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Theodore Mazzone

TitleClinical Professor
InstitutionUniversity of Chicago
DepartmentMedicine
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chandar M, Brockstein B, Zunamon A, Silverman I, Dlouhy S, Ashlevitz K, Tabachow C, Lapin B, Ewigman B, Mazzone T, Obel J. Perspectives of Health-Care Providers Toward Advance Care Planning in Patients With Advanced Cancer and Congestive Heart Failure. Am J Hosp Palliat Care. 2017 Jun; 34(5):423-429. PMID: 26941370.
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    2. Sam S, Scoccia B, Yalamanchi S, Mazzone T. Metabolic dysfunction in obese Hispanic women with polycystic ovary syndrome. Hum Reprod. 2015 Jun; 30(6):1358-64. PMID: 25857311.
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    3. Huang ZH, Reardon CA, Getz GS, Maeda N, Mazzone T. Selective suppression of adipose tissue apoE expression impacts systemic metabolic phenotype and adipose tissue inflammation. J Lipid Res. 2015 Feb; 56(2):215-26. PMID: 25421060.
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    4. Nguyen VT, Li X, Castellanos KJ, Fantuzzi G, Mazzone T, Braunschweig CA. The accuracy of vitamin D assays of circulating 25-hydroxyvitamin D values: influence of 25-hydroxylated ergocalciferol concentration. J AOAC Int. 2014 Jul-Aug; 97(4):1048-55. PMID: 25145136.
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    5. Sam S, Mazzone T. Adipose tissue changes in obesity and the impact on metabolic function. Transl Res. 2014 Oct; 164(4):284-92. PMID: 24929206.
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    6. Davidson MH, Rosenson RS, Maki KC, Nicholls SJ, Ballantyne CM, Mazzone T, Carlson DM, Williams LA, Kelly MT, Camp HS, Lele A, Stolzenbach JC. Effects of fenofibric acid on carotid intima-media thickness in patients with mixed dyslipidemia on atorvastatin therapy: randomized, placebo-controlled study (FIRST). Arterioscler Thromb Vasc Biol. 2014 Jun; 34(6):1298-306. PMID: 24743431.
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    7. Preiss D, Giles TD, Thomas LE, Sun JL, Haffner SM, Holman RR, Standl E, Mazzone T, Rutten GE, Tognoni G, Chiang FT, McMurray JJ, Califf RM. Predictors of stroke in patients with impaired glucose tolerance: results from the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research trial. Stroke. 2013 Sep; 44(9):2590-3. PMID: 23899915.
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    8. Wong YW, Thomas L, Sun JL, McMurray JJ, Krum H, Hernandez AF, Rutten GE, Leiter LA, Standl E, Haffner SM, Mazzone T, Martinez FA, Tognoni G, Giles T, Califf RM. Predictors of incident heart failure hospitalizations among patients with impaired glucose tolerance: insight from the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research study. Circ Heart Fail. 2013 Mar; 6(2):203-10. PMID: 23388113.
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    9. Preiss D, Thomas LE, Sun JL, Haffner SM, Holman RR, Standl E, Leiter LA, Mazzone T, Rutten GE, Tognoni G, Martinez FA, Chiang FT, Califf RM, McMurray JJ. Predictors of cardiovascular events in a contemporary population with impaired glucose tolerance: an observational analysis of the Nateglinide and Valsartan in impaired glucose tolerance outcomes research (NAVIGATOR) trial. BMJ Open. 2012; 2(6). PMID: 23204139.
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    10. Huang ZH, Manickam B, Ryvkin V, Zhou XJ, Fantuzzi G, Mazzone T, Sam S. PCOS is associated with increased CD11c expression and crown-like structures in adipose tissue and increased central abdominal fat depots independent of obesity. J Clin Endocrinol Metab. 2013 Jan; 98(1):E17-24. PMID: 23118428.
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    11. Huang ZH, Reardon CA, Subbaiah PV, Getz GS, Mazzone T. ApoE derived from adipose tissue does not suppress atherosclerosis or correct hyperlipidemia in apoE knockout mice. J Lipid Res. 2013 Jan; 54(1):202-13. PMID: 23071294.
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    12. Yue L, Bian JT, Grizelj I, Cavka A, Phillips SA, Makino A, Mazzone T. Apolipoprotein E enhances endothelial-NO production by modulating caveolin 1 interaction with endothelial NO synthase. Hypertension. 2012 Oct; 60(4):1040-6. PMID: 22914792.
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    13. Shentu TP, Singh DK, Oh MJ, Sun S, Sadaat L, Makino A, Mazzone T, Subbaiah PV, Cho M, Levitan I. The role of oxysterols in control of endothelial stiffness. J Lipid Res. 2012 Jul; 53(7):1348-58. PMID: 22496390.
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    14. Mokhlesi B, Scoccia B, Mazzone T, Sam S. Risk of obstructive sleep apnea in obese and nonobese women with polycystic ovary syndrome and healthy reproductively normal women. Fertil Steril. 2012 Mar; 97(3):786-91. PMID: 22264851.
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    15. Zhao Y, Jiang Z, Zhao T, Ye M, Hu C, Yin Z, Li H, Zhang Y, Diao Y, Li Y, Chen Y, Sun X, Fisk MB, Skidgel R, Holterman M, Prabhakar B, Mazzone T. Reversal of type 1 diabetes via islet ß cell regeneration following immune modulation by cord blood-derived multipotent stem cells. BMC Med. 2012 Jan 10; 10:3. PMID: 22233865.
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    16. Sam S, Haffner S, Davidson MH, D'Agostino R, Perez A, Mazzone T. Pioglitazone-mediated changes in lipoprotein particle composition are predicted by changes in adiponectin level in type 2 diabetes. J Clin Endocrinol Metab. 2012 Jan; 97(1):E110-4. PMID: 22072742.
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    17. Huang ZH, Maeda N, Mazzone T. Expression of the human apoE2 isoform in adipocytes: altered cellular processing and impaired adipocyte lipogenesis. J Lipid Res. 2011 Sep; 52(9):1733-41. PMID: 21743035.
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    18. Sidhwani S, Scoccia B, Sunghay S, Stephens-Archer CN, Mazzone T, Sam S. Polycystic ovary syndrome is associated with atherogenic changes in lipoprotein particle number and size independent of body weight. Clin Endocrinol (Oxf). 2011 Jul; 75(1):76-82. PMID: 21521284.
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    19. Huang ZH, Espiritu DJ, Uy A, Holterman AX, Vitello J, Mazzone T. Adipose tissue depot-specific differences in adipocyte apolipoprotein E expression. Metabolism. 2011 Dec; 60(12):1692-701. PMID: 21664633.
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    20. Miller M, Stone NJ, Ballantyne C, Bittner V, Criqui MH, Ginsberg HN, Goldberg AC, Howard WJ, Jacobson MS, Kris-Etherton PM, Lennie TA, Levi M, Mazzone T, Pennathur S. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2011 May 24; 123(20):2292-333. PMID: 21502576.
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    21. Poirier P, Cornier MA, Mazzone T, Stiles S, Cummings S, Klein S, McCullough PA, Ren Fielding C, Franklin BA. Bariatric surgery and cardiovascular risk factors: a scientific statement from the American Heart Association. Circulation. 2011 Apr 19; 123(15):1683-701. PMID: 21403092.
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    22. Mihailescu DV, Vora A, Mazzone T. Lipid effects of endocrine medications. Curr Atheroscler Rep. 2011 Feb; 13(1):88-94. PMID: 21104166.
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    23. Yue L, Mazzone T. Endogenous adipocyte apolipoprotein E is colocalized with caveolin at the adipocyte plasma membrane. J Lipid Res. 2011 Mar; 52(3):489-98. PMID: 21169230.
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    24. Mazzone T. Intensive glucose lowering and cardiovascular disease prevention in diabetes: reconciling the recent clinical trial data. Circulation. 2010 Nov 23; 122(21):2201-11. PMID: 21098460.
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    25. Zhao Y, Mazzone T. Human cord blood stem cells and the journey to a cure for type 1 diabetes. Autoimmun Rev. 2010 Dec; 10(2):103-7. PMID: 20728583.
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    26. Zhao Y, Guo C, Hwang D, Lin B, Dingeldein M, Mihailescu D, Sam S, Sidhwani S, Zhang Y, Jain S, Skidgel RA, Prabhakar BS, Mazzone T, Holterman MJ. Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model. Biochem Biophys Res Commun. 2010 Sep 03; 399(4):629-36. PMID: 20691153.
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    27. Espiritu DJ, Huang ZH, Zhao Y, Mazzone T. Hyperglycemia and advanced glycosylation end products suppress adipocyte apoE expression: implications for adipocyte triglyceride metabolism. Am J Physiol Endocrinol Metab. 2010 Oct; 299(4):E615-23. PMID: 20647555.
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    28. Davidson MH, Beam CA, Haffner S, Perez A, D'Agostino R, Mazzone T. Pioglitazone versus glimepiride on coronary artery calcium progression in patients with type 2 diabetes mellitus: a secondary end point of the CHICAGO study. Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9):1873-6. PMID: 20576945.
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    29. Effect of nateglinide on the incidence of diabetes and cardiovascular events. N Engl J Med. 2010 Apr 22; 362(16):1463-76. PMID: 20228402.
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    30. Effect of valsartan on the incidence of diabetes and cardiovascular events. N Engl J Med. 2010 Apr 22; 362(16):1477-90. PMID: 20228403.
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    31. Goldberg RB, Guyton JR, Mazzone T, Weinstock RS, Polis AB, Tipping D, Tomassini JE, Tershakovec AM. Relationships between metabolic syndrome and other baseline factors and the efficacy of ezetimibe/simvastatin and atorvastatin in patients with type 2 diabetes and hypercholesterolemia. Diabetes Care. 2010 May; 33(5):1021-4. PMID: 20150290.
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    32. Huang ZH, Minshall RD, Mazzone T. Mechanism for endogenously expressed ApoE modulation of adipocyte very low density lipoprotein metabolism: role in endocytic and lipase-mediated metabolic pathways. J Biol Chem. 2009 Nov 13; 284(46):31512-22. PMID: 19767394.
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    33. Sam S, Haffner S, Davidson MH, D'Agostino RB, Feinstein S, Kondos G, Perez A, Mazzone T. Hypertriglyceridemic waist phenotype predicts increased visceral fat in subjects with type 2 diabetes. Diabetes Care. 2009 Oct; 32(10):1916-20. PMID: 19592623.
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    34. Mazzone T. Hyperglycaemia and coronary heart disease: the meta picture. Lancet. 2009 May 23; 373(9677):1737-8. PMID: 19465212.
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    35. Polonsky T, Mazzone T, Davidson M. The clinical implications of the CHICAGO study for the management of cardiovascular risk in patients with type 2 diabetes mellitus. Trends Cardiovasc Med. 2009 Apr; 19(3):94-9. PMID: 19679266.
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    36. Sam S, Haffner S, Davidson MH, D'Agostino RB, Feinstein S, Kondos G, Perez A, Mazzone T. Relation of abdominal fat depots to systemic markers of inflammation in type 2 diabetes. Diabetes Care. 2009 May; 32(5):932-7. PMID: 19228869.
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    37. Huang ZH, Gu D, Mazzone T. Role of adipocyte-derived apoE in modulating adipocyte size, lipid metabolism, and gene expression in vivo. Am J Physiol Endocrinol Metab. 2009 May; 296(5):E1110-9. PMID: 19223650.
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    38. Yue L, Mazzone T. Peroxisome proliferator-activated receptor {gamma} stimulation of adipocyte ApoE gene transcription mediated by the liver receptor X pathway. J Biol Chem. 2009 Apr 17; 284(16):10453-61. PMID: 19218241.
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    39. Espiritu DJ, Mazzone T. Oxidative stress regulates adipocyte apolipoprotein e and suppresses its expression in obesity. Diabetes. 2008 Nov; 57(11):2992-8. PMID: 18678613.
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    40. Deedwania P, Kosiborod M, Barrett E, Ceriello A, Isley W, Mazzone T, Raskin P. Hyperglycemia and acute coronary syndrome: a scientific statement from the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism. Anesthesiology. 2008 Jul; 109(1):14-24. PMID: 18580168.
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    41. Mazzone T, Chait A, Plutzky J. Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies. Lancet. 2008 May 24; 371(9626):1800-9. PMID: 18502305.
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    42. Sam S, Haffner S, Davidson MH, D'Agostino RB, Feinstein S, Kondos G, Perez A, Mazzone T. Relationship of abdominal visceral and subcutaneous adipose tissue with lipoprotein particle number and size in type 2 diabetes. Diabetes. 2008 Aug; 57(8):2022-7. PMID: 18469202.
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    43. Yue L, Christman JW, Mazzone T. Tumor necrosis factor-alpha-mediated suppression of adipocyte apolipoprotein E gene transcription: primary role for the nuclear factor (NF)-kappaB pathway and NFkappaB p50. Endocrinology. 2008 Aug; 149(8):4051-8. PMID: 18467438.
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    44. Davidson M, Meyer PM, Haffner S, Feinstein S, D'Agostino R, Kondos GT, Perez A, Chen Z, Mazzone T. Increased high-density lipoprotein cholesterol predicts the pioglitazone-mediated reduction of carotid intima-media thickness progression in patients with type 2 diabetes mellitus. Circulation. 2008 Apr 22; 117(16):2123-30. PMID: 18413496.
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    45. Deedwania P, Kosiborod M, Barrett E, Ceriello A, Isley W, Mazzone T, Raskin P. Hyperglycemia and acute coronary syndrome: a scientific statement from the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2008 Mar 25; 117(12):1610-9. PMID: 18299505.
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    46. Weinstock RS, Goldberg RB, Guyton JR, Mazzone T, Polis A, Tomassini JE, Lin J, Shah A, Tershakovec AM. Effect of ezetimibe/simvastatin vs atorvastatin on lowering levels of LDL-C and non-HDL-C, ApoB, and hs-CRP in patients with type 2 diabetes. J Clin Lipidol. 2008 Feb; 2(1):25-35. PMID: 21291712.
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    47. Guyton JR, Goldberg RB, Mazzone T, Weinstock RS, Polis A, Rosenberg E, Tershakovec AM. Lipoprotein and apolipoprotein ratios in the VYTAL trial of ezetimibe/simvastatin compared with atorvastatin in type 2 diabetes. J Clin Lipidol. 2008 Feb; 2(1):19-24. PMID: 21291711.
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    48. Mazzone T. Adipose tissue and the vessel wall. Curr Drug Targets. 2007 Nov; 8(11):1190-5. PMID: 18045097.
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    49. Rao P, Huang ZH, Mazzone T. Angiotensin II regulates adipocyte apolipoprotein E expression. J Clin Endocrinol Metab. 2007 Nov; 92(11):4366-72. PMID: 17785354.
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    50. Mazzone T. Prevention of macrovascular disease in patients with diabetes mellitus: opportunities for intervention. Am J Med. 2007 Sep; 120(9 Suppl 2):S26-32. PMID: 17826043.
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    51. Lucic D, Huang ZH, Gu D, Subbaiah PV, Mazzone T. Cellular sphingolipids regulate macrophage apolipoprotein E secretion. Biochemistry. 2007 Oct 02; 46(39):11196-204. PMID: 17760463.
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    52. Mazzone T. HDL cholesterol and atherosclerosis. Lancet. 2007 Jul 14; 370(9582):107-108. PMID: 17630020.
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    53. Cotler SJ, Guzman G, Layden-Almer J, Mazzone T, Layden TJ, Zhou XJ. Measurement of liver fat content using selective saturation at 3.0 T. J Magn Reson Imaging. 2007 Apr; 25(4):743-8. PMID: 17347995.
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    54. Huang ZH, Luque RM, Kineman RD, Mazzone T. Nutritional regulation of adipose tissue apolipoprotein E expression. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E203-9. PMID: 17389709.
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    55. Mazzone T, Meyer PM, Kondos GT, Davidson MH, Feinstein SB, D'Agostino RB, Perez A, Haffner SM. Relationship of traditional and nontraditional cardiovascular risk factors to coronary artery calcium in type 2 diabetes. Diabetes. 2007 Mar; 56(3):849-55. PMID: 17327456.
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    56. Fantuzzi G, Mazzone T. Adipose tissue and atherosclerosis: exploring the connection. Arterioscler Thromb Vasc Biol. 2007 May; 27(5):996-1003. PMID: 17303782.
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    57. Goldberg RB, Guyton JR, Mazzone T, Weinstock RS, Polis A, Edwards P, Tomassini JE, Tershakovec AM. Ezetimibe/simvastatin vs atorvastatin in patients with type 2 diabetes mellitus and hypercholesterolemia: the VYTAL study. Mayo Clin Proc. 2006 Dec; 81(12):1579-88. PMID: 17165637.
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    58. Huang ZH, Reardon CA, Mazzone T. Endogenous ApoE expression modulates adipocyte triglyceride content and turnover. Diabetes. 2006 Dec; 55(12):3394-402. PMID: 17130485.
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    59. Zhao Y, Huang Z, Qi M, Lazzarini P, Mazzone T. Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell. Immunol Lett. 2007 Jan 15; 108(1):78-87. PMID: 17161871.
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    60. Luque RM, Huang ZH, Shah B, Mazzone T, Kineman RD. Effects of leptin replacement on hypothalamic-pituitary growth hormone axis function and circulating ghrelin levels in ob/ob mice. Am J Physiol Endocrinol Metab. 2007 Mar; 292(3):E891-9. PMID: 17122091.
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    61. Mazzone T, Meyer PM, Feinstein SB, Davidson MH, Kondos GT, D'Agostino RB, Perez A, Provost JC, Haffner SM. Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial. JAMA. 2006 Dec 06; 296(21):2572-81. PMID: 17101640.
      View in: PubMed
    62. Lucic D, Huang ZH, Gu de S, Altenburg MK, Maeda N, Mazzone T. Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor. J Lipid Res. 2007 Feb; 48(2):366-72. PMID: 17079794.
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    63. Zhao Y, Wang H, Mazzone T. Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics. Exp Cell Res. 2006 Aug 01; 312(13):2454-64. PMID: 16716296.
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    64. Zhao Y, Mazzone T. Turning "waste" into gold: identification of novel stem cells from human umbilical cord blood. Discov Med. 2006 Apr; 6(32):87-9. PMID: 17234132.
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    65. Sinnott BP, Mazzone T. Tuberous xanthomas associated with olanzapine therapy and hypertriglyceridemia in the setting of a rare apolipoprotein E mutation. Endocr Pract. 2006 Mar-Apr; 12(2):183-7. PMID: 16690468.
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    66. Huang ZH, Fitzgerald ML, Mazzone T. Distinct cellular loci for the ABCA1-dependent and ABCA1-independent lipid efflux mediated by endogenous apolipoprotein E expression. Arterioscler Thromb Vasc Biol. 2006 Jan; 26(1):157-62. PMID: 16254198.
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    67. Zhao Y, Mazzone T. Human umbilical cord blood-derived f-macrophages retain pluripotentiality after thrombopoietin expansion. Exp Cell Res. 2005 Nov 01; 310(2):311-8. PMID: 16143325.
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    68. Kazlauskaite R, Evans AT, Mazzone T, Fogelfeld LA. Ethnic differences predicting ketonuria in patients with Type 2 diabetes. J Diabetes Complications. 2005 Sep-Oct; 19(5):284-90. PMID: 16112504.
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    69. Mazzone T. Reducing cardiovascular disease in patients with diabetes mellitus. Curr Opin Cardiol. 2005 Jul; 20(4):245-9. PMID: 15956817.
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    70. Babu AR, Herdegen J, Fogelfeld L, Shott S, Mazzone T. Type 2 diabetes, glycemic control, and continuous positive airway pressure in obstructive sleep apnea. Arch Intern Med. 2005 Feb 28; 165(4):447-52. PMID: 15738376.
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    71. Yue L, Rasouli N, Ranganathan G, Kern PA, Mazzone T. Divergent effects of peroxisome proliferator-activated receptor gamma agonists and tumor necrosis factor alpha on adipocyte ApoE expression. J Biol Chem. 2004 Nov 12; 279(46):47626-32. PMID: 15339912.
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    72. Mazzone T. Strategies in ongoing clinical trials to reduce cardiovascular disease in patients with diabetes mellitus and insulin resistance. Am J Cardiol. 2004 Jun 03; 93(11A):27C-31C. PMID: 15178514.
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    73. Huang ZH, Gu D, Mazzone T. Oleic acid modulates the post-translational glycosylation of macrophage ApoE to increase its secretion. J Biol Chem. 2004 Jul 09; 279(28):29195-201. PMID: 15131109.
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    74. Mazzone T. The role of electron beam computed tomography for measuring coronary artery atherosclerosis. Curr Diab Rep. 2004 Feb; 4(1):20-5. PMID: 14764275.
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    75. Akhrass F, Evans AT, Wang Y, Rich S, Kannan CR, Fogelfeld L, Mazzone T. Hormone replacement therapy is associated with less coronary atherosclerosis in postmenopausal women. J Clin Endocrinol Metab. 2003 Dec; 88(12):5611-4. PMID: 14671142.
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    76. Huang ZH, Gu D, Lange Y, Mazzone T. Expression of scavenger receptor BI facilitates sterol movement between the plasma membrane and the endoplasmic reticulum in macrophages. Biochemistry. 2003 Apr 08; 42(13):3949-55. PMID: 12667086.
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    77. Zhao Y, Yue L, Gu D, Mazzone T. Regulation of macrophage ApoE expression and processing by extracellular matrix. J Biol Chem. 2002 Aug 16; 277(33):29477-83. PMID: 12034716.
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    78. Huang ZH, Mazzone T. ApoE-dependent sterol efflux from macrophages is modulated by scavenger receptor class B type I expression. J Lipid Res. 2002 Mar; 43(3):375-82. PMID: 11893773.
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    79. Lukovits TG, Mazzone TM, Gorelick TM. Diabetes mellitus and cerebrovascular disease. Neuroepidemiology. 1999; 18(1):1-14. PMID: 9831810.
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    80. Mazzone T, Pustelnikas L. Growth-related modulation of human skin fibroblast cholesterol distribution and metabolism. Biochim Biophys Acta. 1990 Nov 12; 1047(2):180-6. PMID: 2248975.
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    81. Driscoll DM, Mazzone T, Matsushima T, Getz GS. Apoprotein E biosynthesis in the cholesterol-fed guinea pig. Arteriosclerosis. 1990 Jan-Feb; 10(1):31-9. PMID: 2297345.
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    82. Mazzone T, Basheeruddin K, Poulos C. Regulation of macrophage apolipoprotein E gene expression by cholesterol. J Lipid Res. 1989 Jul; 30(7):1055-64. PMID: 2794789.
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    83. Soltys PA, Mazzone T, Wissler RW, Vahed S, Rangnekar V, Lukens J, Vesselinovitch D, Getz GS. Effects of feeding fish oil on the properties of lipoproteins isolated from rhesus monkeys consuming an atherogenic diet. Atherosclerosis. 1989 Apr; 76(2-3):103-15. PMID: 2730707.
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    84. Getz GS, Mazzone T, Soltys P, Bates SR. Atherosclerosis and apoprotein E. An enigmatic relationship. Arch Pathol Lab Med. 1988 Oct; 112(10):1048-55. PMID: 3052355.
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    85. Soltys PA, Gump H, Hennessy L, Mazzone T, Carey KD, McGill HC, Getz GS, Bates SR. Hepatic perfusate very low density lipoproteins obtained from fat-fed nonhuman primates stimulate cholesterol esterification in macrophages. J Lipid Res. 1988 Feb; 29(2):191-201. PMID: 3367088.
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