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Emmet Hirsch

TitleClinical Professor
InstitutionUniversity of Chicago
DepartmentObstetrics & Gynecology
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Suresh S, Freedman A, Adams M, Hirsch E, Ernst LM. Placental histology for targeted risk assessment of recurrent spontaneous preterm birth. Am J Obstet Gynecol. 2024 Apr; 230(4):452.e1-452.e11. PMID: 37751829.
      Citations:    Fields:    
    2. Kyathanahalli C, Snedden M, Singh L, Regalia C, Keenan-Devlin L, Borders AE, Hirsch E. Maternal plasma and salivary anelloviruses in pregnancy and preterm birth. Front Med (Lausanne). 2023; 10:1191938. PMID: 37396897; PMCID: PMC10309558.
      Citations: 1     
    3. Kyathanahalli C, Snedden M, Hirsch E. Is human labor at term an inflammatory condition?†. Biol Reprod. 2023 01 14; 108(1):23-40. PMID: 36173900; PMCID: PMC10060716.
      Citations: 6     Fields:    Translation:Humans
    4. de Los Reyes S, Singh L, Adams M, Wang C, Hirsch E. Glucose Testing in an Index Pregnancy and Outcomes in a Subsequent Pregnancy: Implications for Screening and a Novel Risk Calculator. Am J Perinatol. 2023 02; 40(3):243-249. PMID: 36427509.
      Citations:    Fields:    Translation:HumansPHPublic Health
    5. Snedden M, Singh L, Kyathanahalli C, Hirsch E. Toxic effects of trace phenol/guanidine isothiocyanate (P/GI) on cells cultured nearby in covered 96-well plates. BMC Biotechnol. 2022 Nov 25; 22(1):35. PMID: 36434619.
      Citations:    Fields:    Translation:AnimalsCells
    6. Suresh S, MacGregor C, Dude A, Hirsch E. Single second-trimester cervical length is predictive of preterm delivery among patients with prophylactic cerclage. Am J Obstet Gynecol. 2022 Dec; 227(6):910-911.e1. PMID: 35863459.
      Citations: 1     Fields:    Translation:Humans
    7. Suresh SC, Freedman AA, Hirsch E, Ernst LM. A comprehensive analysis of the association between placental pathology and recurrent preterm birth. Am J Obstet Gynecol. 2022 12; 227(6):887.e1-887.e15. PMID: 35764136; PMCID: PMC9729378.
      Citations: 2     Fields:    Translation:Humans
    8. Hirsch E. Multiple potential sources of cognitive bias in clinical diagnosis. Am J Obstet Gynecol. 2022 04; 226(4):593. PMID: 34757004.
      Citations:    Fields:    Translation:Humans
    9. de Los Reyes S, Dude A, Adams M, Plunkett B, Hirsch E. Elevated Glucose Challenge Test in a Nondiabetic Index Pregnancy and Gestational Diabetes in a Subsequent Pregnancy. Am J Perinatol. 2021 09; 38(11):1117-1121. PMID: 34044461.
      Citations:    Fields:    Translation:Humans
    10. Mishra P, Hirsch E. Variable Responsiveness to Agonists for TLR2 and TLR7 in Myometrial Cells from Different Sources: Correlation with Receptor Expression. Reprod Sci. 2020 04; 27(4):996-1001. PMID: 32124394.
      Citations:    Fields:    Translation:HumansCells
    11. Hirsch E. Horses and zebras: probabilities, uncertainty, and cognitive bias in clinical diagnosis. Am J Obstet Gynecol. 2020 05; 222(5):469.e1-469.e3. PMID: 31954699.
      Citations: 1     Fields:    Translation:Humans
    12. Shah AA, Wang D, Hirsch E. Nucleic Acid-Based Screening of Maternal Serum to Detect Viruses in Women with Labor or PROM. Reprod Sci. 2020 02; 27(2):537-544. PMID: 31925769.
      Citations: 2     Fields:    Translation:HumansCells
    13. Scholz R, Smith BA, Adams MG, Shah M, Brudner C, Datta A, Hirsch E. A Multifaceted Surgical Site Infection Prevention Bundle for Cesarean Delivery. Am J Perinatol. 2021 06; 38(7):690-697. PMID: 31887748.
      Citations: 8     Fields:    Translation:Humans
    14. Hirsch E. Electronic Fetal Monitoring to Prevent Fetal Brain Injury: A Ubiquitous Yet Flawed Tool. JAMA. 2019 Aug 20; 322(7):611-612. PMID: 31318396.
      Citations: 4     Fields:    
    15. Agrawal V, Jaiswal MK, Beaman KD, Hirsch E. Surfactant protein A suppresses preterm delivery induced by live Escherichia coli in mice. Biol Reprod. 2018 09 01; 99(3):546-555. PMID: 29590302; PMCID: PMC6669354.
      Citations: 3     Fields:    Translation:AnimalsCells
    16. Hirsch E. Lessons from an Angry Patient. N Engl J Med. 2018 Aug 16; 379(7):607-609. PMID: 30110581.
      Citations:    Fields:    Translation:Humans
    17. Dambaeva S, Schneiderman S, Jaiswal MK, Agrawal V, Katara GK, Gilman-Sachs A, Hirsch E, Beaman KD. Interleukin 22 prevents lipopolysaccharide- induced preterm labor in mice. Biol Reprod. 2018 03 01; 98(3):299-308. PMID: 29315356; PMCID: PMC6669419.
      Citations: 15     Fields:    Translation:AnimalsCells
    18. Hirsch E. The most important quality of a physician. Am J Obstet Gynecol. 2018 04; 218(4):459. PMID: 29305830.
      Citations:    Fields:    Translation:Humans
    19. Thaete LG, Qu XW, Neerhof MG, Hirsch E, Jilling T. Fetal Growth Restriction Induced by Transient Uterine Ischemia-Reperfusion: Differential Responses in Different Mouse Strains. Reprod Sci. 2018 07; 25(7):1083-1092. PMID: 28946817; PMCID: PMC6346349.
      Citations: 2     Fields:    Translation:Animals
    20. Hirsch E. Good eggs and bad eggs. Am J Obstet Gynecol. 2016 Dec; 215(6):800-801. PMID: 27659213.
      Citations:    Fields:    Translation:Humans
    21. Hirsch E. Quantity and quality in medicine: lessons from the humble Pap. Am J Obstet Gynecol. 2016 Oct; 215(4):525-6. PMID: 27461991.
      Citations:    Fields:    Translation:Humans
    22. Hirsch E. Complication. Am J Obstet Gynecol. 2016 Jul; 215(1):119. PMID: 27164558.
      Citations:    Fields:    Translation:Humans
    23. Hirsch E. The Case of Mr. George. Obstet Gynecol. 2016 Apr; 127(4):769-770. PMID: 26959216.
      Citations:    Fields:    Translation:Humans
    24. Turrentine MA, Colicchia LC, Hirsch E, Cheng PJ, Tam T, Ramsey PS, Page-Ramsey SM. Efficiency of Screening for the Recurrence of Antenatal Group B Streptococcus Colonization in a Subsequent Pregnancy: A Systematic Review and Meta-analysis with Independent Patient Data. Am J Perinatol. 2016 Apr; 33(5):510-7. PMID: 26683604.
      Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
    25. Filipovich Y, Klein J, Zhou Y, Hirsch E. Maternal and fetal roles in bacterially induced preterm labor in the mouse. Am J Obstet Gynecol. 2016 Mar; 214(3):386.e1-9. PMID: 26478101; PMCID: PMC4775297.
      Citations: 12     Fields:    Translation:AnimalsCells
    26. Jaiswal MK, Agrawal V, Pamarthy S, Katara GK, Kulshrestha A, Gilman-Sachs A, Beaman KD, Hirsch E. Notch Signaling in Inflammation-Induced Preterm Labor. Sci Rep. 2015 Oct 16; 5:15221. PMID: 26472156; PMCID: PMC4607997.
      Citations: 15     Fields:    Translation:AnimalsCells
    27. Agrawal V, Jaiswal MK, Pamarthy S, Katara GK, Kulshrestha A, Gilman-Sachs A, Hirsch E, Beaman KD. Role of Notch signaling during lipopolysaccharide-induced preterm labor. J Leukoc Biol. 2016 08; 100(2):261-74. PMID: 26373439; PMCID: PMC4945351.
      Citations: 13     Fields:    Translation:AnimalsCells
    28. Filipovich Y, Agrawal V, Crawford SE, Fitchev P, Qu X, Klein J, Hirsch E. Depletion of polymorphonuclear leukocytes has no effect on preterm delivery in a mouse model of Escherichia coli-induced labor. Am J Obstet Gynecol. 2015 Nov; 213(5):697.e1-10. PMID: 26215328; PMCID: PMC4631622.
      Citations: 15     Fields:    Translation:AnimalsCells
    29. Agrawal V, Jaiswal MK, Mallers T, Katara GK, Gilman-Sachs A, Beaman KD, Hirsch E. Altered autophagic flux enhances inflammatory responses during inflammation-induced preterm labor. Sci Rep. 2015 Mar 23; 5:9410. PMID: 25797357; PMCID: PMC4369745.
      Citations: 36     Fields:    Translation:AnimalsCells
    30. Lu J, Reese J, Zhou Y, Hirsch E. Progesterone-induced activation of membrane-bound progesterone receptors in murine macrophage cells. J Endocrinol. 2015 Feb; 224(2):183-94. PMID: 25472814; PMCID: PMC4297269.
      Citations: 15     Fields:    Translation:AnimalsCells
    31. Colicchia LC, Lauderdale DS, Du H, Adams M, Hirsch E. Recurrence of group B streptococcus colonization in successive pregnancies. J Perinatol. 2015 Mar; 35(3):173-6. PMID: 25321646.
      Citations: 5     Fields:    Translation:HumansCells
    32. Agrawal V, Jaiswal MK, Ilievski V, Beaman KD, Jilling T, Hirsch E. Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. Biol Reprod. 2014 Nov; 91(5):119. PMID: 25253732; PMCID: PMC4434927.
      Citations: 21     Fields:    Translation:AnimalsCells
    33. Hirsch E, Elue R, Wagner A, Nelson K, Silver RK, Zhou Y, Adams MG. Severe perineal laceration during operative vaginal delivery: the impact of occiput posterior position. J Perinatol. 2014 Dec; 34(12):898-900. PMID: 24875411.
      Citations:    Fields:    Translation:Humans
    34. Jaiswal MK, Agrawal V, Mallers T, Gilman-Sachs A, Hirsch E, Beaman KD. Regulation of apoptosis and innate immune stimuli in inflammation-induced preterm labor. J Immunol. 2013 Dec 01; 191(11):5702-13. PMID: 24163412; PMCID: PMC3870276.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    35. Agrawal V, Smart K, Jilling T, Hirsch E. Surfactant protein (SP)-A suppresses preterm delivery and inflammation via TLR2. PLoS One. 2013; 8(5):e63990. PMID: 23700442; PMCID: PMC3659120.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    36. Thaete LG, Qu XW, Jilling T, Crawford SE, Fitchev P, Hirsch E, Khan S, Neerhof MG. Impact of toll-like receptor 4 deficiency on the response to uterine ischemia/reperfusion in mice. Reproduction. 2013 May; 145(5):517-26. PMID: 23509372.
      Citations: 7     Fields:    Translation:Animals
    37. Abramov Y, Hirsch E, Ilievski V, Goldberg RP, Botros SM, Sand PK. Transforming growth factor ß 1 gene expression during vaginal vs cutaneous surgical woundexpression during vaginal vs cutaneous surgical wound healing in the rabbit. Int Urogynecol J. 2013 Apr; 24(4):671-5. PMID: 22872035.
      Citations: 3     Fields:    Translation:Animals
    38. Abramov Y, Hirsch E, Ilievski V, Goldberg RP, Sand PK. Transforming growth factor beta1 gene expression during vaginal wound healing in a rabbit menopause model. BJOG. 2013 Jan; 120(2):251-256. PMID: 22827859.
      Citations: 5     Fields:    Translation:AnimalsCells
    39. Qu XW, Jilling T, Neerhof MG, Luo K, Hirsch E, Thaete LG. Unilateral uterine ischemia/reperfusion-induced bilateral fetal loss and fetal growth restriction in a murine model require intact complement component 5. J Reprod Immunol. 2012 Sep; 95(1-2):27-35. PMID: 22688254; PMCID: PMC3432748.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    40. Abramov Y, Hirsch E, Ilievski V, Goldberg RP, Botros SM, Sand PK. Expression of platelet-derived growth factor-B mRNA during vaginal vs. dermal incisional wound healing in the rabbit. Eur J Obstet Gynecol Reprod Biol. 2012 Jun; 162(2):216-20. PMID: 22464204.
      Citations: 5     Fields:    Translation:Animals
    41. Tsai HJ, Hong X, Chen J, Liu X, Pearson C, Ortiz K, Hirsch E, Heffner L, Weeks DE, Zuckerman B, Wang X. Role of African ancestry and gene-environment interactions in predicting preterm birth. Obstet Gynecol. 2011 Nov; 118(5):1081-1089. PMID: 22015876; PMCID: PMC3218119.
      Citations: 9     Fields:    Translation:Humans
    42. Agrawal V, Hirsch E. Intrauterine infection and preterm labor. Semin Fetal Neonatal Med. 2012 Feb; 17(1):12-9. PMID: 21944863; PMCID: PMC3242863.
      Citations: 129     Fields:    Translation:Humans
    43. Liu X, Wang G, Hong X, Tsai HJ, Liu R, Zhang S, Wang H, Pearson C, Ortiz K, Wang D, Hirsch E, Zuckerman B, Wang X. Associations between gene polymorphisms in fatty acid metabolism pathway and preterm delivery in a US urban black population. Hum Genet. 2012 Mar; 131(3):341-51. PMID: 21847588; PMCID: PMC4547931.
      Citations: 9     Fields:    Translation:Humans
    44. Ilievski V, Hirsch E. Synergy between viral and bacterial toll-like receptors leads to amplification of inflammatory responses and preterm labor in the mouse. Biol Reprod. 2010 Nov; 83(5):767-73. PMID: 20650880; PMCID: PMC2959106.
      Citations: 39     Fields:    Translation:AnimalsCells
    45. Hirsch E, Lim C, Dobrez D, Adams MG, Noble W. Meteorological factors and timing of the initiating event of human parturition. Int J Biometeorol. 2011 Mar; 55(2):265-72. PMID: 20526783.
      Citations: 4     Fields:    Translation:Humans
    46. Equils O, Moffatt-Blue C, Ishikawa TO, Simmons CF, Ilievski V, Hirsch E. Pretreatment with pancaspase inhibitor (Z-VAD-FMK) delays but does not prevent intraperitoneal heat-killed group B Streptococcus-induced preterm delivery in a pregnant mouse model. Infect Dis Obstet Gynecol. 2009; 2009:749432. PMID: 20069051; PMCID: PMC2801448.
      Citations: 12     Fields:    Translation:AnimalsCells
    47. Hirsch E, Filipovich Y, Romero R. Failure of E. coli bacteria to induce preterm delivery in the rat. J Negat Results Biomed. 2009 Jan 04; 8:1. PMID: 19121225; PMCID: PMC2631604.
      Citations: 5     Fields:    Translation:AnimalsCells
    48. Filipovich Y, Lu SJ, Akira S, Hirsch E. The adaptor protein MyD88 is essential for E coli-induced preterm delivery in mice. Am J Obstet Gynecol. 2009 Jan; 200(1):93.e1-8. PMID: 19121660.
      Citations: 31     Fields:    Translation:AnimalsCells
    49. Hirsch E, Haney EI, Gordon TE, Silver RK. Reducing high-order perineal laceration during operative vaginal delivery. Am J Obstet Gynecol. 2008 Jun; 198(6):668.e1-5. PMID: 18395688.
      Citations: 3     Fields:    Translation:Humans
    50. Ilievski V, Lu SJ, Hirsch E. Activation of toll-like receptors 2 or 3 and preterm delivery in the mouse. Reprod Sci. 2007 May; 14(4):315-20. PMID: 17644803.
      Citations: 53     Fields:    Translation:Animals
    51. Hirsch E, Filipovich Y, Mahendroo M. Signaling via the type I IL-1 and TNF receptors is necessary for bacterially induced preterm labor in a murine model. Am J Obstet Gynecol. 2006 May; 194(5):1334-40. PMID: 16647919.
      Citations: 49     Fields:    Translation:AnimalsCells
    52. Yoshimura K, Hirsch E. Effect of stimulation and antagonism of interleukin-1 signaling on preterm delivery in mice. J Soc Gynecol Investig. 2005 Oct; 12(7):533-8. PMID: 16202930.
      Citations: 12     Fields:    Translation:AnimalsCells
    53. Craft JM, Watterson DM, Hirsch E, Van Eldik LJ. Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid. J Neuroinflammation. 2005 Jun 20; 2:15. PMID: 15967035; PMCID: PMC1190207.
      Citations: 44     Fields:    
    54. Hirsch E, Goldstein M, Filipovich Y, Wang H. Placental expression of enzymes regulating prostaglandin synthesis and degradation. Am J Obstet Gynecol. 2005 Jun; 192(6):1836-42; discussion 1842-3. PMID: 15970823.
      Citations: 3     Fields:    Translation:Humans
    55. Hirsch E, Wang H. The molecular pathophysiology of bacterially induced preterm labor: insights from the murine model. J Soc Gynecol Investig. 2005 Apr; 12(3):145-55. PMID: 15784499.
      Citations: 48     Fields:    Translation:HumansAnimals
    56. Yoshimura K, Hirsch E. Interleukin-6 is neither necessary nor sufficient for preterm labor in a murine infection model. J Soc Gynecol Investig. 2003 Oct; 10(7):423-7. PMID: 14519484.
      Citations: 11     Fields:    Translation:HumansAnimals
    57. Wang H, Hirsch E. Bacterially-induced preterm labor and regulation of prostaglandin-metabolizing enzyme expression in mice: the role of toll-like receptor 4. Biol Reprod. 2003 Dec; 69(6):1957-63. PMID: 12904319.
      Citations: 68     Fields:    Translation:AnimalsCells
    58. Hirsch E, Muhle R, Hirsch E, Muhle R. Intrauterine bacterial inoculation induces labor in the mouse by mechanisms other than progesterone withdrawal. Biol Reprod. 2002 Oct; 67(4):1337-41. PMID: 12297553.
      Citations: 25     Fields:    Translation:Animals
    59. Devlin CM, Kuriakose G, Hirsch E, Tabas I. Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6280-5. PMID: 11983917; PMCID: PMC122940.
      Citations: 52     Fields:    Translation:AnimalsCells
    60. Hirsch E, Muhle RA, Mussalli GM, Blanchard R. Bacterially induced preterm labor in the mouse does not require maternal interleukin-1 signaling. Am J Obstet Gynecol. 2002 Mar; 186(3):523-30. PMID: 11904618.
      Citations: 15     Fields:    Translation:AnimalsCells
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