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Clifton Ragsdale

InstitutionUniversity of Chicago
AddressChicago IL 60637
Phone+1 (773) 702-9609
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    The octopus is rich in evolutionary novelties, from an immense nervous system to prehensile arms to a tremendously sophisticated adaptive coloration system. It is the octopus's brain and behavior that has attracted the greatest study, but much of this research was done in the 20th century and limited by the techniques of the time. The major focus of the Ragsdale laboratory is to bring the modern advances in neuroscience, molecular cell biology and genetic manipulation to the study of cephalopod biology. Our first major step was into genomics and transcriptomics. In 2015, the Ragsdale laboratory, in collaboration with the Rokhsar group at UC-Berkeley, reported the genome of the Ragsdale lab's chosen model organism, Octopus bimaculoides. Current research includes comparative cephalopod genomics, octopus arm regeneration, the organization of the cephalopod nervous system, and the neuroendocrinology of octopus sex and death.

    The other focus of the Ragsdale laboratory is the evolutionary developmental neurobiology of the neocortex.

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    R03HD064887     (RAGSDALE, CLIFTON W.)Apr 1, 2013 - Mar 31, 2015
    Transcriptome resources for a cephalopod model system
    Role: Principal Investigator

    R03HD056094     (RAGSDALE, CLIFTON W.)May 1, 2008 - Apr 30, 2010
    Gene Manipulation of Cephalopod Development
    Role: Principal Investigator

    R01EY016838     (RAGSDALE, CLIFTON W.)May 5, 2006 - Apr 30, 2011
    Role: Principal Investigator

    R01NS035680     (RAGSDALE, CLIFTON W.)Aug 1, 1998 - Nov 30, 2006
    Role: Principal Investigator

    R55NS035680     (RAGSDALE, CLIFTON W.)Sep 4, 1997 - Jul 31, 1998
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Olson CS, Ragsdale CW. Toward an Understanding of Octopus Arm Motor Control. Integr Comp Biol. 2023 Dec 29; 63(6):1277-1284. PMID: 37327080; PMCID: PMC10755184.
      Citations:    Fields:    Translation:Animals
    2. Wang ZY, Pergande MR, Ragsdale CW, Cologna SM. Steroid hormones of the octopus self-destruct system. Curr Biol. 2022 06 06; 32(11):2572-2579.e4. PMID: 35561680.
      Citations: 3     Fields:    Translation:Animals
    3. Albertin CB, Medina-Ruiz S, Mitros T, Schmidbaur H, Sanchez G, Wang ZY, Grimwood J, Rosenthal JJC, Ragsdale CW, Simakov O, Rokhsar DS. Genome and transcriptome mechanisms driving cephalopod evolution. Nat Commun. 2022 05 04; 13(1):2427. PMID: 35508532; PMCID: PMC9068888.
      Citations: 29     Fields:    Translation:AnimalsCells
    4. Briscoe SD, Ragsdale CW. Evolution of the Chordate Telencephalon. Curr Biol. 2019 07 08; 29(13):R647-R662. PMID: 31287987.
      Citations: 27     Fields:    Translation:Animals
    5. Briscoe SD, Ragsdale CW. Homology, neocortex, and the evolution of developmental mechanisms. Science. 2018 10 12; 362(6411):190-193. PMID: 30309947.
      Citations: 35     Fields:    Translation:AnimalsCells
    6. Briscoe SD, Ragsdale CW. Molecular anatomy of the alligator dorsal telencephalon. J Comp Neurol. 2018 07 01; 526(10):1613-1646. PMID: 29520780; PMCID: PMC6242290.
      Citations: 7     Fields:    Translation:AnimalsCells
    7. Briscoe SD, Albertin CB, Rowell JJ, Ragsdale CW. Neocortical Association Cell Types in the Forebrain of Birds and Alligators. Curr Biol. 2018 03 05; 28(5):686-696.e6. PMID: 29456143.
      Citations: 14     Fields:    Translation:AnimalsCells
    8. Albertin CB, Ragsdale CW. More than one way to a central nervous system. Nature. 2018 01 04; 553(7686):34-36. PMID: 29300031.
      Citations:    Fields:    Translation:Humans
    9. Wang ZY, Ragsdale CW. Cadherin genes and evolutionary novelties in the octopus. Semin Cell Dev Biol. 2017 09; 69:151-157. PMID: 28627384.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    10. Albertin CB, Simakov O, Mitros T, Wang ZY, Pungor JR, Edsinger-Gonzales E, Brenner S, Ragsdale CW, Rokhsar DS. The octopus genome and the evolution of cephalopod neural and morphological novelties. Nature. 2015 Aug 13; 524(7564):220-4. PMID: 26268193; PMCID: PMC4795812.
      Citations: 239     Fields:    Translation:AnimalsCells
    11. Shigeno S, Ragsdale CW. The gyri of the octopus vertical lobe have distinct neurochemical identities. J Comp Neurol. 2015 Jun 15; 523(9):1297-317. PMID: 25644267.
      Citations: 15     Fields:    Translation:AnimalsCells
    12. Dugas-Ford J, Rowell JJ, Ragsdale CW. Cell-type homologies and the origins of the neocortex. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):16974-9. PMID: 23027930; PMCID: PMC3479531.
      Citations: 104     Fields:    Translation:AnimalsCells
    13. Hasan KB, Agarwala S, Ragsdale CW. PHOX2A regulation of oculomotor complex nucleogenesis. Development. 2010 Apr; 137(7):1205-13. PMID: 20215354; PMCID: PMC2835333.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
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