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Hilary Kenny

TitleResearch Associate Professor
InstitutionUniversity of Chicago
DepartmentObstetrics and Gynecology
AddressChicago IL 60637
Phone+1 (773) 702-9763
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    K99CA134750     (KENNY, HILARY ANN)Sep 1, 2009 - Aug 31, 2012
    The Role of the Microenvironment in Early Ovarian Cancer Metastasis
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Schweizer L, Krishnan R, Shimizu A, Metousis A, Kenny H, Mendoza R, Nordmann TM, Rauch S, Kelliher L, Heide J, Rosenberger FA, Bilecz A, Borrego SN, Strauss MT, Thielert M, Rodriguez E, Müller-Reif JB, Chen M, Yamada SD, Mund A, Lastra RR, Mann M, Lengyel E. Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression. medRxiv. 2023 Nov 13. PMID: 38014221; PMCID: PMC10680885.
    2. Bajwa P, Kordylewicz K, Bilecz A, Lastra RR, Wroblewski K, Lengyel E, Kenny HA, Rinkevich Y. Cancer-associated mesothelial cell-derived ANGPTL4 and STC1 promote the early steps of ovarian cancer metastasis. JCI Insight. 2023 03 22; 8(6). PMID: 36795484; PMCID: PMC10070116.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Kenny HA, Hart PC, Kordylewicz K, Lal M, Shen M, Kara B, Chen YJ, Grassl N, Alharbi Y, Pattnaik BR, Watters KM, Patankar MS, Ferrer M, Lengyel E. The Natural Product ß-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis. Cancers (Basel). 2021 Aug 04; 13(16). PMID: 34439084; PMCID: PMC8394501.
      Citations: 11     
    4. Cui C, Chakraborty K, Tang XA, Zhou G, Schoenfelt KQ, Becker KM, Hoffman A, Chang YF, Blank A, Reardon CA, Kenny HA, Vaisar T, Lengyel E, Greene G, Becker L. Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis. Cell. 2021 06 10; 184(12):3163-3177.e21. PMID: 33964209; PMCID: PMC10712736.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    5. Hart PC, Bajwa P, Kenny HA. Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity. Adv Exp Med Biol. 2021; 1330:75-94. PMID: 34339031.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    6. Hart PC, Kenny HA, Grassl N, Watters KM, Litchfield LM, Coscia F, Ploetzky L, Fiehn O, Mann M, Lengyel E, Romero IL, Blaženovic I. Mesothelial Cell HIF1a Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk. Cell Rep. 2019 12 17; 29(12):4086-4098.e6. PMID: 31851935; PMCID: PMC7218928.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    7. Ko SY, Lee W, Kenny HA, Dang LH, Ellis LM, Jonasch E, Lengyel E, Naora H. Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake. Commun Biol. 2019 Oct 18; 2(1):386. PMID: 31925178.
    8. Ko SY, Lee W, Kenny HA, Dang LH, Ellis LM, Jonasch E, Lengyel E, Naora H. Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake. Commun Biol. 2019; 2:386. PMID: 31646189; PMCID: PMC6802217.
      Citations: 61     Translation:HumansAnimalsCells
    9. Kenny HA, Lal-Nag M, Shen M, Kara B, Nahotko DA, Wroblewski K, Fazal S, Chen S, Chiang CY, Chen YJ, Brimacombe KR, Marugan J, Ferrer M, Lengyel E. Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis. Mol Cancer Ther. 2020 01; 19(1):52-62. PMID: 31562255; PMCID: PMC6946883.
      Citations: 13     Fields:    Translation:HumansAnimals
    10. McGuire S, Kara B, Hart PC, Montag A, Wroblewski K, Fazal S, Huang XY, Lengyel E, Kenny HA. Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis. Gynecol Oncol. 2019 05; 153(2):405-415. PMID: 30797592; PMCID: PMC6486884.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    11. Lee W, Ko SY, Mohamed MS, Kenny HA, Lengyel E, Naora H. Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum. J Exp Med. 2019 01 07; 216(1):176-194. PMID: 30567719; PMCID: PMC6314534.
      Citations: 183     Fields:    Translation:HumansAnimalsCells
    12. Curtis M, Kenny HA, Ashcroft B, Mukherjee A, Johnson A, Zhang Y, Helou Y, Batlle R, Liu X, Gutierrez N, Gao X, Yamada SD, Lastra R, Montag A, Ahsan N, Locasale JW, Salomon AR, Lengyel E, Nebreda AR. Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. Cell Metab. 2019 01 08; 29(1):141-155.e9. PMID: 30174305; PMCID: PMC6326875.
      Citations: 128     Fields:    Translation:HumansAnimalsCells
    13. Watters KM, Bajwa P, Kenny HA. Organotypic 3D Models of the Ovarian Cancer Tumor Microenvironment. Cancers (Basel). 2018 Aug 09; 10(8). PMID: 30096959; PMCID: PMC6115826.
      Citations: 27     
    14. Ladanyi A, Mukherjee A, Kenny HA, Johnson A, Mitra AK, Sundaresan S, Nieman KM, Pascual G, Benitah SA, Montag A, Yamada SD, Abumrad NA, Lengyel E. Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis. Oncogene. 2018 04; 37(17):2285-2301. PMID: 29398710; PMCID: PMC5920730.
      Citations: 213     Fields:    Translation:HumansAnimalsCells
    15. Mukherjee A, Kenny HA, Lengyel E. Unsaturated Fatty Acids Maintain Cancer Cell Stemness. Cell Stem Cell. 2017 03 02; 20(3):291-292. PMID: 28257705; PMCID: PMC5956908.
      Citations: 39     Fields:    Translation:HumansCells
    16. Lal-Nag M, McGee L, Guha R, Lengyel E, Kenny HA, Ferrer M. A High-Throughput Screening Model of the Tumor Microenvironment for Ovarian Cancer Cell Growth. SLAS Discov. 2017 06; 22(5):494-506. PMID: 28346091; PMCID: PMC5815521.
      Citations: 18     Fields:    Translation:HumansCells
    17. Zhang Y, Sriraman SK, Kenny HA, Luther E, Torchilin V, Lengyel E. Reversal of Chemoresistance in Ovarian Cancer by Co-Delivery of a P-Glycoprotein Inhibitor and Paclitaxel in a Liposomal Platform. Mol Cancer Ther. 2016 10; 15(10):2282-2293. PMID: 27466355; PMCID: PMC5050109.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    18. Kenny HA, Lal-Nag M, White EA, Shen M, Chiang CY, Mitra AK, Zhang Y, Curtis M, Schryver EM, Bettis S, Jadhav A, Boxer MB, Li Z, Ferrer M, Lengyel E. Erratum: Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. Nat Commun. 2016 Feb 03; 7:10649. PMID: 26838815; PMCID: PMC4742809.
      Citations: 1     Fields:    
    19. Peters PN, Schryver EM, Lengyel E, Kenny H. Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity. J Vis Exp. 2015 12 31; (106):e53541. PMID: 26780294; PMCID: PMC4780905.
      Citations: 11     Fields:    Translation:HumansCells
    20. Romero IL, Mukherjee A, Kenny HA, Litchfield LM, Lengyel E. Molecular pathways: trafficking of metabolic resources in the tumor microenvironment. Clin Cancer Res. 2015 Feb 15; 21(4):680-6. PMID: 25691772; PMCID: PMC4333734.
      Citations: 52     Fields:    Translation:HumansCells
    21. Kenny HA, Lal-Nag M, White EA, Shen M, Chiang CY, Mitra AK, Zhang Y, Curtis M, Schryver EM, Bettis S, Jadhav A, Boxer MB, Li Z, Ferrer M, Lengyel E. Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. Nat Commun. 2015 Feb 05; 6:6220. PMID: 25653139; PMCID: PMC4427252.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    22. Kenny HA, Chiang CY, White EA, Schryver EM, Habis M, Romero IL, Ladanyi A, Penicka CV, George J, Matlin K, Montag A, Wroblewski K, Yamada SD, Mazar AP, Bowtell D, Lengyel E. Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. J Clin Invest. 2014 Oct; 124(10):4614-28. PMID: 25202979; PMCID: PMC4191043.
      Citations: 178     Fields:    Translation:HumansAnimalsCells
    23. White EA, Kenny HA, Lengyel E. Three-dimensional modeling of ovarian cancer. Adv Drug Deliv Rev. 2014 Dec 15; 79-80:184-92. PMID: 25034878; PMCID: PMC4426864.
      Citations: 25     Fields:    Translation:HumansAnimals
    24. Zhang Y, Kenny HA, Swindell EP, Mitra AK, Hankins PL, Ahn RW, Gwin K, Mazar AP, O'Halloran TV, Lengyel E. Urokinase plasminogen activator system-targeted delivery of nanobins as a novel ovarian cancer therapy. Mol Cancer Ther. 2013 Dec; 12(12):2628-39. PMID: 24061648; PMCID: PMC3885360.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    25. Lengyel E, Burdette JE, Kenny HA, Matei D, Pilrose J, Haluska P, Nephew KP, Hales DB, Stack MS. Epithelial ovarian cancer experimental models. Oncogene. 2014 Jul 10; 33(28):3619-33. PMID: 23934194; PMCID: PMC3990646.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
    26. Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Yamada SD, Peter ME, Gwin K, Lengyel E, Hotamisligil GS. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med. 2011 Oct 30; 17(11):1498-503. PMID: 22037646; PMCID: PMC4157349.
      Citations: 1095     Fields:    Translation:HumansAnimalsCells
    27. Kenny HA, Nieman KM, Mitra AK, Lengyel E. The first line of intra-abdominal metastatic attack: breaching the mesothelial cell layer. Cancer Discov. 2011 Jul; 1(2):100-2. PMID: 22013555; PMCID: PMC3193939.
      Citations: 45     Fields:    Translation:HumansCells
    28. Kenny HA, Leonhardt P, Ladanyi A, Yamada SD, Montag A, Im HK, Jagadeeswaran S, Shaw DE, Mazar AP, Lengyel E. Targeting the urokinase plasminogen activator receptor inhibits ovarian cancer metastasis. Clin Cancer Res. 2011 Feb 01; 17(3):459-71. PMID: 21149615; PMCID: PMC3073583.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    29. Kaur S, Kenny HA, Jagadeeswaran S, Zillhardt MR, Montag AG, Kistner E, Yamada SD, Mitra AK, Lengyel E. {beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer. Am J Pathol. 2009 Nov; 175(5):2184-96. PMID: 19808644; PMCID: PMC2774080.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    30. Kenny HA, Lengyel E. MMP-2 functions as an early response protein in ovarian cancer metastasis. Cell Cycle. 2009 Mar 01; 8(5):683-8. PMID: 19221481; PMCID: PMC2840625.
      Citations: 61     Fields:    Translation:HumansAnimals
    31. Kenny HA, Dogan S, Zillhardt M, K Mitra A, Yamada SD, Krausz T, Lengyel E. Organotypic models of metastasis: A three-dimensional culture mimicking the human peritoneum and omentum for the study of the early steps of ovarian cancer metastasis. Cancer Treat Res. 2009; 149:335-51. PMID: 19763444; PMCID: PMC3651885.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    32. Sawada K, Mitra AK, Radjabi AR, Bhaskar V, Kistner EO, Tretiakova M, Jagadeeswaran S, Montag A, Becker A, Kenny HA, Peter ME, Ramakrishnan V, Yamada SD, Lengyel E. Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target. Cancer Res. 2008 Apr 01; 68(7):2329-39. PMID: 18381440; PMCID: PMC2665934.
      Citations: 191     Fields:    Translation:HumansAnimalsCells
    33. Kenny HA, Kaur S, Coussens LM, Lengyel E. The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin. J Clin Invest. 2008 Apr; 118(4):1367-79. PMID: 18340378; PMCID: PMC2267016.
      Citations: 178     Fields:    Translation:HumansAnimalsCells
    34. Radjabi AR, Sawada K, Jagadeeswaran S, Eichbichler A, Kenny HA, Montag A, Bruno K, Lengyel E. Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface. J Biol Chem. 2008 Feb 01; 283(5):2822-34. PMID: 18048360; PMCID: PMC2805198.
      Citations: 30     Fields:    Translation:HumansCells
    35. Kenny HA, Krausz T, Yamada SD, Lengyel E. Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum. Int J Cancer. 2007 Oct 01; 121(7):1463-72. PMID: 17546601.
      Citations: 147     Fields:    Translation:HumansCells
    36. Sawada K, Radjabi AR, Shinomiya N, Kistner E, Kenny H, Becker AR, Turkyilmaz MA, Salgia R, Yamada SD, Vande Woude GF, Tretiakova MS, Lengyel E. c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. Cancer Res. 2007 Feb 15; 67(4):1670-9. PMID: 17308108.
      Citations: 138     Fields:    Translation:HumansAnimals
    37. Kenny HA, Woodruff TK. Follicle size class contributes to distinct secretion patterns of inhibin isoforms during the rat estrous cycle. Endocrinology. 2006 Jan; 147(1):51-60. PMID: 16195413.
      Citations: 4     Fields:    Translation:Animals
    38. Tomic D, Miller KP, Kenny HA, Woodruff TK, Hoyer P, Flaws JA. Ovarian follicle development requires Smad3. Mol Endocrinol. 2004 Sep; 18(9):2224-40. PMID: 15192076.
      Citations: 35     Fields:    Translation:AnimalsCells
    39. Kenny HA, Bernard DJ, Horton TH, Woodruff TK. Photoperiod-dependent regulation of inhibin in Siberian hamsters: I. Ovarian inhibin production and secretion. J Endocrinol. 2002 Jul; 174(1):71-83. PMID: 12098665.
      Citations: 7     Fields:    Translation:AnimalsCells
    40. Kenny HA, Bernard DJ, Horton TH, Woodruff TK. Photoperiod-dependent regulation of inhibin in Siberian hamsters: II. Regulation of inhibin production and secretion by pregnant mare serum gonadotropin. J Endocrinol. 2002 Jul; 174(1):85-94. PMID: 12098666.
      Citations: 4     Fields:    Translation:Animals
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