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Albert Bendelac

TitleProfessor
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    Innate and Innate-Like Lymphocytes
    Our laboratory studies the populations of lymphocytes that reside at mucosal barriers and perform rapid innate-like functions to maintain homeostasis and protect against infection, injury and tumor. We use developmental biology and genetic engineering to define the identity and track the function of multiple ‘unconventional’ populations including NKT cells, MAIT cells, gamma-delta T cells, innate lymphoid cells, intraepithelial intestinal T lymphocytes and IgA producing intestinal B cells. Ultimately, these studies help identify the central relationships between immunity and microbiome at the intestinal barrier.


    Collapse Biography 
    Collapse education and training
    University Paris VI, Paris, FranceMD06/1985Medicine
    University Paris VII, Paris, FrancePhD06/1992Immunology
    Collapse awards and honors
    1988Gold Medal of the Residency Program, Assistance Publique Hopitaux de Paris
    1988Oulmont, Laval, Dreyfous Prize, Academie of Medicine Paris
    1994 - 1997Mallinkrodt Foundation Award
    1995 - 1998Cancer Research Institute Investigator Award
    2005 - 2013Howard Hughes Medical Investigator
    2008 - presA.N. Pritzker Professorship, University of Chicago
    2017MERIT Award, National Institutes of Health
    2019Quantrell Teaching Award, University of Chicago

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Borowska MT, Drees C, Yarawsky AE, Viswanathan M, Ryan SM, Bunker JJ, Herr AB, Bendelac A, Adams EJ. The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe. Proc Natl Acad Sci U S A. 2021 09 28; 118(39). PMID: 34548394.
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    2. Kasal DN, Liang Z, Hollinger MK, O'Leary CY, Lisicka W, Sperling AI, Bendelac A. A Gata3 enhancer necessary for ILC2 development and function. Proc Natl Acad Sci U S A. 2021 08 10; 118(32). PMID: 34353913.
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    3. Haynie T, Gubler S, Drees C, Heaton T, Mitton T, Gleave Q, Bendelac A, Deng S, Savage PB. Synthesis of the pentasaccharide repeating unit from Ruminococcus gnavus and measurement of its inflammatory properties. RSC Adv. 2021 Apr 15; 11(24):14357-14361. PMID: 35424013.
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    4. Kasal DN, Bendelac A. Multi-transcription factor reporter mice delineate early precursors to the ILC and LTi lineages. J Exp Med. 2021 02 01; 218(2). PMID: 33104170.
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    5. Boughter CT, Borowska MT, Guthmiller JJ, Bendelac A, Wilson PC, Roux B, Adams EJ. Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops. Elife. 2020 11 10; 9. PMID: 33169668.
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    6. Bunker JJ, Drees C, Watson AR, Plunkett CH, Nagler CR, Schneewind O, Eren AM, Bendelac A. B cell superantigens in the human intestinal microbiota. Sci Transl Med. 2019 08 28; 11(507). PMID: 31462512.
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    7. Bunker JJ, Bendelac A. IgA Responses to Microbiota. Immunity. 2018 08 21; 49(2):211-224. PMID: 30134201.
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    8. McDonald BD, Jabri B, Bendelac A. Diverse developmental pathways of intestinal intraepithelial lymphocytes. Nat Rev Immunol. 2018 08; 18(8):514-525. PMID: 29717233.
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    9. Mao AP, Ishizuka IE, Kasal DN, Mandal M, Bendelac A. Publisher Correction: A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. Nat Commun. 2017 11 30; 8(1):1933. PMID: 29192205.
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    10. McKnight CG, Morris SC, Perkins C, Zhu Z, Hildeman DA, Bendelac A, Finkelman FD. NKT cells contribute to basal IL-4 production but are not required to induce experimental asthma. PLoS One. 2017; 12(11):e0188221. PMID: 29182669.
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    11. Mao AP, Ishizuka IE, Kasal DN, Mandal M, Bendelac A. A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. Nat Commun. 2017 10 16; 8(1):863. PMID: 29038474.
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    12. Bunker JJ, Erickson SA, Flynn TM, Henry C, Koval JC, Meisel M, Jabri B, Antonopoulos DA, Wilson PC, Bendelac A. Natural polyreactive IgA antibodies coat the intestinal microbiota. Science. 2017 10 20; 358(6361). PMID: 28971969.
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    13. Mao AP, Constantinides MG, Mathew R, Zuo Z, Chen X, Weirauch MT, Bendelac A. Multiple layers of transcriptional regulation by PLZF in NKT-cell development. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7602-7. PMID: 27325774.
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    14. Ishizuka IE, Constantinides MG, Gudjonson H, Bendelac A. The Innate Lymphoid Cell Precursor. Annu Rev Immunol. 2016 05 20; 34:299-316. PMID: 27168240.
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    15. Ishizuka IE, Chea S, Gudjonson H, Constantinides MG, Dinner AR, Bendelac A, Golub R. Single-cell analysis defines the divergence between the innate lymphoid cell lineage and lymphoid tissue-inducer cell lineage. Nat Immunol. 2016 Mar; 17(3):269-76. PMID: 26779601.
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    16. McDonald BD, Bunker JJ, Erickson SA, Oh-Hora M, Bendelac A. Crossreactive aß T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection. Immunity. 2015 Nov 17; 43(5):859-69. PMID: 26522985.
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    17. Verhoef PA, Constantinides MG, McDonald BD, Urban JF, Sperling AI, Bendelac A. Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)-deficient mice. J Allergy Clin Immunol. 2016 Feb; 137(2):591-600.e1. PMID: 26602165.
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    18. Bunker JJ, Flynn TM, Koval JC, Shaw DG, Meisel M, McDonald BD, Ishizuka IE, Dent AL, Wilson PC, Jabri B, Antonopoulos DA, Bendelac A. Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A. Immunity. 2015 Sep 15; 43(3):541-53. PMID: 26320660.
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    19. Kain L, Costanzo A, Webb B, Holt M, Bendelac A, Savage PB, Teyton L. Endogenous ligands of natural killer T cells are alpha-linked glycosylceramides. Mol Immunol. 2015 Dec; 68(2 Pt A):94-7. PMID: 26141240.
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    20. Constantinides MG, Gudjonson H, McDonald BD, Ishizuka IE, Verhoef PA, Dinner AR, Bendelac A. PLZF expression maps the early stages of ILC1 lineage development. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):5123-8. PMID: 25838284.
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    21. Kain L, Webb B, Anderson BL, Deng S, Holt M, Costanzo A, Constanzo A, Zhao M, Self K, Teyton A, Everett C, Kronenberg M, Zajonc DM, Bendelac A, Savage PB, Teyton L. The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian a-linked glycosylceramides. Immunity. 2014 Oct 16; 41(4):543-54. PMID: 25367571.
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    22. Tefit JN, Crabé S, Orlandini B, Nell H, Bendelac A, Deng S, Savage PB, Teyton L, Serra V. Efficacy of ABX196, a new NKT agonist, in prophylactic human vaccination. Vaccine. 2014 Oct 21; 32(46):6138-45. PMID: 25218293.
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    23. McDonald BD, Bunker JJ, Ishizuka IE, Jabri B, Bendelac A. Elevated T cell receptor signaling identifies a thymic precursor to the TCRaß(+)CD4(-)CD8ß(-) intraepithelial lymphocyte lineage. Immunity. 2014 Aug 21; 41(2):219-29. PMID: 25131532.
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    24. Mathew R, Mao AP, Chiang AH, Bertozzi-Villa C, Bunker JJ, Scanlon ST, McDonald BD, Constantinides MG, Hollister K, Singer JD, Dent AL, Dinner AR, Bendelac A. A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation. J Exp Med. 2014 Jun 02; 211(6):1137-51. PMID: 24863065.
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    25. Constantinides MG, McDonald BD, Verhoef PA, Bendelac A. A committed precursor to innate lymphoid cells. Nature. 2014 Apr 17; 508(7496):397-401. PMID: 24509713.
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    26. Anderson BL, Teyton L, Bendelac A, Savage PB. Stimulation of natural killer T cells by glycolipids. Molecules. 2013 Dec 16; 18(12):15662-88. PMID: 24352021.
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    27. Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ. Crystal structure of Vd1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human ?d T cells. Immunity. 2013 Dec 12; 39(6):1032-42. PMID: 24239091.
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    28. McDonald BD, Constantinides MG, Bendelac A. Polarized effector programs for innate-like thymocytes. Nat Immunol. 2013 Nov; 14(11):1110-1. PMID: 24145782.
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    29. Bai L, Deng S, Reboulet R, Mathew R, Teyton L, Savage PB, Bendelac A. Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides. Proc Natl Acad Sci U S A. 2013 Oct 01; 110(40):16097-102. PMID: 24043771.
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    30. Zheng Y, Zha Y, Spaapen RM, Mathew R, Barr K, Bendelac A, Gajewski TF. Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergy. Mol Immunol. 2013 Oct; 55(3-4):283-91. PMID: 23548837.
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    31. Constantinides MG, Bendelac A. Transcriptional regulation of the NKT cell lineage. Curr Opin Immunol. 2013 Apr; 25(2):161-7. PMID: 23402834.
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    32. Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A. BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. Nature. 2012 Nov 22; 491(7425):618-21. PMID: 23086144.
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    33. Freigang S, Landais E, Zadorozhny V, Kain L, Yoshida K, Liu Y, Deng S, Palinski W, Savage PB, Bendelac A, Teyton L. Scavenger receptors target glycolipids for natural killer T cell activation. J Clin Invest. 2012 Nov; 122(11):3943-54. PMID: 23064364.
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    34. Bai L, Picard D, Anderson B, Chaudhary V, Luoma A, Jabri B, Adams EJ, Savage PB, Bendelac A. The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vd1 TCR. Eur J Immunol. 2012 Sep; 42(9):2505-10. PMID: 22829134.
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    35. Bai L, Constantinides MG, Thomas SY, Reboulet R, Meng F, Koentgen F, Teyton L, Savage PB, Bendelac A. Distinct APCs explain the cytokine bias of a-galactosylceramide variants in vivo. J Immunol. 2012 Apr 01; 188(7):3053-61. PMID: 22393151.
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    36. Seiler MP, Mathew R, Liszewski MK, Spooner CJ, Spooner C, Barr K, Meng F, Singh H, Bendelac A. Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling. Nat Immunol. 2012 Feb 05; 13(3):264-71. PMID: 22306690.
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    37. Kammertoens T, Qin Z, Briesemeister D, Bendelac A, Blankenstein T. B-cells and IL-4 promote methylcholanthrene-induced carcinogenesis but there is no evidence for a role of T/NKT-cells and their effector molecules (Fas-ligand, TNF-a, perforin). Int J Cancer. 2012 Oct 01; 131(7):1499-508. PMID: 22212899.
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    38. Scanlon ST, Thomas SY, Ferreira CM, Bai L, Krausz T, Savage PB, Bendelac A. Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation. J Exp Med. 2011 Sep 26; 208(10):2113-24. PMID: 21930768.
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    39. Deng S, Mattner J, Zang Z, Bai L, Teyton L, Bendelac A, Savage PB. Impact of sugar stereochemistry on natural killer T cell stimulation by bacterial glycolipids. Org Biomol Chem. 2011 Oct 26; 9(22):7659-62. PMID: 21927724.
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    40. Constantinides MG, Picard D, Savage AK, Bendelac A. A naive-like population of human CD1d-restricted T cells expressing intermediate levels of promyelocytic leukemia zinc finger. J Immunol. 2011 Jul 01; 187(1):309-15. PMID: 21632718.
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    41. Thomas SY, Scanlon ST, Griewank KG, Constantinides MG, Savage AK, Barr KA, Meng F, Luster AD, Bendelac A. PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions. J Exp Med. 2011 Jun 06; 208(6):1179-88. PMID: 21624939.
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    42. Savage AK, Constantinides MG, Bendelac A. Promyelocytic leukemia zinc finger turns on the effector T cell program without requirement for agonist TCR signaling. J Immunol. 2011 May 15; 186(10):5801-6. PMID: 21478405.
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    43. Wang L, Carr T, Xiong Y, Wildt KF, Zhu J, Feigenbaum L, Bendelac A, Bosselut R. The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur J Immunol. 2010 Sep; 40(9):2385-90. PMID: 20706986.
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    44. Verykokakis M, Boos MD, Bendelac A, Kee BL. SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics. Immunity. 2010 Aug 27; 33(2):203-15. PMID: 20674402.
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    45. Freigang S, Zadorozhny V, McKinney MK, Krebs P, Herro R, Pawlak J, Kain L, Schrantz N, Masuda K, Liu Y, Savage PB, Bendelac A, Cravatt BF, Teyton L. Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice. J Clin Invest. 2010 Jun; 120(6):1873-84. PMID: 20484813.
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    46. Verykokakis M, Boos MD, Bendelac A, Adams EJ, Pereira P, Kee BL. Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells. PLoS One. 2010 Feb 19; 5(2):e9303. PMID: 20174563.
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    47. Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12453-8. PMID: 19617548.
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    48. Bai L, Sagiv Y, Liu Y, Freigang S, Yu KO, Teyton L, Porcelli SA, Savage PB, Bendelac A. Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer. Proc Natl Acad Sci U S A. 2009 Jun 23; 106(25):10254-9. PMID: 19506241.
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    49. Dose M, Sleckman BP, Han J, Bredemeyer AL, Bendelac A, Gounari F. Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8641-6. PMID: 19423665.
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    50. Yin N, Long X, Goff RD, Zhou D, Cantu C, Mattner J, Mezard PS, Teyton L, Bendelac A, Savage PB. Alpha anomers of iGb3 and Gb3 stimulate cytokine production by natural killer T cells. ACS Chem Biol. 2009 Mar 20; 4(3):199-208. PMID: 19175331.
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    51. Savage AK, Constantinides MG, Han J, Picard D, Martin E, Li B, Lantz O, Bendelac A. The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity. 2008 Sep 19; 29(3):391-403. PMID: 18703361.
      View in: PubMed
    52. Mattner J, Savage PB, Leung P, Oertelt SS, Wang V, Trivedi O, Scanlon ST, Pendem K, Teyton L, Hart J, Ridgway WM, Wicker LS, Gershwin ME, Bendelac A. Liver autoimmunity triggered by microbial activation of natural killer T cells. Cell Host Microbe. 2008 May 15; 3(5):304-15. PMID: 18474357.
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    53. Zajonc DM, Savage PB, Bendelac A, Wilson IA, Teyton L. Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids. J Mol Biol. 2008 Apr 04; 377(4):1104-16. PMID: 18295796.
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    54. Liu Y, Deng S, Bai L, Freigang S, Mattner J, Teyton L, Bendelac A, Savage PB. Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties. Bioorg Med Chem Lett. 2008 May 15; 18(10):3052-5. PMID: 18206371.
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    55. Li Y, Teneberg S, Thapa P, Bendelac A, Levery SB, Zhou D. Sensitive detection of isoglobo and globo series tetraglycosylceramides in human thymus by ion trap mass spectrometry. Glycobiology. 2008 Feb; 18(2):158-65. PMID: 18056651.
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    56. Griewank K, Borowski C, Rietdijk S, Wang N, Julien A, Wei DG, Mamchak AA, Terhorst C, Bendelac A. Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity. 2007 Nov; 27(5):751-62. PMID: 18031695.
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    57. Allende ML, Zhou D, Kalkofen DN, Benhamed S, Tuymetova G, Borowski C, Bendelac A, Proia RL. S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues. FASEB J. 2008 Jan; 22(1):307-15. PMID: 17785606.
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    58. Long X, Deng S, Mattner J, Zang Z, Zhou D, McNary N, Goff RD, Teyton L, Bendelac A, Savage PB. Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids. Nat Chem Biol. 2007 Sep; 3(9):559-64. PMID: 17660835.
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    59. Sagiv Y, Bai L, Wei DG, Agami R, Savage PB, Teyton L, Bendelac A. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d. J Exp Med. 2007 Apr 16; 204(4):921-8. PMID: 17403933.
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    60. Schrantz N, Sagiv Y, Liu Y, Savage PB, Bendelac A, Teyton L. The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells. J Exp Med. 2007 Apr 16; 204(4):841-52. PMID: 17389239.
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    61. Novak J, Beaudoin L, Park S, Griseri T, Teyton L, Bendelac A, Lehuen A. Prevention of type 1 diabetes by invariant NKT cells is independent of peripheral CD1d expression. J Immunol. 2007 Feb 01; 178(3):1332-40. PMID: 17237379.
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    62. Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annu Rev Immunol. 2007; 25:297-336. PMID: 17150027.
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    63. Zullo AJ, Benlagha K, Bendelac A, Taparowsky EJ. Sensitivity of NK1.1-negative NKT cells to transgenic BATF defines a role for activator protein-1 in the expansion and maturation of immature NKT cells in the thymus. J Immunol. 2007 Jan 01; 178(1):58-66. PMID: 17182540.
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    64. Sagiv Y, Hudspeth K, Mattner J, Schrantz N, Stern RK, Zhou D, Savage PB, Teyton L, Bendelac A. Cutting edge: impaired glycosphingolipid trafficking and NKT cell development in mice lacking Niemann-Pick type C1 protein. J Immunol. 2006 Jul 01; 177(1):26-30. PMID: 16785493.
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    65. Savage PB, Teyton L, Bendelac A. Glycolipids for natural killer T cells. Chem Soc Rev. 2006 Sep; 35(9):771-9. PMID: 16936925.
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    66. Wei DG, Curran SA, Savage PB, Teyton L, Bendelac A. Mechanisms imposing the Vbeta bias of Valpha14 natural killer T cells and consequences for microbial glycolipid recognition. J Exp Med. 2006 May 15; 203(5):1197-207. PMID: 16651387.
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    67. Liu Y, Goff RD, Zhou D, Mattner J, Sullivan BA, Khurana A, Cantu C, Ravkov EV, Ibegbu CC, Altman JD, Teyton L, Bendelac A, Savage PB. A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells. J Immunol Methods. 2006 May 30; 312(1-2):34-9. PMID: 16647712.
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    68. Benlagha K, Wei DG, Veiga J, Teyton L, Bendelac A. Characterization of the early stages of thymic NKT cell development. J Exp Med. 2005 Aug 15; 202(4):485-92. PMID: 16087715.
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    69. Wei DG, Lee H, Park SH, Beaudoin L, Teyton L, Lehuen A, Bendelac A. Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes. J Exp Med. 2005 Jul 18; 202(2):239-48. PMID: 16027237.
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    70. Zajonc DM, Cantu C, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol. 2005 Aug; 6(8):810-8. PMID: 16007091.
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    71. Egawa T, Eberl G, Taniuchi I, Benlagha K, Geissmann F, Hennighausen L, Bendelac A, Littman DR. Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity. 2005 Jun; 22(6):705-16. PMID: 15963785.
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    72. Mattner J, Debord KL, Ismail N, Goff RD, Cantu C, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, Savage PB, Bendelac A. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature. 2005 Mar 24; 434(7032):525-9. PMID: 15791258.
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    73. Borowski C, Bendelac A. Signaling for NKT cell development: the SAP-FynT connection. J Exp Med. 2005 Mar 21; 201(6):833-6. PMID: 15781574.
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    74. Bach JF, Bendelac A, Brenner MB, Cantor H, De Libero G, Kronenberg M, Lanier LL, Raulet DH, Shlomchik MJ, von Herrath MG. The role of innate immunity in autoimmunity. J Exp Med. 2004 Dec 20; 200(12):1527-31. PMID: 15611284.
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    75. Zhou D, Mattner J, Cantu C, Schrantz N, Yin N, Gao Y, Sagiv Y, Hudspeth K, Wu YP, Yamashita T, Teneberg S, Wang D, Proia RL, Levery SB, Savage PB, Teyton L, Bendelac A. Lysosomal glycosphingolipid recognition by NKT cells. Science. 2004 Dec 03; 306(5702):1786-9. PMID: 15539565.
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    76. Goff RD, Gao Y, Mattner J, Zhou D, Yin N, Cantu C, Teyton L, Bendelac A, Savage PB. Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells. J Am Chem Soc. 2004 Oct 27; 126(42):13602-3. PMID: 15493902.
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    77. Bendelac A. Nondeletional pathways for the development of autoreactive thymocytes. Nat Immunol. 2004 Jun; 5(6):557-8. PMID: 15164010.
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    78. Benlagha K, Park SH, Guinamard R, Forestier C, Karlsson L, Chang CH, Bendelac A. Mechanisms governing B cell developmental defects in invariant chain-deficient mice. J Immunol. 2004 Feb 15; 172(4):2076-83. PMID: 14764672.
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    79. Zhou D, Cantu C, Sagiv Y, Schrantz N, Kulkarni AB, Qi X, Mahuran DJ, Morales CR, Grabowski GA, Benlagha K, Savage P, Bendelac A, Teyton L. Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins. Science. 2004 Jan 23; 303(5657):523-7. PMID: 14684827.
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    80. Forestier C, Park SH, Wei D, Benlagha K, Teyton L, Bendelac A. T cell development in mice expressing CD1d directed by a classical MHC class II promoter. J Immunol. 2003 Oct 15; 171(8):4096-104. PMID: 14530331.
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    81. Cantu C, Benlagha K, Savage PB, Bendelac A, Teyton L. The paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs. J Immunol. 2003 May 01; 170(9):4673-82. PMID: 12707346.
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    82. Park SH, Kyin T, Bendelac A, Carnaud C. The contribution of NKT cells, NK cells, and other gamma-chain-dependent non-T non-B cells to IL-12-mediated rejection of tumors. J Immunol. 2003 Feb 01; 170(3):1197-201. PMID: 12538676.
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    83. Honey K, Benlagha K, Beers C, Forbush K, Teyton L, Kleijmeer MJ, Rudensky AY, Bendelac A. Thymocyte expression of cathepsin L is essential for NKT cell development. Nat Immunol. 2002 Nov; 3(11):1069-74. PMID: 12368909.
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    84. Procópio DO, Almeida IC, Torrecilhas AC, Cardoso JE, Teyton L, Travassos LR, Bendelac A, Gazzinelli RT. Glycosylphosphatidylinositol-anchored mucin-like glycoproteins from Trypanosoma cruzi bind to CD1d but do not elicit dominant innate or adaptive immune responses via the CD1d/NKT cell pathway. J Immunol. 2002 Oct 01; 169(7):3926-33. PMID: 12244192.
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    85. Lee PT, Putnam A, Benlagha K, Teyton L, Gottlieb PA, Bendelac A. Testing the NKT cell hypothesis of human IDDM pathogenesis. J Clin Invest. 2002 Sep; 110(6):793-800. PMID: 12235110.
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    86. Bendelac A, Teyton L, Savage PB. Lipid presentation by CD1: the short and the long lipid story. Nat Immunol. 2002 May; 3(5):421-2. PMID: 11976717.
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    87. Benlagha K, Kyin T, Beavis A, Teyton L, Bendelac A. A thymic precursor to the NK T cell lineage. Science. 2002 Apr 19; 296(5567):553-5. PMID: 11968185.
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    88. Zhou XT, Forestier C, Goff RD, Li C, Teyton L, Bendelac A, Savage PB. Synthesis and NKT cell stimulating properties of fluorophore- and biotin-appended 6"-amino-6"-deoxy-galactosylceramides. Org Lett. 2002 Apr 18; 4(8):1267-70. PMID: 11950339.
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    89. Lee PT, Benlagha K, Teyton L, Bendelac A. Distinct functional lineages of human V(alpha)24 natural killer T cells. J Exp Med. 2002 Mar 04; 195(5):637-41. PMID: 11877486.
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    90. Bendelac A, Medzhitov R. Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med. 2002 Mar 04; 195(5):F19-23. PMID: 11877490.
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    91. Oliveira SA, Park SH, Lee P, Bendelac A, Shenk TE. Murine cytomegalovirus m02 gene family protects against natural killer cell-mediated immune surveillance. J Virol. 2002 Jan; 76(2):885-94. PMID: 11752177.
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    92. Chiu YH, Park SH, Benlagha K, Forestier C, Jayawardena-Wolf J, Savage PB, Teyton L, Bendelac A. Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d. Nat Immunol. 2002 Jan; 3(1):55-60. PMID: 11731798.
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    93. Bendelac A, Bonneville M, Kearney JF. Autoreactivity by design: innate B and T lymphocytes. Nat Rev Immunol. 2001 Dec; 1(3):177-86. PMID: 11905826.
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    94. Jayawardena-Wolf J, Benlagha K, Chiu YH, Mehr R, Bendelac A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity. 2001 Dec; 15(6):897-908. PMID: 11754812.
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    95. Dokun AO, Chu DT, Yang L, Bendelac AS, Yokoyama WM. Analysis of in situ NK cell responses during viral infection. J Immunol. 2001 Nov 01; 167(9):5286-93. PMID: 11673544.
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    96. Park SH, Weiss A, Benlagha K, Kyin T, Teyton L, Bendelac A. The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families. J Exp Med. 2001 Apr 16; 193(8):893-904. PMID: 11304550.
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    97. Park SH, Bendelac A. CD1-restricted T-cell responses and microbial infection. Nature. 2000 Aug 17; 406(6797):788-92. PMID: 10963609.
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    98. Benlagha K, Weiss A, Beavis A, Teyton L, Bendelac A. In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers. J Exp Med. 2000 Jun 05; 191(11):1895-903. PMID: 10839805.
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    99. Park SH, Benlagha K, Lee D, Balish E, Bendelac A. Unaltered phenotype, tissue distribution and function of Valpha14(+) NKT cells in germ-free mice. Eur J Immunol. 2000 Feb; 30(2):620-5. PMID: 10671219.
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    100. Carnaud C, Lee D, Donnars O, Park SH, Beavis A, Koezuka Y, Bendelac A. Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol. 1999 Nov 01; 163(9):4647-50. PMID: 10528160.
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    101. Park SH, Guy-Grand D, Lemonnier FA, Wang CR, Bendelac A, Jabri B. Selection and expansion of CD8alpha/alpha(1) T cell receptor alpha/beta(1) intestinal intraepithelial lymphocytes in the absence of both classical major histocompatibility complex class I and nonclassical CD1 molecules. J Exp Med. 1999 Sep 20; 190(6):885-90. PMID: 10499927.
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    102. Tilloy F, Treiner E, Park SH, Garcia C, Lemonnier F, de la Salle H, Bendelac A, Bonneville M, Lantz O. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals. J Exp Med. 1999 Jun 21; 189(12):1907-21. PMID: 10377186.
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    103. Chiu YH, Jayawardena J, Weiss A, Lee D, Park SH, Dautry-Varsat A, Bendelac A. Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments. J Exp Med. 1999 Jan 04; 189(1):103-10. PMID: 9874567.
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    104. Park SH, Chiu YH, Jayawardena J, Roark J, Kavita U, Bendelac A. Innate and adaptive functions of the CD1 pathway of antigen presentation. Semin Immunol. 1998 Oct; 10(5):391-8. PMID: 9799714.
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    105. Park SH, Roark JH, Bendelac A. Tissue-specific recognition of mouse CD1 molecules. J Immunol. 1998 Apr 01; 160(7):3128-34. PMID: 9531267.
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    106. Roark JH, Park SH, Jayawardena J, Kavita U, Shannon M, Bendelac A. CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells. J Immunol. 1998 Apr 01; 160(7):3121-7. PMID: 9531266.
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    107. Bendelac A, Rivera MN, Park SH, Roark JH. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu Rev Immunol. 1997; 15:535-62. PMID: 9143699.
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    108. Bendelac A, Hunziker RD, Lantz O. Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells. J Exp Med. 1996 Oct 01; 184(4):1285-93. PMID: 8879200.
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    109. Bendelac A. Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes. J Exp Med. 1995 Dec 01; 182(6):2091-6. PMID: 7500054.
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    110. Bendelac A, Lantz O, Quimby ME, Yewdell JW, Bennink JR, Brutkiewicz RR. CD1 recognition by mouse NK1+ T lymphocytes. Science. 1995 May 12; 268(5212):863-5. PMID: 7538697.
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    111. Lantz O, Bendelac A. An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans. J Exp Med. 1994 Sep 01; 180(3):1097-106. PMID: 7520467.
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