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Raphael Lee

TitleProfessor
InstitutionUniversity of Chicago
DepartmentSurgery-Plastics
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Lee is a plastic surgeon and biomedical engineer. His professional research interests have focused on the effects of physical forces on tissue injury and repair, therapeutic control of scar formation, molecular engineering of synthetic chaperones, and reconstructive surgery.
    Dr. Lee’s laboratory was the first to report a clinically applicable method to seal disrupted cell membranes resulting in a now widely validated new class of trauma therapeutics that for first time off promise to restore viability damaged tissue following severe injury such as motor vehicle accidents and military trauma. Ongoing research focuses on development synthetic multiblock copolymer synthetic chaperones to restore function to denatured and aggregated proteins which has important implications in tissue preservation and thermal trauma.


    Collapse Biography 
    Collapse education and training
    Harvard/MGH, Boston06/1983Plastic Surgery
    Massachusetts Inst of Tech, CambridgeScD09/1979Bioelectrical Engineering
    University of Chicago, Chicago06;2001General Surgery
    Drexel University, PhiladelphiaM.S.05/1975Biomedical Engineering
    Temple University , PhiladelphiaM.D.06/1975Medicine
    University of South Carolina, ColumbiaB.S.05/1971Electrical Engineering
    Collapse awards and honors
    2015Elected to membership, International Academy Medical and Biological Engineering
    2018Pierre Gillette Award, American Inst Med and Biol Eng
    2009Elected to membership, National Academy of Engineering
    1974American Heart Associate Research Award, American Heart Association
    1975Alpha Omega Alpha, Temple University SOM
    1975Tau Beta Pi, Drexel University
    1997Schering Scholar in Surgery, American College of Surgeons
    1980Sigma Xi, Massachusetts Inst of Technology
    1981 - 1986MacArthur Fellow, John and Catherine MacArthur Foundation
    1865 - 1988Searle Scholar, Searle Foundation
    1986James Barrett Brown Award, American Association of Plastic Surgeons

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Chin J, Mustafi D, Poellmann MJ, Lee RC. Amphiphilic copolymers reduce aggregation of unfolded lysozyme more effectively than polyethylene glycol. Phys Biol. 2017 02 08; 14(1):016003. PMID: 28061483.
      View in: PubMed
    2. Poellmann MJ, Sosnick TR, Meredith SC, Lee RC. The Pentablock Amphiphilic Copolymer T1107 Prevents Aggregation of Denatured and Reduced Lysozyme. Macromol Biosci. 2017 02; 17(2). PMID: 27615730.
      View in: PubMed
    3. Hahn-Ketter A, Aase DM, Paxton J, Fink JW, Kelley KM, Lee RC, Pliskin NH. Psychiatric Outcome Over a Decade After Electrical Injury: Depression as a Predictor of Long-Term Adjustment. J Burn Care Res. 2015 Jul-Aug; 36(4):509-12. PMID: 25377863.
      View in: PubMed
    4. Aase DM, Fink JW, Lee RC, Kelley KM, Pliskin NH. Mood and cognition after electrical injury: a follow-up study. Arch Clin Neuropsychol. 2014 Mar; 29(2):125-30. PMID: 24395352.
      View in: PubMed
    5. Lee RC. Convolving engineering and medical pedagogies for training of tomorrow's health care professionals. IEEE Trans Biomed Eng. 2013 Mar; 60(3):599-601. PMID: 23475328.
      View in: PubMed
    6. He B, Baird R, Butera R, Datta A, George S, Hecht B, Hero A, Lazzi G, Lee RC, Liang J, Neuman M, Peng GC, Perreault EJ, Ramasubramanian M, Wang MD, Wikswo J, Yang GZ, Zhang YT. Grand challenges in interfacing engineering with life sciences and medicine. IEEE Trans Biomed Eng. 2013 Mar; 60(3):589-98. PMID: 23380847.
      View in: PubMed
    7. Soneru AP, Beckett MA, Weichselbaum RR, Lee RC. Mg ATP and antioxidants augment the radioprotective effect of surfactant copolymers. Health Phys. 2011 Dec; 101(6):731-8. PMID: 22048491.
      View in: PubMed
    8. Cela CJ, Lee RC, Lazzi G. Modeling cellular lysis in skeletal muscle due to electric shock. IEEE Trans Biomed Eng. 2011 May; 58(5):1286-93. PMID: 21216705.
      View in: PubMed
    9. Murphy AD, McCormack MC, Bichara DA, Nguyen JT, Randolph MA, Watkins MT, Lee RC, Austen WG. Poloxamer 188 protects against ischemia-reperfusion injury in a murine hind-limb model. Plast Reconstr Surg. 2010 Jun; 125(6):1651-60. PMID: 20517088.
      View in: PubMed
    10. Ramati A, Pliskin NH, Keedy S, Erwin RJ, Fink JW, Bodnar EN, Lee RC, Cooper MA, Kelley K, Sweeney JA. Alteration in functional brain systems after electrical injury. J Neurotrauma. 2009 Oct; 26(10):1815-22. PMID: 19323610.
      View in: PubMed
    11. Despa F, Basati S, Zhang ZD, D'Andrea J, Reilly JP, Bodnar EN, Lee RC. Electromuscular incapacitation results from stimulation of spinal reflexes. Bioelectromagnetics. 2009 Jul; 30(5):411-21. PMID: 19353595.
      View in: PubMed
    12. Ramati A, Rubin LH, Wicklund A, Pliskin NH, Ammar AN, Fink JW, Bodnar EN, Lee RC, Cooper MA, Kelley KM. Psychiatric morbidity following electrical injury and its effects on cognitive functioning. Gen Hosp Psychiatry. 2009 Jul-Aug; 31(4):360-6. PMID: 19555797.
      View in: PubMed
    13. Orgill DP, Manders EK, Sumpio BE, Lee RC, Attinger CE, Gurtner GC, Ehrlich HP. The mechanisms of action of vacuum assisted closure: more to learn. Surgery. 2009 Jul; 146(1):40-51. PMID: 19541009.
      View in: PubMed
    14. Dalal ND, Lee RC. Treatment of burn injury by cellular repair. J Craniofac Surg. 2008 Jul; 19(4):903-6. PMID: 18650709.
      View in: PubMed
    15. Mustafi D, Smith CM, Makinen MW, Lee RC. Multi-block poloxamer surfactants suppress aggregation of denatured proteins. Biochim Biophys Acta. 2008 Jan; 1780(1):7-15. PMID: 17951011.
      View in: PubMed
    16. Collins JM, Despa F, Lee RC. Structural and functional recovery of electropermeabilized skeletal muscle in-vivo after treatment with surfactant poloxamer 188. Biochim Biophys Acta. 2007 May; 1768(5):1238-46. PMID: 17382288.
      View in: PubMed
    17. Matthews KL, Aarsvold JN, Mintzer RA, Chen CT, Lee RC. Tc-99m pyrophosphate imaging of poloxamer-treated electroporated skeletal muscle in an in vivo rat model. Burns. 2006 Sep; 32(6):755-64. PMID: 16837135.
      View in: PubMed
    18. Lee RC, Despa F, Guo L, Betala P, Kuo A, Thiyagarajan P. Surfactant copolymers prevent aggregation of heat denatured lysozyme. Ann Biomed Eng. 2006 Jul; 34(7):1190-200. PMID: 16786393.
      View in: PubMed
    19. Pliskin NH, Ammar AN, Fink JW, Hill SK, Malina AC, Ramati A, Kelley KM, Lee RC. Neuropsychological changes following electrical injury. J Int Neuropsychol Soc. 2006 Jan; 12(1):17-23. PMID: 16433940.
      View in: PubMed
    20. Chen W, Zhongsheng Z, Lee RC. Supramembrane potential-induced electroconformational changes in sodium channel proteins: a potential mechanism involved in electric injury. Burns. 2006 Feb; 32(1):52-9. PMID: 16384650.
      View in: PubMed
    21. Despa F, Orgill DP, Lee RC. Molecular crowding effects on protein stability. Ann N Y Acad Sci. 2005 Dec; 1066:54-66. PMID: 16533918.
      View in: PubMed
    22. Agarwal J, Walsh A, Lee RC. Multimodal strategies for resuscitating injured cells. Ann N Y Acad Sci. 2005 Dec; 1066:295-309. PMID: 16533933.
      View in: PubMed
    23. Gissel H, Despa F, Collins J, Mustafi D, Rojahn K, Karczmar G, Lee R. Magnetic resonance imaging of changes in muscle tissues after membrane trauma. Ann N Y Acad Sci. 2005 Dec; 1066:272-85. PMID: 16533931.
      View in: PubMed
    24. Walsh AM, Mustafi D, Makinen MW, Lee RC. A surfactant copolymer facilitates functional recovery of heat-denatured lysozyme. Ann N Y Acad Sci. 2005 Dec; 1066:321-7. PMID: 16533935.
      View in: PubMed
    25. Lee RC. Cell injury by electric forces. Ann N Y Acad Sci. 2005 Dec; 1066:85-91. PMID: 16533920.
      View in: PubMed
    26. Despa F, Orgill DP, Lee RC. Effects of crowding on the thermal stability of heterogeneous protein solutions. Ann Biomed Eng. 2005 Aug; 33(8):1125-31. PMID: 16133920.
      View in: PubMed
    27. Cooke GL, Chien A, Brodsky A, Lee RC. Incidence of hypertrophic scars among African Americans linked to vitamin D-3 metabolism? J Natl Med Assoc. 2005 Jul; 97(7):1004-9. PMID: 16080671.
      View in: PubMed
    28. Lee RC, Despa F. Distinguishing electroporation from thermal injuries in electrical shock by MR imaging. Conf Proc IEEE Eng Med Biol Soc. 2005; 6:6544-6. PMID: 17281769.
      View in: PubMed
    29. Bier M, Chen W, Bodnar E, Lee RC. Biophysical injury mechanisms associated with lightning injury. NeuroRehabilitation. 2005; 20(1):53-62. PMID: 15798357.
      View in: PubMed
    30. Bier M, Gowrishankar TR, Chen W, Lee RC. Electroporation of a lipid bilayer as a chemical reaction. Bioelectromagnetics. 2004 Dec; 25(8):634-7. PMID: 15515028.
      View in: PubMed
    31. Curry DJ, Wright DA, Lee RC, Kang UJ, Frim DM. Poloxamer 188 volumetrically decreases neuronal loss in the rat in a time-dependent manner. Neurosurgery. 2004 Oct; 55(4):943-8; discussion 948-9. PMID: 15458603.
      View in: PubMed
    32. Greenebaum B, Blossfield K, Hannig J, Carrillo CS, Beckett MA, Weichselbaum RR, Lee RC. Poloxamer 188 prevents acute necrosis of adult skeletal muscle cells following high-dose irradiation. Burns. 2004 Sep; 30(6):539-47. PMID: 15302418.
      View in: PubMed
    33. Lee RC, Rotmensch J. Rectovaginal radiation fistula repair using an obturator fasciocutaneous thigh flap. Gynecol Oncol. 2004 Aug; 94(2):277-82. PMID: 15297162.
      View in: PubMed
    34. Curry DJ, Wright DA, Lee RC, Kang UJ, Frim DM. Surfactant poloxamer 188-related decreases in inflammation and tissue damage after experimental brain injury in rats. J Neurosurg. 2004 Aug; 101(1 Suppl):91-6. PMID: 16206978.
      View in: PubMed
    35. Borgens RB, Bohnert D, Duerstock B, Spomar D, Lee RC. Subcutaneous tri-block copolymer produces recovery from spinal cord injury. J Neurosci Res. 2004 Apr 01; 76(1):141-54. PMID: 15048938.
      View in: PubMed
    36. Frim DM, Wright DA, Curry DJ, Cromie W, Lee R, Kang UJ. The surfactant poloxamer-188 protects against glutamate toxicity in the rat brain. Neuroreport. 2004 Jan 19; 15(1):171-4. PMID: 15106852.
      View in: PubMed
    37. Roseborough IE, Grevious MA, Lee RC. Prevention and treatment of excessive dermal scarring. J Natl Med Assoc. 2004 Jan; 96(1):108-16. PMID: 14746360.
      View in: PubMed
    38. Bier M, Chen W, Gowrishankar TR, Astumian RD, Lee RC. Resealing dynamics of a cell membrane after electroporation. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Dec; 66(6 Pt 1):062905. PMID: 12513333.
      View in: PubMed
    39. Kocsis JD, Toner M, Anderson DK, Brockbank K, Germain L, Lee RC, Ratner BD. Storage and translational issues in reparative medicine: breakout session summary. Ann N Y Acad Sci. 2002 Jun; 961:276-8. PMID: 12081917.
      View in: PubMed
    40. Lee RC. Cytoprotection by stabilization of cell membranes. Ann N Y Acad Sci. 2002 Jun; 961:271-5. PMID: 12081916.
      View in: PubMed
    41. Maskarinec SA, Hannig J, Lee RC, Lee KY. Direct observation of poloxamer 188 insertion into lipid monolayers. Biophys J. 2002 Mar; 82(3):1453-9. PMID: 11867460.
      View in: PubMed
    42. Cunningham DD, Henning TP, Shain EB, Young DF, Hannig J, Barua E, Lee RC. Blood extraction from lancet wounds using vacuum combined with skin stretching. J Appl Physiol (1985). 2002 Mar; 92(3):1089-96. PMID: 11842044.
      View in: PubMed
    43. Lee RC, Zhang D, Hannig J. Biophysical injury mechanisms in electrical shock trauma. Annu Rev Biomed Eng. 2000; 2:477-509. PMID: 11701521.
      View in: PubMed
    44. Lee RC, Myerov A, Maloney CP. Promising Therapy for Cell Membrane Damage. Ann N Y Acad Sci. 1994 May; 720(1):239-245. PMID: 28621850.
      View in: PubMed
    45. Kelley KM, Pliskin N, Meyer G, Lee RC. Neuropsychiatric Aspects of Electrical Injury: The Nature of Psychiatric Disturbance. Ann N Y Acad Sci. 1994 May; 720(1):213-218. PMID: 28621846.
      View in: PubMed
    46. Russo G, Kicska G, Lee RC. Effectiveness of Surface Cooling in Reducing Heat Injury: 3-D, Finite-Element Model of the Arm. Ann N Y Acad Sci. 1994 May; 720(1):79-91. PMID: 28621845.
      View in: PubMed
    47. Mankani MH, Abramov GS, Boddie A, Lee RC. Detection of Peripheral Nerve Injury in Electrical Shock Patients. Ann N Y Acad Sci. 1994 May; 720(1):206-212. PMID: 28621848.
      View in: PubMed
    48. Chen W, Lee RC. Evidence for Electrical Shock-induced Conformational Damage of Voltage-gated Ionic Channelsa. Ann N Y Acad Sci. 1994 May; 720(1):124-135. PMID: 28621860.
      View in: PubMed
    49. Lee RC, Russo G, Kicska G. Kinetics of Heating in Electrical Shock. Ann N Y Acad Sci. 1994 May; 720(1):56-64. PMID: 28621854.
      View in: PubMed
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