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Gregory Dwyer

InstitutionUniversity of Chicago
DepartmentEcology and Evolution
AddressChicago IL 60637
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    My lab studies the ecology and evolution of pathogens, and how pathogens drive the evolution and population dynamics of their hosts. Two major questions that we ask are, how does host variation affect pathogen epidemics and pathogen evolution? And, how does pathogen variation modulate the effects of pathogens on host population dynamics? We attempt to answer these questions by first constructing mathematical models of host-pathogen dynamics, and then by testing the models using a combination of experiments and observations of epidemics in nature. We use insect pathogens as test systems, but the general usefulness of the advanced computing techniques that we use has led to studies of human papillomavirus and salmon conservation. Insect pathogens play a key role in preventing the destruction of forests, and this role has driven new projects on the ecology and economics of biological control, and on the effects of climate change on insect outbreaks.
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    Collapse Biography 
    Collapse education and training
    University of Washington, Seattle, WAPh.D.1990Zoology
    Cornell University, Ithaca, NYB.A. with Honors1983Biology
    Collapse awards and honors
    2014Quantrell Award for Excellence in Undergraduate Teaching, University of Chicago
    1998George Mercer Award for an Outstanding Paper by an Author of Age Less Than 40 , Ecological Society of America

    Collapse Research 
    Collapse research activities and funding
    R01GM096655     (DWYER, GREGORY)Sep 1, 2010 - Feb 28, 2015
    Natural Selection, Host-Pathogen Interactions, and Insect Outbreaks
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Andreasen V, Dwyer G. Seasonality and the Coexistence of Pathogen Strains. Am Nat. 2023 05; 201(5):639-658. PMID: 37130239.
      Citations:    Fields:    Translation:Humans
    2. Dwyer G, Mihaljevic JR, Dukic V. Can Eco-Evo Theory Explain Population Cycles in the Field? Am Nat. 2022 01; 199(1):108-125. PMID: 34978965.
      Citations: 1     Fields:    Translation:Animals
    3. Polivka CM, Mihaljevic JR, Dwyer G. Use of a mechanistic growth model in evaluating post-restoration habitat quality for juvenile salmonids. PLoS One. 2020; 15(6):e0234072. PMID: 32579548; PMCID: PMC7313756.
      Citations:    Fields:    Translation:Animals
    4. Mihaljevic JR, Polivka CM, Mehmel CJ, Li C, Dukic V, Dwyer G. An Empirical Test of the Role of Small-Scale Transmission in Large-Scale Disease Dynamics. Am Nat. 2020 04; 195(4):616-635. PMID: 32216670.
      Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    5. Kyle CH, Liu J, Gallagher ME, Dukic V, Dwyer G. Stochasticity and Infectious Disease Dynamics: Density and Weather Effects on a Fungal Insect Pathogen. Am Nat. 2020 03; 195(3):504-523. PMID: 32097039; PMCID: PMC10465172.
      Citations: 6     Fields:    Translation:AnimalsPHPublic Health
    6. Gallagher ME, Dwyer G. Combined Effects of Natural Enemies and Competition for Resources on a Forest Defoliator: A Theoretical and Empirical Analysis. Am Nat. 2019 12; 194(6):807-822. PMID: 31738098.
      Citations:    Fields:    Translation:Animals
    7. Ranjeva SL, Mihaljevic JR, Joseph MB, Giuliano AR, Dwyer G. Untangling the dynamics of persistence and colonization in microbial communities. ISME J. 2019 12; 13(12):2998-3010. PMID: 31444482; PMCID: PMC6863904.
      Citations: 2     Fields:    Translation:HumansCells
    8. Kennedy DA, Dwyer G. Effects of multiple sources of genetic drift on pathogen variation within hosts. PLoS Biol. 2018 03; 16(3):e2004444. PMID: 29590105; PMCID: PMC5891033.
      Citations: 11     Fields:    Translation:AnimalsCells
    9. Ranjeva SL, Baskerville EB, Dukic V, Giuliano AR, Dwyer G, Cobey S, Villa LL, Lazcano-Ponce E. Recurring infection with ecologically distinct HPV types can explain high prevalence and diversity. Proc Natl Acad Sci U S A. 2017 12 19; 114(51):13573-13578. PMID: 29208707; PMCID: PMC5754802.
      Citations: 33     Fields:    Translation:HumansCells
    10. Dukic V, Dushoff J, Fleming-Davies A, Dwyer G, Páez DJ. Eco-Evolutionary Theory and Insect Outbreaks. Am Nat. 2017 Jun; 189(6):616-629. PMID: 28514636.
      Citations: 3     Fields:    Translation:Animals
    11. Hudson AI, Fleming-Davies AE, Dwyer G, Páez DJ. Genotype-by-genotype interactions between an insect and its pathogen. J Evol Biol. 2016 12; 29(12):2480-2490. PMID: 27622965.
      Citations: 7     Fields:    Translation:AnimalsCells
    12. Fleming-Davies AE, Dwyer G. Phenotypic Variation in Overwinter Environmental Transmission of a Baculovirus and the Cost of Virulence. Am Nat. 2015 Dec; 186(6):797-806. PMID: 26655986.
      Citations: 5     Fields:    Translation:AnimalsCells
    13. Fleming-Davies AE, Dukic V, Andreasen V, Dwyer G. Effects of host heterogeneity on pathogen diversity and evolution. Ecol Lett. 2015 Nov; 18(11):1252-1261. PMID: 26365355; PMCID: PMC10425259.
      Citations: 18     Fields:    
    14. Fleming-Davies AE, Dwyer G, Páez DJ. Effects of pathogen exposure on life-history variation in the gypsy moth (Lymantria dispar). J Evol Biol. 2015 Oct; 28(10):1828-39. PMID: 26201381; PMCID: PMC4604033.
      Citations: 6     Fields:    Translation:AnimalsCells
    15. Hughes JS, Cobbold CA, Haynes K, Dwyer G. Effects of forest spatial structure on insect outbreaks: insights from a host-parasitoid model. Am Nat. 2015 May; 185(5):E130-52. PMID: 25905513.
      Citations: 1     Fields:    Translation:Animals
    16. Eakin L, Wang M, Dwyer G. The effects of the avoidance of infectious hosts on infection risk in an insect-pathogen interaction. Am Nat. 2015 Jan; 185(1):100-12. PMID: 25560556.
      Citations: 7     Fields:    Translation:AnimalsCells
    17. Kennedy DA, Dukic V, Dwyer G. Pathogen growth in insect hosts: inferring the importance of different mechanisms using stochastic models and response-time data. Am Nat. 2014 Sep; 184(3):407-23. PMID: 25141148; PMCID: PMC10495239.
      Citations: 9     Fields:    Translation:AnimalsCells
    18. Elderd BD, Rehill BJ, Haynes KJ, Dwyer G. Induced plant defenses, host-pathogen interactions, and forest insect outbreaks. Proc Natl Acad Sci U S A. 2013 Sep 10; 110(37):14978-83. PMID: 23966566; PMCID: PMC3773759.
      Citations: 19     Fields:    Translation:AnimalsCells
    19. Elderd BD, Dwyer G, Dukic V. Population-level differences in disease transmission: a Bayesian analysis of multiple smallpox epidemics. Epidemics. 2013 Sep; 5(3):146-56. PMID: 24021521; PMCID: PMC3869526.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    20. Fuller E, Elderd BD, Dwyer G. Pathogen persistence in the environment and insect-baculovirus interactions: disease-density thresholds, epidemic burnout, and insect outbreaks. Am Nat. 2012 Mar; 179(3):E70-96. PMID: 22322229; PMCID: PMC3814039.
      Citations: 22     Fields:    Translation:AnimalsCells
    21. Barrett LG, Bell T, Dwyer G, Bergelson J. Cheating, trade-offs and the evolution of aggressiveness in a natural pathogen population. Ecol Lett. 2011 Nov; 14(11):1149-57. PMID: 21951910; PMCID: PMC3190666.
      Citations: 31     Fields:    Translation:AnimalsCells
    22. Parker BJ, Elderd BD, Dwyer G. Host behaviour and exposure risk in an insect-pathogen interaction. J Anim Ecol. 2010 Jul; 79(4):863-70. PMID: 20384645.
      Citations: 18     Fields:    Translation:AnimalsCells
    23. Elderd BD, Dushoff J, Dwyer G. Host-pathogen interactions, insect outbreaks, and natural selection for disease resistance. Am Nat. 2008 Dec; 172(6):829-42. PMID: 18976065.
      Citations: 19     Fields:    Translation:AnimalsCells
    24. Abbott KC, Dwyer G. Using mechanistic models to understand synchrony in forest insect populations: the North American gypsy moth as a case study. Am Nat. 2008 Nov; 172(5):613-24. PMID: 18821838.
      Citations: 3     Fields:    Translation:Animals
    25. Abbott KC, Dwyer G. Food limitation and insect outbreaks: complex dynamics in plant-herbivore models. J Anim Ecol. 2007 Sep; 76(5):1004-14. PMID: 17714279.
      Citations: 6     Fields:    Translation:Animals
    26. Immigration events dispersed in space and time: factors affecting invasion success. Ecological Modelling. 2007; 206:63-78.
    27. Elderd BD, Dukic VM, Dwyer G. Uncertainty in predictions of disease spread and public health responses to bioterrorism and emerging diseases. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15693-7. PMID: 17030819; PMCID: PMC1592533.
      Citations: 29     Fields:    Translation:HumansPHPublic Health
    28. Crozier L, Dwyer G. Combining population-dynamic and ecophysiological models to predict climate-induced insect range shifts. Am Nat. 2006 Jun; 167(6):853-66. PMID: 16685639.
      Citations: 27     Fields:    Translation:Animals
    29. Demographic stochasticity, environmental variability, and windows of invasion risk for Bythotrephes longimanus in North America. Biological invasions. 2006; 8:843-861.
    30. Dwyer G, Morris WF. Resource-dependent dispersal and the speed of biological invasions. Am Nat. 2006 Feb; 167(2):165-76. PMID: 16670978.
      Citations: 5     Fields:    Translation:Animals
    31. Drury KL, Dwyer G. Combining stochastic models with experiments to understand the dynamics of monarch butterfly colonization. Am Nat. 2005 Dec; 166(6):731-50. PMID: 16475089.
      Citations: 3     Fields:    Translation:Animals
    32. Dwyer G, Firestone J, Stevens TE. Should models of disease dynamics in herbivorous insects include the effects of variability in host-plant foliage quality? Am Nat. 2005 Jan; 165(1):16-31. PMID: 15729637.
      Citations: 8     Fields:    Translation:AnimalsCells
    33. Dwyer G, Dushoff J, Yee SH. The combined effects of pathogens and predators on insect outbreaks. Nature. 2004 Jul 15; 430(6997):341-5. PMID: 15254536.
      Citations: 35     Fields:    Translation:Animals
    34. Perry WL, Feder JL, Dwyer G, Lodge DM, Perry WL, Feder JL, Dwyer G, Lodge DM. Hybrid zone dynamics and species replacement between Orconectes crayfishes in a northern Wisconsin lake. Evolution. 2001 Jun; 55(6):1153-66. PMID: 11475051.
      Citations: 16     Fields:    Translation:Animals
    35. Bergelson J, Dwyer G, Emerson JJ. Models and data on plant-enemy coevolution. Annu Rev Genet. 2001; 35:469-99. PMID: 11700291.
      Citations: 44     Fields:    Translation:Animals
    36. Dwyer G, Dushoff J, Elkinton JS, Levin SA. Pathogen-Driven Outbreaks in Forest Defoliators Revisited: Building Models from Experimental Data. Am Nat. 2000 Aug; 156(2):105-120. PMID: 10856195.
      Citations: 33     Fields:    
    37. Stahl EA, Dwyer G, Mauricio R, Kreitman M, Bergelson J. Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis. Nature. 1999 Aug 12; 400(6745):667-71. PMID: 10458161.
      Citations: 223     Fields:    Translation:AnimalsCells
    38. Dwyer G, Elkinton JS, Hajek AE. Spatial scale and the spread of a fungal pathogen of gypsy moth. Am Nat. 1998 Sep; 152(3):485-94. PMID: 18811455.
      Citations: 8     Fields:    
    39. Foliage damage does not affect within-season transmission of an insect virus. Ecology. 1998; 79:1104-1110.
    40. . Outbreaks and interacting factors: Insect population explosions synthesized and dissected. Integrative Biology. 1998; 1:166-177.
    41. Dwyer G, Elkinton JS, Buonaccorsi JP. Host heterogeneity in susceptibility and disease dynamics: tests of a mathematical model. Am Nat. 1997 Dec; 150(6):685-707. PMID: 18811331.
      Citations: 57     Fields:    
    42. Morris WF, Dwyer G. Population consequences of constitutive and inducible plant resistance: herbivore spatial spread. Am Nat. 1997 Jun; 149(6):1071-90. PMID: 18811264.
      Citations: 1     Fields:    
    43. . Virus transmission in gypsy moths is not a mass-action process. Ecology. 1996; 77:201-206.
    44. . Modelling the epizootiology of gypsy moth nuclear polyhedrosis virus. Computers and Electronics in Agriculture. 1995; 13:91-102.
    45. . Host dispersal and the spatial spread of insect pathogens. Ecology. 1995; 143:533-562.
    46. . Density-dependence and spatial structure in the dynamics of insect pathogens. Am Nat. 1994; 143:533-562.
    47. . Using simple models to predict virus epizootics in gypsy-moth populations. J. Anim. Ecol. 1993; 62:1-11.
    48. . On the spatial spread of insect pathogens: theory and experiment. Ecology. 1992; 73:479-494.
    49. . The roles of density, stage and patchiness in the transmission of an insect virus. Ecology. 1991; 72:559-574.
    50. . A simulation model of the population dynamics and evolution of myxomatosis. Ecological Monographs. 1990; 60:423-447.
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