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Steven Roth

TitleEmeritus/Emerita, Professor
InstitutionUniversity of Chicago
AddressChicago IL 60637
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    R21EY028690     (ROTH, STEVEN)Feb 1, 2019 - Jan 31, 2022
    Novel Cell Free Therapy for Glaucoma
    Role: Principal Investigator

    R21EY027447     (ROTH, STEVEN)Sep 30, 2017 - Aug 31, 2020
    Risk factor anaylysis of perioperative visual loss
    Role: Principal Investigator

    R01EY010343     (ROTH, STEVEN)Jan 1, 1994 - Dec 31, 2015
    The Role of Adenosine in Retinal Ischemia
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mathew B, Acha LG, Torres LA, Huang CC, Liu A, Kalinin S, Leung K, Dai Y, Feinstein DL, Ravindran S, Roth S. MicroRNA-based engineering of mesenchymal stem cell extracellular vesicles for treatment of retinal ischemic disorders: Engineered extracellular vesiclesand retinal ischemia. Acta Biomater. 2023 03 01; 158:782-797. PMID: 36638942; PMCID: PMC10005109.
      Citations: 6     Fields:    Translation:AnimalsCells
    2. Roth S, Moss HE, Vajaranant TS, Sweitzer B. Perioperative Care of the Patient with Eye Pathologies Undergoing Nonocular Surgery. Anesthesiology. 2022 11 01; 137(5):620-643. PMID: 36179149; PMCID: PMC9588701.
      Citations: 1     Fields:    Translation:Humans
    3. Shah SH, Xiao L, Chen YF, Moss HE, Rubin DS, Roth S. Perioperative Ischemic Optic Neuropathy after Cardiac Surgery: Development and Validation of a Preoperative Risk Prediction Model. J Cardiothorac Vasc Anesth. 2022 12; 36(12):4266-4272. PMID: 36114093; PMCID: PMC10874298.
      Citations:    Fields:    Translation:Humans
    4. Aneesh A, Liu A, Moss HE, Feinstein D, Ravindran S, Mathew B, Roth S. Emerging concepts in the treatment of optic neuritis: mesenchymal stem cell-derived extracellular vesicles. Stem Cell Res Ther. 2021 Dec 04; 12(1):594. PMID: 34863294; PMCID: PMC8642862.
      Citations: 11     Fields:    Translation:AnimalsCells
    5. Chandrakantan A, Adler AC, Tohsun M, Kheradamand F, Ray RS, Roth S. Intermittent Hypoxia and Effects on Early Learning/Memory: Exploring the Hippocampal Cellular Effects of Pediatric Obstructive Sleep Apnea. Anesth Analg. 2021 07 01; 133(1):93-103. PMID: 33234943; PMCID: PMC8134503.
      Citations: 1     Fields:    Translation:HumansAnimals
    6. Mathew B, Torres LA, Gamboa Acha L, Tran S, Liu A, Patel R, Chennakesavalu M, Aneesh A, Huang CC, Feinstein DL, Mehraeen S, Ravindran S, Roth S. Uptake and Distribution of Administered Bone Marrow Mesenchymal Stem Cell Extracellular Vesicles in Retina. Cells. 2021 03 25; 10(4). PMID: 33806128; PMCID: PMC8064505.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    7. Roth S, Raphael J. Cardiac Surgery and Ischemic Optic Neuropathy. J Cardiothorac Vasc Anesth. 2021 01; 35(1):39-40. PMID: 33004268.
      Citations: 1     Fields:    Translation:Humans
    8. Mathew B, Chennakesavalu M, Sharma M, Torres LA, Stelman CR, Tran S, Patel R, Burg N, Salkovski M, Kadzielawa K, Seiler F, Aldrich LN, Roth S. Autophagy and post-ischemic conditioning in retinal ischemia. Autophagy. 2021 06; 17(6):1479-1499. PMID: 32452260; PMCID: PMC8205079.
      Citations: 20     Fields:    Translation:AnimalsCells
    9. Eklund JE, Shah SH, Rubin DS, Mehta AI, Minev EM, Lee HH, Roth S. Incidence of and factors associated with acute kidney injury after scoliosis surgery in pediatric patients. Spine Deform. 2020 10; 8(5):991-999. PMID: 32378041.
      Citations:    Fields:    Translation:Humans
    10. Shah SH, Chen YF, Moss HE, Rubin DS, Joslin CE, Roth S. Predicting Risk of Perioperative Ischemic Optic Neuropathy in Spine Fusion Surgery: A Cohort Study Using the National Inpatient Sample. Anesth Analg. 2020 04; 130(4):967-974. PMID: 31490255; PMCID: PMC8098669.
      Citations: 4     Fields:    Translation:Humans
    11. Moss HE, Joslin CE, Rubin DS, Roth S. Big Data Research in Neuro-Ophthalmology: Promises and Pitfalls. J Neuroophthalmol. 2019 12; 39(4):480-486. PMID: 30688751; PMCID: PMC6658354.
      Citations: 3     Fields:    Translation:Humans
    12. Chandrakantan A, Adler AC, Stayer S, Roth S. National Institutes of Health-Funded Anesthesiology Research and Anesthesiology Physician-Scientists: Trends, Promises, and Concerns. Anesth Analg. 2019 12; 129(6):1761-1766. PMID: 31743198.
      Citations: 5     Fields:    Translation:Humans
    13. Chandrakantan A, Adler AC, Stayer S, Roth S. National Institutes of Health-Funded Anesthesiology Research and Anesthesiology Physician-Scientists: Trends, Promises, and Concerns. Anesth Analg. 2019 Jul 23. PMID: 31348052.
    14. Mathew B, Ravindran S, Liu X, Torres L, Chennakesavalu M, Huang CC, Feng L, Zelka R, Lopez J, Sharma M, Roth S. Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion. Biomaterials. 2019 03; 197:146-160. PMID: 30654160; PMCID: PMC6425741.
      Citations: 116     Fields:    Translation:HumansAnimalsCells
    15. Roth S, Dreixler J, Newman NJ. Haemodilution and head-down tilting induce functional injury in the rat optic nerve: A model for peri-operative ischemic optic neuropathy. Eur J Anaesthesiol. 2018 11; 35(11):840-847. PMID: 29771733; PMCID: PMC6168371.
      Citations: 11     Fields:    Translation:Animals
    16. Rattani A, Lim J, Mistry AM, Prablek MA, Roth SG, Jordan LC, Shannon CN, Naftel RP. Incidence of Epilepsy and Associated Risk Factors in Perinatal Ischemic Stroke Survivors. Pediatr Neurol. 2019 01; 90:44-55. PMID: 30409458.
      Citations: 7     Fields:    Translation:Humans
    17. Roth S, Moss HE. Update on Perioperative Ischemic Optic Neuropathy Associated With Non-ophthalmic Surgery. Front Neurol. 2018; 9:557. PMID: 30042726; PMCID: PMC6048244.
      Citations: 8     
    18. Kadzielawa K, Mathew B, Stelman CR, Lei AZ, Torres L, Roth S. Gene expression in retinal ischemic post-conditioning. Graefes Arch Clin Exp Ophthalmol. 2018 May; 256(5):935-949. PMID: 29504043; PMCID: PMC5911419.
      Citations: 7     Fields:    Translation:Animals
    19. Calway T, Rubin DS, Moss HE, Joslin CE, Mehta AI, Roth S. Perioperative Retinal Artery Occlusion: Incidence and Risk Factors in Spinal Fusion Surgery From the US National Inpatient Sample 1998-2013. J Neuroophthalmol. 2018 03; 38(1):36-41. PMID: 28665867; PMCID: PMC5764807.
      Citations: 4     Fields:    Translation:Humans
    20. Rubin DS, Matsumoto MM, Weinberg G, Roth S. Local Anesthetic Systemic Toxicity in Total Joint Arthroplasty: Incidence and Risk Factors in the United States From the National Inpatient Sample 1998-2013. Reg Anesth Pain Med. 2018 Feb; 43(2):131-137. PMID: 29280923; PMCID: PMC5777869.
      Citations: 15     Fields:    Translation:Humans
    21. Bhimani AD, Kheirkhah P, Arnone GD, Nahhas CR, Kumar P, Wonais M, Hidrogo H, Aguilar E, Spalinski D, Gopalka M, Roth S, Mehta AI. Functional gait analysis in a spinal contusion rat model. Neurosci Biobehav Rev. 2017 Dec; 83:540-546. PMID: 28893554.
      Citations: 12     Fields:    Translation:HumansAnimals
    22. Mathew B, Poston JN, Dreixler JC, Torres L, Lopez J, Zelkha R, Balyasnikova I, Lesniak MS, Roth S. Bone-marrow mesenchymal stem-cell administration significantly improves outcome after retinal ischemia in rats. Graefes Arch Clin Exp Ophthalmol. 2017 Aug; 255(8):1581-1592. PMID: 28523456; PMCID: PMC5841582.
      Citations: 23     Fields:    Translation:AnimalsCells
    23. Rubin DS, Matsumoto MM, Moss HE, Joslin CE, Tung A, Roth S. Ischemic Optic Neuropathy in Cardiac Surgery: Incidence and Risk Factors in the United States from the National Inpatient Sample 1998 to 2013. Anesthesiology. 2017 05; 126(5):810-821. PMID: 28244936; PMCID: PMC5395417.
      Citations: 13     Fields:    Translation:Humans
    24. Calway T, Rubin DS, Moss HE, Joslin CE, Beckmann K, Roth S. Perioperative Retinal Artery Occlusion: Risk Factors in Cardiac Surgery from the United States National Inpatient Sample 1998-2013. Ophthalmology. 2017 02; 124(2):189-196. PMID: 27914836; PMCID: PMC5542395.
      Citations: 8     Fields:    Translation:Humans
    25. Rubin DS, Parakati I, Lee LA, Moss HE, Joslin CE, Roth S. Perioperative Visual Loss in Spine Fusion Surgery: Ischemic Optic Neuropathy in the United States from 1998 to 2012 in the Nationwide Inpatient Sample. Anesthesiology. 2016 09; 125(3):457-64. PMID: 27362870; PMCID: PMC5270754.
      Citations: 25     Fields:    Translation:Humans
    26. Roth S, Dreixler JC, Mathew B, Balyasnikova I, Mann JR, Boddapati V, Xue L, Lesniak MS. Hypoxic-Preconditioned Bone Marrow Stem Cell Medium Significantly Improves Outcome After Retinal Ischemia in Rats. Invest Ophthalmol Vis Sci. 2016 06 01; 57(7):3522-32. PMID: 27367588; PMCID: PMC4961056.
      Citations: 18     Fields:    Translation:AnimalsCells
    27. Roth S. Inhaled Anesthesia, Apoptosis, and the Developing Retina: A Window into the Brain? Anesth Analg. 2015 Nov; 121(5):1117-8. PMID: 26484449; PMCID: PMC5527293.
      Citations: 2     Fields:    Translation:AnimalsCells
    28. De La Cruz P, Fama C, Roth S, Haller J, Wilock M, Lange S, Pilitsis J. Predictors of Spinal Cord Stimulation Success. Neuromodulation. 2015 Oct; 18(7):599-602; discussion 602. PMID: 26119040; PMCID: PMC4615463.
      Citations: 9     Fields:    Translation:Humans
    29. Sampat A, Parakati I, Kunnavakkam R, Glick DB, Lee NK, Tenney M, Eggener S, Roth S. Corneal abrasion in hysterectomy and prostatectomy: role of laparoscopic and robotic assistance. Anesthesiology. 2015 May; 122(5):994-1001. PMID: 25734923; PMCID: PMC5836305.
      Citations: 5     Fields:    Translation:Humans
    30. Dreixler JC, Poston JN, Balyasnikova I, Shaikh AR, Tupper KY, Conway S, Boddapati V, Marcet MM, Lesniak MS, Roth S. Delayed administration of bone marrow mesenchymal stem cell conditioned medium significantly improves outcome after retinal ischemia in rats. Invest Ophthalmol Vis Sci. 2014 Apr 03; 55(6):3785-96. PMID: 24699381; PMCID: PMC4062399.
      Citations: 25     Fields:    Translation:AnimalsCells
    31. Marcet MM, Meyer DR, Greenwald MJ, Roth S, Selva D. Proximal tarsal attachments of the levator aponeurosis: implications for blepharoptosis repair. Ophthalmology. 2013 Sep; 120(9):1924-9. PMID: 23601804.
      Citations: 2     Fields:    Translation:Humans
    32. David J, Melamud A, Kesner L, Roth S, Rosenbaum PS, Barone FC, Popp S, Hassen GW, Stracher A, Rosenbaum DM. A novel calpain inhibitor for treatment of transient retinal ischemia in the rat. Neuroreport. 2011 Sep 14; 22(13):633-6. PMID: 21841454; PMCID: PMC3156414.
      Citations: 11     Fields:    Translation:Animals
    33. Marcet MM, Lemke BN, Greenwald MJ, Fountain TR, Roth S, Dubovy SR. Eyelid eversion for visualisation of the upper eyelid lamellae: an anatomical cadaver study. Br J Ophthalmol. 2011 Oct; 95(10):1376-8. PMID: 21746734.
      Citations:    Fields:    Translation:Humans
    34. Dreixler JC, Sampat A, Shaikh AR, Alexander M, Marcet MM, Roth S. Protein kinase B (Akt) and mitogen-activated protein kinase p38a in retinal ischemic post-conditioning. J Mol Neurosci. 2011 Oct; 45(2):309-20. PMID: 21573888; PMCID: PMC5836301.
      Citations: 7     Fields:    Translation:Animals
    35. Dreixler JC, Poston JN, Shaikh AR, Alexander M, Tupper KY, Marcet MM, Bernaudin M, Roth S. Delayed post-ischemic conditioning significantly improves the outcome after retinal ischemia. Exp Eye Res. 2011 Jun; 92(6):521-7. PMID: 21501608; PMCID: PMC3833257.
      Citations: 13     Fields:    Translation:AnimalsCells
    36. Dreixler JC, Bratton A, Du E, Shaikh AR, Savoie B, Alexander M, Marcet MM, Roth S. Mitogen-activated protein kinase phosphatase-1 (MKP-1) in retinal ischemic preconditioning. Exp Eye Res. 2011 Oct; 93(4):340-9. PMID: 21094639; PMCID: PMC3074007.
      Citations: 14     Fields:    Translation:AnimalsCells
    37. Dreixler JC, Shaikh AR, Alexander M, Savoie B, Roth S. Post-ischemic conditioning in the rat retina is dependent upon ischemia duration and is not additive with ischemic pre-conditioning. Exp Eye Res. 2010 Dec; 91(6):844-52. PMID: 20599964; PMCID: PMC2976837.
      Citations: 14     Fields:    Translation:Animals
    38. Rosenbaum DM, Degterev A, David J, Rosenbaum PS, Roth S, Grotta JC, Cuny GD, Yuan J, Savitz SI. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res. 2010 May 15; 88(7):1569-76. PMID: 20025059; PMCID: PMC7713513.
      Citations: 125     Fields:    Translation:AnimalsCells
    39. Hughey AB, Lesniak MS, Ansari SA, Roth S. What will anesthesiologists be anesthetizing? Trends in neurosurgical procedure usage. Anesth Analg. 2010 Jun 01; 110(6):1686-97. PMID: 20142356.
      Citations: 7     Fields:    Translation:Humans
    40. Schmotzer CL, Brown AE, Roth S, Johnson J, Ines-Castillejo M, Reisner A, Hillyer CD, Josephson CD. Procedure-specific preoperative red blood cell preparation and utilization management in pediatric surgical patients. Transfusion. 2010 Apr; 50(4):861-7. PMID: 20003058.
      Citations: 2     Fields:    Translation:Humans
    41. Roth S. Perioperative visual loss: what do we know, what can we do? Br J Anaesth. 2009 Dec; 103 Suppl 1:i31-40. PMID: 20007988; PMCID: PMC2791856.
      Citations: 44     Fields:    Translation:Humans
    42. Shen Y, Drum M, Roth S. The prevalence of perioperative visual loss in the United States: a 10-year study from 1996 to 2005 of spinal, orthopedic, cardiac, and general surgery. Anesth Analg. 2009 Nov; 109(5):1534-45. PMID: 19713263.
      Citations: 70     Fields:    Translation:Humans
    43. Awad H, Santilli S, Ohr M, Roth A, Yan W, Fernandez S, Roth S, Patel V. The effects of steep trendelenburg positioning on intraocular pressure during robotic radical prostatectomy. Anesth Analg. 2009 Aug; 109(2):473-8. PMID: 19608821.
      Citations: 71     Fields:    Translation:Humans
    44. Dreixler JC, Barone FC, Shaikh AR, Du E, Roth S. Mitogen-activated protein kinase p38alpha and retinal ischemic preconditioning. Exp Eye Res. 2009 Nov; 89(5):782-90. PMID: 19631642; PMCID: PMC2782459.
      Citations: 16     Fields:    Translation:AnimalsCells
    45. Dreixler JC, Hagevik S, Hemmert JW, Shaikh AR, Rosenbaum DM, Roth S. Involvement of erythropoietin in retinal ischemic preconditioning. Anesthesiology. 2009 Apr; 110(4):774-80. PMID: 19322943; PMCID: PMC2891304.
      Citations: 15     Fields:    Translation:AnimalsCells
    46. Dauber MH, Roth S. Operating table failure: another hazard of spine surgery. Anesth Analg. 2009 Mar; 108(3):904-5. PMID: 19224801.
      Citations: 1     Fields:    Translation:Humans
    47. Shen Y, Silverstein JC, Roth S. In-hospital complications and mortality after elective spinal fusion surgery in the united states: a study of the nationwide inpatient sample from 2001 to 2005. J Neurosurg Anesthesiol. 2009 Jan; 21(1):21-30. PMID: 19098620.
      Citations: 26     Fields:    Translation:Humans
    48. Dreixler JC, Hemmert JW, Shenoy SK, Shen Y, Lee HT, Shaikh AR, Rosenbaum DM, Roth S. The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning. Exp Eye Res. 2009 Mar; 88(3):512-21. PMID: 19084003; PMCID: PMC2709455.
      Citations: 19     Fields:    Translation:Animals
    49. Dreixler JC, Shaikh AR, Shenoy SK, Shen Y, Roth S. Protein kinase C subtypes and retinal ischemic preconditioning. Exp Eye Res. 2008 Oct; 87(4):300-11. PMID: 18722601; PMCID: PMC2602824.
      Citations: 17     Fields:    Translation:AnimalsCells
    50. Roth S, Tung A, Ksiazek S. Visual loss in a prone-positioned spine surgery patient with the head on a foam headrest and goggles covering the eyes: an old complication with a new mechanism. Anesth Analg. 2007 May; 104(5):1185-7, tables of contents. PMID: 17456671.
      Citations: 16     Fields:    Translation:Humans
    51. Tung A, Roth S, O'Connor MF, Liu W, Ellis JE. Fulminant liver failure after radical prostatectomy in the hyperlordotic position. Anesth Analg. 2006 Oct; 103(4):986-8. PMID: 17000817.
      Citations:    Fields:    Translation:Humans
    52. Lee LA, Roth S, Posner KL, Cheney FW, Caplan RA, Newman NJ, Domino KB. The American Society of Anesthesiologists Postoperative Visual Loss Registry: analysis of 93 spine surgery cases with postoperative visual loss. Anesthesiology. 2006 Oct; 105(4):652-9; quiz 867-8. PMID: 17006060.
      Citations: 73     Fields:    Translation:Humans
    53. Roth S, Dreixler JC, Shaikh AR, Lee KH, Bindokas V. Mitochondrial potassium ATP channels and retinal ischemic preconditioning. Invest Ophthalmol Vis Sci. 2006 May; 47(5):2114-24. PMID: 16639023; PMCID: PMC2610248.
      Citations: 25     Fields:    Translation:AnimalsCells
    54. Ho VT, Newman NJ, Song S, Ksiazek S, Roth S. Ischemic optic neuropathy following spine surgery. J Neurosurg Anesthesiol. 2005 Jan; 17(1):38-44. PMID: 15632541; PMCID: PMC2699455.
      Citations: 16     Fields:    Translation:Humans
    55. Moitra V, Permut TA, Penn RM, Roth S. Venous air embolism in an awake patient undergoing placement of deep brain stimulators. J Neurosurg Anesthesiol. 2004 Oct; 16(4):321-2. PMID: 15557843.
      Citations:    Fields:    Translation:Humans
    56. Roth S. Endogenous neuroprotection in the retina. Brain Res Bull. 2004 Feb 15; 62(6):461-6. PMID: 15036558.
      Citations: 21     Fields:    Translation:HumansAnimals
    57. Roth S, Shaikh AR, Hennelly MM, Li Q, Bindokas V, Graham CE. Mitogen-activated protein kinases and retinal ischemia. Invest Ophthalmol Vis Sci. 2003 Dec; 44(12):5383-95. PMID: 14638742.
      Citations: 54     Fields:    Translation:AnimalsCells
    58. Li Y, Roth S, Laser M, Ma JX, Crosson CE. Retinal preconditioning and the induction of heat-shock protein 27. Invest Ophthalmol Vis Sci. 2003 Mar; 44(3):1299-304. PMID: 12601062.
      Citations: 35     Fields:    Translation:AnimalsCells
    59. Lee LA, Lam AM, Roth S. Causes of elevated intraocular pressure during prone spine surgery. Anesthesiology. 2002 Sep; 97(3):759; author reply 760. PMID: 12218559.
      Citations: 2     Fields:    Translation:Humans
    60. Zhang C, Rosenbaum DM, Shaikh AR, Li Q, Rosenbaum PS, Pelham DJ, Roth S, Zhang C, Rosenbaum DM, Shaikh AR, Li Q, Rosenbaum PS, Pelham DJ, Roth S. Ischemic preconditioning attenuates apoptotic cell death in the rat retina. Invest Ophthalmol Vis Sci. 2002 Sep; 43(9):3059-66. PMID: 12202530.
      Citations: 32     Fields:    Translation:AnimalsCells
    61. Junk AK, Mammis A, Savitz SI, Singh M, Roth S, Malhotra S, Rosenbaum PS, Cerami A, Brines M, Rosenbaum DM. Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10659-64. PMID: 12130665; PMCID: PMC125005.
      Citations: 122     Fields:    Translation:AnimalsCells
    62. Benumof JL, Mazzei W, Roth S, Barach P, Lam AM, Lee LA. Multifactorial etiology of postoperative vision loss. Anesthesiology. 2002 Jun; 96(6):1531-2; author reply 1532-3. PMID: 12170079.
      Citations: 2     Fields:    Translation:Humans
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