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Margaret Wardle

TitleRESEARCH ASSOCIATE (ASSISTANT PROFESSOR)
InstitutionUniversity of Chicago
DepartmentPsychiatry & Behav. Neurosci
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nunez C, Yoon JH, de Dios C, Dang V, Lane SD, Vincent JN, Schmitz JM, Wardle MC. Undervaluing nondrug rewards or overvaluing cocaine? Cocaine demand relates to cocaine use severity more strongly than anhedonia in individuals with cocaine use disorder. Exp Clin Psychopharmacol. 2024 Aug 29. PMID: 39207396.
      Citations:    Fields:    
    2. Miloslavich K, Wardle M. Anger is more strongly associated with alcohol and tobacco use and use disorders compared to other substances in American adults. Am J Drug Alcohol Abuse. 2024 Jul 03; 50(4):433-441. PMID: 39023422.
      Citations:    Fields:    Translation:Humans
    3. Wardle MC, Webber HE, Yoon JH, Heads AM, Stotts AL, Lane SD, Schmitz JM. Behavioral therapies targeting reward mechanisms in substance use disorders. Pharmacol Biochem Behav. 2024 Jul; 240:173787. PMID: 38705285.
      Citations:    Fields:    Translation:HumansAnimals
    4. Wardle MC, Hoots JK, Miloslavich K, Nunez C, Dios C, Holden C, Ahluwahlia A, Green CE, Lane SD, Schmitz JM. Deficits in consummatory reward relate to severity of cocaine use. Drug Alcohol Depend. 2023 Aug 01; 249:109950. PMID: 37301068; PMCID: PMC10405525.
      Citations:    Fields:    Translation:Humans
    5. Hamidovic A, Davis J, Wardle M, Naveed A, Soumare F. Periovulatory Subphase of the Menstrual Cycle Is Marked by a Significant Decrease in Heart Rate Variability. Biology (Basel). 2023 May 29; 12(6). PMID: 37372070; PMCID: PMC10295577.
      Citations:    
    6. Suchting R, Razouq D, Jose L, Nascimento E Silva F, Wardle MC, Soares JC, Teixeira AL, Selvaraj S. Effects of an experimentally induced inflammatory stimulus on motivational behavior in remitted depressed patients. J Psychiatr Res. 2023 05; 161:106-111. PMID: 36917867.
      Citations:    Fields:    Translation:Humans
    7. Miloslavich K, Leonard SJ, Wardle MC, Vujanovic AA. Alcohol Use Severity, Anger and Drinking Motives among Firefighters. Subst Use Misuse. 2023; 58(5):601-609. PMID: 36803652.
      Citations:    Fields:    Translation:Humans
    8. Hamidovic A, Davis J, Soumare F, Naveed A, Ghani Y, Semiz S, Khalil D, Wardle M. Allopregnanolone Is Associated with a Stress-Induced Reduction of Heart Rate Variability in Premenstrual Dysphoric Disorder. J Clin Med. 2023 Feb 16; 12(4). PMID: 36836088; PMCID: PMC9967763.
      Citations: 5     
    9. Webber HE, Yoon JH, de Dios C, Suchting R, Dang V, Versace F, Green CE, Wardle MC, Lane SD, Schmitz JM. Assessing cocaine motivational value: Comparison of brain reactivity bias toward cocaine cues and cocaine demand. Exp Clin Psychopharmacol. 2023 Aug; 31(4):861-867. PMID: 36480395; PMCID: PMC10247896.
      Citations:    Fields:    Translation:Humans
    10. Nunez C, Hoots JK, Schepers ST, Bower M, de Wit H, Wardle MC. Pharmacological investigations of effort-based decision-making in humans: Naltrexone and nicotine. PLoS One. 2022; 17(10):e0275027. PMID: 36197897; PMCID: PMC9534411.
      Citations: 1     Fields:    Translation:Humans
    11. Zegel M, McGrew SJ, Wardle MC, Vujanovic AA. The main and interactive effects of distress tolerance and reward function on posttraumatic stress disorder symptoms among firefighters. Psychol Trauma. 2023 Sep; 15(Suppl 2):S319-S326. PMID: 35482680; PMCID: PMC10191145.
      Citations:    Fields:    Translation:Humans
    12. Wardle MC, Pabon E, Webber HE, de Wit H. Delta-9-tetrahydrocannabinol reduces willingness to exert effort in women. Psychopharmacology (Berl). 2022 May; 239(5):1487-1497. PMID: 35102424; PMCID: PMC8803458.
      Citations: 2     Fields:    Translation:HumansAnimals
    13. Vujanovic AA, Webber HE, Wardle MC, Green CE, Lane SD, Schmitz JM. Nonjudgmental acceptance: Associations with substance-related cue reactivity in adults with substance use disorders and posttraumatic stress. Addict Behav. 2022 03; 126:107211. PMID: 34923324; PMCID: PMC8713456.
      Citations:    Fields:    Translation:Humans
    14. Naveed A, Dang N, Gonzalez P, Choi SH, Mathew A, Wardle M, Garey L, Hamidovic A. E-Cigarette Dependence and Weight-Related Attitudes/Behaviors Associated With Eating Disorders in Adolescent Girls. Front Psychiatry. 2021; 12:713094. PMID: 34526923; PMCID: PMC8437144.
      Citations: 3     
    15. Webber HE, Kessler DA, Lathan EC, Wardle MC, Green CE, Schmitz JM, Lane SD, Vujanovic AA. Posttraumatic stress symptom clusters differentially predict late positive potential to cocaine imagery cues in trauma-exposed adults with cocaine use disorder. Drug Alcohol Depend. 2021 10 01; 227:108929. PMID: 34340161; PMCID: PMC8464512.
      Citations: 1     Fields:    Translation:Humans
    16. Hoots JK, Webber HE, Nunez C, Cooper JA, Lopez-Gamundi P, Lawlor VM, Lane SD, Treadway MT, Wardle MC. Acute drug effects differentially predict desire to take dextroamphetamine again for work and recreation. Psychopharmacology (Berl). 2021 Oct; 238(10):2815-2826. PMID: 34137904.
      Citations: 1     Fields:    Translation:Humans
    17. Webber HE, de Dios C, Wardle MC, Suchting R, Green CE, Schmitz JM, Lane SD, Versace F. Electrophysiological responses to emotional and cocaine cues reveal individual neuroaffective profiles in cocaine users. Exp Clin Psychopharmacol. 2022 Oct; 30(5):514-524. PMID: 33630644; PMCID: PMC8406778.
      Citations: 5     Fields:    Translation:Humans
    18. Webber HE, Lopez-Gamundi P, Stamatovich SN, de Wit H, Wardle MC. Using pharmacological manipulations to study the role of dopamine in human reward functioning: A review of studies in healthy adults. Neurosci Biobehav Rev. 2021 01; 120:123-158. PMID: 33202256; PMCID: PMC7855845.
      Citations: 12     Fields:    Translation:HumansAnimals
    19. Stamatovich SN, Lopez-Gamundi P, Suchting R, Colpo GD, Walss-Bass C, Lane SD, Schmitz JM, Wardle MC. Plasma pro- and anti-inflammatory cytokines may relate to cocaine use, cognitive functioning, and depressive symptoms in cocaine use disorder. Am J Drug Alcohol Abuse. 2021 01 02; 47(1):52-64. PMID: 33119414.
      Citations: 11     Fields:    Translation:Humans
    20. Jennings AN, Soder HE, Wardle MC, Schmitz JM, Vujanovic AA. Objective analysis of language use in cognitive-behavioral therapy: associations with symptom change in adults with co-occurring substance use disorders and posttraumatic stress. Cogn Behav Ther. 2021 03; 50(2):89-103. PMID: 33021143; PMCID: PMC7897212.
      Citations:    Fields:    Translation:Humans
    21. Soder HE, Cooper JA, Lopez-Gamundi P, Hoots JK, Nunez C, Lawlor VM, Lane SD, Treadway MT, Wardle MC. Dose-response effects of d-amphetamine on effort-based decision-making and reinforcement learning. Neuropsychopharmacology. 2021 05; 46(6):1078-1085. PMID: 32722661; PMCID: PMC8115674.
      Citations: 19     Fields:    Translation:Humans
    22. Hamidovic A, Van Hedger K, Choi SH, Flowers S, Wardle M, Childs E. Quantitative meta-analysis of heart rate variability finds reduced parasympathetic cardiac tone in women compared to men during laboratory-based social stress. Neurosci Biobehav Rev. 2020 07; 114:194-200. PMID: 32320815; PMCID: PMC7422617.
      Citations: 13     Fields:    Translation:Humans
    23. Soder HE, Berumen AM, Gomez KE, Green CE, Suchting R, Wardle MC, Vincent J, Teixeira AL, Schmitz JM, Lane SD. Elevated Neutrophil to Lymphocyte Ratio in Older Adults with Cocaine Use Disorder as a Marker of Chronic Inflammation. Clin Psychopharmacol Neurosci. 2020 Feb 29; 18(1):32-40. PMID: 31958903; PMCID: PMC7006975.
      Citations: 15     
    24. Agurto C, Cecchi GA, Norel R, Ostrand R, Kirkpatrick M, Baggott MJ, Wardle MC, Wit H, Bedi G. Detection of acute 3,4-methylenedioxymethamphetamine (MDMA) effects across protocols using automated natural language processing. Neuropsychopharmacology. 2020 04; 45(5):823-832. PMID: 31978933; PMCID: PMC7075895.
      Citations: 13     Fields:    Translation:Humans
    25. Addicott MA, Wardle MC, Selig JP. Effort-based decision making varies by smoking status. Psychopharmacology (Berl). 2020 Apr; 237(4):1081-1090. PMID: 31900525; PMCID: PMC7125005.
      Citations: 2     Fields:    Translation:Humans
    26. Soder HE, Wardle MC, Schmitz JM, Lane SD, Green C, Vujanovic AA. Baseline resting heart rate variability predicts post-traumatic stress disorder treatment outcomes in adults with co-occurring substance use disorders and post-traumatic stress. Psychophysiology. 2019 08; 56(8):e13377. PMID: 30968959; PMCID: PMC6650323.
      Citations: 9     Fields:    Translation:HumansCTClinical Trials
    27. Suchting R, Vincent JN, Lane SD, Green CE, Schmitz JM, Wardle MC. Using a data science approach to predict cocaine use frequency from depressive symptoms. Drug Alcohol Depend. 2019 01 01; 194:310-317. PMID: 30472571; PMCID: PMC6317336.
      Citations: 1     Fields:    Translation:Humans
    28. D'Souza JM, Wardle M, Green CE, Lane SD, Schmitz JM, Vujanovic AA. Resting Heart Rate Variability: Exploring Associations With Symptom Severity in Adults With Substance Use Disorders and Posttraumatic Stress. J Dual Diagn. 2019 Jan-Mar; 15(1):2-7. PMID: 30418104; PMCID: PMC6511322.
      Citations: 6     Fields:    Translation:Humans
    29. Fries GR, Khan S, Stamatovich S, Dyukova E, Walss-Bass C, Lane SD, Schmitz JM, Wardle MC. Anhedonia in cocaine use disorder is associated with inflammatory gene expression. PLoS One. 2018; 13(11):e0207231. PMID: 30408130; PMCID: PMC6224118.
      Citations: 7     Fields:    Translation:Humans
    30. Wardle MC, Lopez-Gamundi P, LaVoy EC. Effects of an acute bout of physical exercise on reward functioning in healthy adults. Physiol Behav. 2018 10 01; 194:552-559. PMID: 30017698; PMCID: PMC6086604.
      Citations: 2     Fields:    Translation:Humans
    31. Vujanovic AA, Wardle MC, Bakhshaie J, Smith LJ, Green CE, Lane SD, Schmitz JM. Distress tolerance: Associations with trauma and substance cue reactivity in low-income, inner-city adults with substance use disorders and posttraumatic stress. Psychol Addict Behav. 2018 05; 32(3):264-276. PMID: 29771557; PMCID: PMC5962030.
      Citations: 8     Fields:    Translation:Humans
    32. Lopez-Gamundi P, Wardle MC. The cognitive effort expenditure for rewards task (C-EEfRT): A novel measure of willingness to expend cognitive effort. Psychol Assess. 2018 Sep; 30(9):1237-1248. PMID: 29620381.
      Citations: 12     Fields:    Translation:Humans
    33. Wardle MC, Lopez-Gamundi P, Flagel SB. Measuring appetitive conditioned responses in humans. Physiol Behav. 2018 05 01; 188:140-150. PMID: 29408238; PMCID: PMC5845787.
      Citations: 10     Fields:    Translation:Humans
    34. Vujanovic AA, Wardle MC, Smith LJ, Berenz EC. Reward functioning in posttraumatic stress and substance use disorders. Curr Opin Psychol. 2017 Apr; 14:49-55. PMID: 28813319.
      Citations: 15     Fields:    
    35. Wardle MC, Vincent JN, Suchting R, Green CE, Lane SD, Schmitz JM. Anhedonia Is Associated with Poorer Outcomes in Contingency Management for Cocaine Use Disorder. J Subst Abuse Treat. 2017 01; 72:32-39. PMID: 27646197; PMCID: PMC5154907.
      Citations: 17     Fields:    Translation:Humans
    36. Bershad AK, Weafer JJ, Kirkpatrick MG, Wardle MC, Miller MA, de Wit H. Oxytocin receptor gene variation predicts subjective responses to MDMA. Soc Neurosci. 2016 12; 11(6):592-9. PMID: 26787430; PMCID: PMC4988944.
      Citations: 18     Fields:    Translation:Humans
    37. Wardle MC, Bershad AK, de Wit H. Naltrexone alters the processing of social and emotional stimuli in healthy adults. Soc Neurosci. 2016 12; 11(6):579-91. PMID: 26710657; PMCID: PMC4958027.
      Citations: 19     Fields:    Translation:Humans
    38. Vujanovic AA, Wardle MC, Liu S, Dias NR, Lane SD. Attentional bias in adults with cannabis use disorders. J Addict Dis. 2016; 35(2):144-53. PMID: 26566718; PMCID: PMC4867847.
      Citations: 9     Fields:    Translation:Humans
    39. Wardle MC, Marcus BA, de Wit H. A Preliminary Investigation of Individual Differences in Subjective Responses to D-Amphetamine, Alcohol, and Delta-9-Tetrahydrocannabinol Using a Within-Subjects Randomized Trial. PLoS One. 2015; 10(10):e0140501. PMID: 26513587; PMCID: PMC4626040.
      Citations: 12     Fields:    Translation:HumansCTClinical Trials
    40. Clark CM, Frye CG, Wardle MC, Norman GJ, de Wit H. Acute effects of MDMA on autonomic cardiac activity and their relation to subjective prosocial and stimulant effects. Psychophysiology. 2015 Mar; 52(3):429-35. PMID: 25208727; PMCID: PMC4634859.
      Citations: 7     Fields:    Translation:Humans
    41. Wardle MC, Fitzgerald DA, Angstadt M, Rabinak CA, de Wit H, Phan KL. Effects of oxycodone on brain responses to emotional images. Psychopharmacology (Berl). 2014 Nov; 231(22):4403-15. PMID: 24800897; PMCID: PMC6720110.
      Citations: 9     Fields:    Translation:Humans
    42. Wardle MC, de Wit H. MDMA alters emotional processing and facilitates positive social interaction. Psychopharmacology (Berl). 2014 Oct; 231(21):4219-29. PMID: 24728603; PMCID: PMC4194242.
      Citations: 40     Fields:    Translation:Humans
    43. Wardle MC, Kirkpatrick MG, de Wit H. 'Ecstasy' as a social drug: MDMA preferentially affects responses to emotional stimuli with social content. Soc Cogn Affect Neurosci. 2014 Aug; 9(8):1076-81. PMID: 24682132; PMCID: PMC4127030.
      Citations: 26     Fields:    Translation:Humans
    44. Kirkpatrick MG, Lee R, Wardle MC, Jacob S, de Wit H. Effects of MDMA and Intranasal oxytocin on social and emotional processing. Neuropsychopharmacology. 2014 Jun; 39(7):1654-63. PMID: 24448644; PMCID: PMC4023138.
      Citations: 60     Fields:    Translation:Humans
    45. Frye CG, Wardle MC, Norman GJ, de Wit H. MDMA decreases the effects of simulated social rejection. Pharmacol Biochem Behav. 2014 Feb; 117:1-6. PMID: 24316346; PMCID: PMC3910346.
      Citations: 41     Fields:    Translation:Humans
    46. Wardle MC, Fitzgerald DA, Angstadt M, Sripada CS, McCabe K, Phan KL. The caudate signals bad reputation during trust decisions. PLoS One. 2013; 8(6):e68884. PMID: 23922638; PMCID: PMC3688684.
      Citations: 11     Fields:    Translation:Humans
    47. Yusef-Zadeh F, Wardle M, Lis D, Viti S, Brogan C, Chambers E, Pound M, Rickert M. 74 MHz nonthermal emission from molecular clouds: evidence for a cosmic ray dominated region at the galactic center. J Phys Chem A. 2013 Oct 03; 117(39):9404-19. PMID: 23635333.
      Citations:    Fields:    
    48. Wardle MC, de Wit H, Penton-Voak I, Lewis G, Munafò MR. Lack of association between COMT and working memory in a population-based cohort of healthy young adults. Neuropsychopharmacology. 2013 Jun; 38(7):1253-63. PMID: 23337869; PMCID: PMC3656369.
      Citations: 32     Fields:    Translation:Humans
    49. Wardle MC, Hart AB, Palmer AA, de Wit H. Does COMT genotype influence the effects of d-amphetamine on executive functioning? Genes Brain Behav. 2013 Feb; 12(1):13-20. PMID: 23231539; PMCID: PMC3553317.
      Citations: 15     Fields:    Translation:Humans
    50. Conrad M, Wardle M, King A, de Wit H. Relationship of self-reported and acute stress to smoking in emerging adult smokers. J Clin Psychol. 2013 Jul; 69(7):710-7. PMID: 23280768; PMCID: PMC4795009.
      Citations: 3     Fields:    Translation:Humans
    51. Hart AB, Engelhardt BE, Wardle MC, Sokoloff G, Stephens M, de Wit H, Palmer AA. Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). PLoS One. 2012; 7(8):e42646. PMID: 22952603; PMCID: PMC3429486.
      Citations: 54     Fields:    Translation:Humans
    52. Wardle MC, Treadway MT, de Wit H. Caffeine increases psychomotor performance on the effort expenditure for rewards task. Pharmacol Biochem Behav. 2012 Oct; 102(4):526-31. PMID: 22750066; PMCID: PMC3578395.
      Citations: 9     Fields:    Translation:Humans
    53. Wardle MC, Garner MJ, de Wit H, Munafò MR. Amphetamine as a social drug: effects of d-amphetamine on social processing and behavior. Psychopharmacology (Berl). 2012 Sep; 223(2):199-210. PMID: 22526538; PMCID: PMC3422595.
      Citations: 29     Fields:    Translation:HumansCTClinical Trials
    54. Wardle MC, Treadway MT, Mayo LM, Zald DH, de Wit H. Amping up effort: effects of d-amphetamine on human effort-based decision-making. J Neurosci. 2011 Nov 16; 31(46):16597-602. PMID: 22090487; PMCID: PMC3234999.
      Citations: 122     Fields:    Translation:Humans
    55. Wardle MC, de Wit H. Effects of amphetamine on reactivity to emotional stimuli. Psychopharmacology (Berl). 2012 Mar; 220(1):143-53. PMID: 21947316; PMCID: PMC3277682.
      Citations: 25     Fields:    Translation:Humans
    56. Wardle MC, Yang A, de Wit H. Effect of d-amphetamine on post-error slowing in healthy volunteers. Psychopharmacology (Berl). 2012 Mar; 220(1):109-15. PMID: 21894485; PMCID: PMC4241763.
      Citations: 12     Fields:    Translation:Humans
    57. Wardle M, Cederbaum K, de Wit H. Quantifying talk: developing reliable measures of verbal productivity. Behav Res Methods. 2011 Mar; 43(1):168-78. PMID: 21287128; PMCID: PMC3049967.
      Citations: 9     Fields:    Translation:Humans
    58. Veilleux JC, Kassel JD, Heinz AJ, Braun A, Wardle MC, Greenstein J, Evatt DP, Conrad M. Predictors and sequelae of smoking topography over the course of a single cigarette in adolescent light smokers. J Adolesc Health. 2011 Feb; 48(2):176-81. PMID: 21257117; PMCID: PMC3044318.
      Citations: 16     Fields:    Translation:Humans
    59. Wardle MC, de Wit H, Munafò MR. Effect of social stress during acute nicotine abstinence. Psychopharmacology (Berl). 2011 Nov; 218(1):39-48. PMID: 21234550; PMCID: PMC3094594.
      Citations: 16     Fields:    Translation:Humans
    60. Wardle MC, Gonzalez R, Bechara A, Martin-Thormeyer EM. Iowa Gambling Task performance and emotional distress interact to predict risky sexual behavior in individuals with dual substance and HIV diagnoses. J Clin Exp Neuropsychol. 2010 Dec; 32(10):1110-21. PMID: 20480423; PMCID: PMC3639122.
      Citations: 21     Fields:    Translation:Humans
    61. Greenstein JE, Kassel JD, Wardle MC, Veilleux JC, Evatt DP, Heinz AJ, Roesch LL, Braun AR, Yates MC. The separate and combined effects of nicotine and alcohol on working memory capacity in nonabstinent smokers. Exp Clin Psychopharmacol. 2010 Apr; 18(2):120-8. PMID: 20384423.
      Citations: 6     Fields:    Translation:Humans
    62. Gonzalez R, Wardle M, Jacobus J, Vassileva J, Martin-Thormeyer EM. Influence of procedural learning on Iowa Gambling Task performance among HIV+ individuals with history of substance dependence. Arch Clin Neuropsychol. 2010 Feb; 25(1):28-38. PMID: 19939850; PMCID: PMC2809553.
      Citations: 6     Fields:    Translation:Humans
    63. Majounie E, Wardle M, Muzaimi M, Cross WC, Robertson NP, Williams NM, Morris HR. Case control analysis of repeat expansion size in ataxia. Neurosci Lett. 2007 Dec 11; 429(1):28-32. PMID: 17961920.
      Citations: 8     Fields:    Translation:HumansCells
    64. Kassel JD, Evatt DP, Greenstein JE, Wardle MC, Yates MC, Veilleux JC. The acute effects of nicotine on positive and negative affect in adolescent smokers. J Abnorm Psychol. 2007 Aug; 116(3):543-53. PMID: 17696710.
      Citations: 33     Fields:    Translation:Humans
    65. Kassel JD, Greenstein JE, Evatt DP, Wardle MC, Yates MC, Veilleux JC, Eissenberg T. Smoking topography in response to denicotinized and high-yield nicotine cigarettes in adolescent smokers. J Adolesc Health. 2007 Jan; 40(1):54-60. PMID: 17185206.
      Citations: 24     Fields:    Translation:Humans
    66. Kassel JD, Wardle M, Roberts JE. Adult attachment security and college student substance use. Addict Behav. 2007 Jun; 32(6):1164-76. PMID: 16996225.
      Citations: 29     Fields:    Translation:Humans
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