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Wen-Liang Kuo

TitleSenior Research Associate
InstitutionUniversity of Chicago
DepartmentMedicine
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sundaravel S, Kuo WL, Jeong JJ, Choudhary GS, Gordon-Mitchell S, Liu H, Bhagat TD, McGraw KL, Gurbuxani S, List AF, Verma A, Wickrema A. Loss of Function of DOCK4 in Myelodysplastic Syndromes Stem Cells is Restored by Inhibitors of DOCK4 Signaling Networks. Clin Cancer Res. 2019 09 15; 25(18):5638-5649. PMID: 31308061.
      View in: PubMed
    2. Jeong JJ, Gu X, Nie J, Sundaravel S, Liu H, Kuo WL, Bhagat TD, Pradhan K, Cao J, Nischal S, McGraw KL, Bhattacharyya S, Bishop MR, Artz A, Thirman MJ, Moliterno A, Ji P, Levine RL, Godley LA, Steidl U, Bieker JJ, List AF, Saunthararajah Y, He C, Verma A, Wickrema A. Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis. Cancer Discov. 2019 06; 9(6):778-795. PMID: 30944118.
      View in: PubMed
    3. Kuo WL, Sharifi MN, Lingen MW, Ahmed O, Liu J, Nagilla M, Macleod KF, Cohen EE. p62/SQSTM1 accumulation in squamous cell carcinoma of head and neck predicts sensitivity to phosphatidylinositol 3-kinase pathway inhibitors. PLoS One. 2014; 9(3):e90171. PMID: 24599075.
      View in: PubMed
    4. Yun J, Frankenberger CA, Kuo WL, Boelens MC, Eves EM, Cheng N, Liang H, Li WH, Ishwaran H, Minn AJ, Rosner MR. Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer. EMBO J. 2011 Aug 26; 30(21):4500-14. PMID: 21873975.
      View in: PubMed
    5. Liu J, Kuo WL, Seiwert TY, Lingen M, Ciaccio MF, Jones RB, Rosner MR, Cohen EE. Effect of complementary pathway blockade on efficacy of combination enzastaurin and rapamycin. Head Neck. 2011 Dec; 33(12):1774-82. PMID: 21438065.
      View in: PubMed
    6. Kuo WL, Liu J, Mauceri H, Vokes EE, Weichselbaum R, Rosner MR, Cohen EE. Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context. Mol Cancer Ther. 2010 Oct; 9(10):2814-24. PMID: 20876745.
      View in: PubMed
    7. Chou YH, Kuo WL, Rosner MR, Tang WJ, Goldman RD. Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme. FASEB J. 2009 Nov; 23(11):3734-42. PMID: 19584300.
      View in: PubMed
    8. Cohen EE, Zhu H, Lingen MW, Martin LE, Kuo WL, Choi EA, Kocherginsky M, Parker JS, Chung CH, Rosner MR. A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. Cancer Res. 2009 Jan 01; 69(1):65-74. PMID: 19117988.
      View in: PubMed
    9. Li P, Kuo WL, Yousef M, Rosner MR, Tang WJ. The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition. Biochem Biophys Res Commun. 2006 May 19; 343(4):1032-7. PMID: 16574064.
      View in: PubMed
    10. Kuo WL, Duke CJ, Abe MK, Kaplan EL, Gomes S, Rosner MR. ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathway. J Biol Chem. 2004 May 28; 279(22):23073-81. PMID: 15033983.
      View in: PubMed
    11. Abe MK, Kuo WL, Hershenson MB, Rosner MR. Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth. Mol Cell Biol. 1999 Feb; 19(2):1301-12. PMID: 9891064.
      View in: PubMed
    12. Abe MK, Kartha S, Karpova AY, Li J, Liu PT, Kuo WL, Hershenson MB. Hydrogen peroxide activates extracellular signal-regulated kinase via protein kinase C, Raf-1, and MEK1. Am J Respir Cell Mol Biol. 1998 Apr; 18(4):562-9. PMID: 9533945.
      View in: PubMed
    13. Kuo WL, Chung KC, Rosner MR. Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: roles for Ras and Src. Mol Cell Biol. 1997 Aug; 17(8):4633-43. PMID: 9234720.
      View in: PubMed
    14. Karpova AY, Abe MK, Li J, Liu PT, Rhee JM, Kuo WL, Hershenson MB. MEK1 is required for PDGF-induced ERK activation and DNA synthesis in tracheal myocytes. Am J Physiol. 1997 Mar; 272(3 Pt 1):L558-65. PMID: 9124614.
      View in: PubMed
    15. Kuo WL, Abe M, Rhee J, Eves EM, McCarthy SA, Yan M, Templeton DJ, McMahon M, Rosner MR. Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells. Mol Cell Biol. 1996 Apr; 16(4):1458-70. PMID: 8657119.
      View in: PubMed
    16. Kuo WL, Gehm BD, Rosner MR, Li W, Keller G. Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line. J Biol Chem. 1994 Sep 09; 269(36):22599-606. PMID: 8077210.
      View in: PubMed
    17. Perlman RK, Gehm BD, Kuo WL, Rosner MR. Functional analysis of conserved residues in the active site of insulin-degrading enzyme. J Biol Chem. 1993 Oct 15; 268(29):21538-44. PMID: 8104941.
      View in: PubMed
    18. Gehm BD, Kuo WL, Perlman RK, Rosner MR. Mutations in a zinc-binding domain of human insulin-degrading enzyme eliminate catalytic activity but not insulin binding. J Biol Chem. 1993 Apr 15; 268(11):7943-8. PMID: 8463315.
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    19. Kuo WL, Montag AG, Rosner MR. Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues. Endocrinology. 1993 Feb; 132(2):604-11. PMID: 7678795.
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    20. Kuo WL, Gehm BD, Rosner MR. Regulation of insulin degradation: expression of an evolutionarily conserved insulin-degrading enzyme increases degradation via an intracellular pathway. Mol Endocrinol. 1991 Oct; 5(10):1467-76. PMID: 1775131.
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    21. Espinosa R, Lemons RS, Perlman RK, Kuo WL, Rosner MR, Le Beau MM. Localization of the gene encoding insulin-degrading enzyme to human chromosome 10, bands q23----q25. Cytogenet Cell Genet. 1991; 57(4):184-6. PMID: 1743072.
      View in: PubMed
    22. Kuo WL, Gehm BD, Rosner MR. Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme. Mol Endocrinol. 1990 Oct; 4(10):1580-91. PMID: 2126597.
      View in: PubMed
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