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Kristen Lauing

InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Johnson M, Bell A, Lauing KL, Ladomersky E, Zhai L, Penco-Campillo M, Shah Y, Mauer E, Xiu J, Nicolaides T, Drumm M, McCortney K, Elemento O, Kim M, Bommi P, Low JT, Memon R, Wu J, Zhao J, Mi X, Glantz MJ, Sengupta S, Castro B, Yamini B, Horbinski C, Baker DJ, Walunas TL, Schiltz GE, Lukas RV, Wainwright DA. Advanced age in humans and mouse models of glioblastoma show decreased survival from extratumoral influence. Clin Cancer Res. 2023 Sep 19. PMID: 37725593.
      Citations:    Fields:    
    2. Bollu LR, Bommi PV, Monsen PJ, Zhai L, Lauing KL, Bell A, Kim M, Ladomersky E, Yang X, Platanias LC, Matei DE, Bonini MG, Munshi HG, Hashizume R, Wu JD, Zhang B, James CD, Chen P, Kocherginsky M, Horbinski C, Cameron MD, Grigorescu AA, Yamini B, Lukas RV, Schiltz GE, Wainwright DA. Identification and Characterization of a Novel Indoleamine 2,3-Dioxygenase 1 Protein Degrader for Glioblastoma. J Med Chem. 2022 12 08; 65(23):15642-15662. PMID: 36410047; PMCID: PMC9743093.
      Citations: 2     Fields:    Translation:HumansAnimals
    3. Nguyen TT, Shin DH, Sohoni S, Singh SK, Rivera-Molina Y, Jiang H, Fan X, Gumin J, Lang FF, Alvarez-Breckenridge C, Godoy-Vitorino F, Zhu L, Zheng WJ, Zhai L, Ladomersky E, Lauing KL, Wainwright DA, Gomez-Manzano C, Fueyo J, Alonso MM. Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry. J Immunother Cancer. 2022 07; 10(7). PMID: 35902132; PMCID: PMC9341188.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    4. Rabin EE, Kim M, Mozny A, Cardoza K, Bell AC, Zhai L, Bommi P, Lauing KL, King AL, Armstrong TS, Walunas TL, Fang D, Roy I, Peipert JD, Sieg E, Mi X, Amidei C, Lukas RV, Wainwright DA. A systematic review of pharmacologic treatment efficacy for depression in older patients with cancer. Brain Behav Immun Health. 2022 May; 21:100449. PMID: 35368609; PMCID: PMC8968450.
      Citations: 3     
    5. Kim M, Ladomersky E, Mozny A, Kocherginsky M, O'Shea K, Reinstein ZZ, Zhai L, Bell A, Lauing KL, Bollu L, Rabin E, Dixit K, Kumthekar P, Platanias LC, Hou L, Zheng Y, Wu J, Zhang B, Hrachova M, Merrill SA, Mrugala MM, Prabhu VC, Horbinski C, James CD, Yamini B, Ostrom QT, Johnson MO, Reardon DA, Lukas RV, Wainwright DA. Glioblastoma as an age-related neurological disorder in adults. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab125. PMID: 34647022; PMCID: PMC8500689.
      Citations: 20     
    6. Zhai L, Bell A, Ladomersky E, Lauing KL, Bollu L, Nguyen B, Genet M, Kim M, Chen P, Mi X, Wu JD, Schipma MJ, Wray B, Griffiths J, Unwin RD, Acharya R, Bao R, Horbinski C, Lukas RV, Schiltz GE, Wainwright DA, Clark SJ. Tumor Cell IDO Enhances Immune Suppression and Decreases Survival Independent of Tryptophan Metabolism in Glioblastoma. Clin Cancer Res. 2021 12 01; 27(23):6514-6528. PMID: 34479957; PMCID: PMC8639612.
      Citations: 26     Fields:    Translation:HumansAnimals
    7. Ladomersky E, Zhai L, Lauing KL, Bell A, Xu J, Kocherginsky M, Zhang B, Wu JD, Podojil JR, Platanias LC, Mochizuki AY, Prins RM, Kumthekar P, Raizer JJ, Dixit K, Lukas RV, Horbinski C, Wei M, Zhou C, Campisi J, Grohmann U, Prendergast GC, Munn DH, Wainwright DA, Pawelec G. Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma. Clin Cancer Res. 2020 10 01; 26(19):5232-5245. PMID: 32546647; PMCID: PMC7541490.
      Citations: 37     Fields:    Translation:HumansAnimals
    8. Zhai L, Bell A, Ladomersky E, Lauing KL, Bollu L, Sosman JA, Zhang B, Wu JD, Miller SD, Meeks JJ, Lukas RV, Wyatt E, Doglio L, Schiltz GE, McCusker RH, Wainwright DA. Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies. Front Immunol. 2020; 11:1185. PMID: 32612606; PMCID: PMC7308527.
      Citations: 69     Fields:    Translation:HumansAnimals
    9. Otto-Meyer S, DeFaccio R, Dussold C, Ladomersky E, Zhai L, Lauing KL, Bollu LR, Amidei C, Lukas RV, Scholtens DM, Wainwright DA. A retrospective survival analysis of Glioblastoma patients treated with selective serotonin reuptake inhibitors. Brain Behav Immun Health. 2020 Feb; 2. PMID: 32190845; PMCID: PMC7079579.
      Citations: 18     
    10. Zhai L, Ladomersky E, Bell A, Dussold C, Cardoza K, Qian J, Lauing KL, Wainwright DA. Quantification of IDO1 enzyme activity in normal and malignant tissues. Methods Enzymol. 2019; 629:235-256. PMID: 31727243; PMCID: PMC7347075.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    11. Ladomersky E, Scholtens DM, Kocherginsky M, Hibler EA, Bartom ET, Otto-Meyer S, Zhai L, Lauing KL, Choi J, Sosman JA, Wu JD, Zhang B, Lukas RV, Wainwright DA. The Coincidence Between Increasing Age, Immunosuppression, and the Incidence of Patients With Glioblastoma. Front Pharmacol. 2019; 10:200. PMID: 30971917; PMCID: PMC6446059.
      Citations: 51     
    12. Otto-Meyer S, Lumibao J, Kim E, Ladomersky E, Zhai L, Lauing KL, Scholtens DM, Penedo F, Amidei C, Lukas RV, Wainwright DA. The interplay among psychological distress, the immune system, and brain tumor patient outcomes. Curr Opin Behav Sci. 2019 Aug; 28:44-50. PMID: 31049368; PMCID: PMC6487487.
      Citations: 14     
    13. Zhai L, Ladomersky E, Lauing KL, Wu M, Scholtens DM, Savoor R, Zhang B, Wu JD, Horbinski C, Lukas RV, Binder DC, Wainwright DA. Commentary: preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma by Garg et al. (2017). Oncoimmunology. 2019; 8(3):1548242. PMID: 30723577; PMCID: PMC6350838.
      Citations:    Fields:    Translation:Humans
    14. Rosenberg AJ, Wainwright DA, Rademaker A, Galvez C, Genet M, Zhai L, Lauing KL, Mulcahy MF, Hayes JP, Odell DD, Horbinski C, Komanduri S, Tetreault MP, Kim KA, Villaflor VM. Indoleamine 2,3-dioxygenase 1 and overall survival of patients diagnosed with esophageal cancer. Oncotarget. 2018 May 04; 9(34):23482-23493. PMID: 29805749; PMCID: PMC5955099.
      Citations: 15     Fields:    
    15. Binder DC, Ladomersky E, Lenzen A, Zhai L, Lauing KL, Otto-Meyer SD, Lukas RV, Wainwright DA. Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma. Transl Cancer Res. 2018 Apr; 7(Suppl 4):S510-S513. PMID: 30283731; PMCID: PMC6166880.
      Citations: 12     
    16. Ladomersky E, Zhai L, Lenzen A, Lauing KL, Qian J, Scholtens DM, Gritsina G, Sun X, Liu Y, Yu F, Gong W, Liu Y, Jiang B, Tang T, Patel R, Platanias LC, James CD, Stupp R, Lukas RV, Binder DC, Wainwright DA. IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma. Clin Cancer Res. 2018 06 01; 24(11):2559-2573. PMID: 29500275; PMCID: PMC5984675.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    17. Zhai L, Ladomersky E, Lenzen A, Nguyen B, Patel R, Lauing KL, Wu M, Wainwright DA. IDO1 in cancer: a Gemini of immune checkpoints. Cell Mol Immunol. 2018 May; 15(5):447-457. PMID: 29375124; PMCID: PMC6068130.
      Citations: 155     Fields:    Translation:HumansAnimals
    18. Zhai L, Ladomersky E, Lauing KL, Wu M, Genet M, Gritsina G, Brastianos PK, Binder DC, Sosman JA, Giles FJ, James CD, Horbinski C, Stupp R, Wainwright DA, Gyorffy B. Infiltrating T Cells Increase IDO1 Expression in Glioblastoma and Contribute to Decreased Patient Survival. Clin Cancer Res. 2017 Nov 01; 23(21):6650-6660. PMID: 28751450; PMCID: PMC5850948.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    19. Zhai L, Ladomersky E, Dostal CR, Lauing KL, Swoap K, Billingham LK, Gritsina G, Wu M, McCusker RH, Binder DC, Wainwright DA. Non-tumor cell IDO1 predominantly contributes to enzyme activity and response to CTLA-4/PD-L1 inhibition in mouse glioblastoma. Brain Behav Immun. 2017 May; 62:24-29. PMID: 28179106; PMCID: PMC5514839.
      Citations: 33     Fields:    Translation:Animals
    20. Lenzen A, Zhai L, Lauing KL, Gritsina G, Ladomersky E, Genet M, James CD, Bloch O, Wainwright DA. The Kynurenine/Tryptophan Ratio and Glioblastoma Patients Treated with Hsppc-96 Vaccine. Immunotherapy (Los Angel). 2016 Sep; 2(3). PMID: 27819068; PMCID: PMC5095693.
      Citations: 5     
    21. Ladomersky E, Zhai L, Gritsina G, Genet M, Lauing KL, Wu M, James CD, Wainwright DA. Advanced age negatively impacts survival in an experimental brain tumor model. Neurosci Lett. 2016 Sep 06; 630:203-208. PMID: 27493076; PMCID: PMC5006183.
      Citations: 15     Fields:    Translation:AnimalsCells
    22. Ladomersky E, Genet M, Zhai L, Gritsina G, Lauing KL, Lulla RR, Fangusaro J, Lenzen A, Kumthekar P, Raizer JJ, Binder DC, James CD, Wainwright DA. Improving vaccine efficacy against malignant glioma. Oncoimmunology. 2016 Aug; 5(8):e1196311. PMID: 27622066; PMCID: PMC5007967.
      Citations: 10     Fields:    
    23. Zhai L, Spranger S, Binder DC, Gritsina G, Lauing KL, Giles FJ, Wainwright DA. Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy. Clin Cancer Res. 2015 Dec 15; 21(24):5427-33. PMID: 26519060; PMCID: PMC4681601.
      Citations: 144     Fields:    Translation:HumansAnimalsCells
    24. Zhai L, Dey M, Lauing KL, Gritsina G, Kaur R, Lukas RV, Nicholas MK, Rademaker AW, Dostal CR, McCusker RH, Raizer JJ, Parsa AT, Bloch O, Wainwright DA. The kynurenine to tryptophan ratio as a prognostic tool for glioblastoma patients enrolling in immunotherapy. J Clin Neurosci. 2015 Dec; 22(12):1964-8. PMID: 26279502; PMCID: PMC4548799.
      Citations: 39     Fields:    Translation:Humans
    25. Zhai L, Lauing KL, Chang AL, Dey M, Qian J, Cheng Y, Lesniak MS, Wainwright DA. The role of IDO in brain tumor immunotherapy. J Neurooncol. 2015 Jul; 123(3):395-403. PMID: 25519303; PMCID: PMC4641522.
      Citations: 48     Fields:    Translation:HumansAnimals
    26. Lauing KL, Cortes M, Domowicz MS, Henry JG, Baria AT, Schwartz NB. Aggrecan is required for growth plate cytoarchitecture and differentiation. Dev Biol. 2014 Dec 15; 396(2):224-36. PMID: 25446537; PMCID: PMC4261049.
      Citations: 46     Fields:    Translation:AnimalsCells
    27. Lauing KL, Sundaramurthy S, Nauer RK, Callaci JJ. Exogenous activation of Wnt/ß-catenin signaling attenuates binge alcohol-induced deficient bone fracture healing. Alcohol Alcohol. 2014 Jul-Aug; 49(4):399-408. PMID: 24627571; PMCID: PMC4060733.
      Citations: 15     Fields:    Translation:AnimalsCells
    28. Cappello T, Nuelle JA, Katsantonis N, Nauer RK, Lauing KL, Jagodzinski JE, Callaci JJ. Ketorolac administration does not delay early fracture healing in a juvenile rat model: a pilot study. J Pediatr Orthop. 2013 Jun; 33(4):415-21. PMID: 23653032; PMCID: PMC3907123.
      Citations: 6     Fields:    Translation:Animals
    29. Obermeyer TS, Yonick D, Lauing K, Stock SR, Nauer R, Strotman P, Shankar R, Gamelli R, Stover M, Callaci JJ. Mesenchymal stem cells facilitate fracture repair in an alcohol-induced impaired healing model. J Orthop Trauma. 2012 Dec; 26(12):712-8. PMID: 23010646; PMCID: PMC3645443.
      Citations: 21     Fields:    Translation:Animals
    30. Lauing KL, Roper PM, Nauer RK, Callaci JJ. Acute alcohol exposure impairs fracture healing and deregulates ß-catenin signaling in the fracture callus. Alcohol Clin Exp Res. 2012 Dec; 36(12):2095-103. PMID: 22691115; PMCID: PMC3443513.
      Citations: 29     Fields:    Translation:AnimalsCells
    31. Volkmer DL, Sears B, Lauing KL, Nauer RK, Roper PM, Yong S, Stover M, Callaci JJ. Antioxidant therapy attenuates deficient bone fracture repair associated with binge alcohol exposure. J Orthop Trauma. 2011 Aug; 25(8):516-21. PMID: 21738068; PMCID: PMC3139786.
      Citations: 16     Fields:    Translation:Animals
    32. Sears BW, Volkmer D, Yong S, Himes RD, Lauing K, Morgan M, Stover MD, Callaci JJ. Binge alcohol exposure modulates rodent expression of biomarkers of the immunoinflammatory response to orthopaedic trauma. J Bone Joint Surg Am. 2011 Apr 20; 93(8):739-49. PMID: 21508281; PMCID: PMC3073017.
      Citations: 11     Fields:    Translation:Animals
    33. Jung MK, Callaci JJ, Lauing KL, Otis JS, Radek KA, Jones MK, Kovacs EJ. Alcohol exposure and mechanisms of tissue injury and repair. Alcohol Clin Exp Res. 2011 Mar; 35(3):392-9. PMID: 21118273; PMCID: PMC3117956.
      Citations: 36     Fields:    Translation:HumansAnimals
    34. Sears BW, Volkmer D, Yong S, Himes RD, Lauing K, Morgan M, Stover MD, Callaci JJ. Correlation of measurable serum markers of inflammation with lung levels following bilateral femur fracture in a rat model. J Inflamm Res. 2010 08 01; 2010(3):105-114. PMID: 21442011; PMCID: PMC3062967.
      Citations: 7     
    35. Callaci JJ, Himes R, Lauing K, Roper P. Long-term modulations in the vertebral transcriptome of adolescent-stage rats exposed to binge alcohol. Alcohol Alcohol. 2010 Jul-Aug; 45(4):332-46. PMID: 20554695; PMCID: PMC2899847.
      Citations: 16     Fields:    Translation:Animals
    36. Callaci JJ, Himes R, Lauing K, Wezeman FH, Brownson K. Binge alcohol-induced bone damage is accompanied by differential expression of bone remodeling-related genes in rat vertebral bone. Calcif Tissue Int. 2009 Jun; 84(6):474-84. PMID: 19330277; PMCID: PMC2693714.
      Citations: 24     Fields:    Translation:Animals
    37. Lauing K, Himes R, Rachwalski M, Strotman P, Callaci JJ. Binge alcohol treatment of adolescent rats followed by alcohol abstinence is associated with site-specific differences in bone loss and incomplete recovery of bone mass and strength. Alcohol. 2008 Dec; 42(8):649-56. PMID: 19038696; PMCID: PMC2633927.
      Citations: 40     Fields:    Translation:Animals
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