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Last Name

Clifton Ragsdale

InstitutionUniversity of Chicago
AddressChicago IL 60637
Phone+1 (773) 702-9609
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    The octopus is rich in evolutionary novelties, from an immense nervous system to prehensile arms to a tremendously sophisticated adaptive coloration system. It is the octopus's brain and behavior that has attracted the greatest study, but much of this research was done in the 20th century and limited by the techniques of the time. The major focus of the Ragsdale laboratory is to bring the modern advances in neuroscience, molecular cell biology and genetic manipulation to the study of cephalopod biology. Our first major step was into genomics and transcriptomics. In 2015, the Ragsdale laboratory, in collaboration with the Rokhsar group at UC-Berkeley, reported the genome of the Ragsdale lab's chosen model organism, Octopus bimaculoides. Current research includes comparative cephalopod genomics, octopus arm regeneration, the organization of the cephalopod nervous system, and the neuroendocrinology of octopus sex and death.

    The other focus of the Ragsdale laboratory is the evolutionary developmental neurobiology of the neocortex.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang ZY, Pergande MR, Ragsdale CW, Cologna SM. Steroid hormones of the octopus self-destruct system. Curr Biol. 2022 May 05. PMID: 35561680.
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    2. Albertin CB, Medina-Ruiz S, Mitros T, Schmidbaur H, Sanchez G, Wang ZY, Grimwood J, Rosenthal JJC, Ragsdale CW, Simakov O, Rokhsar DS. Genome and transcriptome mechanisms driving cephalopod evolution. Nat Commun. 2022 May 04; 13(1):2427. PMID: 35508532.
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    3. Briscoe SD, Ragsdale CW. Evolution of the Chordate Telencephalon. Curr Biol. 2019 07 08; 29(13):R647-R662. PMID: 31287987.
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    4. Briscoe SD, Ragsdale CW. Homology, neocortex, and the evolution of developmental mechanisms. Science. 2018 10 12; 362(6411):190-193. PMID: 30309947.
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    5. Briscoe SD, Ragsdale CW. Molecular anatomy of the alligator dorsal telencephalon. J Comp Neurol. 2018 07 01; 526(10):1613-1646. PMID: 29520780.
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    6. Briscoe SD, Albertin CB, Rowell JJ, Ragsdale CW. Neocortical Association Cell Types in the Forebrain of Birds and Alligators. Curr Biol. 2018 03 05; 28(5):686-696.e6. PMID: 29456143.
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    7. Albertin CB, Ragsdale CW. More than one way to a central nervous system. Nature. 2018 01 04; 553(7686):34-36. PMID: 29300031.
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    8. Wang ZY, Ragsdale CW. Cadherin genes and evolutionary novelties in the octopus. Semin Cell Dev Biol. 2017 09; 69:151-157. PMID: 28627384.
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    9. Albertin CB, Simakov O, Mitros T, Wang ZY, Pungor JR, Edsinger-Gonzales E, Brenner S, Ragsdale CW, Rokhsar DS. The octopus genome and the evolution of cephalopod neural and morphological novelties. Nature. 2015 Aug 13; 524(7564):220-4. PMID: 26268193.
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    10. Shigeno S, Ragsdale CW. The gyri of the octopus vertical lobe have distinct neurochemical identities. J Comp Neurol. 2015 Jun 15; 523(9):1297-317. PMID: 25644267.
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    11. Dugas-Ford J, Rowell JJ, Ragsdale CW. Cell-type homologies and the origins of the neocortex. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):16974-9. PMID: 23027930.
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    12. Hasan KB, Agarwala S, Ragsdale CW. PHOX2A regulation of oculomotor complex nucleogenesis. Development. 2010 Apr; 137(7):1205-13. PMID: 20215354.
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