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Gregory Hudalla

InstitutionUniversity of Chicago
AddressChicago IL 60637
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    R35GM133697     (HUDALLA, GREGORY)Sep 1, 2019 - Jun 30, 2024
    Glycosylation as a Structural Determinant in Peptide Fibrillization
    Role: Principal Investigator

    R21EB024762     (HUDALLA, GREGORY)Sep 7, 2017 - Jun 30, 2021
    Supramolecular hydrogels for localized delivery of immunomodulatory enzymes
    Role: Principal Investigator

    R03EB019684     (HUDALLA, GREGORY)Sep 16, 2015 - Jul 31, 2018
    Modular Nanomedicines Based on Heterogeneous Fusion Protein Co-Assembly
    Role: Principal Investigator

    F32AI096769     (HUDALLA, GREGORY)Aug 1, 2011 - Jul 31, 2014
    Molecular assemblies as immunomodulators
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu R, Seroski DT, Hudalla GA, Hall CK, Dong XY. Programming co-assembled peptide nanofiber morphology via anionic amino acid type: Insights from molecular dynamics simulations. PLoS Comput Biol. 2023 Dec; 19(12):e1011685. PMID: 38048311; PMCID: PMC10729967.
      Citations: 2     Fields:    Translation:Cells
    2. Liu R, Dong X, Seroski DT, Soto Morales B, Wong KM, Robang AS, Melgar L, Angelini TE, Paravastu AK, Hall CK, Hudalla GA. Side-Chain Chemistry Governs Hierarchical Order of Charge-Complementary ß-sheet Peptide Coassemblies. Angew Chem Int Ed Engl. 2023 Dec 18; 62(51):e202314531. PMID: 37931093; PMCID: PMC10841972.
      Citations: 1     Fields:    Translation:Cells
    3. Partain BD, Bracho-Sanchez E, Farhadi SA, Yarmola EG, Keselowsky BG, Hudalla GA, Allen KD. Intra-articular delivery of an indoleamine 2,3-dioxygenase galectin-3 fusion protein for osteoarthritis treatment in male Lewis rats. Arthritis Res Ther. 2023 09 18; 25(1):173. PMID: 37723593; PMCID: PMC10506271.
      Citations: 1     Fields:    Translation:Animals
    4. Cosgriff-Hernandez EM, Aguado BA, Akpa B, Fleming GC, Moore E, Porras AM, Boyle PM, Chan DD, Chesler N, Christman KL, Desai TA, Harley BAC, Hudalla GA, Killian ML, Maisel K, Maitland KC, Peyton SR, Pruitt BL, Stabenfeldt SE, Stevens KR, Bowden AK. Equitable hiring strategies towards a diversified faculty. Nat Biomed Eng. 2023 08; 7(8):961-968. PMID: 37580521.
      Citations:    Fields:    Translation:Humans
    5. Bracho-Sanchez E, Rocha FG, Bedingfield SK, Partain BD, Macias SL, Brusko MA, Colazo JM, Fettis MM, Farhadi SA, Helm EY, Koenders K, Kwiatkowski AJ, Restuccia A, Morales BS, Wanchoo A, Avram D, Allen KD, Duvall CL, Wallet SM, Hudalla GA, Keselowsky BG. Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase. Nat Biomed Eng. 2023 09; 7(9):1156-1169. PMID: 37127708; PMCID: PMC10504068.
      Citations: 2     Fields:    Translation:Animals
    6. Partain BD, Bracho-Sanchez E, Farhadi SA, Yarmola EG, Keselowsky BG, Hudalla GA, Allen KD. Intra-Articular Delivery of an Indoleamine 2,3-Dioxygenase Galectin-3 Fusion Protein for Osteoarthritis Treatment in Male Lewis Rats. Res Sq. 2023 Apr 21. PMID: 37131836; PMCID: PMC10153358.
    7. Sarma S, Herrera SM, Xiao X, Hudalla GA, Hall CK. Computational Design and Experimental Validation of ACE2-Derived Peptides as SARS-CoV-2 Receptor Binding Domain Inhibitors. J Phys Chem B. 2022 10 20; 126(41):8129-8139. PMID: 36219223.
      Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
    8. Rodriguez CD, Farhadi SA, Hudalla GA, Sarntinoranont M, Simmons CS, Piñeiro-Llanes J. Experimental and Computational Models of Transport of Galectin-3 Through Glycosylated Matrix. Ann Biomed Eng. 2022 Jun; 50(6):703-715. PMID: 35352215; PMCID: PMC10621651.
      Citations:    Fields:    Translation:Cells
    9. Hudalla GA. Medical Applications of Glycomaterials. Adv Healthc Mater. 2022 02; 11(4):e2200096. PMID: 35170235.
      Citations:    Fields:    
    10. Wong KM, Robang AS, Lint AH, Wang Y, Dong X, Xiao X, Seroski DT, Liu R, Shao Q, Hudalla GA, Hall CK, Paravastu AK. Engineering ß-Sheet Peptide Coassemblies for Biomaterial Applications. J Phys Chem B. 2021 12 23; 125(50):13599-13609. PMID: 34905370.
      Citations: 3     Fields:    Translation:Cells
    11. McKitrick TR, Ackerman ME, Anthony RM, Bennett CS, Demetriou M, Hudalla GA, Ribbeck K, Ruhl S, Woo CM, Yang L, Zost SJ, Schnaar RL, Doering TL. The Crossroads of Glycoscience, Infection, and Immunology. Front Microbiol. 2021; 12:731008. PMID: 34646251; PMCID: PMC8504252.
      Citations: 2     
    12. Farhadi SA, Restuccia A, Sorrentino A, Hudalla GA, Cruz-Sánchez A. Heterogeneous protein co-assemblies with tunable functional domain stoichiometry. Mol Syst Des Eng. 2022 Jan 01; 7(1):44-57. PMID: 35495737; PMCID: PMC9053397.
    13. Xiao X, Wang Y, Seroski DT, Wong KM, Liu R, Paravastu AK, Hudalla GA, Hall CK. De novo design of peptides that coassemble into ß sheet-based nanofibrils. Sci Adv. 2021 Sep 03; 7(36):eabf7668. PMID: 34516924; PMCID: PMC8442925.
      Citations: 7     Fields:    
    14. Hlavac N, Seroski DT, Agrawal NK, Astrab L, Liu R, Hudalla GA, Schmidt CE. Chondroitinase ABC/galectin-3 fusion proteins with hyaluronan-based hydrogels stabilize enzyme and provide targeted enzyme activity for neural applications. J Neural Eng. 2021 06 22; 18(4). PMID: 34082409.
      Citations:    Fields:    Translation:Animals
    15. Zuo R, Liu R, Olguin J, Hudalla GA. Glycosylation of a Nonfibrillizing Appendage Alters the Self-Assembly Pathway of a Synthetic ß-Sheet Fibrillizing Peptide. J Phys Chem B. 2021 06 24; 125(24):6559-6571. PMID: 34128680; PMCID: PMC9191660.
      Citations: 1     Fields:    Translation:Cells
    16. Kane BJ, Fettis MM, Farhadi SA, Liu R, Hudalla GA. Site-Specific Cross-Linking of Galectin-1 Homodimers via Poly(ethylene glycol) Bismaleimide. Cell Mol Bioeng. 2021 Oct; 14(5):523-534. PMID: 34777608; PMCID: PMC8548478.
      Citations: 3     
    17. Farhadi SA, Liu R, Becker MW, Phelps EA, Hudalla GA. Physical tuning of galectin-3 signaling. Proc Natl Acad Sci U S A. 2021 05 11; 118(19). PMID: 33941700; PMCID: PMC8126866.
      Citations: 12     Fields:    Translation:HumansCells
    18. Wong KM, Shao Q, Wang Y, Seroski DT, Liu R, Lint AH, Hudalla GA, Hall CK, Paravastu AK. CATCH Peptides Coassemble into Structurally Heterogeneous ß-Sheet Nanofibers with Little Preference to ß-Strand Alignment. J Phys Chem B. 2021 04 29; 125(16):4004-4015. PMID: 33876641.
      Citations: 2     Fields:    Translation:Cells
    19. Liu R, Zuo R, Hudalla GA. Harnessing molecular recognition for localized drug delivery. Adv Drug Deliv Rev. 2021 03; 170:238-260. PMID: 33484737; PMCID: PMC8274479.
      Citations: 6     Fields:    Translation:Humans
    20. Soto Morales B, Liu R, Olguin J, Ziegler AM, Herrera SM, Backer-Kelley KL, Kelley KL, Hudalla GA. Injectable nanofibrillar hydrogels based on charge-complementary peptide co-assemblies. Biomater Sci. 2021 Apr 07; 9(7):2494-2507. PMID: 33438696; PMCID: PMC8274480.
      Citations: 2     Fields:    
    21. Russo AJ, Vasudevan SO, Kumari P, Menoret A, Duduskar S, Wang C, Fettis MM, Li C, Liu R, Wanchoo A, Chandiran K, Ruan J, Vanaja SK, Bauer M, Sponholz C, Hudalla GA, Vella AT, Zhou B, Deshmukh SD, Rathinam VA, Méndez-Huergo SP, Pérez Sáez JM, Rabinovich GA. Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin. Nat Immunol. 2021 02; 22(2):154-165. PMID: 33398185; PMCID: PMC8916041.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    22. Seroski DT, Dong X, Wong KM, Liu R, Shao Q, Paravastu AK, Hall CK, Hudalla GA. Charge guides pathway selection in ß-sheet fibrillizing peptide co-assembly. Commun Chem. 2020 Nov 13; 3(1):172. PMID: 36703436; PMCID: PMC9814569.
      Citations: 10     
    23. Shao Q, Wong KM, Seroski DT, Wang Y, Liu R, Paravastu AK, Hudalla GA, Hall CK. Anatomy of a selectively coassembled ß-sheet peptide nanofiber. Proc Natl Acad Sci U S A. 2020 03 03; 117(9):4710-4717. PMID: 32071201; PMCID: PMC7060663.
      Citations: 15     Fields:    Translation:Cells
    24. Wong KM, Wang Y, Seroski DT, Larkin GE, Mehta AK, Hudalla GA, Hall CK, Paravastu AK. Molecular complementarity and structural heterogeneity within co-assembled peptide ß-sheet nanofibers. Nanoscale. 2020 Feb 21; 12(7):4506-4518. PMID: 32039428.
      Citations: 12     Fields:    Translation:Cells
    25. Liu R, Boehlein SK, Tracy WF, Resende MFR, Hudalla GA. Characterizing the Physical Properties and Cell Compatibility of Phytoglycogen Extracted from Different Sweet Corn Varieties. Molecules. 2020 Feb 01; 25(3). PMID: 32024194; PMCID: PMC7037141.
      Citations: 1     Fields:    Translation:AnimalsCells
    26. Farhadi SA, Fettis MM, Liu R, Hudalla GA. A Synthetic Tetramer of Galectin-1 and Galectin-3 Amplifies Pro-apoptotic Signaling by Integrating the Activity of Both Galectins. Front Chem. 2019; 7:898. PMID: 31998689; PMCID: PMC6966408.
      Citations: 4     
    27. Fettis MM, Farhadi SA, Hudalla GA. A chimeric, multivalent assembly of galectin-1 and galectin-3 with enhanced extracellular activity. Biomater Sci. 2019 Apr 23; 7(5):1852-1862. PMID: 30899922; PMCID: PMC6553642.
      Citations: 8     Fields:    Translation:HumansCells
    28. Liu R, Hudalla GA. Using Self-Assembling Peptides to Integrate Biomolecules into Functional Supramolecular Biomaterials. Molecules. 2019 Apr 12; 24(8). PMID: 31013712; PMCID: PMC6514692.
      Citations: 18     Fields:    
    29. Farhadi SA, Bracho-Sanchez E, Fettis MM, Seroski DT, Freeman SL, Restuccia A, Keselowsky BG, Hudalla GA. Locally anchoring enzymes to tissues via extracellular glycan recognition. Nat Commun. 2018 11 22; 9(1):4943. PMID: 30467349; PMCID: PMC6250738.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    30. Restuccia A, Hudalla GA. Tuning carbohydrate density enhances protein binding and inhibition by glycosylated ß-sheet peptide nanofibers. Biomater Sci. 2018 Aug 21; 6(9):2327-2335. PMID: 30059078.
      Citations: 5     Fields:    Translation:HumansCells
    31. Fettis MM, Hudalla GA. Engineering Reactive Oxygen Species-Resistant Galectin-1 Dimers with Enhanced Lectin Activity. Bioconjug Chem. 2018 07 18; 29(7):2489-2496. PMID: 29920086.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    32. Farhadi SA, Bracho-Sanchez E, Freeman SL, Keselowsky BG, Hudalla GA. Enzymes as Immunotherapeutics. Bioconjug Chem. 2018 03 21; 29(3):649-656. PMID: 29285931; PMCID: PMC5993548.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    33. Farhadi SA, Hudalla GA. Engineering galectin-glycan interactions for immunotherapy and immunomodulation. Exp Biol Med (Maywood). 2016 05; 241(10):1074-83. PMID: 27229902; PMCID: PMC4950369.
      Citations: 10     Fields:    Translation:HumansAnimals
    34. Fettis MM, Wei Y, Restuccia A, Kurian JJ, Wallet SM, Hudalla GA. Microgels with tunable affinity-controlled protein release via desolvation of self-assembled peptide nanofibers. J Mater Chem B. 2016 May 14; 4(18):3054-3064. PMID: 32263044.
      Citations: 6     Fields:    
    35. Sun T, Han H, Hudalla GA, Wen Y, Pompano RR, Collier JH. Thermal stability of self-assembled peptide vaccine materials. Acta Biomater. 2016 Jan; 30:62-71. PMID: 26584836; PMCID: PMC4821069.
      Citations: 22     Fields:    Translation:AnimalsCells
    36. Restuccia A, Fettis MM, Hudalla GA. Glycomaterials for immunomodulation, immunotherapy, and infection prophylaxis. J Mater Chem B. 2016 Mar 07; 4(9):1569-1585. PMID: 32263013.
      Citations: 6     Fields:    
    37. Restuccia A, Tian YF, Collier JH, Hudalla GA. Self-assembled glycopeptide nanofibers as modulators of galectin-1 bioactivity. Cell Mol Bioeng. 2015 Sep 01; 8(3):471-487. PMID: 26495044; PMCID: PMC4610397.
      Citations: 26     
    38. Hudalla GA, Sun T, Gasiorowski JZ, Han H, Tian YF, Chong AS, Collier JH. Gradated assembly of multiple proteins into supramolecular nanomaterials. Nat Mater. 2014 Aug; 13(8):829-36. PMID: 24930032; PMCID: PMC4180598.
      Citations: 75     Fields:    Translation:AnimalsCells
    39. Tian YF, Hudalla GA, Han H, Collier JH. Controllably degradable ß-sheet nanofibers and gels from self-assembling depsipeptides. Biomater Sci. 2013 Oct 01; 1(10). PMID: 24224082; PMCID: PMC3819105.
      Citations: 15     Fields:    
    40. Parlato M, Johnson A, Hudalla GA, Murphy WL. Adaptable poly(ethylene glycol) microspheres capable of mixed-mode degradation. Acta Biomater. 2013 Dec; 9(12):9270-80. PMID: 23958780; PMCID: PMC3907088.
      Citations: 9     Fields:    Translation:Cells
    41. Hudalla GA, Modica JA, Tian YF, Rudra JS, Chong AS, Sun T, Mrksich M, Collier JH. A self-adjuvanting supramolecular vaccine carrying a folded protein antigen. Adv Healthc Mater. 2013 Aug; 2(8):1114-9. PMID: 23436779; PMCID: PMC3817840.
      Citations: 47     Fields:    Translation:AnimalsCells
    42. Hudalla GA, Koepsel JT, Murphy WL. Surfaces that sequester serum-borne heparin amplify growth factor activity. Adv Mater. 2011 Dec 01; 23(45):5415-8. PMID: 22028244; PMCID: PMC4410730.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    43. Hudalla GA, Murphy WL. Chemically well-defined self-assembled monolayers for cell culture: toward mimicking the natural ECM. Soft Matter. 2011 Oct 21; 7(20):9561-9571. PMID: 25214878; PMCID: PMC4159093.
      Citations: 16     Fields:    
    44. Hudalla GA, Kouris NA, Koepsel JT, Ogle BM, Murphy WL. Harnessing endogenous growth factor activity modulates stem cell behavior. Integr Biol (Camb). 2011 Aug; 3(8):832-42. PMID: 21720642; PMCID: PMC3996706.
      Citations: 35     Fields:    Translation:HumansCells
    45. Hudalla GA, Murphy WL. Biomaterials that regulate growth factor activity via bioinspired interactions. Adv Funct Mater. 2011 May 24; 21(10):1754-1768. PMID: 21921999; PMCID: PMC3171147.
      Citations: 61     
    46. Hudalla GA, Murphy WL. Immobilization of peptides with distinct biological activities onto stem cell culture substrates using orthogonal chemistries. Langmuir. 2010 May 04; 26(9):6449-56. PMID: 20353153; PMCID: PMC2860651.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    47. Hudalla GA, Murphy WL. Using "click" chemistry to prepare SAM substrates to study stem cell adhesion. Langmuir. 2009 May 19; 25(10):5737-46. PMID: 19326875; PMCID: PMC2694954.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    48. Hudalla GA, Eng TS, Murphy WL. An approach to modulate degradation and mesenchymal stem cell behavior in poly(ethylene glycol) networks. Biomacromolecules. 2008 Mar; 9(3):842-9. PMID: 18288800.
      Citations: 36     Fields:    Translation:HumansCells
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