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Erika C. Claud

TitleProfessor
InstitutionUniversity of Chicago
DepartmentPediatrics-Neonatology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Claud is a physician scientist who intended to be a full time clinician but discovered a passion for answering questions through laboratory investigation. She is committed to the questions being explored in her laboratory but also to encouraging medical students and trainees to consider research as an essential and feasible means of improving patient care.

    Dr. Claud is a Professor in the Department of Pediatrics, Section of Neonatology, and the Department of Medicine, Section of Gastroenterology. She received her combined undergraduate and medical degree at Northwestern University through the six year Honors Program in Medical Education, and then completed her Residency in Pediatrics at Children’s Memorial Hospital in Chicago. After spending 18 months in rural Kenya as a missionary physician, she returned to Chicago to complete her Neonatology Fellowship at Children’s Memorial Hospital.

    Following her clinical fellowship she was recruited to Harvard Medical School where she held a clinical position at The Boston Children’s Hospital and completed a research fellowship at Massachusetts General Hospital. She joined the faculty of the University of Chicago in 2004. She is NIH funded to investigate the role of microbes in intestinal development of the preterm infant and leads the MIND (Microbiome in Neonatal Development) cohort. The interaction between the intestine and its resident microbiota is a complex relationship with risk and benefit for the host. Perturbations in environmental cues or altered patterns of microbial selection can affect health and increase risk of disease in susceptible individuals. The simple microbial communities and limited environmental variation of the preterm infant provide a unique model in which to investigate microbial perturbations. Her laboratory utilizes state-of-the-art experimental approaches including: 16S rRNA and shotgun metagenomic analyses of the microbiome, gnotobiotic mouse models, rodent models of Neonatal Necrotizing Enterocolitis, as well as cell culture models of immature and mature intestine to investigate the health impact of the microbiome on health outcomes of preterm infants.

    She is co-director of the Basic Science Track within the Scholarship and Discovery Program of the Pritzker School of Medicine and Faculty Co-Chair Pritzker School of Medicine Summer Research Program. She is also Director of Neonatology Research and a member of the Faculty Leadership Cabinet for the Duchossois Family Institute.


    Collapse Biography 
    Collapse education and training
    Northwestern University, Evanston, ILBS1988Medicine
    Northwestern Feinberg School of Medicine, Chicago, ILMD1990Medicine
    Children's Memorial Hospital, Chicago, ILInternship and Residency1993Pediatrics
    Children's Memorial Hospital, Chicago, ILFellowship2000Neonatology
    Massachusetts General Hospital, Boston, MAResearch Fellowship2003
    Collapse awards and honors
    1984 - 1990Honors Program in Medical Education, Northwestern University
    1989Alpha Omega Alpha
    1997Frederick M. Kenny Award in Pediatric Research
    2005Elected to Society for Pediatric Research
    2009 - 2011March of Dimes Basil O’Connor Starter Scholar Award
    2014Elected to American Pediatrics Society
    2014The George M Eisenberg Foundation for Charities Excellence in Pediatrics Award, The University of Chicago
    2018The Inaugural Peter Huttenlocher Award for Scholarly Excellence, The University of Chicago

    Collapse Research 
    Collapse research activities and funding
    K08HD043839     (CLAUD, ERIKA C)Jan 15, 2004 - Dec 31, 2008
    NIH
    Regulation of Inflammation in Immature Intestine
    Role: Principal Investigator

    R21HD055237     (CLAUD, ERIKA C)Apr 1, 2008 - Mar 31, 2010
    NIH
    Early Enterocyte Injury in Neonatal Necrotizing Enterocolitis
    Role: Principal Investigator

    R21AT004044     (CLAUD, ERIKA C)Aug 1, 2008 - Jun 30, 2010
    NIH
    Use of Probiotic Conditioned Media to Protect Against Necrotizing Enterocolitis
    Role: Principal Investigator

    R01HD059123     (CLAUD, ERIKA C)Jan 1, 2009 - Dec 31, 2014
    NIH
    Immature intestinal NF-kB regulation, probiotics, and necrotizing enterocolitis
    Role: Principal Investigator

    R01HD083481     (CLAUD, ERIKA C)Mar 1, 2015 - Jan 31, 2020
    NIH
    Preterm infant susceptibility to NEC due to early intestinal microbiome function
    Role: Principal Investigator

    UG3OD023281     (CLAUD, ERIKA C)Sep 21, 2016 - Aug 31, 2018
    NIH
    The microbiome as a potential mediator of socio-economic disparities in preterm infant neurodevelopmental trajectories from NICU discharge to school age
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Baranowski JR, Claud EC. Necrotizing Enterocolitis and the Preterm Infant Microbiome. Adv Exp Med Biol. 2019; 1125:25-36. PMID: 30680646.
      View in: PubMed
    2. Kim CS, Claud EC. Necrotizing Enterocolitis Pathophysiology: How Microbiome Data Alter Our Understanding. Clin Perinatol. 2019 03; 46(1):29-38. PMID: 30771817.
      View in: PubMed
    3. Lu J, Claud EC. Connection between gut microbiome and brain development in preterm infants. Dev Psychobiol. 2019 Jul; 61(5):739-751. PMID: 30460694.
      View in: PubMed
    4. Guzman-Rodriguez M, McDonald JAK, Hyde R, Allen-Vercoe E, Claud EC, Sheth PM, Petrof EO. Using bioreactors to study the effects of drugs on the human microbiota. Methods. 2018 10 01; 149:31-41. PMID: 30102990.
      View in: PubMed
    5. Lu J, Synowiec S, Lu L, Yu Y, Bretherick T, Takada S, Yarnykh V, Caplan J, Caplan M, Claud EC, Drobyshevsky A. Microbiota influence the development of the brain and behaviors in C57BL/6J mice. PLoS One. 2018; 13(8):e0201829. PMID: 30075011.
      View in: PubMed
    6. Lu J, Lu L, Yu Y, Cluette-Brown J, Martin CR, Claud EC. Effects of Intestinal Microbiota on Brain Development in Humanized Gnotobiotic Mice. Sci Rep. 2018 Apr 03; 8(1):5443. PMID: 29615691.
      View in: PubMed
    7. Lu L, Claud EC. Intrauterine Inflammation, Epigenetics, and Microbiome Influences on Preterm Infant Health. Curr Pathobiol Rep. 2018; 6(1):15-21. PMID: 29938128.
      View in: PubMed
    8. Ravi A, Estensmo ELF, Abée-Lund TML, Foley SL, Allgaier B, Martin CR, Claud EC, Rudi K. Association of the gut microbiota mobilome with hospital location and birth weight in preterm infants. Pediatr Res. 2017 Nov; 82(5):829-838. PMID: 28665922.
      View in: PubMed
    9. Yu Y, Lu L, Sun J, Petrof EO, Claud EC. Preterm infant gut microbiota affects intestinal epithelial development in a humanized microbiome gnotobiotic mouse model. Am J Physiol Gastrointest Liver Physiol. 2016 09 01; 311(3):G521-32. PMID: 27492329.
      View in: PubMed
    10. Martz SL, Guzman-Rodriguez M, He SM, Noordhof C, Hurlbut DJ, Gloor GB, Carlucci C, Weese S, Allen-Vercoe E, Sun J, Claud EC, Petrof EO. A human gut ecosystem protects against C. difficile disease by targeting TcdA. J Gastroenterol. 2017 Apr; 52(4):452-465. PMID: 27329502.
      View in: PubMed
    11. Munoz S, Guzman-Rodriguez M, Sun J, Zhang YG, Noordhof C, He SM, Allen-Vercoe E, Claud EC, Petrof EO. Rebooting the microbiome. Gut Microbes. 2016 07 03; 7(4):353-363. PMID: 27176179.
      View in: PubMed
    12. Grady NG, Petrof EO, Claud EC. Microbial therapeutic interventions. Semin Fetal Neonatal Med. 2016 12; 21(6):418-423. PMID: 27133778.
      View in: PubMed
    13. DiBartolomeo ME, Claud EC. The Developing Microbiome of the Preterm Infant. Clin Ther. 2016 04; 38(4):733-9. PMID: 26947798.
      View in: PubMed
    14. Cortese R, Lu L, Yu Y, Ruden D, Claud EC. Epigenome-Microbiome crosstalk: A potential new paradigm influencing neonatal susceptibility to disease. Epigenetics. 2016 03 03; 11(3):205-15. PMID: 26909656.
      View in: PubMed
    15. Claud EC, Petrof EO. Is Promoting Gut Microbial Diversity in Neonatal Enterocolitis the NECst Step? Dig Dis Sci. 2015 Dec; 60(12):3499-501. PMID: 26458920.
      View in: PubMed
    16. Martz SL, McDonald JA, Sun J, Zhang YG, Gloor GB, Noordhof C, He SM, Gerbaba TK, Blennerhassett M, Hurlbut DJ, Allen-Vercoe E, Claud EC, Petrof EO. Administration of defined microbiota is protective in a murine Salmonella infection model. Sci Rep. 2015 Nov 04; 5:16094. PMID: 26531327.
      View in: PubMed
    17. Rodriguez NA, Vento M, Claud EC, Wang CE, Caplan MS. Oropharyngeal administration of mother's colostrum, health outcomes of premature infants: study protocol for a randomized controlled trial. Trials. 2015 Oct 12; 16:453. PMID: 26458907.
      View in: PubMed
    18. Zhang YG, Wu S, Lu R, Zhou D, Zhou J, Carmeliet G, Petrof E, Claud EC, Sun J. Tight junction CLDN2 gene is a direct target of the vitamin D receptor. Sci Rep. 2015 Jul 27; 5:10642. PMID: 26212084.
      View in: PubMed
    19. Wu S, Yoon S, Zhang YG, Lu R, Xia Y, Wan J, Petrof EO, Claud EC, Chen D, Sun J. Vitamin D receptor pathway is required for probiotic protection in colitis. Am J Physiol Gastrointest Liver Physiol. 2015 Sep 01; 309(5):G341-9. PMID: 26159695.
      View in: PubMed
    20. Lu L, Yu Y, Guo Y, Wang Y, Chang EB, Claud EC. Transcriptional modulation of intestinal innate defense/inflammation genes by preterm infant microbiota in a humanized gnotobiotic mouse model. PLoS One. 2015; 10(4):e0124504. PMID: 25928420.
      View in: PubMed
    21. Claud EC, McDonald JA, He SM, Yu Y, Duong L, Sun J, Petrof EO. Differential expression of 26S proteasome subunits and functional activity during neonatal development. Biomolecules. 2014 Aug 29; 4(3):812-26. PMID: 25177858.
      View in: PubMed
    22. Wu S, Zhang YG, Lu R, Xia Y, Zhou D, Petrof EO, Claud EC, Chen D, Chang EB, Carmeliet G, Sun J. Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis. Gut. 2015 Jul; 64(7):1082-94. PMID: 25080448.
      View in: PubMed
    23. Mustafi D, Shiou SR, Fan X, Markiewicz E, Karczmar GS, Claud EC. MRI of neonatal necrotizing enterocolitis in a rodent model. NMR Biomed. 2014 Mar; 27(3):272-9. PMID: 24318809.
      View in: PubMed
    24. Shiou SR, Yu Y, Guo Y, Westerhoff M, Lu L, Petrof EO, Sun J, Claud EC. Oral administration of transforming growth factor-ß1 (TGF-ß1) protects the immature gut from injury via Smad protein-dependent suppression of epithelial nuclear factor ?B (NF-?B) signaling and proinflammatory cytokine production. J Biol Chem. 2013 Nov 29; 288(48):34757-66. PMID: 24129565.
      View in: PubMed
    25. Yu Y, Shiou SR, Guo Y, Lu L, Westerhoff M, Sun J, Petrof EO, Claud EC. Erythropoietin protects epithelial cells from excessive autophagy and apoptosis in experimental neonatal necrotizing enterocolitis. PLoS One. 2013; 8(7):e69620. PMID: 23936061.
      View in: PubMed
    26. Claud EC, Keegan KP, Brulc JM, Lu L, Bartels D, Glass E, Chang EB, Meyer F, Antonopoulos DA. Bacterial community structure and functional contributions to emergence of health or necrotizing enterocolitis in preterm infants. Microbiome. 2013 Jul 10; 1(1):20. PMID: 24450928.
      View in: PubMed
    27. Shiou SR, Yu Y, Guo Y, He SM, Mziray-Andrew CH, Hoenig J, Sun J, Petrof EO, Claud EC. Synergistic protection of combined probiotic conditioned media against neonatal necrotizing enterocolitis-like intestinal injury. PLoS One. 2013; 8(5):e65108. PMID: 23717690.
      View in: PubMed
    28. Petrof EO, Claud EC, Gloor GB, Allen-Vercoe E. Microbial ecosystems therapeutics: a new paradigm in medicine? Benef Microbes. 2013 Mar 01; 4(1):53-65. PMID: 23257018.
      View in: PubMed
    29. Musch MW, Wang Y, Claud EC, Chang EB. Lubiprostone decreases mouse colonic inner mucus layer thickness and alters intestinal microbiota. Dig Dis Sci. 2013 Mar; 58(3):668-77. PMID: 23329012.
      View in: PubMed
    30. Claud EC. First do no harm. J Pediatr Pharmacol Ther. 2012 Oct; 17(4):298-301. PMID: 23412919.
      View in: PubMed
    31. Lu R, Liu X, Wu S, Xia Y, Zhang YG, Petrof EO, Claud EC, Sun J. Consistent activation of the ß-catenin pathway by Salmonella type-three secretion effector protein AvrA in chronically infected intestine. Am J Physiol Gastrointest Liver Physiol. 2012 Nov 15; 303(10):G1113-25. PMID: 22982337.
      View in: PubMed
    32. Zhang YG, Wu S, Xia Y, Chen D, Petrof EO, Claud EC, Hsu W, Sun J. Axin1 prevents Salmonella invasiveness and inflammatory response in intestinal epithelial cells. PLoS One. 2012; 7(4):e34942. PMID: 22509369.
      View in: PubMed
    33. Costello JM, McQuillen PS, Claud EC, Steinhorn RH. Prematurity and congenital heart disease. World J Pediatr Congenit Heart Surg. 2011 Jul 01; 2(3):457-67. PMID: 23803997.
      View in: PubMed
    34. Liedel JL, Guo Y, Yu Y, Shiou SR, Chen S, Petrof EO, Hu S, Musch MW, Claud EC. Mother's milk-induced Hsp70 expression preserves intestinal epithelial barrier function in an immature rat pup model. Pediatr Res. 2011 May; 69(5 Pt 1):395-400. PMID: 21263375.
      View in: PubMed
    35. Nanthakumar N, Meng D, Goldstein AM, Zhu W, Lu L, Uauy R, Llanos A, Claud EC, Walker WA. The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: an immature innate immune response. PLoS One. 2011 Mar 21; 6(3):e17776. PMID: 21445298.
      View in: PubMed
    36. Claud EC. Probiotics and neonatal necrotizing enterocolitis. Anaerobe. 2011 Aug; 17(4):180-5. PMID: 21376824.
      View in: PubMed
    37. Shiou SR, Yu Y, Chen S, Ciancio MJ, Petrof EO, Sun J, Claud EC. Erythropoietin protects intestinal epithelial barrier function and lowers the incidence of experimental neonatal necrotizing enterocolitis. J Biol Chem. 2011 Apr 08; 286(14):12123-32. PMID: 21262973.
      View in: PubMed
    38. Hu S, Wang Y, Lichtenstein L, Tao Y, Musch MW, Jabri B, Antonopoulos D, Claud EC, Chang EB. Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins. Am J Physiol Gastrointest Liver Physiol. 2010 Dec; 299(6):G1266-75. PMID: 20864653.
      View in: PubMed
    39. Wu S, Ye Z, Liu X, Zhao Y, Xia Y, Steiner A, Petrof EO, Claud EC, Sun J. Salmonella typhimurium infection increases p53 acetylation in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2010 May; 298(5):G784-94. PMID: 20224008.
      View in: PubMed
    40. Hu S, Claud EC, Musch MW, Chang EB. Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-gamma and tumor necrosis factor-alpha. Am J Physiol Gastrointest Liver Physiol. 2010 Apr; 298(4):G481-92. PMID: 20110459.
      View in: PubMed
    41. Petrof EO, Claud EC, Sun J, Abramova T, Guo Y, Waypa TS, He SM, Nakagawa Y, Chang EB. Bacteria-free solution derived from Lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function. Inflamm Bowel Dis. 2009 Oct; 15(10):1537-47. PMID: 19373789.
      View in: PubMed
    42. Claud EC. Neonatal Necrotizing Enterocolitis -Inflammation and Intestinal Immaturity. Antiinflamm Antiallergy Agents Med Chem. 2009 Sep; 8(3):248-259. PMID: 20498729.
      View in: PubMed
    43. Wang Y, Hoenig JD, Malin KJ, Qamar S, Petrof EO, Sun J, Antonopoulos DA, Chang EB, Claud EC. 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis. ISME J. 2009 Aug; 3(8):944-54. PMID: 19369970.
      View in: PubMed
    44. Claud EC, Walker WA. Bacterial colonization, probiotics, and necrotizing enterocolitis. J Clin Gastroenterol. 2008 Jul; 42 Suppl 2:S46-52. PMID: 18520617.
      View in: PubMed
    45. Liao AP, Petrof EO, Kuppireddi S, Zhao Y, Xia Y, Claud EC, Sun J. Salmonella type III effector AvrA stabilizes cell tight junctions to inhibit inflammation in intestinal epithelial cells. PLoS One. 2008 Jun 04; 3(6):e2369. PMID: 18523661.
      View in: PubMed
    46. Claud EC, Lu J, Wang XQ, Abe M, Petrof EO, Sun J, Nelson DJ, Marks J, Jilling T. Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2008 May; 294(5):G1191-200. PMID: 18339705.
      View in: PubMed
    47. Petrof EO, Musch MW, Ciancio M, Sun J, Hobert ME, Claud EC, Gewirtz A, Chang EB. Flagellin is required for salmonella-induced expression of heat shock protein Hsp25 in intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G808-18. PMID: 18202113.
      View in: PubMed
    48. Ye Z, Petrof EO, Boone D, Claud EC, Sun J. Salmonella effector AvrA regulation of colonic epithelial cell inflammation by deubiquitination. Am J Pathol. 2007 Sep; 171(3):882-92. PMID: 17690189.
      View in: PubMed
    49. Claud EC, Zhang X, Petrof EO, Sun J. Developmentally regulated tumor necrosis factor-alpha induced nuclear factor-kappaB activation in intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 2007 May; 292(5):G1411-9. PMID: 17307728.
      View in: PubMed
    50. Claud EC, Lu L, Anton PM, Savidge T, Walker WA, Cherayil BJ. Developmentally regulated IkappaB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7404-8. PMID: 15123821.
      View in: PubMed
    51. Claud EC, Savidge T, Walker WA. Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors. Pediatr Res. 2003 Mar; 53(3):419-25. PMID: 12595589.
      View in: PubMed
    52. Claud EC, Li D, Xiao Y, Caplan MS, Jilling T. Platelet-activating factor regulates chloride transport in colonic epithelial cell monolayers. Pediatr Res. 2002 Aug; 52(2):155-62. PMID: 12149490.
      View in: PubMed
    53. Claud EC, Walker WA. Hypothesis: inappropriate colonization of the premature intestine can cause neonatal necrotizing enterocolitis. FASEB J. 2001 Jun; 15(8):1398-403. PMID: 11387237.
      View in: PubMed
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