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Dorothy Hanck to Sodium Channels

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This is a "connection" page, showing publications Dorothy Hanck has written about Sodium Channels.
Dorothy Hanck
Connection Strength
6.502
Sodium Channels
  1. Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels. Biophys J. 2015 Dec 01; 109(11):2277-86.
    View in: PubMed
    Score: 0.485
  2. Lidocaine partially depolarizes the S4 segment in domain IV of the sodium channel. Pflugers Arch. 2011 Jan; 461(1):91-7.
    View in: PubMed
    Score: 0.340
  3. Sodium channel molecular conformations and antiarrhythmic drug affinity. Trends Cardiovasc Med. 2010 Jan; 20(1):16-21.
    View in: PubMed
    Score: 0.322
  4. Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity. Circ Res. 2009 Aug 28; 105(5):492-9.
    View in: PubMed
    Score: 0.313
  5. Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5. Toxicon. 2008 Sep 01; 52(3):489-500.
    View in: PubMed
    Score: 0.290
  6. Site-3 toxins and cardiac sodium channels. Toxicon. 2007 Feb; 49(2):181-93.
    View in: PubMed
    Score: 0.256
  7. An inner pore residue (Asn406) in the Nav1.5 channel controls slow inactivation and enhances mibefradil block to T-type Ca2+ channel levels. Mol Pharmacol. 2006 Nov; 70(5):1514-23.
    View in: PubMed
    Score: 0.254
  8. Charge immobilization of the voltage sensor in domain IV is independent of sodium current inactivation. J Physiol. 2005 Feb 15; 563(Pt 1):83-93.
    View in: PubMed
    Score: 0.226
  9. State-dependent mibefradil block of Na+ channels. Mol Pharmacol. 2004 12; 66(6):1652-61.
    View in: PubMed
    Score: 0.226
  10. Molecular action of lidocaine on the voltage sensors of sodium channels. J Gen Physiol. 2003 Feb; 121(2):163-75.
    View in: PubMed
    Score: 0.199
  11. The outermost lysine in the S4 of domain III contributes little to the gating charge in sodium channels. Biophys J. 2002 Jun; 82(6):3048-55.
    View in: PubMed
    Score: 0.190
  12. Point mutations in domain III of a Drosophila neuronal Na channel confer resistance to allethrin. Insect Biochem Mol Biol. 2000 Nov; 30(11):1051-9.
    View in: PubMed
    Score: 0.170
  13. The role of the putative inactivation lid in sodium channel gating current immobilization. J Gen Physiol. 2000 May; 115(5):609-20.
    View in: PubMed
    Score: 0.165
  14. Lidocaine alters activation gating of cardiac Na channels. Pflugers Arch. 2000 Apr; 439(6):814-21.
    View in: PubMed
    Score: 0.164
  15. The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4. Biophys J. 1999 Aug; 77(2):747-57.
    View in: PubMed
    Score: 0.156
  16. Gating of skeletal and cardiac muscle sodium channels in mammalian cells. J Physiol. 1999 Jan 15; 514 ( Pt 2):425-36.
    View in: PubMed
    Score: 0.150
  17. Heartthrobs. Science. 1998 Feb 13; 279(5353):1004.
    View in: PubMed
    Score: 0.141
  18. A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B. J Biol Chem. 1998 Jan 02; 273(1):80-4.
    View in: PubMed
    Score: 0.140
  19. Nonequilibrium response spectroscopy of voltage-sensitive ion channel gating. Biophys J. 1998 Jan; 74(1):210-29.
    View in: PubMed
    Score: 0.140
  20. Differences in the binding sites of two site-3 sodium channel toxins. Pflugers Arch. 1997 Nov; 434(6):742-9.
    View in: PubMed
    Score: 0.138
  21. Optimization of a mammalian expression system for the measurement of sodium channel gating currents. Am J Physiol. 1996 Sep; 271(3 Pt 1):C1001-6.
    View in: PubMed
    Score: 0.128
  22. Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms. Physiol Rev. 1996 Jul; 76(3):887-926.
    View in: PubMed
    Score: 0.126
  23. Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8. Am J Physiol. 1996 May; 270(5 Pt 1):C1522-31.
    View in: PubMed
    Score: 0.125
  24. Modification of inactivation in cardiac sodium channels: ionic current studies with Anthopleurin-A toxin. J Gen Physiol. 1995 Oct; 106(4):601-16.
    View in: PubMed
    Score: 0.120
  25. Voltage-dependent open-state inactivation of cardiac sodium channels: gating current studies with Anthopleurin-A toxin. J Gen Physiol. 1995 Oct; 106(4):617-40.
    View in: PubMed
    Score: 0.120
  26. A direct effect of forskolin on sodium channel bursting. Pflugers Arch. 1995 Feb; 429(4):561-9.
    View in: PubMed
    Score: 0.114
  27. Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study. J Gen Physiol. 1994 Jan; 103(1):19-43.
    View in: PubMed
    Score: 0.106
  28. Modification of sodium channel inactivation by alpha-chymotrypsin in canine cardiac Purkinje cells. J Cardiovasc Electrophysiol. 1993 Dec; 4(6):686-94.
    View in: PubMed
    Score: 0.105
  29. Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics. Circ Res. 1993 Apr; 72(4):807-15.
    View in: PubMed
    Score: 0.101
  30. Extracellular divalent and trivalent cation effects on sodium current kinetics in single canine cardiac Purkinje cells. J Physiol. 1992 Aug; 454:267-98.
    View in: PubMed
    Score: 0.096
  31. Mechanisms of extracellular divalent and trivalent cation block of the sodium current in canine cardiac Purkinje cells. J Physiol. 1992 Aug; 454:299-320.
    View in: PubMed
    Score: 0.096
  32. Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATXII. Circ Res. 1992 Feb; 70(2):285-301.
    View in: PubMed
    Score: 0.093
  33. Atrionatriuretic peptide and calcium-conducting sodium channels. Science. 1991 Apr 19; 252(5004):449-52.
    View in: PubMed
    Score: 0.088
  34. Two components of use-dependent block of sodium current by lidocaine in voltage clamped cardiac Purkinje cells. J Mol Cell Cardiol. 1991 Feb; 23 Suppl 1:95-102.
    View in: PubMed
    Score: 0.087
  35. Gating currents associated with Na channels in canine cardiac Purkinje cells. J Gen Physiol. 1990 Mar; 95(3):439-57.
    View in: PubMed
    Score: 0.081
  36. Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels. J Physiol. 2007 Jul 01; 582(Pt 1):317-34.
    View in: PubMed
    Score: 0.067
  37. Isoform-dependent interaction of voltage-gated sodium channels with protons. J Physiol. 2006 Oct 15; 576(Pt 2):493-501.
    View in: PubMed
    Score: 0.063
  38. Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents. J Physiol. 2004 Dec 01; 561(Pt 2):403-13.
    View in: PubMed
    Score: 0.056
  39. Role of Asn-16 and Ser-19 in anthopleurin B binding. Implications for the electrostatic nature of Na(V) site 3. Biochemistry. 2004 Jun 08; 43(22):7082-9.
    View in: PubMed
    Score: 0.055
  40. Augmentation of recovery from inactivation by site-3 Na channel toxins. A single-channel and whole-cell study of persistent currents. J Gen Physiol. 1999 Feb; 113(2):333-46.
    View in: PubMed
    Score: 0.038
  41. Role for Pro-13 in directing high-affinity binding of anthopleurin B to the voltage-sensitive sodium channel. Biochemistry. 1996 Nov 12; 35(45):14157-64.
    View in: PubMed
    Score: 0.032
  42. Leucine 18, a hydrophobic residue essential for high affinity binding of anthopleurin B to the voltage-sensitive sodium channel. J Biol Chem. 1996 Apr 19; 271(16):9422-8.
    View in: PubMed
    Score: 0.031
  43. Multiple cationic residues of anthopleurin B that determine high affinity and channel isoform discrimination. Biochemistry. 1995 Jul 11; 34(27):8533-41.
    View in: PubMed
    Score: 0.029
  44. Time-dependent changes in kinetics of Na+ current in single canine cardiac Purkinje cells. Am J Physiol. 1992 Apr; 262(4 Pt 2):H1197-207.
    View in: PubMed
    Score: 0.023
  45. Kinetic analysis of single sodium channels from canine cardiac Purkinje cells. J Gen Physiol. 1990 Mar; 95(3):411-37.
    View in: PubMed
    Score: 0.020
  46. Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels. J Physiol. 2007 Jun 01; 581(Pt 2):741-55.
    View in: PubMed
    Score: 0.017
  47. Arg-14 loop of site 3 anemone toxins: effects of glycine replacement on toxin affinity. Biochemistry. 2003 Dec 16; 42(49):14515-21.
    View in: PubMed
    Score: 0.013
  48. Is there a second external lidocaine binding site on mammalian cardiac cells? Am J Physiol. 1989 Jul; 257(1 Pt 2):H79-84.
    View in: PubMed
    Score: 0.005
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