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Karl S. Matlin

TitleEmeritus/Emerita, Professor
InstitutionUniversity of Chicago
DepartmentSurgery-Surgical Res.
AddressChicago IL 60637
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    G13LM009860     (MATLIN, KARL S)Sep 1, 2009 - Aug 31, 2012
    A History of Cell Biology from the Perspective of the Signal Hypothesis
    Role: Principal Investigator

    R01DK068568     (MATLIN, KARL S)May 1, 2006 - Apr 30, 2013
    Cell-Matrix Interactions in Epithelial Polarization
    Role: Principal Investigator

    R01DK046768     (MATLIN, KARL S)Apr 1, 1994 - Mar 31, 2004
    Role: Principal Investigator

    R55DK046768     (MATLIN, KARL S)Sep 30, 1992 - Mar 31, 1994
    Role: Principal Investigator

    S10RR004951     (MATLIN, KARL S)Apr 10, 1989 - Apr 9, 1990
    Role: Principal Investigator

    R01GM038100     (MATLIN, KARL S)Sep 1, 1986 - Aug 31, 1988
    Role: Principal Investigator

    R01CA044331     (MATLIN, KARL S)Jul 1, 1986 - Dec 31, 1990
    Role: Principal Investigator

    R01GM034030     (MATLIN, KARL S)Sep 1, 1984 - Aug 31, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Matlin KS. Andrew S. Reynolds, The Third Lens: Metaphor and the Creation of Modern Cell Biology (Chicago: University of Chicago Press, 2018), 272 pp., $30.00 Paper, ISBN: 9780226563121. J Hist Biol. 2019 Feb 14. PMID: 30762150.
    2. Raykhel I, Moafi F, Greciano PG, Matlin KS, Moyano JV, Manninen A, Myllyharju J, Myllymäki SM. BAMBI is a novel HIF1-dependent modulator of TGFß-mediated disruption of cell polarity during hypoxia. J Cell Sci. 2018 05 23; 131(10). PMID: 29685894.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    3. Matlin KS, Manninen A, Myllymäki SM. Laminins in Epithelial Cell Polarization: Old Questions in Search of New Answers. Cold Spring Harb Perspect Biol. 2017 Oct 03; 9(10). PMID: 28159878; PMCID: PMC5629996.
      Citations: 8     Fields:    Translation:AnimalsCells
    4. Matlin KS, Caplan MJ. The secretory pathway at 50: a golden anniversary for some momentous grains of silver. Mol Biol Cell. 2017 01 15; 28(2):229-232. PMID: 28082520; PMCID: PMC5231891.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    5. Matlin KS. The Heuristic of Form: Mitochondrial Morphology and the Explanation of Oxidative Phosphorylation. J Hist Biol. 2016 Feb; 49(1):37-94. PMID: 26238091.
      Citations: 5     Fields:    Translation:Cells
    6. Kenny HA, Chiang CY, White EA, Schryver EM, Habis M, Romero IL, Ladanyi A, Penicka CV, George J, Matlin K, Montag A, Wroblewski K, Yamada SD, Mazar AP, Bowtell D, Lengyel E. Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. J Clin Invest. 2014 Oct; 124(10):4614-28. PMID: 25202979; PMCID: PMC4191043.
      Citations: 178     Fields:    Translation:HumansAnimalsCells
    7. Friedrichs J, Strohmeyer N, Moyano JV, Wu C, Matlin KS, Muller DJ, Manninen A, Teräväinen TP, Myllymäki SM. aV-integrins are required for mechanotransduction in MDCK epithelial cells. PLoS One. 2013; 8(8):e71485. PMID: 23977051; PMCID: PMC3747215.
      Citations: 12     Fields:    Translation:AnimalsCells
    8. Sherer R, Dong H, Yunfeng Z, Stern S, Jiong Y, Matlin K, Baoping Y, Husain AN, Morgan I, Cooper B, Juan F, Mehta S. Medical education reform in wuhan university, china: a preliminary report of an international collaboration. Teach Learn Med. 2013; 25(2):148-54. PMID: 23530677.
      Citations: 11     Fields:    Translation:Humans
    9. Greciano PG, Moyano JV, Buschmann MM, Tang J, Lu Y, Rudnicki J, Manninen A, Matlin KS. Laminin 511 partners with laminin 332 to mediate directional migration of Madin-Darby canine kidney epithelial cells. Mol Biol Cell. 2012 Jan; 23(1):121-36. PMID: 22031290; PMCID: PMC3248892.
      Citations: 8     Fields:    Translation:AnimalsCells
    10. Matlin KS. Spatial expression of the genome: the signal hypothesis at forty. Nat Rev Mol Cell Biol. 2011 05; 12(5):333-40. PMID: 21487438.
      Citations: 10     Fields:    Translation:Cells
    11. Moyano JV, Greciano PG, Buschmann MM, Koch M, Matlin KS. Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells. Mol Biol Cell. 2010 Nov 01; 21(21):3654-68. PMID: 20844080; PMCID: PMC2965683.
      Citations: 17     Fields:    Translation:AnimalsCells
    12. Tang J, Bouyer P, Mykoniatis A, Buschmann M, Matlin KS, Matthews JB. Activated PKC{delta} and PKC{epsilon} inhibit epithelial chloride secretion response to cAMP via inducing internalization of the Na+-K+-2Cl- cotransporter NKCC1. J Biol Chem. 2010 Oct 29; 285(44):34072-85. PMID: 20732874; PMCID: PMC2962506.
      Citations: 9     Fields:    Translation:HumansCells
    13. Mykoniatis A, Shen L, Fedor-Chaiken M, Tang J, Tang X, Worrell RT, Delpire E, Turner JR, Matlin KS, Bouyer P, Matthews JB. Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway. Am J Physiol Cell Physiol. 2010 Jan; 298(1):C85-97. PMID: 19864322; PMCID: PMC2806153.
      Citations: 12     Fields:    Translation:AnimalsCells
    14. Kawedia JD, Jiang M, Kulkarni A, Waechter HE, Matlin KS, Pauletti GM, Menon AG. The protein kinase A pathway contributes to Hg2+-induced alterations in phosphorylation and subcellular distribution of occludin associated with increased tight junction permeability of salivary epithelial cell monolayers. J Pharmacol Exp Ther. 2008 Sep; 326(3):829-37. PMID: 18550693; PMCID: PMC2677297.
      Citations: 13     Fields:    Translation:AnimalsCells
    15. Juncosa-Melvin N, Matlin KS, Holdcraft RW, Nirmalanandhan VS, Butler DL. Mechanical stimulation increases collagen type I and collagen type III gene expression of stem cell-collagen sponge constructs for patellar tendon repair. Tissue Eng. 2007 Jun; 13(6):1219-26. PMID: 17518715.
      Citations: 64     Fields:    Translation:AnimalsCells
    16. Mak GZ, Kavanaugh GM, Buschmann MM, Stickley SM, Koch M, Goss KH, Waechter H, Zuk A, Matlin KS. Regulated synthesis and functions of laminin 5 in polarized madin-darby canine kidney epithelial cells. Mol Biol Cell. 2006 Aug; 17(8):3664-77. PMID: 16775009; PMCID: PMC1525223.
      Citations: 13     Fields:    Translation:AnimalsCells
    17. Solomkin JS, Robinson CT, Cave CM, Umanskiy K, Matlin K, Williams MA, Lentsch AB. Formation of focal adhesion-like structures in circulating human neutrophils after severe injury: triggering of a tissue-phase response in the vascular space. Shock. 2006 May; 25(5):440-5. PMID: 16680007.
      Citations:    Fields:    Translation:HumansCells
    18. Del Castillo IC, Fedor-Chaiken M, Song JC, Starlinger V, Yoo J, Matlin KS, Matthews JB. Dynamic regulation of Na(+)-K(+)-2Cl(-) cotransporter surface expression by PKC-{epsilon} in Cl(-)--secretory epithelia. Am J Physiol Cell Physiol. 2005 Nov; 289(5):C1332-42. PMID: 16000638.
      Citations: 26     Fields:    Translation:HumansCells
    19. Matlin KS. Clues to occludin. Focus on "Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells". Am J Physiol Cell Physiol. 2005 Jun; 288(6):C1191-2. PMID: 15897320.
      Citations:    Fields:    Translation:AnimalsCells
    20. Yu W, Datta A, Leroy P, O'Brien LE, Mak G, Jou TS, Matlin KS, Mostov KE, Zegers MM. Beta1-integrin orients epithelial polarity via Rac1 and laminin. Mol Biol Cell. 2005 Feb; 16(2):433-45. PMID: 15574881; PMCID: PMC545874.
      Citations: 178     Fields:    Translation:AnimalsCells
    21. Mammen JM, Song JC, Yoo J, Kim PS, Davis HW, Calvo MI, Worrell RT, Matlin KS, Matthews JB. Differential subcellular targeting of PKC-epsilon in response to pharmacological or ischemic stimuli in intestinal epithelia. Am J Physiol Gastrointest Liver Physiol. 2005 Jan; 288(1):G135-42. PMID: 15358594.
      Citations: 2     Fields:    Translation:HumansCells
    22. Wang Z, Zahedi K, Barone S, Tehrani K, Rabb H, Matlin K, Casero RA, Soleimani M. Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury. J Am Soc Nephrol. 2004 Jul; 15(7):1844-52. PMID: 15213272.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    23. Prahalad P, Calvo I, Waechter H, Matthews JB, Zuk A, Matlin KS. Regulation of MDCK cell-substratum adhesion by RhoA and myosin light chain kinase after ATP depletion. Am J Physiol Cell Physiol. 2004 Mar; 286(3):C693-707. PMID: 14644769.
      Citations: 11     Fields:    Translation:AnimalsCells
    24. Matlin KS, Haus B, Zuk A. Integrins in epithelial cell polarity: using antibodies to analyze adhesive function and morphogenesis. Methods. 2003 Jul; 30(3):235-46. PMID: 12798138.
      Citations: 12     Fields:    Translation:AnimalsCells
    25. Yoo J, Nichols A, Mammen J, Calvo I, Song JC, Worrell RT, Matlin K, Matthews JB. Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins. Am J Physiol Cell Physiol. 2003 Aug; 285(2):C300-9. PMID: 12660149.
      Citations: 15     Fields:    Translation:HumansCells
    26. Yoo J, Nichols A, Song JC, Mammen J, Calvo I, Worrell RT, Cuppoletti J, Matlin K, Matthews JB. Bryostatin-1 attenuates TNF-induced epithelial barrier dysfunction: role of novel PKC isozymes. Am J Physiol Gastrointest Liver Physiol. 2003 Apr; 284(4):G703-12. PMID: 12505880.
      Citations: 7     Fields:    Translation:HumansCells
    27. Zuk A, Matlin KS. Induction of a laminin isoform and alpha(3)beta(1)-integrin in renal ischemic injury and repair in vivo. Am J Physiol Renal Physiol. 2002 Nov; 283(5):F971-84. PMID: 12372773.
      Citations: 7     Fields:    Translation:AnimalsCells
    28. Matlin KS. The strange case of the signal recognition particle. Nat Rev Mol Cell Biol. 2002 07; 3(7):538-42. PMID: 12094220.
      Citations:    Fields:    
    29. Zuk A, Bonventre JV, Matlin KS. Expression of fibronectin splice variants in the postischemic rat kidney. Am J Physiol Renal Physiol. 2001 Jun; 280(6):F1037-53. PMID: 11352844.
      Citations: 13     Fields:    Translation:AnimalsCells
    30. Matlin KS, Matlin KS. When cell biology grew up. Traffic. 2000 Mar; 1(3):291-2. PMID: 11208112.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    31. Matlin KS, van Meer G. [Nobel prize in physiology or medicine for the discovery that proteins have intrinsic signals regulating their transport and localization within the cell]. Ned Tijdschr Geneeskd. 1999 Dec 25; 143(52):2604-7. PMID: 10633804.
      Citations: 1     Fields:    Translation:Cells
    32. Matlin KS, Libert E, McArdle PJ, Howell TH. Implementing the problem-based curriculum at Harvard School of Dental Medicine. J Dent Educ. 1998 Sep; 62(9):693-708. PMID: 9789496.
      Citations:    Fields:    Translation:Humans
    33. Zuk A, Bonventre JV, Brown D, Matlin KS. Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney. Am J Physiol. 1998 09; 275(3):C711-31. PMID: 9730955.
      Citations: 40     Fields:    Translation:AnimalsCells
    34. Huber LA, Pasquali C, Gagescu R, Zuk A, Gruenberg J, Matlin KS. Endosomal fractions from viral K-ras-transformed MDCK cells reveal transformation specific changes on two-dimensional gel maps. Electrophoresis. 1996 Nov; 17(11):1734-40. PMID: 8982606.
      Citations: 1     Fields:    Translation:AnimalsCells
    35. Zuk A, Matlin KS. Apical beta 1 integrin in polarized MDCK cells mediates tubulocyst formation in response to type I collagen overlay. J Cell Sci. 1996 Jul; 109 ( Pt 7):1875-89. PMID: 8832410.
      Citations: 14     Fields:    Translation:AnimalsCells
    36. Zinkl GM, Zuk A, van der Bijl P, van Meer G, Matlin KS. An antiglycolipid antibody inhibits Madin-Darby canine kidney cell adhesion to laminin and interferes with basolateral polarization and tight junction formation. J Cell Biol. 1996 May; 133(3):695-708. PMID: 8636242; PMCID: PMC2120812.
      Citations: 9     Fields:    Translation:AnimalsCells
    37. Howell TH, Matlin K. Damn the torpedoes--innovations for the future: the new curriculum at the Harvard School of Dental Medicine. J Dent Educ. 1995 Sep; 59(9):893-8. PMID: 7560433.
      Citations:    Fields:    Translation:Humans
    38. Zuk A, Zinkl GM, Kendall D, Matlin KS, Schoenenberger CA. Integrin expression and localization in normal MDCK cells and transformed MDCK cells lacking apical polarity. J Cell Sci. 1994 Feb; 107 ( Pt 2):527-41. PMID: 7515897.
      Citations: 42     Fields:    Translation:AnimalsCells
    39. Matlin KS. W(h)ither default? Sorting and polarization in epithelial cells. Curr Opin Cell Biol. 1992 Aug; 4(4):623-8. PMID: 1419044.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    40. Narula N, McMorrow I, Plopper G, Doherty J, Matlin KS, Burke B, Stow JL. Identification of a 200-kD, brefeldin-sensitive protein on Golgi membranes. J Cell Biol. 1992 Apr; 117(1):27-38. PMID: 1556155; PMCID: PMC2289406.
      Citations: 37     Fields:    Translation:AnimalsCells
    41. Matlin KS, Schoenenberger CA. Cell polarity and epithelial oncogenesis. Trends Cell Biol. 1991 Oct; 1(4):87-92. PMID: 14731794.
      Citations: 13     Fields:    
    42. Schoenenberger CA, Zuk A, Kendall D, Matlin KS. Multilayering and loss of apical polarity in MDCK cells transformed with viral K-ras. J Cell Biol. 1991 Mar; 112(5):873-89. PMID: 1999461; PMCID: PMC2288880.
      Citations: 32     Fields:    Translation:AnimalsCells
    43. van Zeijl MJ, Matlin KS. Microtubule perturbation inhibits intracellular transport of an apical membrane glycoprotein in a substrate-dependent manner in polarized Madin-Darby canine kidney epithelial cells. Cell Regul. 1990 Nov; 1(12):921-36. PMID: 1983109; PMCID: PMC362862.
      Citations: 18     Fields:    Translation:AnimalsCells
    44. Zuk A, Matlin KS, Hay ED. Type I collagen gel induces Madin-Darby canine kidney cells to become fusiform in shape and lose apical-basal polarity. J Cell Biol. 1989 Mar; 108(3):903-19. PMID: 2537838; PMCID: PMC2115371.
      Citations: 17     Fields:    Translation:AnimalsCells
    45. Skibbens JE, Roth MG, Matlin KS. Differential extractability of influenza virus hemagglutinin during intracellular transport in polarized epithelial cells and nonpolar fibroblasts. J Cell Biol. 1989 Mar; 108(3):821-32. PMID: 2522097; PMCID: PMC2115377.
      Citations: 69     Fields:    Translation:AnimalsCells
    46. Matlin KS, Skibbens J, McNeil PL. Reduced extracellular pH reversibly inhibits oligomerization, intracellular transport, and processing of the influenza hemagglutinin in infected Madin-Darby canine kidney cells. J Biol Chem. 1988 Aug 15; 263(23):11478-85. PMID: 3042769.
      Citations: 8     Fields:    Translation:AnimalsCells
    47. Matlin KS. The sorting of proteins to the plasma membrane in epithelial cells. J Cell Biol. 1986 Dec; 103(6 Pt 2):2565-8. PMID: 3025218; PMCID: PMC2114633.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    48. Matlin KS. Ammonium chloride slows transport of the influenza virus hemagglutinin but does not cause mis-sorting in a polarized epithelial cell line. J Biol Chem. 1986 Nov 15; 261(32):15172-8. PMID: 3771570.
      Citations: 22     Fields:    Translation:AnimalsCells
    49. Griffiths G, Pfeiffer S, Simons K, Matlin K. Exit of newly synthesized membrane proteins from the trans cisterna of the Golgi complex to the plasma membrane. J Cell Biol. 1985 Sep; 101(3):949-64. PMID: 2863275; PMCID: PMC2113726.
      Citations: 155     Fields:    Translation:AnimalsCells
    50. Matlin KS, Simons K. Sorting of an apical plasma membrane glycoprotein occurs before it reaches the cell surface in cultured epithelial cells. J Cell Biol. 1984 Dec; 99(6):2131-9. PMID: 6501415; PMCID: PMC2113546.
      Citations: 94     Fields:    Translation:AnimalsCells
    51. Burke B, Matlin K, Bause E, Legler G, Peyrieras N, Ploegh H. Inhibition of N-linked oligosaccharide trimming does not interfere with surface expression of certain integral membrane proteins. EMBO J. 1984 Mar; 3(3):551-6. PMID: 6232135; PMCID: PMC557385.
      Citations: 40     Fields:    Translation:AnimalsCells
    52. Matlin K, Bainton DF, Pesonen M, Louvard D, Genty N, Simons K. Transepithelial transport of a viral membrane glycoprotein implanted into the apical plasma membrane of Madin-Darby canine kidney cells. I. Morphological evidence. J Cell Biol. 1983 Sep; 97(3):627-37. PMID: 6885914; PMCID: PMC2112569.
      Citations: 46     Fields:    Translation:AnimalsCells
    53. Matlin KS, Simons K. Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation. Cell. 1983 Aug; 34(1):233-43. PMID: 6883510.
      Citations: 213     Fields:    Translation:AnimalsCells
    54. Marsh M, Helenius A, Matlin K, Simons K. Binding, endocytosis, and degradation of enveloped animal viruses. Methods Enzymol. 1983; 98:260-6. PMID: 6321902.
      Citations: 3     Fields:    Translation:AnimalsCells
    55. Matlin KS, Reggio H, Helenius A, Simons K. Pathway of vesicular stomatitis virus entry leading to infection. J Mol Biol. 1982 Apr 15; 156(3):609-31. PMID: 6288961.
      Citations: 167     Fields:    Translation:AnimalsCells
    56. Marsh M, Matlin K, Simons K, Reggio H, White J, Kartenbeck J, Helenius A. Are lysosomes a site of enveloped-virus penetration? Cold Spring Harb Symp Quant Biol. 1982; 46 Pt 2:835-43. PMID: 6286223.
      Citations: 15     Fields:    Translation:AnimalsCells
    57. Matlin KS, Reggio H, Helenius A, Simons K. The entry of enveloped viruses into an epithelial cell line. Prog Clin Biol Res. 1982; 91:599-611. PMID: 6292951.
      Citations: 3     Fields:    Translation:AnimalsCells
    58. Matlin KS, Reggio H, Helenius A, Simons K. Infectious entry pathway of influenza virus in a canine kidney cell line. J Cell Biol. 1981 Dec; 91(3 Pt 1):601-13. PMID: 7328111; PMCID: PMC2112819.
      Citations: 279     Fields:    Translation:AnimalsCells
    59. White J, Matlin K, Helenius A. Cell fusion by Semliki Forest, influenza, and vesicular stomatitis viruses. J Cell Biol. 1981 Jun; 89(3):674-9. PMID: 6265470; PMCID: PMC2111813.
      Citations: 246     Fields:    Translation:AnimalsCells
    60. Schmidt GW, Matlin KS, Chua NH. A rapid procedure for selective enrichment of photosynthetic electron transport mutants. Proc Natl Acad Sci U S A. 1977 Feb; 74(2):610-4. PMID: 265526; PMCID: PMC392341.
      Citations: 31     Fields:    Translation:AnimalsCells
    61. Chua NH, Matlin K, Bennoun P. A chlorophyll-protein complex lacking in photosystem I mutants of Chlamydomonas reinhardtii. J Cell Biol. 1975 Nov; 67(2PT.1):361-77. PMID: 1194353; PMCID: PMC2109600.
      Citations: 43     Fields:    Translation:AnimalsCells
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