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Rima McLeod

InstitutionUniversity of Chicago
DepartmentOphthalmology and Visual Science
AddressChicago IL 60637
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    Collapse Overview 

    Collapse Biography 
    Collapse education and training
    Stanford University School of Medicine, Stanford, CAFellowship1978Infectious Disease
    University of California, San Francisco, CASr Asst Resident1974Medicine
    University of Pennsylvania, Philadelphia, PAJr Asst Resident1973Medicine
    University of Pennsylvania, Philadelphia, PAIntern1972Medicine
    University of California School of Medicine, San Francisco, CAMD1971Medicine
    University of California, Berkeley, CABA1967Zoology
    Collapse awards and honors
    1978NIH Training Grant, Stanford University
    1965California Heart Association and USPHS Student Fellowships, University of California, San Francisco
    1996 - nowDirectorToxoplasmosis Center, The University of Chicago

    Collapse Research 
    Collapse research activities and funding
         Jan 1, 2017 - Dec 31, 2020
    Thrasher Foundation Children's Charity
    POC testing to prevent congenital Toxoplasmosis

         Jan 1, 2016 - Dec 31, 2019
    NIH Uof C
    Multimodal Neuroimaging of Toxoplasma Infected Human Brain

         Jan 1, 2015 - Dec 31, 2020
    NIH U19, JCVI
    DNA Sequencing for Toxoplasmosis Research

    Global Health Award     (Kamal El Bissati, PhD)Jan 1, 2015 - Dec 31, 2019
    Global Health Center, University of Chicago; IDSA: Fullbright Award
    Toxoplasmosis Programs in Panama and Morocco, including student scholar awards:

    U01AI082180     (MCLEOD, RIMA L)Apr 1, 2009 - Mar 31, 2015
    Optimizing Inhibitors of T. gondii ENR
    Role: Principal Investigator

    U01AI077887     (MCLEOD, RIMA L)Jul 24, 2008 - Jun 30, 2014
    Towards a Vaccine to Prevent Toxoplasmosis
    Role: Principal Investigator

    R13AI044822     (MCLEOD, RIMA L)Feb 1, 1999 - Jul 31, 1999
    Role: Principal Investigator

    R01AI043228     (MCLEOD, RIMA L)Sep 30, 1997 - Mar 31, 2008
    Role: Principal Investigator

    R01AI027530     (MCLEOD, RIMA L)Sep 1, 1989 - Aug 31, 2013
    Treatment of Congenital Toxoplasmosis
    Role: Principal Investigator

    R01AI016945     (MCLEOD, RIMA L)Jul 1, 1980 - Jun 30, 2001
    Role: Principal Investigator

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Londo?o-Martinez JC, Velasco-Velasquez S, Cordero-Lopez S, Osorio MF, Celis-Giraldo D, Thibodeau J, Baird I, McLeod R, Gomez-Marin J. Evaluation of the acceptability of point of care diagnostic test for prenatal toxoplasmosis (translational research phase III). J Infect Public Health. 2022 Nov 23; 16(1):15-24. PMID: 36446203.
      Citations:    Fields:    
    2. Montoya JG, Laessig K, Fazeli MS, Siliman G, Yoon SS, Drake-Shanahan E, Zhu C, Akbary A, McLeod R. A fresh look at the role of spiramycin in preventing a neglected disease: meta-analyses of observational studies. Eur J Med Res. 2021 Dec 11; 26(1):143. PMID: 34895348; PMCID: PMC8665510.
      Citations: 4     Fields:    Translation:Humans
    3. El Mansouri B, Amarir F, Peyron F, Adlaoui EB, Piarroux R, Lykins J, El Abbassi M, Nekkal N, Bouhlal N, Makkaoui K, Barkat A, Lyaghfouri A, Zhou Y, Rais S, Oudghiri M, Elkoraichi I, Zekri M, Belkadi N, Mellouk H, Rhajaoui M, Boutajangout A, Sadak A, Limonne D, McLeod R, El Bissati K. High performance of a novel point-of-care blood test for Toxoplasma infection in women from diverse regions of Morocco. Emerg Microbes Infect. 2021 Dec; 10(1):1675-1682. PMID: 34165384; PMCID: PMC8381951.
      Citations: 2     Fields:    Translation:HumansAnimals
    4. Del Valle Mojica C, Montoya JG, McGuire J, Palma KL, Shekdar KV, McLeod R, Contopoulos-Ioannidis DG. Late Diagnosis of Congenital Toxoplasmosis with Macrocephaly in Dizygotic Twins after Incidental Detection of Leukocoria: A Case Report. J Pediatr. 2021 Sep; 236:301-306. PMID: 34023345; PMCID: PMC9642312.
      Citations: 3     Fields:    Translation:Humans
    5. El Bissati K, Zhou Y, Paulillo SM, Raman SK, Karch CP, Reed S, Estes A, Estes A, Lykins J, Burkhard P, McLeod R. Engineering and characterization of a novel Self Assembling Protein for Toxoplasma peptide vaccine in HLA-A*11:01, HLA-A*02:01 and HLA-B*07:02 transgenic mice. Sci Rep. 2020 10 12; 10(1):16984. PMID: 33046728; PMCID: PMC7552409.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    6. McPhillie MJ, Zhou Y, Hickman MR, Gordon JA, Weber CR, Li Q, Lee PJ, Amporndanai K, Johnson RM, Darby H, Woods S, Li ZH, Priestley RS, Ristroph KD, Biering SB, El Bissati K, Hwang S, Hakim FE, Dovgin SM, Lykins JD, Roberts L, Hargrave K, Cong H, Sinai AP, Muench SP, Dubey JP, Prud'homme RK, Lorenzi HA, Biagini GA, Moreno SN, Roberts CW, Antonyuk SV, Fishwick CWG, McLeod R. Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites. Front Cell Infect Microbiol. 2020; 10:203. PMID: 32626661; PMCID: PMC7311950.
      Citations: 9     Fields:    Translation:Animals
    7. McPhillie M, Zhou Y, El Bissati K, Dubey J, Lorenzi H, Capper M, Lukens AK, Hickman M, Muench S, Verma SK, Weber CR, Wheeler K, Gordon J, Sanders J, Moulton H, Wang K, Kim TK, He Y, Santos T, Woods S, Lee P, Donkin D, Kim E, Fraczek L, Lykins J, Esaa F, Alibana-Clouser F, Dovgin S, Weiss L, Brasseur G, Wirth D, Kent M, Hood L, Meunieur B, Roberts CW, Hasnain SS, Antonyuk SV, Fishwick C, McLeod R. Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections. Sci Rep. 2020 Mar 23; 10(1):5512. PMID: 32251362; PMCID: PMC7089975.
      Citations:    Fields:    
    8. McLone D, Frim D, Penn R, Swisher CN, Heydemann P, Boyer KM, Noble AG, Rabiah PK, Withers S, Wroblewski K, Karrison T, Hutson S, Wheeler K, Cohen W, Lykins J, McLeod R. Outcomes of hydrocephalus secondary to congenital toxoplasmosis. J Neurosurg Pediatr. 2019 Sep 06; 1-8. PMID: 31491752.
      Citations: 4     Fields:    
    9. Aguirre AA, Longcore T, Barbieri M, Dabritz H, Hill D, Klein PN, Lepczyk C, Lilly EL, McLeod R, Milcarsky J, Murphy CE, Su C, VanWormer E, Yolken R, Sizemore GC. Correction to: The One Health Approach to Toxoplasmosis: Epidemiology, Control, and Prevention Strategies. Ecohealth. 2019 Jun; 16(2):391. PMID: 31168721; PMCID: PMC6828319.
      Citations:    Fields:    
    10. Ng? HM, Zhou Y, Lorenzi H, Wang K, Kim TK, Zhou Y, El Bissati K, Mui E, Fraczek L, Rajagopala SV, Roberts CW, Henriquez FL, Montpetit A, Blackwell JM, Jamieson SE, Wheeler K, Begeman IJ, Naranjo-Galvis C, Alliey-Rodriguez N, Davis RG, Soroceanu L, Cobbs C, Steindler DA, Boyer K, Noble AG, Swisher CN, Heydemann PT, Rabiah P, Withers S, Soteropoulos P, Hood L, McLeod R. Publisher Correction: Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer. Sci Rep. 2019 May 28; 9(1):8110. PMID: 31133744; PMCID: PMC6536492.
      Citations:    Fields:    
    11. Aguirre AA, Longcore T, Barbieri M, Dabritz H, Hill D, Klein PN, Lepczyk C, Lilly EL, McLeod R, Milcarsky J, Murphy CE, Su C, VanWormer E, Yolken R, Sizemore GC. The One Health Approach to Toxoplasmosis: Epidemiology, Control, and Prevention Strategies. Ecohealth. 2019 06; 16(2):378-390. PMID: 30945159; PMCID: PMC6682582.
      Citations: 56     Fields:    Translation:HumansAnimals
    12. McLeod R, Wheeler K, Boyer K. . Congenital and Perinatal Infections Infectious Diseases of the Fetus and Newborn Infant. Congenital Toxoplasmosis. 2019.
    13. McLeod R, Boyer K. . Toxoplasmosis. 2019.
    14. Gomez CA, Budvytyte LN, Press C, Zhou L, McLeod R, Maldonado Y, Montoya JG, Contopoulos-Ioannidis DG. Evaluation of Three Point-of-Care Tests for Detection of Toxoplasma Immunoglobulin IgG and IgM in the United States: Proof of Concept and Challenges. Open Forum Infect Dis. 2018 Oct; 5(10):ofy215. PMID: 30393749; PMCID: PMC6204989.
      Citations: 9     
    15. Lykins JD, Filippova EV, Halavaty AS, Minasov G, Zhou Y, Dubrovska I, Flores KJ, Shuvalova LA, Ruan J, El Bissati K, Dovgin S, Roberts CW, Woods S, Moulton JD, Moulton H, McPhillie MJ, Muench SP, Fishwick CWG, Sabini E, Shanmugam D, Roos DS, McLeod R, Anderson WF, Ng? HM. CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii. Front Cell Infect Microbiol. 2018; 8:352. PMID: 30345257; PMCID: PMC6182094.
      Citations: 9     Fields:    Translation:AnimalsCells
    16. El Bissati K, Levigne P, Lykins J, Adlaoui EB, Barkat A, Berraho A, Laboudi M, El Mansouri B, Ibrahimi A, Rhajaoui M, Quinn F, Murugesan M, Seghrouchni F, G?mez-Mar?n JE, Peyron F, McLeod R. Global initiative for congenital toxoplasmosis: an observational and international comparative clinical analysis. Emerg Microbes Infect. 2018 Sep 27; 7(1):165. PMID: 30262847; PMCID: PMC6160433.
      Citations: 32     Fields:    Translation:HumansAnimalsPHPublic Health
    17. Lykins J, Li X, Levigne P, Zhou Y, El Bissati K, Clouser F, Wallon M, Morel F, Leahy K, El Mansouri B, Siddiqui M, Leong N, Michalowski M, Irwin E, Goodall P, Ismail M, Christmas M, Adlaoui EB, Rhajaoui M, Barkat A, Cong H, Begeman IJ, Lai BS, Contopoulos-Ioannidis DG, Montoya JG, Maldonado Y, Ramirez R, Press C, Peyron F, McLeod R. Rapid, inexpensive, fingerstick, whole-blood, sensitive, specific, point-of-care test for anti-Toxoplasma antibodies. PLoS Negl Trop Dis. 2018 08; 12(8):e0006536. PMID: 30114251; PMCID: PMC6095485.
      Citations: 11     Fields:    Translation:HumansAnimals
    18. Naranjo-Galvis CA, de-la-Torre A, Mantilla-Muriel LE, Beltr?n-Angarita L, Elcoroaristizabal-Mart?n X, McLeod R, Alliey-Rodriguez N, Begeman IJ, L?pez de Mesa C, G?mez-Mar?n JE, Sep?lveda-Arias JC. Genetic Polymorphisms in Cytokine Genes in Colombian Patients with Ocular Toxoplasmosis. Infect Immun. 2018 04; 86(4). PMID: 29426041; PMCID: PMC5865049.
      Citations: 9     Fields:    Translation:HumansCells
    19. Ng? HM, Zhou Y, Lorenzi H, Wang K, Kim TK, Zhou Y, El Bissati K, Mui E, Fraczek L, Rajagopala SV, Roberts CW, Henriquez FL, Montpetit A, Blackwell JM, Jamieson SE, Wheeler K, Begeman IJ, Naranjo-Galvis C, Alliey-Rodriguez N, Davis RG, Soroceanu L, Cobbs C, Steindler DA, Boyer K, Noble AG, Swisher CN, Heydemann PT, Rabiah P, Withers S, Soteropoulos P, Hood L, McLeod R. Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer. Sci Rep. 2017 09 13; 7(1):11496. PMID: 28904337; PMCID: PMC5597608.
      Citations: 49     Fields:    
    20. El Bissati K, Zhou Y, Paulillo SM, Raman SK, Karch CP, Roberts CW, Lanar DE, Reed S, Fox C, Carter D, Alexander J, Sette A, Sidney J, Lorenzi H, Begeman IJ, Burkhard P, McLeod R. Protein nanovaccine confers robust immunity against Toxoplasma. NPJ Vaccines. 2017; 2:24. PMID: 29263879; PMCID: PMC5627305.
      Citations: 23     
    21. Begeman IJ, Lykins J, Zhou Y, Lai BS, Levigne P, El Bissati K, Boyer K, Withers S, Clouser F, Noble AG, Rabiah P, Swisher CN, Heydemann PT, Contopoulos-Ioannidis DG, Montoya JG, Maldonado Y, Ramirez R, Press C, Stillwaggon E, Peyron F, McLeod R. Point-of-care testing for Toxoplasma gondii IgG/IgM using Toxoplasma ICT IgG-IgM test with sera from the United States and implications for developing countries. PLoS Negl Trop Dis. 2017 Jun; 11(6):e0005670. PMID: 28650970; PMCID: PMC5501679.
      Citations: 21     Fields:    Translation:HumansAnimals
    22. Edelblum KL, Sharon G, Singh G, Odenwald MA, Sailer A, Cao S, Ravens S, Thomsen I, El Bissati K, McLeod R, Dong C, Gurbuxani S, Prinz I, Mazmanian SK, Turner JR. The Microbiome Activates CD4 T-cell-mediated Immunity to?Compensate for Increased Intestinal Permeability. Cell Mol Gastroenterol Hepatol. 2017 Sep; 4(2):285-297. PMID: 28795125; PMCID: PMC5540699.
      Citations: 28     Fields:    
    23. Ying Y, Verma SK, Kwok OCH, Alibana F, Mcleod R, Su C, Dubey JP, Pradhan AK. Prevalence and genetic characterization of Toxoplasma gondii in free-range chickens from grocery stores and farms in Maryland, Ohio and Massachusetts, USA. Parasitol Res. 2017 May; 116(5):1591-1595. PMID: 28337538.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    24. Rengifo-Herrera C, Pile E, Garc?a A, P?rez A, P?rez D, Nguyen FK, de la Guardia V, Mcleod R, Caballero Z. Seroprevalence of Toxoplasma gondii in domestic pets from metropolitan regions of Panama. Parasite. 2017; 24:9. PMID: 28287391; PMCID: PMC5364778.
      Citations: 6     Fields:    Translation:Animals
    25. El Bissati K, Chentoufi AA, Krishack PA, Zhou Y, Woods S, Dubey JP, Vang L, Lykins J, Broderick KE, Mui E, Suzuki Y, Sa Q, Bi S, Cardona N, Verma SK, Fraczek L, Reardon CA, Sidney J, Alexander J, Sette A, Vedvick T, Fox C, Guderian JA, Reed S, Roberts CW, McLeod R. Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii. JCI Insight. 2016 09 22; 1(15):e85955. PMID: 27699241; PMCID: PMC5033759.
      Citations: 22     Fields:    Translation:AnimalsCells
    26. McPhillie M, Zhou Y, El Bissati K, Dubey J, Lorenzi H, Capper M, Lukens AK, Hickman M, Muench S, Verma SK, Weber CR, Wheeler K, Gordon J, Sanders J, Moulton H, Wang K, Kim TK, He Y, Santos T, Woods S, Lee P, Donkin D, Kim E, Fraczek L, Lykins J, Esaa F, Alibana-Clouser F, Dovgin S, Weiss L, Brasseur G, Wirth D, Kent M, Hood L, Meunieur B, Roberts CW, Hasnain SS, Antonyuk SV, Fishwick C, McLeod R. New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections. Sci Rep. 2016 07 14; 6:29179. PMID: 27412848; PMCID: PMC4944145.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    27. Lykins J, Wang K, Wheeler K, Clouser F, Dixon A, El Bissati K, Zhou Y, Lyttle C, Rzhetsky A, McLeod R. Understanding Toxoplasmosis in the United States Through "Large Data" Analyses. Clin Infect Dis. 2016 08 15; 63(4):468-75. PMID: 27353665; PMCID: PMC4967610.
      Citations: 20     Fields:    Translation:Humans
    28. McMurtrey C, Trolle T, Sansom T, Remesh SG, Kaever T, Bardet W, Jackson K, McLeod R, Sette A, Nielsen M, Zajonc DM, Blader IJ, Peters B, Hildebrand W. Toxoplasma gondii peptide ligands open the gate of the HLA class I binding groove. Elife. 2016 Jan 29; 5. PMID: 26824387; PMCID: PMC4775218.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    29. McLeod R, Wheeler KM, Boyer K. Reply to Wallon and Peyron. Clin Infect Dis. 2016 Mar 15; 62(6):812-4. PMID: 26689955; PMCID: PMC4772842.
      Citations: 2     Fields:    
    30. Contopoulos-Ioannidis D, Wheeler KM, Ramirez R, Press C, Mui E, Zhou Y, Van Tubbergen C, Prasad S, Maldonado Y, Withers S, Boyer KM, Noble AG, Rabiah P, Swisher CN, Heydemann P, Wroblewski K, Karrison T, Grigg ME, Montoya JG, McLeod R. Clustering of Toxoplasma gondii Infections Within Families of Congenitally Infected Infants. Clin Infect Dis. 2015 Dec 15; 61(12):1815-24. PMID: 26405150; PMCID: PMC4657536.
      Citations: 8     Fields:    Translation:Humans
    31. Hutson SL, Wheeler KM, McLone D, Frim D, Penn R, Swisher CN, Heydemann PT, Boyer KM, Noble AG, Rabiah P, Withers S, Montoya JG, Wroblewski K, Karrison T, Grigg ME, McLeod R. Patterns of Hydrocephalus Caused by Congenital Toxoplasma gondii Infection Associate With Parasite Genetics. Clin Infect Dis. 2015 Dec 15; 61(12):1831-4. PMID: 26405147; PMCID: PMC4657535.
      Citations: 15     Fields:    Translation:HumansAnimals
    32. Sanders JL, Zhou Y, Moulton HM, Moulton ZX, McLeod R, Dubey JP, Weiss LM, Kent ML. The zebrafish, Danio rerio, as a model for Toxoplasma gondii: an initial description of infection in fish. J Fish Dis. 2015 Jul; 38(7):675-9. PMID: 25951508; PMCID: PMC4548885.
      Citations: 10     Fields:    Translation:Animals
    33. Edelblum KL, Singh G, Odenwald MA, Lingaraju A, El Bissati K, McLeod R, Sperling AI, Turner JR. ?d Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice. Gastroenterology. 2015 Jun; 148(7):1417-26. PMID: 25747597; PMCID: PMC4685713.
      Citations: 54     Fields:    Translation:AnimalsCells
    34. El Bissati K, Zhou Y, Dasgupta D, Cobb D, Dubey JP, Burkhard P, Lanar DE, McLeod R. Effectiveness of a novel immunogenic nanoparticle platform for Toxoplasma peptide vaccine in HLA transgenic mice. Vaccine. 2014 May 30; 32(26):3243-8. PMID: 24736000; PMCID: PMC4084734.
      Citations: 37     Fields:    Translation:AnimalsCells
    35. McLeod R. Utility and limitations of T. gondii-specific IgM serum antibodies in the diagnosis of congenital toxoplasmosis in Porto Alegre. J Pediatr (Rio J). 2014 Jul-Aug; 90(4):329-31. PMID: 24726454.
      Citations: 3     Fields:    Translation:Humans
    36. Witola WH, Liu SR, Montpetit A, Welti R, Hypolite M, Roth M, Zhou Y, Mui E, Cesbron-Delauw MF, Fournie GJ, Cavailles P, Bisanz C, Boyer K, Withers S, Noble AG, Swisher CN, Heydemann PT, Rabiah P, Muench SP, McLeod R. ALOX12 in human toxoplasmosis. Infect Immun. 2014 Jul; 82(7):2670-9. PMID: 24686056; PMCID: PMC4097613.
      Citations: 15     Fields:    Translation:HumansCells
    37. Zhou Y, Fomovska A, Muench S, Lai BS, Mui E, McLeod R. Spiroindolone that inhibits PfATPase4 is a potent, cidal inhibitor of Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2014; 58(3):1789-92. PMID: 24366743; PMCID: PMC3957861.
      Citations: 14     Fields:    Translation:HumansAnimals
    38. Wilkinson C, McPhillie MJ, Zhou Y, Woods S, Afanador GA, Rawson S, Khaliq F, Prigge ST, Roberts CW, Rice DW, McLeod R, Fishwick CW, Muench SP. The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target. Bioorg Med Chem Lett. 2014 Feb 01; 24(3):911-6. PMID: 24398298; PMCID: PMC3966656.
      Citations: 3     Fields:    Translation:AnimalsCells
    39. Afanador GA, Muench SP, McPhillie M, Fomovska A, Sch?n A, Zhou Y, Cheng G, Stec J, Freundlich JS, Shieh HM, Anderson JW, Jacobus DP, Fidock DA, Kozikowski AP, Fishwick CW, Rice DW, Freire E, McLeod R, Prigge ST. Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay. Biochemistry. 2013 Dec 23; 52(51):9155-66. PMID: 24295325; PMCID: PMC3953223.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    40. Stec J, Fomovska A, Afanador GA, Muench SP, Zhou Y, Lai BS, El Bissati K, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Sommervile C, Woods S, Roberts CW, Rice D, Prigge ST, McLeod R, Kozikowski AP. Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii. ChemMedChem. 2013 Jul; 8(7):1138-60. PMID: 23776166; PMCID: PMC3755765.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    41. Muench SP, Stec J, Zhou Y, Afanador GA, McPhillie MJ, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Prigge ST, Rice DW, McLeod R. Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides. Bioorg Med Chem Lett. 2013 Jun 15; 23(12):3551-5. PMID: 23664871; PMCID: PMC3683578.
      Citations: 3     Fields:    Translation:AnimalsCells
    42. Cheng G, Muench SP, Zhou Y, Afanador GA, Mui EJ, Fomovska A, Lai BS, Prigge ST, Woods S, Roberts CW, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Rice DW, McLeod R. Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase. Bioorg Med Chem Lett. 2013 Apr 01; 23(7):2035-43. PMID: 23453069; PMCID: PMC3625046.
      Citations: 8     Fields:    Translation:AnimalsCells
    43. B?la SR, Dutra MS, Mui E, Montpetit A, Oliveira FS, Oliveira SC, Arantes RM, Antonelli LR, McLeod R, Gazzinelli RT. Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii. Infect Immun. 2012 Dec; 80(12):4298-308. PMID: 23027530; PMCID: PMC3497418.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    44. Fomovska A, Wood RD, Mui E, Dubey JP, Ferreira LR, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Welsh WJ, Sommerville C, Woods S, Roberts C, McLeod R. Salicylanilide inhibitors of Toxoplasma gondii. J Med Chem. 2012 Oct 11; 55(19):8375-91. PMID: 22970937; PMCID: PMC3498903.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    45. Lai BS, Witola WH, El Bissati K, Zhou Y, Mui E, Fomovska A, McLeod R. Molecular target validation, antimicrobial delivery, and potential treatment of Toxoplasma gondii infections. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14182-7. PMID: 22891343; PMCID: PMC3435209.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    46. Fayez R, Roy M, Villeneuve S, AlMuntashery A, Demyttenaere S, Christou N, Court O, Bodie G, Bonrath E, Hagen J, Okrainec A, Sullivan P, Grantcharov T, Almamar A, Sharma A, Karmali S, Birch DW, Gill RS, Majumdar SR, Wang X, Tuepah R, Klarenbach SW, Birch DW, Karmali S, Sharma AM, Padwal RJ, Ra?che I, Smith C, Haggar F, Moloo H, Poulin EC, Martel G, Yelle JD, Mamazza J, Mueller CL, Jackson TD, Penner T, Pitzul K, Urbach DR, Moustarah F, Biertho L, Hould FS, Lebel S, Lescelleur O, Marceau S, Marceau P, Biron S, Khokhotva M, Grantcharov T, Anvari M, Sharma A, Yusuf S, Kwong J, Okrainec A, Pitzul KB, Urbach DR, Jackson T, Elkassem S, Lindsay D, Sullivan P, Smith L, Bonrath E, Zevin B, Dedy N, Grantcharov TP, Zevin B, Bonrath EM, Aggarwal R, Grantcharov T, Sockalingam S, Cassin S, Crawford S, Pitzul K, Khan A, Hawa R, Jackson T, Okrainec A, Smith C, Brar B, Mamazza J, Ra?che I, Yelle JD, Haggar F, Moloo H, Dent R, Whitlock KA, Gill RS, Ali T, Shi X, Birch DW, Karmali S, Gill RS, Whitlock KA, Shi X, Sarkhosh K, Birch DW, Karmali S, Suri M, Turner JM, Nation PN, Wizzard P, Brubaker PL, Gisalet DL, Wales PW, Palter VN, Grantcharov TP, Wakeam E, Tien H, Spencer F, Brenneman F, Khan RSA, Kowal J, Wiseman SM, Martelli V, Fraser SA, Vedel I, Deban M, Holcroft C, Monette M, Monette J, Bergman S, Malik A, Bell C, Stukel T, Urbach DR, Young PY, Mueller TF, Lucykx VA, Lukowski CM, Compston CA, Churchill TA, Khadaroo RG, Daigle C, Grantcharov T, McCreery G, Vogt K, Dubois L, Gray D, Seth R, Ananth A, Tai LH, Lam T, Falls T, Souza C, Bell J, Auer R, Paskar D, Crawford S, Parry N, Leslie K, Sudarshan M, Alhabboubi M, St-Louis E, Deckelbaum D, Razek T, Feldman LS, Khwaja K, Richardson D, Porter G, Johnson P, Haggar F, Boushey R, Moloo H, Raiche I, Mamazza J, Davis VW, Schiller DE, Eurich D, Sawyer MB, Rivard J, Vergis A, Unger B, Hardy K, Andrew C, Gillman L, Park J, Agzarian J, Prodger J, Kelly W, Kelly S, Prodger D, Racz J, Ewara E, Martin J, Sarma S, Chu M, Schlachta C, Zaric G, Winocour J, Al-Ali K, Briggs K, George R, Zilbert NR, Murnaghan ML, Leung A, Regehr G, Moulton CA, Decker C, Neumann K, Mahmud S, Metcalfe J, McKay A, Park J, Hochman D, Gosney JE, Burkle FM, Redmond AD, McQueen K, Wissanji H, Desrosiers E, Gilbert A, Chadi SA, Leslie K, Ott MC, Alhabboubi M, Sudarshan M, Jessula S, Alburakan A, Deckelbaum D, Razek T, Iqbal S, Khwaja K, Partridge E, Aikins C, Alhabboubi M, Sudarshan M, Deckelbaum D, Iqbal S, Khwaja K, Razek T, Olszewski M, Roberts N, Moulton CA, Murnaghan ML, Cil T, Chan R, Marshall J, Pederson K, Erichsen S, White J, Nadler A, Aarts MA, Okrainec A, Victor JC, Pearsall E, McLeod RS, Hameed U, Jackson TD, Okrainec A, Penner TP, Urbach DR, Brotherhood H, Karimuddin A, Hall C, Bawan S, Malik S, Hayashi A, Menezes AS, Gill RS, McAlister C, Zhang N, DesRosiers E, Mills A, Crozier M, Lee L, Maxwell J, Partridge E, Chad S, Steigerwald S, Mapiour D, Roberts D, MacPherson C, Donahoe L, MacDonald B, Mercer D, Hopman W, Rakovich G, Latulippe JF, Hilsden R, Knowles S, Moffat B, Parry N, Merani S, Switzer N, Tul Y, Widder S, Davis P, Molinari M, Levy A, Johnson P, Davis PJB, Bailey J, Molinari M, Hayden J, Johnson P, Cools-Lartigue J, Benlolo S, Marcus V, Ferri L, Ojah J, Finley R, Anderson D, Julien F, Gagn? JP, Carter D, Chan S, Wong S, Li J, Michael A, Choi D, Liu E, Hoogenes J, Dath D, Pitt D, Aubin JM, Banks BA, Mew D, McConnell Y, Rudovics A, Classen D, Kanthan S, Ravichandran P, Croome KP, Kovacs MJ, Lazo-Langner A, Hernandez-Alejandro R, Anantha R, Crawford S, Parry N, Leslie K, Aad I, Kholdebarin R, Khoshgoo N, Iwasiow BM, Keijzer R, Aird LNF, Brown CJ, Wong SL, Isa D, Pace D, Payne JRM, Widder S, Tul Y, Primrose M, Hudson D, Khadaroo RG, Hallet J, Lauzier F, Mailloux O, Trottier V, ARchambault P, Zarychanski R, Turgeon AF, Farries L, Hardy P, Muirhead RM, Raiche I, Masters J, Haggar F, Poulin HMEC, Martel G, Mamazza J, Botkin C, Milbrandt C, Keijzer R, Morency D, Sideris L, Grenier-Vall?e P, Latulippe JF, et al. Canadian Surgery Forum. Can J Surg. 2012 Aug; 55(4 Suppl 1):S63-S135. PMID: 35488395; PMCID: PMC3432251.
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    47. McLeod R, Boyer KM, Lee D, Mui E, Wroblewski K, Karrison T, Noble AG, Withers S, Swisher CN, Heydemann PT, Sautter M, Babiarz J, Rabiah P, Meier P, Grigg ME, Toxoplasmosis Study Group. Prematurity and severity are associated with Toxoplasma gondii alleles (NCCCTS, 1981-2009). Clin Infect Dis. 2012 Jun; 54(11):1595-605. PMID: 22499837; PMCID: PMC3348955.
      Citations: 66     Fields:    Translation:HumansAnimals
    48. Stec J, Huang Q, Pieroni M, Kaiser M, Fomovska A, Mui E, Witola WH, Bettis S, McLeod R, Brun R, Kozikowski AP. Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania. J Med Chem. 2012 Apr 12; 55(7):3088-100. PMID: 22352841; PMCID: PMC3330251.
      Citations: 10     Fields:    Translation:Animals
    49. Burrowes D, Boyer K, Swisher CN, Noble AG, Sautter M, Heydemann P, Rabiah P, Lee D, McLeod R, the Toxoplasmosis Study Group. Spinal Cord Lesions in Congenital Toxoplasmosis Demonstrated with Neuroimaging, Including Their Successful Treatment in an Adult. J Neuroparasitology. 2012 Mar; 3(2012). PMID: 23487348; PMCID: PMC3593714.
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    50. Fomovska A, Huang Q, El Bissati K, Mui EJ, Witola WH, Cheng G, Zhou Y, Sommerville C, Roberts CW, Bettis S, Prigge ST, Afanador GA, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Pieroni M, Stec J, Muench SP, Rice DW, Kozikowski AP, McLeod R. Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway. Antimicrob Agents Chemother. 2012 May; 56(5):2666-82. PMID: 22354304; PMCID: PMC3346615.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    51. Olariu TR, Remington JS, McLeod R, Alam A, Montoya JG. Severe congenital toxoplasmosis in the United States: clinical and serologic findings in untreated infants. Pediatr Infect Dis J. 2011 Dec; 30(12):1056-61. PMID: 21956696.
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    52. Dubey JP, Ferreira LR, Martins J, McLeod R. Oral oocyst-induced mouse model of toxoplasmosis: effect of infection with Toxoplasma gondii strains of different genotypes, dose, and mouse strains (transgenic, out-bred, in-bred) on pathogenesis and mortality. Parasitology. 2012 Jan; 139(1):1-13. PMID: 22078010; PMCID: PMC3683600.
      Citations: 31     Fields:    Translation:AnimalsCells
    53. Boyer K, Hill D, Mui E, Wroblewski K, Karrison T, Dubey JP, Sautter M, Noble AG, Withers S, Swisher C, Heydemann P, Hosten T, Babiarz J, Lee D, Meier P, McLeod R, Toxoplasmosis Study Group. Unrecognized ingestion of Toxoplasma gondii oocysts leads to congenital toxoplasmosis and causes epidemics in North America. Clin Infect Dis. 2011 Dec; 53(11):1081-9. PMID: 22021924; PMCID: PMC3246875.
      Citations: 60     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    54. Cong H, Mui EJ, Witola WH, Sidney J, Alexander J, Sette A, Maewal A, El Bissati K, Zhou Y, Suzuki Y, Lee D, Woods S, Sommerville C, Henriquez FL, Roberts CW, McLeod R. Toxoplasma gondii HLA-B*0702-restricted GRA7(20-28) peptide with adjuvants and a universal helper T cell epitope elicits CD8(+) T cells producing interferon-? and reduces parasite burden in HLA-B*0702 mice. Hum Immunol. 2012 Jan; 73(1):1-10. PMID: 22027386; PMCID: PMC3246109.
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    55. Stillwaggon E, Carrier CS, Sautter M, McLeod R. Maternal serologic screening to prevent congenital toxoplasmosis: a decision-analytic economic model. PLoS Negl Trop Dis. 2011 Sep; 5(9):e1333. PMID: 21980546; PMCID: PMC3181241.
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    56. Delair E, Latkany P, Noble AG, Rabiah P, McLeod R, Br?zin A. Clinical manifestations of ocular toxoplasmosis. Ocul Immunol Inflamm. 2011 Apr; 19(2):91-102. PMID: 21428746.
      Citations: 29     Fields:    Translation:Humans
    57. Hill D, Coss C, Dubey JP, Wroblewski K, Sautter M, Hosten T, Mu?oz-Zanzi C, Mui E, Withers S, Boyer K, Hermes G, Coyne J, Jagdis F, Burnett A, McLeod P, Morton H, Robinson D, McLeod R. Identification of a sporozoite-specific antigen from Toxoplasma gondii. J Parasitol. 2011 Apr; 97(2):328-37. PMID: 21506817; PMCID: PMC3684278.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    58. Kortagere S, Mui E, McLeod R, Welsh WJ. Rapid discovery of inhibitors of Toxoplasma gondii using hybrid structure-based computational approach. J Comput Aided Mol Des. 2011 May; 25(5):403-11. PMID: 21359560.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    59. Cong H, Mui EJ, Witola WH, Sidney J, Alexander J, Sette A, Maewal A, McLeod R. Human immunome, bioinformatic analyses using HLA supermotifs and the parasite genome, binding assays, studies of human T cell responses, and immunization of HLA-A*1101 transgenic mice including novel adjuvants provide a foundation for HLA-A03 restricted CD8+T cell epitope based, adjuvanted vaccine protective against Toxoplasma gondii. Immunome Res. 2010 Dec 03; 6:12. PMID: 21129215; PMCID: PMC3009956.
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    60. Witola WH, Mui E, Hargrave A, Liu S, Hypolite M, Montpetit A, Cavailles P, Bisanz C, Cesbron-Delauw MF, Fourni? GJ, McLeod R. NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells. Infect Immun. 2011 Feb; 79(2):756-66. PMID: 21098108; PMCID: PMC3028851.
      Citations: 93     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    61. Hutson SL, Mui E, Kinsley K, Witola WH, Behnke MS, El Bissati K, Muench SP, Rohrman B, Liu SR, Wollmann R, Ogata Y, Sarkeshik A, Yates JR, McLeod R. T. gondii RP promoters & knockdown reveal molecular pathways associated with proliferation and cell-cycle arrest. PLoS One. 2010 Nov 22; 5(11):e14057. PMID: 21124925; PMCID: PMC2989910.
      Citations: 17     Fields:    Translation:AnimalsCellsPHPublic Health
    62. Cong H, Mui EJ, Witola WH, Sidney J, Alexander J, Sette A, Maewal A, McLeod R. Towards an immunosense vaccine to prevent toxoplasmosis: protective Toxoplasma gondii epitopes restricted by HLA-A*0201. Vaccine. 2011 Jan 17; 29(4):754-62. PMID: 21095258; PMCID: PMC3014376.
      Citations: 29     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    63. Tipparaju SK, Muench SP, Mui EJ, Ruzheinikov SN, Lu JZ, Hutson SL, Kirisits MJ, Prigge ST, Roberts CW, Henriquez FL, Kozikowski AP, Rice DW, McLeod RL. Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase. J Med Chem. 2010 Sep 09; 53(17):6287-300. PMID: 20698542; PMCID: PMC2932859.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    64. Atlas H, Safa N, Denis R, Garneau P, Moustarah F, Marceau S, Lebel S, Biertho L, Hould F, Marceau P, Biron S, Anvari M, Sharma A, Goldsmith CH, Lacobellis G, Cadeddu M, Misra M, Taylor V, Tarride J, Hubert E, Tiboni M, Hong D, Wiebe S, Klassen D, Bonjer J, Lawlor D, Plowman J, Ransom T, Vallis M, Ellsmere J, Graham PJ, Kaban GK, Vizhul A, Birch DW, Menezes AC, Shi X, Karmali S, Seth R, MacKenzie L, Kus A, Bell J, Carrier M, Atkins H, Boushey R, Auer R, Croome KP, Yamashita M, Aarts MA, Okrainec A, Glicksman A, Pearsall E, Pitzul K, Huang H, McLeod RS, Sarkhosh K, Robertson M, Boctor D, Lam V, Sigalet D, Johner A, Faulds J, Wiseman SM, Pemberton J, Gordon ML, Prashad C, Rambaran M, Cameron B, Neville A, Sarosi GA, Wei Y, Gibbs JO, Reda DJ, McCarthy M, Fitzgibbons RJ, Barkun JST, Fenech DS, Forbes S, Chung J, Glickman A, Victor JC, Nathens A, Fitzmaurice GJ, Mone F, Brown R, Cranley B, Conlon EF, Todd RAJ, O'Donnell ME, Tran TT, Kaneva PA, Finch LE, Fried GM, Mayo NE, Feldman LS, VanHouwellingen L, Vogt KN, Stewart TC, Williamson J, Parry N, DeRose G, Gray D, Harriman S, Rodych N, Hayes P, Moser M, Jamal MH, Doi S, Rousseau M, Snell L, Meterissian S, Zolfaghari S, Friedlich MS, Kurashima Y, Al-Sabah S, Kaneva PA, Feldman LS, Fried GM, Vassiliou MC, Tran TT, Kaneva PA, Mayo NE, Fried GM, Feldman LS, Sheth U, Fenech D, McKenzie M, Ghaderi I, Vaillancourt M, Sroka G, Kaneva PA, Vassiliou MC, Seagull FJ, Sutton E, Godinez C, George I, Park A, Choy I, Okrainec A, Brintzenhoff R, Prabhu A, Heniford BT, Stefanidis D, Fried GM, Feldman LS, Igric A, Vogt KN, Girotti M, Parry NG, Vinden C, Kim SHH, Zhang NN, Russo JJ, El-Salfiti IK, Kowalczuk M, Rajaee AN, Bal M, Gill MS, Lysecki PJ, Hoogenes J, Dath D, Nassar AK, Reid S, Mohaisen KN, Winch J, Omar D, Hanna WC, Mulder DS, El-Hilali MM, Khwaja KA, Jamal MH, Rayment J, Doi SA, Megueditchian A, Meterissian S, Tso D, Langer M, Blair G, Butterworth S, Vaillancourt M, Bergman S, Davenport E, Haggar F, Trottier D, Huynh H, Soto C, Shamji FM, Seely A, Sundaresan S, Pagliarello G, Tadros S, Yelle JD, Maziak D, Moloo H, Poulin EC, Mamazza J, Knowlton LM, Chackungal S, MacQueen KA, Anvari M, Allen C, Goldsmith C, ELVIS Research Group, Ghaderi I, Madani A, de Gara C, Schlachta CM, Zakrison TL, Tee MC, Chan S, Nguyen V, Yang J, Holmes D, Levine D, Bugis S, Wiseman SM, Sandhu L, Zhai J, Kennedy ED, Baxter NN, Gagliardi AR, Urbach DR, Wei AC, Sabalbal M, McAlister VC, Balayla J, Bergman S, Feldman LS, Ghitulescu G, Fraser SA, Daigle R, Urquart R, Cox M, Grunfeld E, Porter G, Hallet J, Labidi S, Clairoux A, Gagn? JP, Gill RS, Manouchehri N, Liu JQ, Lee TF, Bigam DL, Cheung PY, Van Koughnett JA, Colquhoun PH, Gordon ML, Cornacchi S, Farrokhyar F, Hodgson N, Porter G, Quan ML, Wright F, Lovrics P, Datta I, Brar SS, Ball CG, Heine JA, Rothwell B, Crozier M, Ting H, Boone D, O'Regan N, Brown C, Bandrauk N, Hapgood J, Hogan M, McDonald LA, Da'as S, Sorensen PHB, Berman JN, Ameer A, Jamal M, Aljiffry M, Doi S, Hasanain M, Chaudhury P, Metrakos P, Tchervenkov J, Lapierre S, Mohammad W, Balaa N, Akil M, Mimeault R, Fairfull-Smith R, Teague BD, Butler MS, Garneau PY, Sample CB, Kapoor A, Cadeddu MO, Anvari M, Hanna WC, Jamal MH, Nguyen L, Kwan K, Wallis CJD, Jones S, Fraser T, Masterso J, Blair G, Duffy D, Roberts DJ, Kirkpatrick AW, Datta I, Feliciano DV, Kortbeek JB, Laupland KB, Ball CG, Haggar F, Davenport E, Moloo H, Mamazza J, Manouchehri N, Bigam D, Churchill T, Joynt C, Cheung PY, Al-Sairafi R, Sample CB, Paquette F, Fraser SA, Feldman LS, Fried GM, Weissglas I, Ghitulescu G, Meterissian S, Bergman S, Al-Dohayan A, Al-Naami M, Bamehriz F, Madkhali A, Hallet J, LeBlanc M, Gilbert A, Daigle C, Tien G, Atkins MS, Zheng B, Tanin H, Swindells C, Meneghetti A, Panton ONM, Qayumi AK, Chhiv M, Drolet S, Sirois-Gigu?re ?, Gilbert A, Doyle JD, Sheth U, Huang H, Pearsall E, McLeod RS, Nathens AB, Suri RR, Vora P, Kirby JM, Chan K, et al. Canadian Surgery Forum. Can J Surg. 2010 Aug; 53(4):S51-S104. PMID: 35488396; PMCID: PMC2912011.
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    65. Henriquez FL, Woods S, Cong H, McLeod R, Roberts CW. Immunogenetics of Toxoplasma gondii informs vaccine design. Trends Parasitol. 2010 Nov; 26(11):550-5. PMID: 20580611.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    66. Lees MP, Fuller SJ, McLeod R, Boulter NR, Miller CM, Zakrzewski AM, Mui EJ, Witola WH, Coyne JJ, Hargrave AC, Jamieson SE, Blackwell JM, Wiley JS, Smith NC. P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages. J Immunol. 2010 Jun 15; 184(12):7040-6. PMID: 20488797; PMCID: PMC2931343.
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    67. Tan TG, Mui E, Cong H, Witola WH, Montpetit A, Muench SP, Sidney J, Alexander J, Sette A, Grigg ME, Maewal A, McLeod R. Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans. Vaccine. 2010 May 21; 28(23):3977-89. PMID: 20347630; PMCID: PMC2895808.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    68. Noble AG, Latkany P, Kusmierczyk J, Mets M, Rabiah P, Boyer K, Jalbrzikowski J, Wroblewski K, Karrison T, Swisher CN, Mieler WF, Meier P, McLeod R, the Toxoplasmosis Study Group. Chorioretinal lesions in mothers of children with congenital toxoplasmosis in the National Collaborative Chicago-based, Congenital Toxoplasmosis Study. Sci Med (Porto Alegre). 2010; 20(1):20-26. PMID: 22577474; PMCID: PMC3347882.
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    69. Jamieson SE, Cordell H, Petersen E, McLeod R, Gilbert RE, Blackwell JM. Host genetic and epigenetic factors in toxoplasmosis. Mem Inst Oswaldo Cruz. 2009 Mar; 104(2):162-9. PMID: 19430638; PMCID: PMC2735098.
      Citations: 11     Fields:    Translation:Humans
    70. McLeod R, Kieffer F, Sautter M, Hosten T, Pelloux H. Why prevent, diagnose and treat congenital toxoplasmosis? Mem Inst Oswaldo Cruz. 2009 Mar; 104(2):320-44. PMID: 19430661; PMCID: PMC2735102.
      Citations: 58     Fields:    Translation:HumansAnimalsPHPublic Health
    71. Hermes G, Ajioka JW, Kelly KA, Mui E, Roberts F, Kasza K, Mayr T, Kirisits MJ, Wollmann R, Ferguson DJ, Roberts CW, Hwang JH, Trendler T, Kennan RP, Suzuki Y, Reardon C, Hickey WF, Chen L, McLeod R. Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection. J Neuroinflammation. 2008 Oct 23; 5:48. PMID: 18947414; PMCID: PMC2588578.
      Citations: 86     Fields:    Translation:AnimalsCells
    72. Benevento JD, Jager RD, Noble AG, Latkany P, Mieler WF, Sautter M, Meyers S, Mets M, Grassi MA, Rabiah P, Boyer K, Swisher C, McLeod R, Toxoplasmosis Study Group. Toxoplasmosis-associated neovascular lesions treated successfully with ranibizumab and antiparasitic therapy. Arch Ophthalmol. 2008 Aug; 126(8):1152-6. PMID: 18695115; PMCID: PMC2741687.
      Citations: 22     Fields:    Translation:Humans
    73. Phan L, Kasza K, Jalbrzikowski J, Noble AG, Latkany P, Kuo A, Mieler W, Meyers S, Rabiah P, Boyer K, Swisher C, Mets M, Roizen N, Cezar S, Sautter M, Remington J, Meier P, McLeod R, Toxoplasmosis Study Group. Longitudinal study of new eye lesions in children with toxoplasmosis who were not treated during the first year of life. Am J Ophthalmol. 2008 Sep; 146(3):375-384. PMID: 18619570; PMCID: PMC2747816.
      Citations: 33     Fields:    Translation:HumansAnimals
    74. Jamieson SE, de Roubaix LA, Cortina-Borja M, Tan HK, Mui EJ, Cordell HJ, Kirisits MJ, Miller EN, Peacock CS, Hargrave AC, Coyne JJ, Boyer K, Bessieres MH, Buffolano W, Ferret N, Franck J, Kieffer F, Meier P, Nowakowska DE, Paul M, Peyron F, Stray-Pedersen B, Prusa AR, Thulliez P, Wallon M, Petersen E, McLeod R, Gilbert RE, Blackwell JM. Genetic and epigenetic factors at COL2A1 and ABCA4 influence clinical outcome in congenital toxoplasmosis. PLoS One. 2008 Jun 04; 3(6):e2285. PMID: 18523590; PMCID: PMC2390765.
      Citations: 39     Fields:    Translation:Humans
    75. Mui EJ, Schiehser GA, Milhous WK, Hsu H, Roberts CW, Kirisits M, Muench S, Rice D, Dubey JP, Fowble JW, Rathod PK, Queener SF, Liu SR, Jacobus DP, McLeod R. Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo. PLoS Negl Trop Dis. 2008 Mar 05; 2(3):e190. PMID: 18320016; PMCID: PMC2254147.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    76. Bott? C, Sa?dani N, Mondragon R, Mondrag?n M, Isaac G, Mui E, McLeod R, Dubremetz JF, Vial H, Welti R, Cesbron-Delauw MF, Mercier C, Mar?chal E. Subcellular localization and dynamics of a digalactolipid-like epitope in Toxoplasma gondii. J Lipid Res. 2008 Apr; 49(4):746-62. PMID: 18182683.
      Citations: 11     Fields:    Translation:AnimalsCells
    77. Arun V, Noble AG, Latkany P, Troia RN, Jalbrzikowski J, Kasza K, Karrison T, Cezar S, Sautter M, Greenwald MJ, Mieler W, Mets MB, Alam A, Boyer K, Swisher CN, Roizen N, Rabiah P, Del Monte MA, McLeod R, Toxoplasmosis Study Group. Cataracts in congenital toxoplasmosis. J AAPOS. 2007 Dec; 11(6):551-4. PMID: 18086432; PMCID: PMC2194289.
      Citations: 11     Fields:    Translation:Humans
    78. Welti R, Mui E, Sparks A, Wernimont S, Isaac G, Kirisits M, Roth M, Roberts CW, Bott? C, Mar?chal E, McLeod R. Lipidomic analysis of Toxoplasma gondii reveals unusual polar lipids. Biochemistry. 2007 Dec 04; 46(48):13882-90. PMID: 17988103; PMCID: PMC2576749.
      Citations: 33     Fields:    Translation:HumansAnimals
    79. Phan L, Kasza K, Jalbrzikowski J, Noble AG, Latkany P, Kuo A, Mieler W, Meyers S, Rabiah P, Boyer K, Swisher C, Mets M, Roizen N, Cezar S, Remington J, Meier P, McLeod R, Toxoplasmosis Study Group. Longitudinal study of new eye lesions in treated congenital toxoplasmosis. Ophthalmology. 2008 Mar; 115(3):553-559.e8. PMID: 17825418.
      Citations: 22     Fields:    Translation:Humans
    80. Muench SP, Prigge ST, McLeod R, Rafferty JB, Kirisits MJ, Roberts CW, Mui EJ, Rice DW. Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents. Acta Crystallogr D Biol Crystallogr. 2007 Mar; 63(Pt 3):328-38. PMID: 17327670; PMCID: PMC2483495.
      Citations: 20     Fields:    Translation:AnimalsCells
    81. Richards TA, Dacks JB, Campbell SA, Blanchard JL, Foster PG, McLeod R, Roberts CW. Evolutionary origins of the eukaryotic shikimate pathway: gene fusions, horizontal gene transfer, and endosymbiotic replacements. Eukaryot Cell. 2006 Sep; 5(9):1517-31. PMID: 16963634; PMCID: PMC1563581.
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    82. Roizen N, Kasza K, Karrison T, Mets M, Noble AG, Boyer K, Swisher C, Meier P, Remington J, Jalbrzikowski J, McLeod R, Kipp M, Rabiah P, Chamot D, Estes R, Cezar S, Mack D, Pfiffner L, Stein M, Danis B, Patel D, Hopkins J, Holfels E, Stein L, Withers S, Cameron A, Perkins J, Heydemann P. Impact of visual impairment on measures of cognitive function for children with congenital toxoplasmosis: implications for compensatory intervention strategies. Pediatrics. 2006 Aug; 118(2):e379-90. PMID: 16864640.
      Citations: 18     Fields:    Translation:Humans
    83. Kennedy ED, Rothwell DM, Cohen Z, McLeod RS. Increased experience and surgical technique lead to improved outcome after ileal pouch-anal anastomosis: a population-based study. Dis Colon Rectum. 2006 Jul; 49(7):958-65. PMID: 16703449.
      Citations: 7     Fields:    Translation:Humans
    84. Muench SP, Prigge ST, Zhu L, Kirisits MJ, Roberts CW, Wernimont S, McLeod R, Rice DW. Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jun 01; 62(Pt 6):604-6. PMID: 16754994; PMCID: PMC2243092.
      Citations: 7     Fields:    Translation:AnimalsCells
    85. McLeod R, Boyer K, Karrison T, Kasza K, Swisher C, Roizen N, Jalbrzikowski J, Remington J, Heydemann P, Noble AG, Mets M, Holfels E, Withers S, Latkany P, Meier P, Toxoplasmosis Study Group. Outcome of treatment for congenital toxoplasmosis, 1981-2004: the National Collaborative Chicago-Based, Congenital Toxoplasmosis Study. Clin Infect Dis. 2006 May 15; 42(10):1383-94. PMID: 16619149.
      Citations: 86     Fields:    Translation:Humans
    86. McLeod R, Khan AR, Noble GA, Latkany P, Jalbrzikowski J, Boyer K, Toxoplasmosis Study Group. Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis. Pediatr Infect Dis J. 2006 Mar; 25(3):270-2. PMID: 16511396.
      Citations: 23     Fields:    Translation:HumansAnimals
    87. Mui EJ, Jacobus D, Milhous WK, Schiehser G, Hsu H, Roberts CW, Kirisits MJ, McLeod R. Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2005 Aug; 49(8):3463-7. PMID: 16048961; PMCID: PMC1196210.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    88. Boyer KM, Holfels E, Roizen N, Swisher C, Mack D, Remington J, Withers S, Meier P, McLeod R, Toxoplasmosis Study Group. Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: Implications for prenatal management and screening. Am J Obstet Gynecol. 2005 Feb; 192(2):564-71. PMID: 15696004.
      Citations: 52     Fields:    Translation:Humans
    89. Henriquez FL, Richards TA, Roberts F, McLeod R, Roberts CW. The unusual mitochondrial compartment of Cryptosporidium parvum. Trends Parasitol. 2005 Feb; 21(2):68-74. PMID: 15664529.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    90. Roberts CW, Roberts F, Henriquez FL, Akiyoshi D, Samuel BU, Richards TA, Milhous W, Kyle D, McIntosh L, Hill GC, Chaudhuri M, Tzipori S, McLeod R. Evidence for mitochondrial-derived alternative oxidase in the apicomplexan parasite Cryptosporidium parvum: a potential anti-microbial agent target. Int J Parasitol. 2004 Mar 09; 34(3):297-308. PMID: 15003491.
      Citations: 25     Fields:    Translation:AnimalsCells
    91. Samuel BU, Hearn B, Mack D, Wender P, Rothbard J, Kirisits MJ, Mui E, Wernimont S, Roberts CW, Muench SP, Rice DW, Prigge ST, Law AB, McLeod R. Delivery of antimicrobials into parasites. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14281-6. PMID: 14623959; PMCID: PMC283583.
      Citations: 32     Fields:    Translation:AnimalsCells
    92. Muench SP, Rafferty JB, McLeod R, Rice DW, Prigge ST. Expression, purification and crystallization of the Plasmodium falciparum enoyl reductase. Acta Crystallogr D Biol Crystallogr. 2003 Jul; 59(Pt 7):1246-8. PMID: 12832774.
      Citations: 22     Fields:    Translation:AnimalsCells
    93. Br?zin AP, Thulliez P, Couvreur J, Nobr? R, Mcleod R, Mets MB. Ophthalmic outcomes after prenatal and postnatal treatment of congenital toxoplasmosis. Am J Ophthalmol. 2003 Jun; 135(6):779-84. PMID: 12788116.
      Citations: 18     Fields:    Translation:HumansPHPublic Health
    94. Johnson JJ, Roberts CW, Pope C, Roberts F, Kirisits MJ, Estes R, Mui E, Krieger T, Brown CR, Forman J, McLeod R. In vitro correlates of Ld-restricted resistance to toxoplasmic encephalitis and their critical dependence on parasite strain. J Immunol. 2002 Jul 15; 169(2):966-73. PMID: 12097403.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    95. Lyons RE, McLeod R, Roberts CW. Toxoplasma gondii tachyzoite-bradyzoite interconversion. Trends Parasitol. 2002 May; 18(5):198-201. PMID: 11983592.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    96. Roberts CW, Roberts F, Lyons RE, Kirisits MJ, Mui EJ, Finnerty J, Johnson JJ, Ferguson DJ, Coggins JR, Krell T, Coombs GH, Milhous WK, Kyle DE, Tzipori S, Barnwell J, Dame JB, Carlton J, McLeod R. The shikimate pathway and its branches in apicomplexan parasites. J Infect Dis. 2002 Feb 15; 185 Suppl 1:S25-36. PMID: 11865437.
      Citations: 32     Fields:    Translation:AnimalsCells
    97. Johnson J, Suzuki Y, Mack D, Mui E, Estes R, David C, Skamene E, Forman J, McLeod R. Genetic analysis of influences on survival following Toxoplasma gondii infection. Int J Parasitol. 2002 Feb; 32(2):179-85. PMID: 11812495.
      Citations: 17     Fields:    Translation:Animals
    98. Rioux JD, Daly MJ, Silverberg MS, Lindblad K, Steinhart H, Cohen Z, Delmonte T, Kocher K, Miller K, Guschwan S, Kulbokas EJ, O'Leary S, Winchester E, Dewar K, Green T, Stone V, Chow C, Cohen A, Langelier D, Lapointe G, Gaudet D, Faith J, Branco N, Bull SB, McLeod RS, Griffiths AM, Bitton A, Greenberg GR, Lander ES, Siminovitch KA, Hudson TJ, Rioux JD, Daly MJ, Silverberg MS, Lindblad K, Steinhart H, Cohen Z, Delmonte T, Kocher K, Miller K, Guschwan S, Kulbokas EJ, O'Leary S, Winchester E, Dewar K, Green T, Stone V, Chow C, Cohen A, Langelier D, Lapointe G, Gaudet D, Faith J, Branco N, Bull SB, McLeod RS, Griffiths AM, Bitton A, Greenberg GR, Lander ES, Siminovitch KA, Hudson TJ. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet. 2001 Oct; 29(2):223-8. PMID: 11586304.
      Citations: 210     Fields:    Translation:HumansCells
    99. Thompson-Fawcett MW, Marcus V, Redston M, Cohen Z, McLeod RS, Thompson-Fawcett MW, Marcus V, Redston M, Cohen Z, McLeod RS. Risk of dysplasia in long-term ileal pouches and pouches with chronic pouchitis. Gastroenterology. 2001 Aug; 121(2):275-81. PMID: 11487537.
      Citations: 22     Fields:    Translation:Humans
    100. McLeod R, Muench SP, Rafferty JB, Kyle DE, Mui EJ, Kirisits MJ, Mack DG, Roberts CW, Samuel BU, Lyons RE, Dorris M, Milhous WK, Rice DW. Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I. Int J Parasitol. 2001 Feb; 31(2):109-13. PMID: 11239932.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    101. Inoue YZ, Frassica FJ, Sim FH, Unni KK, Petersen IA, McLeod RA. Clinicopathologic features and treatment of postirradiation sarcoma of bone and soft tissue. J Surg Oncol. 2000 Sep; 75(1):42-50. PMID: 11025461.
      Citations: 25     Fields:    Translation:Humans
    102. Kirisits MJ, Mui E, McLeod R. Measurement of the efficacy of vaccines and antimicrobial therapy against infection with Toxoplasma gondii. Int J Parasitol. 2000 Feb; 30(2):149-55. PMID: 10704598.
      Citations: 16     Fields:    Translation:Animals
    103. McLeod R, Boyer K, Roizen N, Stein L, Swisher C, Holfels E, Hopkins J, Mack D, Karrison T, Patel D, Pfiffner L, Remington J, Withers S, Meyers S, Aitchison V, Mets M, Rabiah P, Meier P. The child with congenital toxoplasmosis. Curr Clin Top Infect Dis. 2000; 20:189-208. PMID: 10943525.
      Citations: 8     Fields:    Translation:HumansPHPublic Health
    104. Roberts F, Roberts CW, Ferguson DJ, McLeod R. Inhibition of nitric oxide production exacerbates chronic ocular toxoplasmosis. Parasite Immunol. 2000 Jan; 22(1):1-5. PMID: 10607284.
      Citations: 17     Fields:    Translation:Animals
    105. Zuther E, Johnson JJ, Haselkorn R, McLeod R, Gornicki P. Growth of Toxoplasma gondii is inhibited by aryloxyphenoxypropionate herbicides targeting acetyl-CoA carboxylase. Proc Natl Acad Sci U S A. 1999 Nov 09; 96(23):13387-92. PMID: 10557330; PMCID: PMC23957.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    106. Mack DG, Johnson JJ, Roberts F, Roberts CW, Estes RG, David C, Grumet FC, McLeod R. HLA-class II genes modify outcome of Toxoplasma gondii infection. Int J Parasitol. 1999 Sep; 29(9):1351-8. PMID: 10579423.
      Citations: 40     Fields:    Translation:HumansAnimalsPHPublic Health
    107. McLeod RS, Wolff BG, Steinhart AH, Carryer PW, O'Rourke K, Andrews DF, Blair JE, Cangemi JR, Cohen Z, Cullen JB, Chaytor RG, Greenberg GR, Jaffer NM, Jeejeebhoy KN, MacCarty RL, Ready RL, Weiland LH. Risk and significance of endoscopic/radiological evidence of recurrent Crohn's disease. Gastroenterology. 1997 Dec; 113(6):1823-7. PMID: 9394721.
      Citations: 17     Fields:    Translation:HumansCTClinical Trials
    108. Vogel N, Kirisits M, Michael E, Bach H, Hostetter M, Boyer K, Simpson R, Holfels E, Hopkins J, Mack D, Mets MB, Swisher CN, Patel D, Roizen N, Stein L, Stein M, Withers S, Mui E, Egwuagu C, Remington J, Dorfman R, McLeod R. Congenital toxoplasmosis transmitted from an immunologically competent mother infected before conception. Clin Infect Dis. 1996 Nov; 23(5):1055-60. PMID: 8922802.
      Citations: 25     Fields:    Translation:HumansAnimalsPHPublic Health
    109. Serra J, Cohen Z, McLeod RS. Natural history of strictureplasty in Crohn's disease: 9-year experience. Can J Surg. 1995 Dec; 38(6):481-5. PMID: 7497360.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    110. McLeod RS. Costs of major parasites to the Australian livestock industries. Int J Parasitol. 1995 Nov; 25(11):1363-7. PMID: 8635886.
      Citations: 26     Fields:    Translation:Animals
    111. McLeod RS, Wolff BG, Steinhart AH, Carryer PW, O'Rourke K, Andrews DF, Blair JE, Cangemi JR, Cohen Z, Cullen JB, et al. Prophylactic mesalamine treatment decreases postoperative recurrence of Crohn's disease. Gastroenterology. 1995 Aug; 109(2):404-13. PMID: 7615189.
      Citations: 41     Fields:    Translation:HumansCTClinical Trials
    112. McLeod RS, Robbins C, Burns A, Yao Z, Pritchard PH. Deletion of the propeptide of apolipoprotein A-I impairs exit of nascent apolipoprotein A-I from the endoplasmic reticulum. Biochem J. 1994 Sep 15; 302 ( Pt 3):641-8. PMID: 7945187; PMCID: PMC1137279.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    113. Brown CR, David CS, Khare SJ, McLeod R. Effects of human class I transgenes on Toxoplasma gondii cyst formation. J Immunol. 1994 May 01; 152(9):4537-41. PMID: 8157968.
      Citations: 12     Fields:    Translation:HumansAnimals
    114. McLeod RS, Zhao Y, Selby SL, Westerlund J, Yao Z. Carboxyl-terminal truncation impairs lipid recruitment by apolipoprotein B100 but does not affect secretion of the truncated apolipoprotein B-containing lipoproteins. J Biol Chem. 1994 Jan 28; 269(4):2852-62. PMID: 8300620.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    115. Park YK, Unni KK, McLeod RA, Pritchard DJ. Osteofibrous dysplasia: clinicopathologic study of 80 cases. Hum Pathol. 1993 Dec; 24(12):1339-47. PMID: 8276381.
      Citations: 23     Fields:    Translation:Humans
    116. Vergel De Dios AM, Bond JR, Shives TC, McLeod RA, Unni KK. Aneurysmal bone cyst. A clinicopathologic study of 238 cases. Cancer. 1992 Jun 15; 69(12):2921-31. PMID: 1591685.
      Citations: 128     Fields:    Translation:Humans
    117. McLeod RS, Churchill DN, Lock AM, Vanderburgh S, Cohen Z. Quality of life of patients with ulcerative colitis preoperatively and postoperatively. Gastroenterology. 1991 Nov; 101(5):1307-13. PMID: 1936801.
      Citations: 31     Fields:    Translation:Humans
    118. Brown CR, McLeod R. Class I MHC genes and CD8+ T cells determine cyst number in Toxoplasma gondii infection. J Immunol. 1990 Nov 15; 145(10):3438-41. PMID: 2121825.
      Citations: 90     Fields:    Translation:AnimalsCells
    119. Zimmer WD, Berquist TH, McLeod RA, Sim FH, Pritchard DJ, Shives TC, Wold LE, May GR. Magnetic resonance imaging of osteosarcomas. Comparison with computed tomography. Clin Orthop Relat Res. 1986 Jul; (208):289-99. PMID: 3459602.
      Citations: 3     Fields:    Translation:Humans
    120. Nojima T, Unni KK, McLeod RA, Pritchard DJ. Periosteal chondroma and periosteal chondrosarcoma. Am J Surg Pathol. 1985 Sep; 9(9):666-77. PMID: 4051099.
      Citations: 25     Fields:    Translation:Humans
    121. Levine DZ, McLeod RA, Raman S. Steroid modulation of response of plasma bicarbonate concentration to NH4Cl loading: gamma distribution analysis. Can J Physiol Pharmacol. 1983 Jun; 61(6):641-6. PMID: 6411311.
      Citations:    Fields:    Translation:Animals
    122. Peterson HA, Klassen RA, McLeod RA, Hoffman AD. The use of computerised tomography in dislocation of the hip and femoral neck anteversion in children. J Bone Joint Surg Br. 1981 Aug; 63-B(2):198-208. PMID: 7217142.
      Citations: 9     Fields:    Translation:Humans
    123. Levine DZ, Byers MK, McLeod RA, Luisello JA, Raman S. Loop of Henle bicarbonate accumulation in vivo in the rat. J Clin Invest. 1979 Jan; 63(1):59-66. PMID: 762247; PMCID: PMC371918.
      Citations: 9     Fields:    Translation:Animals
    124. McLeod RA, Dahlin DC, Beabout JW. The spectrum of osteoblastoma. AJR Am J Roentgenol. 1976 Feb; 126(2):321-5. PMID: 175701.
      Citations: 54     Fields:    Translation:Humans
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