner

AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jorgensen SCJ, McDonald P, Mynatt RP, Pogue JM, Lerner SA, Dhar S, Salimnia H, Rybak MJ. Averting the post-antibiotic era: successful use of meropenem/vaborbactam for carbapenem-resistant Serratia marcescens and Enterobacter aerogenes bacteraemia in a haemodialysis patient. J Antimicrob Chemother. 2018 12 01; 73(12):3529-3531. PMID: 30188993.
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    2. Thiagaraj AK, Malviya M, Htun WW, Telila T, Lerner SA, Elder MD, Schreiber TL. A novel approach in the management of right-sided endocarditis: percutaneous vegectomy using the AngioVac cannula. Future Cardiol. 2017 05; 13(3):211-217. PMID: 28326804.
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    3. Navalkele BD, Lerner SA. Intravenous Tigecycline Facilitates Cure of Severe Clostridium difficile Infection (CDI) After Failure of Standard Therapy: A Case Report and Literature Review of Tigecycline Use in CDI. Open Forum Infect Dis. 2016 Apr; 3(2):ofw094. PMID: 27419166.
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    4. Bush K, Courvalin P, Dantas G, Davies J, Eisenstein B, Huovinen P, Jacoby GA, Kishony R, Kreiswirth BN, Kutter E, Lerner SA, Levy S, Lewis K, Lomovskaya O, Miller JH, Mobashery S, Piddock LJ, Projan S, Thomas CM, Tomasz A, Tulkens PM, Walsh TR, Watson JD, Witkowski J, Witte W, Wright G, Yeh P, Zgurskaya HI. Tackling antibiotic resistance. Nat Rev Microbiol. 2011 11 02; 9(12):894-6. PMID: 22048738.
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    5. Juretschko S, Labombardi VJ, Lerner SA, Schreckenberger PC. Accuracies of beta-lactam susceptibility test results for Pseudomonas aeruginosa with four automated systems (BD Phoenix, MicroScan WalkAway, Vitek, and Vitek 2). J Clin Microbiol. 2007 Apr; 45(4):1339-42. PMID: 17229867.
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    6. Juzych NS, Banerjee M, Essenmacher L, Lerner SA. Improvements in antimicrobial prescribing for treatment of upper respiratory tract infections through provider education. J Gen Intern Med. 2005 Oct; 20(10):901-5. PMID: 16191135.
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    7. Walanj R, Young P, Baker HM, Baker EN, Metcalf P, Chow JW, Lerner S, Vakulenko S, Smith CA. Purification, crystallization and preliminary X-ray analysis of Enterococcus faecium aminoglycoside-2''-phosphotransferase-Ib [APH(2'')-Ib]. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Apr 01; 61(Pt 4):410-3. PMID: 16511055.
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    8. Vakulenko SB, Donabedian SM, Voskresenskiy AM, Zervos MJ, Lerner SA, Chow JW. Multiplex PCR for detection of aminoglycoside resistance genes in enterococci. Antimicrob Agents Chemother. 2003 Apr; 47(4):1423-6. PMID: 12654683.
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    9. Lee HK, Vakulenko SB, Clewell DB, Lerner SA, Chow JW. Mutations in the aph(2")-Ic gene are responsible for increased levels of aminoglycoside resistance. Antimicrob Agents Chemother. 2002 Oct; 46(10):3253-6. PMID: 12234853.
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    10. Shahin GS, Lerner SA. Rare presentation of Streptococcus pneumoniae pneumonia with bacteremia and multiple subcutaneous abscesses. Eur J Clin Microbiol Infect Dis. 2002 Aug; 21(8):611-2. PMID: 12226693.
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    11. Vakulenko SB, Golemi D, Geryk B, Suvorov M, Knox JR, Mobashery S, Lerner SA. Mutational replacement of Leu-293 in the class C Enterobacter cloacae P99 beta-lactamase confers increased MIC of cefepime. Antimicrob Agents Chemother. 2002 Jun; 46(6):1966-70. PMID: 12019116.
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    12. Hinojosa R, Nelson EG, Lerner SA, Redleaf MI, Schramm DR. Aminoglycoside ototoxicity: a human temporal bone study. Laryngoscope. 2001 Oct; 111(10):1797-805. PMID: 11801948.
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    13. Chow JW, Kak V, You I, Kao SJ, Petrin J, Clewell DB, Lerner SA, Miller GH, Shaw KJ. Aminoglycoside resistance genes aph(2")-Ib and aac(6')-Im detected together in strains of both Escherichia coli and Enterococcus faecium. Antimicrob Agents Chemother. 2001 Oct; 45(10):2691-4. PMID: 11557456.
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    14. Grapsas I, Lerner SA, Mobashery S. Conjoint molecules of cephalosporins and aminoglycosides. Arch Pharm (Weinheim). 2001 Sep; 334(8-9):295-301. PMID: 11688141.
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    15. Torres C, Perlin MH, Baquero F, Lerner DL, Lerner SA. High-level amikacin resistance in Pseudomonas aeruginosa associated with a 3'-phosphotransferase with high affinity for amikacin. Int J Antimicrob Agents. 2000 Aug; 15(4):257-63. PMID: 10929874.
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    16. Vakulenko SB, Taibi-Tronche P, Tóth M, Massova I, Lerner SA, Mobashery S. Effects on substrate profile by mutational substitutions at positions 164 and 179 of the class A TEM(pUC19) beta-lactamase from Escherichia coli. J Biol Chem. 1999 Aug 13; 274(33):23052-60. PMID: 10438473.
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    17. Rybak MJ, Abate BJ, Kang SL, Ruffing MJ, Lerner SA, Drusano GL. Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity. Antimicrob Agents Chemother. 1999 Jul; 43(7):1549-55. PMID: 10390201.
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    18. Brown PD, Lerner SA. Community-acquired pneumonia. Lancet. 1998 Oct 17; 352(9136):1295-302. PMID: 9788476.
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    19. Vakulenko SB, Geryk B, Kotra LP, Mobashery S, Lerner SA. Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene. Antimicrob Agents Chemother. 1998 Jul; 42(7):1542-8. PMID: 9660980.
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    20. Alangaden GJ, Kreiswirth BN, Aouad A, Khetarpal M, Igno FR, Moghazeh SL, Manavathu EK, Lerner SA. Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1998 May; 42(5):1295-7. PMID: 9593173.
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    21. Slavik RS, Rybak MJ, Lerner SA. Trimethoprim/sulfamethoxazole-induced tremor in a patient with AIDS. Ann Pharmacother. 1998 Feb; 32(2):189-92. PMID: 9496403.
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    22. Lerner SA. Clinical impact of antibiotic resistance. Adv Exp Med Biol. 1998; 456:7-15. PMID: 10549361.
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    23. Alangaden GJ, Lerner SA. The clinical use of fluoroquinolones for the treatment of mycobacterial diseases. Clin Infect Dis. 1997 Nov; 25(5):1213-21. PMID: 9402384.
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    24. Chow JW, Zervos MJ, Lerner SA, Thal LA, Donabedian SM, Jaworski DD, Tsai S, Shaw KJ, Clewell DB. A novel gentamicin resistance gene in Enterococcus. Antimicrob Agents Chemother. 1997 Mar; 41(3):511-4. PMID: 9055984.
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    25. Manavathu EK, Alangaden GJ, Lerner SA. A comparative study of the broth micro- and macro-dilution techniques for the determination of the in vitro susceptibility of Aspergillus fumigatus. Can J Microbiol. 1996 Sep; 42(9):960-4. PMID: 8864219.
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    26. Manavathu EK, Vakulenko SB, Obedeanu N, Lerner SA. Isolation and characterization of a species-specific DNA probe for the detection of Candida krusei. Curr Microbiol. 1996 Sep; 33(3):147-51. PMID: 8672089.
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    27. Vakulenko SB, Tóth M, Taibi P, Mobashery S, Lerner SA. Effects of Asp-179 mutations in TEMpUC19 beta-lactamase on susceptibility to beta-lactams. Antimicrob Agents Chemother. 1995 Aug; 39(8):1878-80. PMID: 7486939.
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    28. Alangaden GJ, Manavathu EK, Vakulenko SB, Zvonok NM, Lerner SA. Characterization of fluoroquinolone-resistant mutant strains of Mycobacterium tuberculosis selected in the laboratory and isolated from patients. Antimicrob Agents Chemother. 1995 Aug; 39(8):1700-3. PMID: 7486904.
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    29. Imtiaz U, Manavathu EK, Mobashery S, Lerner SA. Reversal of clavulanate resistance conferred by a Ser-244 mutant of TEM-1 beta-lactamase as a result of a second mutation (Arg to Ser at position 164) that enhances activity against ceftazidime. Antimicrob Agents Chemother. 1994 May; 38(5):1134-9. PMID: 8067751.
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    30. Siregar JJ, Lerner SA, Mobashery S. Purification and characterization of aminoglycoside 3'-phosphotransferase type IIa and kinetic comparison with a new mutant enzyme. Antimicrob Agents Chemother. 1994 Apr; 38(4):641-7. PMID: 8031025.
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    31. Imtiaz U, Manavathu EK, Lerner SA, Mobashery S. Critical hydrogen bonding by serine 235 for cephalosporinase activity of TEM-1 beta-lactamase. Antimicrob Agents Chemother. 1993 Nov; 37(11):2438-42. PMID: 8285630.
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    32. Zafaralla G, Manavathu EK, Lerner SA, Mobashery S. Elucidation of the role of arginine-244 in the turnover processes of class A beta-lactamases. Biochemistry. 1992 Apr 21; 31(15):3847-52. PMID: 1567841.
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    33. Moore RD, Lerner SA, Levine DP. Nephrotoxicity and ototoxicity of aztreonam versus aminoglycoside therapy in seriously ill nonneutropenic patients. J Infect Dis. 1992 Apr; 165(4):683-8. PMID: 1552197.
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    34. Oren I, Manavathu EK, Lerner SA. Isolation and characterization of a species-specific DNA probe for Candida albicans. Nucleic Acids Res. 1991 Dec; 19(25):7113-6. PMID: 1766872.
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    35. Rybak MJ, Lerner SA, Levine DP, Albrecht LM, McNeil PL, Thompson GA, Kenny MT, Yuh L. Teicoplanin pharmacokinetics in intravenous drug abusers being treated for bacterial endocarditis. Antimicrob Agents Chemother. 1991 Apr; 35(4):696-700. PMID: 1829880.
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    36. Kaatz GW, Seo SM, Dorman NJ, Lerner SA. Emergence of teicoplanin resistance during therapy of Staphylococcus aureus endocarditis. J Infect Dis. 1990 Jul; 162(1):103-8. PMID: 2141343.
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    37. Levine DP, McNeil P, Lerner SA. Randomized, double-blind comparative study of intravenous ciprofloxacin versus ceftazidime in the treatment of serious infections. Am J Med. 1989 Nov 30; 87(5A):160S-163S. PMID: 2686416.
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    38. Gaynes R, Groisman E, Nelson E, Casadaban M, Lerner SA. Isolation, characterization, and cloning of a plasmid-borne gene encoding a phosphotransferase that confers high-level amikacin resistance in enteric bacilli. Antimicrob Agents Chemother. 1988 Sep; 32(9):1379-84. PMID: 2848443.
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    39. Mobashery S, Lerner SA, Johnston M. Monitoring beta-lactamase activity in vivo by 13C nuclear magnetic resonance spectroscopy. Antimicrob Agents Chemother. 1988 Aug; 32(8):1196-203. PMID: 3056254.
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    40. Hinojosa R, Lerner SA. Cochlear neural degeneration without hair cell loss in two patients with aminoglycoside ototoxicity. J Infect Dis. 1987 Sep; 156(3):449-55. PMID: 3611831.
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    41. Cheung KS, Boisvert W, Lerner SA, Johnston M. Chloroalanyl antibiotic peptides: antagonism of their antimicrobial effects by L-alanine and L-alanyl peptides in gram-negative bacteria. J Med Chem. 1986 Oct; 29(10):2060-8. PMID: 3093682.
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    42. Boisvert W, Cheung KS, Lerner SA, Johnston M. Mechanisms of action of chloroalanyl antibacterial peptides. Identification of the intracellular enzymes inactivated on treatment of Escherichia coli JSR-O with the dipeptide beta Cl-LAla-beta Cl-LAla. J Biol Chem. 1986 Jun 15; 261(17):7871-8. PMID: 3519614.
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    43. Perlin MH, Lerner SA. High-level amikacin resistance in Escherichia coli due to phosphorylation and impaired aminoglycoside uptake. Antimicrob Agents Chemother. 1986 Feb; 29(2):216-24. PMID: 2424366.
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    44. DeHertogh DA, Lerner SA. Correlation of aminoglycoside resistance with the KmS and Vmax/Km ratios of enzymatic modification of aminoglycosides by 2''-O-nucleotidyltransferase. Antimicrob Agents Chemother. 1985 Apr; 27(4):670-1. PMID: 2988434.
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    45. Lerner SA, Quinn JP. Emergence of resistance to beta-lactam antibiotics in Pseudomonas aeruginosa during treatment with new beta-lactams. Chemioterapia. 1985 Feb; 4(1):95-101. PMID: 3921267.
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    46. Hinojosa R, Seligsohn R, Lerner SA. Ganglion cell counts in the cochleae of patients with normal audiograms. Acta Otolaryngol. 1985 Jan-Feb; 99(1-2):8-13. PMID: 3976399.
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    47. Garcia-Riestra C, Perlin MH, Lerner SA. Lack of accumulation of exogenous adenylyl dihydrostreptomycin by whole cells or spheroplasts of Escherichia coli. Antimicrob Agents Chemother. 1985 Jan; 27(1):114-9. PMID: 2580478.
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    48. Lerner SA, Dudek EJ, Boisvert WE, Berndt KD. Effect of highly potent antipseudomonal beta-lactam agents alone and in combination with aminoglycosides against Pseudomonas aeruginosa. Rev Infect Dis. 1984 Sep-Oct; 6 Suppl 3:S678-88. PMID: 6443769.
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    49. Cheung KS, Wasserman SA, Dudek E, Lerner SA, Johnston M. Chloralanyl and propargylglycyl dipeptides. Suicide substrate containing antibacterials. J Med Chem. 1983 Dec; 26(12):1733-41. PMID: 6417332.
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    50. Dudek EJ, Stephenson JD, Bohnhoff M, Lerner SA. Susceptibility of Neisseria meningitidis and Neisseria gonorrhoeae isolates to N-formimidoyl thienamycin. Antimicrob Agents Chemother. 1982 Nov; 22(5):926-9. PMID: 6817708.
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    51. Perlin MH, Lerner SA. Decreased susceptibility to 4'-deoxy-6'-N-methylamikacin (BB-K311) conferred by a mutant plasmid in Escherichia coli. Antimicrob Agents Chemother. 1982 Jul; 22(1):78-82. PMID: 6289743.
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    52. Lerner SA, Matz GJ. Aminoglycoside ototoxicity. Am J Otolaryngol. 1980 Feb; 1(2):169-79. PMID: 6969550.
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    53. Perlin MH, Lerner SA. Amikacin resistance associated with a plasmid-borne aminoglycoside phosphotransferase in Escherichia coli. Antimicrob Agents Chemother. 1979 Nov; 16(5):598-604. PMID: 393165.
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    54. Rusthoven JJ, Davies TA, Lerner SA. Clinical isolation and characterization of aminoglycoside-resistant small colony variants of Enterobacter aerogenes. Am J Med. 1979 Oct; 67(4):702-6. PMID: 495639.
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    55. Sirisanthana T, Lerner SA. Effect of clavulanic acid on the in vitro synergism between carbenicillin and gentamicin against Serratia marcescens. Antimicrob Agents Chemother. 1979 Apr; 15(4):630-2. PMID: 380465.
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    56. Lerner SA, Matz GJ. Suggestions for monitoring patients during treatment with aminoglycoside antibiotics. Otolaryngol Head Neck Surg (1979). 1979 Mar-Apr; 87(2):222-8. PMID: 503492.
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    57. Bhattacharya I, Seligsohn R, Lerner SA. Effects of radiopharmaceuticals on radioenzymatic assays of aminoglycoside antibiotics: interference by gallium-67 and its elimination. Antimicrob Agents Chemother. 1978 Sep; 14(3):448-53. PMID: 360985.
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    58. Robison LR, Seligsohn R, Lerner SA. Simplified radioenzymatic assay for chloramphenicol. Antimicrob Agents Chemother. 1978 Jan; 13(1):25-9. PMID: 626488.
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    59. Pogwizd SM, Lerner SA. In vitro activity of gentamicin, amikacin and netilmicin alone and in combination with carbenicillin against Serratia marcescens. Antimicrob Agents Chemother. 1976 Dec; 10(6):878-84. PMID: 795373.
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