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Hemant Roy

Title
InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Collapse Research 
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    R01CA289294     (BACKMAN, VADIM)May 1, 2025 - Apr 30, 2030
    NIH
    Optical hyperspectral nanoscale chromatin analysis for colon cancer risk-stratification
    Role: Co-Principal Investigator
    R21MD013631     (BACKMAN, VADIM ;MOHANTY, ARPAN ;ROY, HEMANT K.)Feb 6, 2020 - Dec 31, 2022
    NIH
    Unraveling Racial Disparities in Portal Hypertension: A Clinical, Spectroscopic andSNP Approach
    Role: Principal Investigator
    R01CA225002     (BACKMAN, VADIM)Apr 15, 2018 - Jul 31, 2029
    NIH
    Translating buccal nanocytology for lung cancer screening into clinical practice
    Role: Co-Principal Investigator
    R01CA228272     (BACKMAN, VADIM ;ROY, HEMANT K.;SZLEIFER, IGAL G)Apr 9, 2018 - Mar 31, 2024
    NIH
    Reducing Cancer Transcriptional Heterogeneity through Regulation of Chromatin Structure
    Role: Co-Principal Investigator
    R01CA224911     (BACKMAN, VADIM ;ROY, HEMANT K.)Mar 5, 2018 - Feb 29, 2024
    NIH
    Microvasculature in Colon Field Carcinogenesis: Clinical-Biological Implications
    Role: Principal Investigator
    R33CA225323     (ROY, HEMANT K.)Sep 30, 2017 - Aug 31, 2021
    NIH
    Area B: Minimally Intrusive Colorectal Cancer Risk Stratification with Nanocytology: Targeting Underscreened Populations
    Role: Principal Investigator
    R01CA200064     (BACKMAN, VADIM)Aug 14, 2015 - Jul 31, 2021
    NIH
    Risk-stratification of Prostate Cancers via Field Carcinogenesis Nanocytology
    Role: Co-Principal Investigator
    R03CA195143     (ROY, HEMANT K.)Apr 1, 2015 - Mar 31, 2018
    NIH
    Towards Development of an in vitro Assay to Personalize Colonic Chemoprevention
    Role: Principal Investigator
    R01CA183101     (BACKMAN, VADIM)Jan 1, 2015 - Dec 31, 2020
    NIH
    Biophotonics to Couple Pancreatic with Upper GI Screening via Ultrathin Endoscopy
    Role: Co-Principal Investigator
    R01CA165309     (BACKMAN, VADIM)Sep 1, 2012 - Jun 30, 2018
    NIH
    Nanoscale/Molecular analysis of Fecal Colonocytes for Colorectal Cancer Screening
    Role: Co-Principal Investigator
    R42CA168055     (ROY, HEMANT K.)Sep 1, 2012 - Aug 31, 2016
    NIH
    Nanocytological Fecal Assessment to Personalize Colonoscopic Surveillance
    Role: Principal Investigator
    R01CA155284     (BACKMAN, VADIM)Sep 26, 2011 - Jul 31, 2017
    NIH
    Optical Nanoscale Analysis of Buccal Cells: Transforming Lung Cancer Screening
    Role: Co-Principal Investigator
    R21CA156944     (BACKMAN, VADIM)Feb 7, 2011 - Jan 31, 2014
    NIH
    Biophotonics Noninvasive Detection of Ovarian Cancer
    Role: Co-Principal Investigator
    R01CA156186     (ROY, HEMANT K.)Dec 15, 2010 - Nov 30, 2017
    NIH
    Transforming Colorectal Cancer Screening through Multimodal Spectral Markers
    Role: Principal Investigator
    R21CA141112     (WALI, RAMESH K)Aug 1, 2009 - Jul 31, 2012
    NIH
    Gender Selectivity to Colon Cancer Chemoprevention by NSAIDS
    Role: Co-Principal Investigator
    R21CA140936     (ROY, HEMANT K)Jul 1, 2009 - Jun 30, 2011
    NIH
    Improving Flexible Sigmoidoscopy in Women by Optical Analysis of Microvasculature
    Role: Principal Investigator
    R42CA130508     (ROY, HEMANT K)Sep 28, 2007 - Feb 28, 2011
    NIH
    Improving colonoscopic miss rate by real time microvascular blood analysis
    Role: Principal Investigator
    U01CA111257     (ROY, HEMANT K.)Sep 27, 2004 - Jun 30, 2016
    NIH
    Spectral Markers for Early Detection of Colon Neoplasia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chang A, Prabhala S, Daneshkhah A, Lin J, Subramanian H, Roy HK, Backman V. Early screening of colorectal cancer using feature engineering with artificial intelligence-enhanced analysis of nanoscale chromatin modifications. Sci Rep. 2024 04 02; 14(1):7808. PMID: 38565871; PMCID: PMC10987630.
      Citations: 3     Fields:    Translation:HumansCells
    2. Daneshkhah A, Agrawal V, Eshein A, Subramanian H, Roy HK, Backman V. Correction: Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients. Aging Clin Exp Res. 2023 Dec; 35(12):3263. PMID: 38064110; PMCID: PMC10721697.
      Citations:    Fields:    
    3. Chang A, Prabhala S, Daneshkhah A, Lin J, Subramanian H, Roy HK, Backman V. Early screening of colorectal cancer using feature engineering with artificial intelligence-enhanced analysis of nanoscale chromatin modifications. medRxiv. 2023 Oct 31. PMID: 37961299; PMCID: PMC10635240.
      Citations:    
    4. Chang A, Prabhala S, Daneshkhah A, Lin J, Subramanian H, Roy HK, Backman V. Early screening of colorectal cancer using feature engineering with artificial intelligence-enhanced analysis of nanoscale chromatin modifications. Res Sq. 2023 Oct 31. PMID: 37961494; PMCID: PMC10635400.
      Citations:    
    5. Daneshkhah A, Prabhala S, Viswanathan P, Subramanian H, Lin J, Chang AS, Bharat A, Roy HK, Backman V. Early detection of lung cancer using artificial intelligence-enhanced optical nanosensing of chromatin alterations in field carcinogenesis. Sci Rep. 2023 08 22; 13(1):13702. PMID: 37608214; PMCID: PMC10444865.
      Citations: 5     Fields:    Translation:HumansCells
    6. Daneshkhah A, Agrawal V, Eshein A, Subramanian H, Roy HK, Backman V. Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients. Aging Clin Exp Res. 2020 Oct; 32(10):2141-2158. PMID: 32876941; PMCID: PMC7465887.
      Citations: 82     Fields:    Translation:HumansCellsPHPublic Health
    7. Virk RKA, Wu W, Almassalha LM, Bauer GM, Li Y, VanDerway D, Frederick J, Zhang D, Eshein A, Roy HK, Szleifer I, Backman V. Disordered chromatin packing regulates phenotypic plasticity. Sci Adv. 2020 01; 6(2):eaax6232. PMID: 31934628; PMCID: PMC6949045.
      Citations: 30     Fields:    Translation:HumansCells
    8. Petersile M, Haroon M, Belkin D, Pinheiro A, Weinberg J, Roy HK, Jacobson BC. The impact of a multidisciplinary algorithmic approach to acute lower gastrointestinal bleeding. Am J Emerg Med. 2019 09; 37(9):1751-1753. PMID: 31257123.
      Citations:    Fields:    Translation:Humans
    9. Ruderman S, Eshein A, Valuckaite V, Dougherty U, Almoghrabi A, Gomes A, Singh A, Pabla B, Roy HK, Hart J, Bissonnette M, Konda V, Backman V. Early increase in blood supply (EIBS) is associated with tumor risk in the Azoxymethane model of colon cancer. BMC Cancer. 2018 Aug 13; 18(1):814. PMID: 30103733; PMCID: PMC6090821.
      Citations: 2     Fields:    Translation:HumansAnimals
    10. Kalman RS, Stawarz A, Nunes D, Zhang D, Dela Cruz MA, Mohanty A, Subramanian H, Backman V, Roy HK. Correction: Biophotonic detection of high order chromatin alterations in field carcinogenesis predicts risk of future hepatocellular carcinoma: A pilot study. PLoS One. 2018; 13(7):e0201500. PMID: 30040862; PMCID: PMC6057665.
      Citations:    Fields:    
    11. Eshein A, Radosevich A, Gould B, Wu W, Konda V, Yang L, Koons A, Feder S, Valuckaite V, Roy H, Backman V, Nguyen TQ. Fully automated fiber-based optical spectroscopy system for use in a clinical setting. J Biomed Opt. 2018 07; 23(7):1-10. PMID: 29981224; PMCID: PMC8357326.
      Citations: 2     Fields:    Translation:Humans
    12. Kalman RS, Stawarz A, Nunes D, Zhang D, Dela Cruz MA, Mohanty A, Subramanian H, Backman V, Roy HK. Biophotonic detection of high order chromatin alterations in field carcinogenesis predicts risk of future hepatocellular carcinoma: A pilot study. PLoS One. 2018; 13(5):e0197427. PMID: 29771950; PMCID: PMC5957523.
      Citations: 2     Fields:    Translation:HumansCells
    13. Wali RK, Bianchi L, Kupfer S, De La Cruz M, Jovanovic B, Weber C, Goldberg MJ, Rodriguez LM, Bergan R, Rubin D, Tull MB, Richmond E, Parker B, Khan S, Roy HK. Prevention of colonic neoplasia with polyethylene glycol: A short term randomized placebo-controlled double-blinded trial. PLoS One. 2018; 13(4):e0193544. PMID: 29617381; PMCID: PMC5884487.
      Citations:    Fields:    Translation:Humans
    14. Mohapatra SS, Batra SK, Bharadwaj S, Bouvet M, Cosman B, Goel A, Jogunoori W, Kelley MJ, Mishra L, Mishra B, Mohapatra S, Patel B, Pisegna JR, Raufman JP, Rao S, Roy H, Scheuner M, Singh S, Vidyarthi G, White J. Precision Medicine for CRC Patients in the Veteran Population: State-of-the-Art, Challenges and Research Directions. Dig Dis Sci. 2018 05; 63(5):1123-1138. PMID: 29572615; PMCID: PMC5895694.
      Citations: 1     Fields:    Translation:Humans
    15. Gladstein S, Damania D, Almassalha LM, Smith LT, Gupta V, Subramanian H, Rex DK, Roy HK, Backman V. Correlating colorectal cancer risk with field carcinogenesis progression using partial wave spectroscopic microscopy. Cancer Med. 2018 05; 7(5):2109-2120. PMID: 29573208; PMCID: PMC5943438.
      Citations: 13     Fields:    Translation:HumansCells
    16. Datta S, Sherva RM, De La Cruz M, Long MT, Roy P, Backman V, Chowdhury S, Roy HK. Single Nucleotide Polymorphism Facilitated Down-Regulation of the Cohesin Stromal Antigen-1: Implications for Colorectal Cancer Racial Disparities. Neoplasia. 2018 03; 20(3):289-294. PMID: 29471289; PMCID: PMC5883624.
      Citations: 6     Fields:    Translation:HumansCells
    17. Roy P, Chowdhury S, Roy HK. Exercise-induced myokines as emerging therapeutic agents in colorectal cancer prevention and treatment. Future Oncol. 2018 02; 14(4):309-312. PMID: 29318900.
      Citations: 9     Fields:    Translation:Humans
    18. Almassalha LM, Bauer GM, Wu W, Cherkezyan L, Zhang D, Kendra A, Gladstein S, Chandler JE, VanDerway D, Seagle BL, Ugolkov A, Billadeau DD, O'Halloran TV, Mazar AP, Roy HK, Szleifer I, Shahabi S, Backman V. Macrogenomic engineering via modulation of the scaling of chromatin packing density. Nat Biomed Eng. 2017 Nov; 1(11):902-913. PMID: 29450107; PMCID: PMC5809134.
      Citations: 30     Fields:    
    19. Bauer GM, Stypula-Cyrus Y, Subramanian H, Cherkezyan L, Viswanathan P, Zhang D, Iyengar R, Bagalkar S, Derbas J, Graff T, Gladstein S, Almassalha LM, Chandler JE, Roy HK, Backman V. The transformation of the nuclear nanoarchitecture in human field carcinogenesis. Future Sci OA. 2017 Aug; 3(3):FSO206. PMID: 28884003; PMCID: PMC5583697.
      Citations: 6     
    20. Datta S, Chowdhury S, Roy HK. Metabolism, microbiome and colorectal cancer. Aging (Albany NY). 2017 Apr; 9(4):1086-1087. PMID: 28455972; PMCID: PMC5425114.
      Citations: 7     Fields:    Translation:Humans
    21. Cruz MD, Ledbetter S, Chowdhury S, Tiwari AK, Momi N, Wali RK, Bliss C, Huang C, Lichtenstein D, Bhattacharya S, Varma-Wilson A, Backman V, Roy HK. Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis. Oncotarget. 2017 Mar 28; 8(13):20543-20557. PMID: 28423551; PMCID: PMC5400525.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    22. Shao D, Han J, Hou X, Fry J, Behring JB, Seta F, Long MT, Roy HK, Cohen RA, Matsui R, Bachschmid MM. Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. Antioxid Redox Signal. 2017 08 20; 27(6):313-327. PMID: 27958883; PMCID: PMC5563925.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    23. Drew DA, Chin SM, Gilpin KK, Parziale M, Pond E, Schuck MM, Stewart K, Flagg M, Rawlings CA, Backman V, Carolan PJ, Chung DC, Colizzo FP, Freedman M, Gala M, Garber JJ, Huttenhower C, Kedrin D, Khalili H, Kwon DS, Markowitz SD, Milne GL, Nishioka NS, Richter JM, Roy HK, Staller K, Wang M, Chan AT. ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial. Trials. 2017 02 01; 18(1):50. PMID: 28143522; PMCID: PMC5286828.
      Citations: 23     Fields:    Translation:Humans
    24. Krishn SR, Kaur S, Sheinin YM, Smith LM, Gautam SK, Patel A, Jain M, Juvvigunta V, Pai P, Lazenby AJ, Roy HK, Batra SK. Mucins and associated O-glycans based immunoprofile for stratification of colorectal polyps: clinical implication for improved colon surveillance. Oncotarget. 2017 Jan 24; 8(4):7025-7038. PMID: 27705923; PMCID: PMC5351688.
      Citations: 11     Fields:    Translation:Humans
    25. Almassalha LM, Tiwari A, Ruhoff PT, Stypula-Cyrus Y, Cherkezyan L, Matsuda H, Dela Cruz MA, Chandler JE, White C, Maneval C, Subramanian H, Szleifer I, Roy HK, Backman V. The Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene Expression. Sci Rep. 2017 01 24; 7:41061. PMID: 28117353; PMCID: PMC5259786.
      Citations: 28     Fields:    Translation:HumansCells
    26. Chowdhury S, Roy HK. The genetics and molecular biology of colonic neoplasia: practical implications for the clinician. Curr Opin Gastroenterol. 2017 01; 33(1):47-52. PMID: 27798442; PMCID: PMC9646238.
      Citations: 1     Fields:    Translation:Humans
    27. Calderwood AH, Lasser KE, Roy HK. Colon adenoma features and their impact on risk of future advanced adenomas and colorectal cancer. World J Gastrointest Oncol. 2016 Dec 15; 8(12):826-834. PMID: 28035253; PMCID: PMC5156849.
      Citations: 16     
    28. Wu W, Radosevich AJ, Eshein A, Nguyen TQ, Yi J, Cherkezyan L, Roy HK, Szleifer I, Backman V. Using electron microscopy to calculate optical properties of biological samples. Biomed Opt Express. 2016 Nov 01; 7(11):4749-4762. PMID: 27896013; PMCID: PMC5119613.
      Citations: 6     
    29. Almassalha LM, Bauer GM, Chandler JE, Gladstein S, Cherkezyan L, Stypula-Cyrus Y, Weinberg S, Zhang D, Thusgaard Ruhoff P, Roy HK, Subramanian H, Chandel NS, Szleifer I, Backman V. Label-free imaging of the native, living cellular nanoarchitecture using partial-wave spectroscopic microscopy. Proc Natl Acad Sci U S A. 2016 10 18; 113(42):E6372-E6381. PMID: 27702891; PMCID: PMC5081614.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    30. Subramanian H, Viswanathan P, Cherkezyan L, Iyengar R, Rozhok S, Verleye M, Derbas J, Czarnecki J, Roy HK, Backman V. Procedures for risk-stratification of lung cancer using buccal nanocytology. Biomed Opt Express. 2016 Sep 01; 7(9):3795-3810. PMID: 27699138; PMCID: PMC5030050.
      Citations: 8     
    31. Wali RK, Momi N, Dela Cruz M, Calderwood AH, Stypula-Cyrus Y, Almassalha L, Chhaparia A, Weber CR, Radosevich A, Tiwari AK, Latif B, Backman V, Roy HK. Higher Order Chromatin Modulator Cohesin SA1 Is an Early Biomarker for Colon Carcinogenesis: Race-Specific Implications. Cancer Prev Res (Phila). 2016 Nov; 9(11):844-854. PMID: 27549371; PMCID: PMC5093027.
      Citations: 7     Fields:    Translation:HumansCells
    32. Almassalha LM, Bauer GM, Chandler JE, Gladstein S, Szleifer I, Roy HK, Backman V. The Greater Genomic Landscape: The Heterogeneous Evolution of Cancer. Cancer Res. 2016 10 01; 76(19):5605-5609. PMID: 27550448; PMCID: PMC5084919.
      Citations: 15     Fields:    Translation:HumansCells
    33. Yi J, Stypula-Cyrus Y, Blaha CS, Roy HK, Backman V. Fractal Characterization of Chromatin Decompaction in Live Cells. Biophys J. 2015 Dec 01; 109(11):2218-26. PMID: 26636933; PMCID: PMC4675813.
      Citations: 12     Fields:    Translation:HumansCells
    34. Roy HK, Turzhitsky V, Wali R, Radosevich AJ, Jovanovic B, Della'Zanna G, Umar A, Rubin DT, Goldberg MJ, Bianchi L, De La Cruz M, Bogojevic A, Helenowski IB, Rodriguez L, Chatterton R, Skripkauskas S, Page K, Weber CR, Huang X, Richmond E, Bergan RC, Backman V. Spectral biomarkers for chemoprevention of colonic neoplasia: a placebo-controlled double-blinded trial with aspirin. Gut. 2017 02; 66(2):285-292. PMID: 26503631; PMCID: PMC5108693.
      Citations: 20     Fields:    Translation:Humans
    35. Momi N, Backman V, Brendler CB, Roy HK. Harnessing novel modalities: field carcinogenesis detection for personalizing prostate cancer management. Future Oncol. 2015; 11(20):2737-41. PMID: 26374598; PMCID: PMC4868392.
      Citations:    Fields:    Translation:Humans
    36. Das S, Rachagani S, Sheinin Y, Smith LM, Gurumurthy CB, Roy HK, Batra SK. Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer. Oncogene. 2016 05 19; 35(20):2645-54. PMID: 26364605; PMCID: PMC5555307.
      Citations: 49     Fields:    Translation:AnimalsCells
    37. Tiwari AK, Roy HK, Lynch HT. Lynch syndrome in the 21st century: clinical perspectives. QJM. 2016 Mar; 109(3):151-8. PMID: 26224055.
      Citations: 48     Fields:    Translation:HumansCells
    38. Radosevich AJ, Bajaj S, Konda V, Siddiqui UD, Waxman I, Goldberg MJ, Rogers JD, Gould B, Eshein A, Upadhye S, Koons A, Gonzalez-Haba Ruiz M, Roy HK, Backman V, Mutyal NN. In vivo risk analysis of pancreatic cancer through optical characterization of duodenal mucosa. Pancreas. 2015 Jul; 44(5):735-41. PMID: 25906443; PMCID: PMC4464933.
      Citations: 10     Fields:    Translation:Humans
    39. Radosevich AJ, Mutyal NN, Eshein A, Nguyen TQ, Gould B, Rogers JD, Goldberg MJ, Bianchi LK, Yen EF, Konda V, Rex DK, Van Dam J, Backman V, Roy HK. Rectal Optical Markers for In Vivo Risk Stratification of Premalignant Colorectal Lesions. Clin Cancer Res. 2015 Oct 01; 21(19):4347-4355. PMID: 25991816; PMCID: PMC4592390.
      Citations: 10     Fields:    Translation:Humans
    40. Jovanovic BD, Subramanian H, Helenowski IB, Roy HK, Backman V. Clinical Trial Laboratory Data Nested With in Subject: Components of Variance, Sample Size and Cost. Biom Biostat Int J. 2015; 2(3). PMID: 26457336; PMCID: PMC4596537.
      Citations: 1     
    41. Roy HK, Brendler CB, Subramanian H, Zhang D, Maneval C, Chandler J, Bowen L, Kaul KL, Helfand BT, Wang CH, Quinn M, Petkewicz J, Paterakos M, Backman V. Nanocytological field carcinogenesis detection to mitigate overdiagnosis of prostate cancer: a proof of concept study. PLoS One. 2015; 10(2):e0115999. PMID: 25706755; PMCID: PMC4338151.
      Citations: 21     Fields:    Translation:Humans
    42. Radosevich AJ, Mutyal NN, Rogers JD, Gould B, Hensing TA, Ray D, Backman V, Roy HK. Buccal spectral markers for lung cancer risk stratification. PLoS One. 2014; 9(10):e110157. PMID: 25299667; PMCID: PMC4192585.
      Citations: 15     Fields:    Translation:Humans
    43. Cruz MD, Wali RK, Bianchi LK, Radosevich AJ, Crawford SE, Jepeal L, Goldberg MJ, Weinstein J, Momi N, Roy P, Calderwood AH, Backman V, Roy HK. Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender. Cancer Epidemiol Biomarkers Prev. 2014 Nov; 23(11):2413-21. PMID: 25155760; PMCID: PMC4470400.
      Citations: 8     Fields:    Translation:HumansAnimals
    44. Wali RK, Hensing TA, Ray DW, Dela Cruz M, Tiwari AK, Radosevich A, Jepeal L, Fernando HC, Litle VR, Charlot M, Momi N, Backman V, Roy HK. Buccal microRNA dysregulation in lung field carcinogenesis: gender-specific implications. Int J Oncol. 2014 Sep; 45(3):1209-15. PMID: 24919547; PMCID: PMC4144027.
      Citations: 11     Fields:    Translation:Humans
    45. Khunger M, Kumar U, Roy HK, Tiwari AK. Dysplasia and cancer screening in 21st century. APMIS. 2014 Aug; 122(8):674-82. PMID: 24910362.
      Citations: 1     Fields:    Translation:Humans
    46. Patel M, Gomes A, Ruderman S, Hardee D, Crespo S, Raimondo M, Woodward T, Backman V, Roy H, Wallace M. Polarization gating spectroscopy of normal-appearing duodenal mucosa to detect pancreatic cancer. Gastrointest Endosc. 2014 Nov; 80(5):786-93.e1-2. PMID: 24861243; PMCID: PMC4241379.
      Citations: 5     Fields:    Translation:Humans
    47. Cherkezyan L, Stypula-Cyrus Y, Subramanian H, White C, Dela Cruz M, Wali RK, Goldberg MJ, Bianchi LK, Roy HK, Backman V. Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study. BMC Cancer. 2014 Mar 14; 14:189. PMID: 24629088; PMCID: PMC3995586.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    48. Yi J, Radosevich AJ, Stypula-Cyrus Y, Mutyal NN, Azarin SM, Horcher E, Goldberg MJ, Bianchi LK, Bajaj S, Roy HK, Backman V. Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomography. J Biomed Opt. 2014 Mar; 19(3):36013. PMID: 24643530; PMCID: PMC4019430.
      Citations: 32     Fields:    Translation:Humans
    49. Stypula-Cyrus Y, Mutyal NN, Dela Cruz M, Kunte DP, Radosevich AJ, Wali R, Roy HK, Backman V. End-binding protein 1 (EB1) up-regulation is an early event in colorectal carcinogenesis. FEBS Lett. 2014 Mar 03; 588(5):829-35. PMID: 24492008; PMCID: PMC4103177.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    50. Radosevich AJ, Mutyal NN, Yi J, Stypula-Cyrus Y, Rogers JD, Goldberg MJ, Bianchi LK, Bajaj S, Roy HK, Backman V. Ultrastructural alterations in field carcinogenesis measured by enhanced backscattering spectroscopy. J Biomed Opt. 2013 Sep; 18(9):097002. PMID: 24008865; PMCID: PMC3764252.
      Citations: 17     Fields:    Translation:Humans
    51. Roy HK, Damania DP, DelaCruz M, Kunte DP, Subramanian H, Crawford SE, Tiwari AK, Wali RK, Backman V. Nano-architectural alterations in mucus layer fecal colonocytes in field carcinogenesis: potential for screening. Cancer Prev Res (Phila). 2013 Oct; 6(10):1111-9. PMID: 23983085; PMCID: PMC3873747.
      Citations: 9     Fields:    Translation:AnimalsPHPublic Health
    52. Stypula-Cyrus Y, Damania D, Kunte DP, Cruz MD, Subramanian H, Roy HK, Backman V. HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure. PLoS One. 2013; 8(5):e64600. PMID: 23724067; PMCID: PMC3665824.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    53. Qi W, Fitchev PS, Cornwell ML, Greenberg J, Cabe M, Weber CR, Roy HK, Crawford SE, Savkovic SD. FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density. J Biol Chem. 2013 Jun 07; 288(23):16274-16281. PMID: 23603907; PMCID: PMC3675566.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    54. Damania D, Roy HK, Kunte D, Hurteau JA, Subramanian H, Cherkezyan L, Krosnjar N, Shah M, Backman V. Insights into the field carcinogenesis of ovarian cancer based on the nanocytology of endocervical and endometrial epithelial cells. Int J Cancer. 2013 Sep 01; 133(5):1143-52. PMID: 23436651; PMCID: PMC3695064.
      Citations: 22     Fields:    Translation:HumansCells
    55. Backman V, Roy HK. Advances in biophotonics detection of field carcinogenesis for colon cancer risk stratification. J Cancer. 2013; 4(3):251-61. PMID: 23459690; PMCID: PMC3584838.
      Citations: 26     
    56. Mutyal NN, Radosevich A, Tiwari AK, Stypula Y, Wali R, Kunte D, Roy HK, Backman V. Biological mechanisms underlying structural changes induced by colorectal field carcinogenesis measured with low-coherence enhanced backscattering (LEBS) spectroscopy. PLoS One. 2013; 8(2):e57206. PMID: 23431406; PMCID: PMC3576387.
      Citations: 7     Fields:    Translation:AnimalsCells
    57. Calderwood AH, Roy HK. Increasing colorectal cancer screening adherence: comment on "A randomized comparison of print and web communication on colorectal cancer screening". JAMA Intern Med. 2013 Jan 28; 173(2):129-31. PMID: 23247843; PMCID: PMC3873733.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    58. Roy HK. NIH: Drop re-review for big grant holders. Nature. 2012 Oct 11; 490(7419):176. PMID: 23060177.
      Citations:    Fields:    Translation:Humans
    59. Roy HK, Backman V. Spectroscopic applications in gastrointestinal endoscopy. Clin Gastroenterol Hepatol. 2012 Dec; 10(12):1335-41. PMID: 23059052; PMCID: PMC3756813.
      Citations: 8     Fields:    Translation:Humans
    60. Kunte DP, DelaCruz M, Wali RK, Menon A, Du H, Stypula Y, Patel A, Backman V, Roy HK. Dysregulation of microRNAs in colonic field carcinogenesis: implications for screening. PLoS One. 2012; 7(9):e45591. PMID: 23049818; PMCID: PMC3458063.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    61. Tiwari AK, Laird-Fick HS, Wali RK, Roy HK. Surveillance for gastrointestinal malignancies. World J Gastroenterol. 2012 Sep 07; 18(33):4507-16. PMID: 22969223; PMCID: PMC3435775.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    62. Roy HK, Khandekar JD. APC gene testing for familial adenomatosis polyposis. JAMA. 2012 Aug 01; 308(5):514-5. PMID: 22851119; PMCID: PMC3771684.
      Citations: 1     Fields:    Translation:Humans
    63. Radosevich AJ, Rogers JD, Turzhitsky V, Mutyal NN, Yi J, Roy HK, Backman V. Polarized Enhanced Backscattering Spectroscopy for Characterization of Biological Tissues at Subdiffusion Length-scales. IEEE J Sel Top Quantum Electron. 2012 Jul; 18(4):1313-1325. PMID: 24163574; PMCID: PMC3806115.
      Citations: 15     
    64. Wali RK, Kunte DP, De La Cruz M, Tiwari AK, Brasky J, Weber CR, Gibson TP, Patel A, Savkovic SD, Brockstein BE, Roy HK. Topical polyethylene glycol as a novel chemopreventive agent for oral cancer via targeting of epidermal growth factor response. PLoS One. 2012; 7(6):e38047. PMID: 22675506; PMCID: PMC3366973.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    65. Damania D, Roy HK, Subramanian H, Weinberg DS, Rex DK, Goldberg MJ, Muldoon J, Cherkezyan L, Zhu Y, Bianchi LK, Shah D, Pradhan P, Borkar M, Lynch H, Backman V. Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization. Cancer Res. 2012 Jun 01; 72(11):2720-7. PMID: 22491589; PMCID: PMC3557939.
      Citations: 38     Fields:    Translation:Humans
    66. Marsh Rde W, Alonzo M, Bajaj S, Baker M, Elton E, Farrell TA, Gore RM, Hall C, Nowak J, Roy H, Shaikh A, Talamonti MS. Comprehensive review of the diagnosis and treatment of biliary tract cancer 2012. Part II: multidisciplinary management. J Surg Oncol. 2012 Sep 01; 106(3):339-45. PMID: 22488601.
      Citations: 12     Fields:    Translation:Humans
    67. Marsh Rde W, Alonzo M, Bajaj S, Baker M, Elton E, Farrell TA, Gore RM, Hall C, Nowak J, Roy H, Shaikh A, Talamonti MS. Comprehensive review of the diagnosis and treatment of biliary tract cancer 2012. Part I: diagnosis-clinical staging and pathology. J Surg Oncol. 2012 Sep 01; 106(3):332-8. PMID: 22488652.
      Citations: 22     Fields:    Translation:Humans
    68. Gomes AJ, Ruderman S, DelaCruz M, Wali RK, Roy HK, Backman V. In vivo measurement of the shape of the tissue-refractive-index correlation function and its application to detection of colorectal field carcinogenesis. J Biomed Opt. 2012 Apr; 17(4):047005. PMID: 22559696; PMCID: PMC3382344.
      Citations: 10     Fields:    Translation:Animals
    69. Roy HK, Bianchi LK. Sex-specific prevalence of adenomas and colorectal cancer. JAMA. 2012 Jan 11; 307(2):142; author reply 143-4. PMID: 22235076.
      Citations:    Fields:    Translation:HumansPHPublic Health
    70. Simon MS, Rosenberg CA, Rodabough RJ, Greenland P, Ockene I, Roy HK, Lane DS, Cauley JA, Khandekar J. Prospective analysis of association between use of statins or other lipid-lowering agents and colorectal cancer risk. Ann Epidemiol. 2012 Jan; 22(1):17-27. PMID: 22056480; PMCID: PMC3804112.
      Citations: 28     Fields:    Translation:Humans
    71. Tiwari AK, Roy HK. Progress against cancer (1971-2011): how far have we come? J Intern Med. 2012 Apr; 271(4):392-9. PMID: 21950375; PMCID: PMC3270124.
      Citations: 8     Fields:    Translation:Humans
    72. Qi W, Joshi S, Weber CR, Wali RK, Roy HK, Savkovic SD. Polyethylene glycol diminishes pathological effects of Citrobacter rodentium infection by blocking bacterial attachment to the colonic epithelia. Gut Microbes. 2011 Sep 01; 2(5):267-73. PMID: 22067938; PMCID: PMC3242793.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    73. Yen EF, Pokhrel B, Bianchi LK, Roy HK, Du H, Patel A, Hall CR, Witt BL. Decreased colorectal cancer and adenoma risk in patients with microscopic colitis. Dig Dis Sci. 2012 Jan; 57(1):161-9. PMID: 21847567.
      Citations: 14     Fields:    Translation:Humans
    74. Gandhi SR, Tiwari AK, Kunte DP, De la Cruz MA, Stypula Y, Gibson T, Brasky J, Backman V, Wali RK, Roy HK. Association of stem-like cells in gender-specific chemoprevention against intestinal neoplasia in MIN mouse. Oncol Rep. 2011 Nov; 26(5):1127-32. PMID: 21769438; PMCID: PMC3557947.
      Citations: 1     Fields:    Translation:AnimalsCells
    75. Roy HK, Goldberg MJ, Bajaj S, Backman V. Colonoscopy and optical biopsy: bridging technological advances to clinical practice. Gastroenterology. 2011 Jun; 140(7):1863-7. PMID: 21521641; PMCID: PMC3557924.
      Citations: 12     Fields:    Translation:Humans
    76. Tiwari AK, Crawford SE, Radosevich A, Wali RK, Stypula Y, Kunte DP, Mutyal N, Ruderman S, Gomes A, Cornwell ML, De La Cruz M, Brasky J, Gibson TP, Backman V, Roy HK. Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis. Cancer Lett. 2011 Jul 28; 306(2):205-13. PMID: 21493000; PMCID: PMC3569093.
      Citations: 19     Fields:    Translation:Animals
    77. Pradhan P, Damania D, Joshi HM, Turzhitsky V, Subramanian H, Roy HK, Taflove A, Dravid VP, Backman V. Quantification of nanoscale density fluctuations by electron microscopy: probing cellular alterations in early carcinogenesis. Phys Biol. 2011 Apr; 8(2):026012. PMID: 21441647; PMCID: PMC3332100.
      Citations: 9     Fields:    Translation:HumansCells
    78. Roy HK, Hensing T, Backman V. Nanocytology for field carcinogenesis detection: novel paradigm for lung cancer risk stratification. Future Oncol. 2011 Jan; 7(1):1-3. PMID: 21174531; PMCID: PMC4123752.
      Citations: 10     Fields:    Translation:Humans
    79. Roy HK, Koetsier JL, Tiwari AK, Joshi S, Kunte DP, Ward TP, Gandhi SR, Wali RK. Involvement of p21cip1/waf1 in the anti-proliferative effects of polyethylene glycol in colon carcinogenesis. Int J Oncol. 2011 Feb; 38(2):529-36. PMID: 21170505.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    80. Pradhan P, Damania D, Joshi HM, Turzhitsky V, Subramanian H, Roy HK, Taflove A, Dravid VP, Backman V. Quantification of nanoscale density fluctuations using electron microscopy: Light-localization properties of biological cells. Appl Phys Lett. 2010 Dec 13; 97(24):243704. PMID: 21221251; PMCID: PMC3017571.
      Citations: 11     
    81. Qi W, Weber CR, Wasland K, Roy H, Wali R, Joshi S, Savkovic SD. Tumor suppressor FOXO3 mediates signals from the EGF receptor to regulate proliferation of colonic cells. Am J Physiol Gastrointest Liver Physiol. 2011 Feb; 300(2):G264-72. PMID: 21109589; PMCID: PMC3043652.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    82. Backman V, Roy HK. Light-scattering technologies for field carcinogenesis detection: a modality for endoscopic prescreening. Gastroenterology. 2011 Jan; 140(1):35-41. PMID: 21078318; PMCID: PMC3319699.
      Citations: 32     Fields:    
    83. Radosevich AJ, Turzhitsky VM, Mutyal NN, Rogers JD, Stoyneva V, Tiwari AK, De La Cruz M, Kunte DP, Wali RK, Roy HK, Backman V. Depth-resolved measurement of mucosal microvascular blood content using ?low-coherence enhanced backscattering spectroscopy. Biomed Opt Express. 2010 Oct 20; 1(4):1196-1208. PMID: 21258541; PMCID: PMC3018078.
      Citations: 7     
    84. Roy HK, Subramanian H, Damania D, Hensing TA, Rom WN, Pass HI, Ray D, Rogers JD, Bogojevic A, Shah M, Kuzniar T, Pradhan P, Backman V. Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening. Cancer Res. 2010 Oct 15; 70(20):7748-54. PMID: 20924114; PMCID: PMC3703950.
      Citations: 35     Fields:    
    85. Damania D, Subramanian H, Tiwari AK, Stypula Y, Kunte D, Pradhan P, Roy HK, Backman V. Role of cytoskeleton in controlling the disorder strength of cellular nanoscale architecture. Biophys J. 2010 Aug 04; 99(3):989-96. PMID: 20682278; PMCID: PMC2913198.
      Citations: 38     Fields:    
    86. Roy HK, Bianchi LK. Moving toward personalization of colorectal cancer screening: Comment on "Influence of race and sex on prevalence and recurrence of colon polyps". Arch Intern Med. 2010 Jul 12; 170(13):1132-4. PMID: 20625019.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    87. Roy HK, Gomes AJ, Ruderman S, Bianchi LK, Goldberg MJ, Stoyneva V, Rogers JD, Turzhitsky V, Kim Y, Yen E, Jameel M, Bogojevic A, Backman V. Optical measurement of rectal microvasculature as an adjunct to flexible sigmoidosocopy: gender-specific implications. Cancer Prev Res (Phila). 2010 Jul; 3(7):844-51. PMID: 20570881; PMCID: PMC3418881.
      Citations: 10     Fields:    Translation:Humans
    88. Turzhitsky V, Rogers JD, Mutyal NN, Roy HK, Backman V. Characterization of light transport in scattering media at sub-diffusion length scales with Low-coherence Enhanced Backscattering. IEEE J Sel Top Quantum Electron. 2010; 16(3):619-626. PMID: 21037980; PMCID: PMC2964859.
      Citations: 15     
    89. Roy HK, Bianchi LK. Differences in colon adenomas and carcinomas among women and men: potential clinical implications. JAMA. 2009 Oct 21; 302(15):1696-7. PMID: 19843905; PMCID: PMC2913287.
      Citations: 8     Fields:    
    90. Brand RE, Greer JB, Zolotarevsky E, Brand R, Du H, Simeone D, Zisman A, Gorchow A, Lee SY, Roy HK, Anderson MA. Pancreatic cancer patients who smoke and drink are diagnosed at younger ages. Clin Gastroenterol Hepatol. 2009 Sep; 7(9):1007-12. PMID: 19560558; PMCID: PMC2736339.
      Citations: 24     Fields:    
    91. Subramanian H, Roy HK, Pradhan P, Goldberg MJ, Muldoon J, Brand RE, Sturgis C, Hensing T, Ray D, Bogojevic A, Mohammed J, Chang JS, Backman V. Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy. Cancer Res. 2009 Jul 01; 69(13):5357-63. PMID: 19549915; PMCID: PMC2802178.
      Citations: 78     Fields:    
    92. Huo D, Hetzel JT, Roy H, Rubin DT. Association of colorectal cancer and prostate cancer and impact of radiation therapy. Cancer Epidemiol Biomarkers Prev. 2009 Jul; 18(7):1979-85. PMID: 19531678.
      Citations: 15     Fields:    Translation:Humans
    93. Roy HK, Turzhitsky V, Kim Y, Goldberg MJ, Watson P, Rogers JD, Gomes AJ, Kromine A, Brand RE, Jameel M, Bogovejic A, Pradhan P, Backman V. Association between rectal optical signatures and colonic neoplasia: potential applications for screening. Cancer Res. 2009 May 15; 69(10):4476-83. PMID: 19417131; PMCID: PMC2722930.
      Citations: 35     Fields:    
    94. Gomes AJ, Roy HK, Turzhitsky V, Kim Y, Rogers JD, Ruderman S, Stoyneva V, Goldberg MJ, Bianchi LK, Yen E, Kromine A, Jameel M, Backman V. Rectal mucosal microvascular blood supply increase is associated with colonic neoplasia. Clin Cancer Res. 2009 May 01; 15(9):3110-7. PMID: 19383816; PMCID: PMC2745222.
      Citations: 19     Fields:    
    95. Subramanian H, Pradhan P, Liu Y, Capoglu IR, Rogers JD, Roy HK, Brand RE, Backman V. Partial-wave microscopic spectroscopy detects subwavelength refractive index fluctuations: an application to cancer diagnosis. Opt Lett. 2009 Feb 15; 34(4):518-20. PMID: 19373360; PMCID: PMC2701738.
      Citations: 46     Fields:    
    96. Backman V, Subramanian H, Pradhan P, Liu Y, Capoglu I, Rogers JD, Roy HK, Taflove A. Detecting alterations in cell ultrastructure with optical imaging. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:6325-6. PMID: 19964153.
      Citations: 1     Fields:    Translation:Animals
    97. Walker SL, Nicholls PG, Butlin CR, Nery JA, Roy HK, Rangel E, Sales AM, Lockwood DN. Development and validation of a severity scale for leprosy type 1 reactions. PLoS Negl Trop Dis. 2008; 2(12):e351. PMID: 19104651; PMCID: PMC2596969.
      Citations: 17     Fields:    Translation:Humans
    98. Subramanian H, Pradhan P, Liu Y, Capoglu IR, Li X, Rogers JD, Heifetz A, Kunte D, Roy HK, Taflove A, Backman V. Optical methodology for detecting histologically unapparent nanoscale consequences of genetic alterations in biological cells. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20118-23. PMID: 19073935; PMCID: PMC2629261.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    99. Senapati S, Sharma P, Bafna S, Roy HK, Batra SK. The MUC gene family: their role in the diagnosis and prognosis of gastric cancer. Histol Histopathol. 2008 12; 23(12):1541-52. PMID: 18830939.
      Citations: 19     Fields:    Translation:Humans
    100. Turzhitsky VM, Gomes AJ, Kim YL, Liu Y, Kromine A, Rogers JD, Jameel M, Roy HK, Backman V. Measuring mucosal blood supply in vivo with a polarization-gating probe. Appl Opt. 2008 Nov 10; 47(32):6046-57. PMID: 19002229; PMCID: PMC2728617.
      Citations: 22     Fields:    
    101. Roy HK, Bianchi LK. Colorectal cancer risk: black, white, or shades of gray? JAMA. 2008 Sep 24; 300(12):1459-61. PMID: 18812539; PMCID: PMC3767294.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    102. Senapati S, Chaturvedi P, Sharma P, Venkatraman G, Meza JL, El-Rifai W, Roy HK, Batra SK. Deregulation of MUC4 in gastric adenocarcinoma: potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer. Br J Cancer. 2008 Sep 16; 99(6):949-56. PMID: 18781152; PMCID: PMC2538752.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    103. Wali RK, Kunte DP, Koetsier JL, Bissonnette M, Roy HK. Polyethylene glycol-mediated colorectal cancer chemoprevention: roles of epidermal growth factor receptor and Snail. Mol Cancer Ther. 2008 Sep; 7(9):3103-11. PMID: 18790788; PMCID: PMC2547487.
      Citations: 10     Fields:    
    104. Kunte DP, Wali RK, Koetsier JL, Roy HK. Antiproliferative effect of sulindac in colonic neoplasia prevention: role of COOH-terminal Src kinase. Mol Cancer Ther. 2008 Jul; 7(7):1797-806. PMID: 18644992; PMCID: PMC2493571.
      Citations: 8     Fields:    
    105. Roy HK, Gomes A, Turzhitsky V, Goldberg MJ, Rogers J, Ruderman S, Young KL, Kromine A, Brand RE, Jameel M, Vakil P, Hasabou N, Backman V. Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia risk. Gastroenterology. 2008 Oct; 135(4):1069-78. PMID: 18722372; PMCID: PMC3405534.
      Citations: 31     Fields:    Translation:CTClinical Trials
    106. Roy HK, Turzhitsky V, Kim YL, Goldberg MJ, Muldoon JP, Liu Y, Brand RE, Hall C, Hasabou N, Jameel M, Backman V. Spectral slope from the endoscopically-normal mucosa predicts concurrent colonic neoplasia: a pilot ex-vivo clinical study. Dis Colon Rectum. 2008 Sep; 51(9):1381-6. PMID: 18536963; PMCID: PMC2913285.
      Citations: 7     Fields:    
    107. Hensing TA, Subramanian H, Roy HK, Breault D, Bogojevic Z, Ray D, Hasabou N, Backman V. Identification of malignancy-associated change in buccal mucosa with partial wave spectroscopy (PWS): A potential biomarker for lung cancer risk. J Clin Oncol. 2008 May 20; 26(15_suppl):11045. PMID: 27947658.
      Citations:    
    108. Roy HK, Bianchi LK. Purging the colon while preserving the kidneys. Arch Intern Med. 2008 Mar 24; 168(6):565-7. PMID: 18362246.
      Citations:    Fields:    Translation:Humans
    109. Turzhitsky V, Liu Y, Hasabou N, Goldberg M, Roy HK, Backman V, Brand R. Investigating population risk factors of pancreatic cancer by evaluation of optical markers in the duodenal mucosa. Dis Markers. 2008; 25(6):313-21. PMID: 19208949; PMCID: PMC2730822.
      Citations: 12     Fields:    
    110. Backman V, Roy HK. Optical spectroscopic markers of cancer. Dis Markers. 2008; 25(6):279. PMID: 19208945; PMCID: PMC3827807.
      Citations: 1     Fields:    Translation:HumansAnimals
    111. Roy HK, Khandekar JD. Biomarkers for the early detection of cancer: an inflammatory concept. Arch Intern Med. 2007 Sep 24; 167(17):1822-4. PMID: 17893302.
      Citations: 3     Fields:    Translation:Humans
    112. Liu Y, Brand RE, Turzhitsky V, Kim YL, Roy HK, Hasabou N, Sturgis C, Shah D, Hall C, Backman V. Optical markers in duodenal mucosa predict the presence of pancreatic cancer. Clin Cancer Res. 2007 Aug 01; 13(15 Pt 1):4392-9. PMID: 17671121.
      Citations: 12     Fields:    Translation:Humans
    113. Roy HK, Wali RK, Kim Y, Liu Y, Hart J, Kunte DP, Koetsier JL, Goldberg MJ, Backman V. Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis. FEBS Lett. 2007 Aug 07; 581(20):3857-62. PMID: 17658518; PMCID: PMC2913280.
      Citations: 8     Fields:    
    114. Backman V, Kim Y, Liu Y, Turzhitsky V, Subramanian H, Pradhan P, Roy H, Goldberg M. Low-coherence enhanced backscattering and its applications. Annu Int Conf IEEE Eng Med Biol Soc. 2007; 2007:521-3. PMID: 18002007.
      Citations:    Fields:    Translation:HumansAnimals
    115. Kelloff GJ, Sullivan DC, Baker H, Clarke LP, Nordstrom R, Tatum JL, Dorfman GS, Jacobs P, Berg CD, Pomper MG, Birrer MJ, Tempero M, Higley HR, Petty BG, Sigman CC, Maley C, Sharma P, Wax A, Ginsberg GG, Dannenberg AJ, Hawk ET, Messing EM, Grossman HB, Harisinghani M, Bigio IJ, Griebel D, Henson DE, Fabian CJ, Ferrara K, Fantini S, Schnall MD, Zujewski JA, Hayes W, Klein EA, DeMarzo A, Ocak I, Ketterling JA, Tempany C, Shtern F, Parnes HL, Gomez J, Srivastava S, Szabo E, Lam S, Seibel EJ, Massion P, McLennan G, Cleary K, Suh R, Burt RW, Pfeiffer RM, Hoffman JM, Roy HK, Wang T, Limburg PJ, El-Deiry WS, Papadimitrakopoulou V, Hittelman WN, MacAulay C, Veltri RW, Solomon D, Jeronimo J, Richards-Kortum R, Johnson KA, Viner JL, Stratton SP, Rajadhyaksha M, Dhawan A, Workshop Program Committee. Workshop on imaging science development for cancer prevention and preemption. Cancer Biomark. 2007; 3(1):1-33. PMID: 17655039.
      Citations: 7     Fields:    Translation:Humans
    116. Roy HK, Backman V, Goldberg MJ. Colon cancer screening: the good, the bad, and the ugly. Arch Intern Med. 2006 Nov 13; 166(20):2177-9. PMID: 17101934.
      Citations: 10     Fields:    Translation:HumansPHPublic Health
    117. Roy HK, Kunte DP, Koetsier JL, Hart J, Kim YL, Liu Y, Bissonnette M, Goldberg M, Backman V, Wali RK. Chemoprevention of colon carcinogenesis by polyethylene glycol: suppression of epithelial proliferation via modulation of SNAIL/beta-catenin signaling. Mol Cancer Ther. 2006 Aug; 5(8):2060-9. PMID: 16928827.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    118. Brand RM, Jones DD, Lynch HT, Brand RE, Watson P, Ashwathnayaran R, Roy HK. Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking. World J Gastroenterol. 2006 Jul 28; 12(28):4485-91. PMID: 16874859; PMCID: PMC4125634.
      Citations: 10     Fields:    Translation:Humans
    119. Allison M, Garland C, Chlebowski R, Criqui M, Langer R, Wu L, Roy H, McTiernan A, Kuller L, Women's Health Initiative Investigators. The association between aspirin use and the incidence of colorectal cancer in women. Am J Epidemiol. 2006 Sep 15; 164(6):567-75. PMID: 16847042.
      Citations: 12     Fields:    Translation:HumansPHPublic Health
    120. Kim YL, Turzhitsky VM, Liu Y, Roy HK, Wali RK, Subramanian H, Pradhan P, Backman V. Low-coherence enhanced backscattering: review of principles and applications for colon cancer screening. J Biomed Opt. 2006 Jul-Aug; 11(4):041125. PMID: 16965153.
      Citations: 10     Fields:    Translation:HumansAnimals
    121. Zisman AL, Nickolov A, Brand RE, Gorchow A, Roy HK. Associations between the age at diagnosis and location of colorectal cancer and the use of alcohol and tobacco: implications for screening. Arch Intern Med. 2006 Mar 27; 166(6):629-34. PMID: 16567601.
      Citations: 46     Fields:    Translation:HumansPHPublic Health
    122. Roy HK, Kim YL, Liu Y, Wali RK, Goldberg MJ, Turzhitsky V, Horwitz J, Backman V. Risk stratification of colon carcinogenesis through enhanced backscattering spectroscopy analysis of the uninvolved colonic mucosa. Clin Cancer Res. 2006 Feb 01; 12(3 Pt 1):961-8. PMID: 16467111.
      Citations: 14     Fields:    Translation:HumansAnimals
    123. Siegel MP, Kim YL, Roy HK, Wali RK, Backman V. Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy. Appl Opt. 2006 Jan 10; 45(2):335-42. PMID: 16422163.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    124. Au A, Li B, Wang W, Roy H, Koehler K, Birt D. Effect of dietary apigenin on colonic ornithine decarboxylase activity, aberrant crypt foci formation, and tumorigenesis in different experimental models. Nutr Cancer. 2006; 54(2):243-51. PMID: 16898869.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    125. Bhardwaj S, Roy H, Heikura T, Ylä-Herttuala S. VEGF-A, VEGF-D and VEGF-D(DeltaNDeltaC) induced intimal hyperplasia in carotid arteries. Eur J Clin Invest. 2005 Nov; 35(11):669-76. PMID: 16269016.
      Citations: 28     Fields:    Translation:AnimalsCells
    126. Rubinstein WS, Roy HK. Practicing medicine at the front lines of the genomic revolution. Arch Intern Med. 2005 Sep 12; 165(16):1815-7. PMID: 16157823.
      Citations: 3     Fields:    Translation:Humans
    127. Kunte DP, Wali RK, Koetsier JL, Hart J, Kostjukova MN, Kilimnik AY, Pyatkin IG, Strelnikova SR, Roy HK. Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferation. FEBS Lett. 2005 Jul 04; 579(17):3497-502. PMID: 15961079.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    128. Roy HK, Kim YL, Wali RK, Liu Y, Koetsier J, Kunte DP, Goldberg MJ, Backman V. Spectral markers in preneoplastic intestinal mucosa: an accurate predictor of tumor risk in the MIN mouse. Cancer Epidemiol Biomarkers Prev. 2005 Jul; 14(7):1639-45. PMID: 16030095.
      Citations: 7     Fields:    Translation:Animals
    129. Wali RK, Roy HK, Kim YL, Liu Y, Koetsier JL, Kunte DP, Goldberg MJ, Turzhitsky V, Backman V. Increased microvascular blood content is an early event in colon carcinogenesis. Gut. 2005 May; 54(5):654-60. PMID: 15831911; PMCID: PMC1262671.
      Citations: 24     Fields:    Translation:HumansAnimals
    130. Kim YL, Liu Y, Turzhitsky VM, Wali RK, Roy HK, Backman V. Depth-resolved low-coherence enhanced backscattering. Opt Lett. 2005 Apr 01; 30(7):741-3. PMID: 15832924.
      Citations: 5     Fields:    Translation:Animals
    131. Roy HK, Karolski WJ, Wali RK, Ratashak A, Hart J, Smyrk TC. The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesis. Cancer Lett. 2005 Jan 20; 217(2):161-9. PMID: 15617833.
      Citations: 2     Fields:    Translation:AnimalsCells
    132. Kim YL, Liu Y, Wali RK, Roy HK, Backman V. Low-coherent backscattering spectroscopy for tissue characterization. Appl Opt. 2005 Jan 20; 44(3):366-77. PMID: 15717826.
      Citations: 14     Fields:    Translation:Animals
    133. Roy HK, Smyrk TC, Koetsier J, Victor TA, Wali RK. The transcriptional repressor SNAIL is overexpressed in human colon cancer. Dig Dis Sci. 2005 Jan; 50(1):42-6. PMID: 15712635.
      Citations: 43     Fields:    Translation:Humans
    134. Watson P, Ashwathnarayan R, Lynch HT, Roy HK. Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome). Arch Intern Med. 2004 Dec 13-27; 164(22):2429-31. PMID: 15596632.
      Citations: 34     Fields:    Translation:Humans
    135. Roy HK, Gulizia J, DiBaise JK, Karolski WJ, Ansari S, Madugula M, Hart J, Bissonnette M, Wali RK. Polyethylene glycol inhibits intestinal neoplasia and induces epithelial apoptosis in Apc(min) mice. Cancer Lett. 2004 Nov 08; 215(1):35-42. PMID: 15374630.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    136. Roy HK, Iversen P, Hart J, Liu Y, Koetsier JL, Kim Y, Kunte DP, Madugula M, Backman V, Wali RK. Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: modulation of apoptosis, proliferation, and fractal dimension. Mol Cancer Ther. 2004 Sep; 3(9):1159-65. PMID: 15367710.
      Citations: 21     Fields:    Translation:AnimalsCells
    137. Kim YL, Liu Y, Turzhitsky VM, Roy HK, Wali RK, Backman V. Coherent backscattering spectroscopy. Opt Lett. 2004 Aug 15; 29(16):1906-8. PMID: 15357355.
      Citations: 15     Fields:    Translation:Animals
    138. Roy HK, Liu Y, Wali RK, Kim YL, Kromine AK, Goldberg MJ, Backman V. Four-dimensional elastic light-scattering fingerprints as preneoplastic markers in the rat model of colon carcinogenesis. Gastroenterology. 2004 Apr; 126(4):1071-81; discussion 948. PMID: 15057746.
      Citations: 29     Fields:    Translation:Animals
    139. Roy HK, Lynch HT. Diagnosing Lynch syndrome: is the answer in the mouth? Gut. 2003 Dec; 52(12):1665-7. PMID: 14633939; PMCID: PMC1773873.
      Citations: 8     Fields:    Translation:Humans
    140. Sanjeevi A, Roy HK. Necrobiotic nodules: a rare pulmonary manifestion of Crohn's disease. Am J Gastroenterol. 2003 Apr; 98(4):941-3. PMID: 12738489.
      Citations: 1     Fields:    Translation:Humans
    141. Ozden N, Saruc M, Smith LM, Sanjeevi A, Roy HK. Increased cumulative incidence of prostate malignancies in colorectal cancer patients. Int J Gastrointest Cancer. 2003; 34(1):49-54. PMID: 15235135.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    142. Roy HK, Gulizia JM, Karolski WJ, Ratashak A, Sorrell MF, Tuma D. Ethanol promotes intestinal tumorigenesis in the MIN mouse. Multiple intestinal neoplasia. Cancer Epidemiol Biomarkers Prev. 2002 Nov; 11(11):1499-502. PMID: 12433735.
      Citations: 11     Fields:    Translation:Animals
    143. Roy HK, Olusola BF, Clemens DL, Karolski WJ, Ratashak A, Lynch HT, Smyrk TC. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis. 2002 Jan; 23(1):201-5. PMID: 11756242.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    144. Zack DL, DiBaise JK, Quigley EM, Roy HK. Colorectal cancer screening compliance by medicine residents: perceived and actual. Am J Gastroenterol. 2001 Oct; 96(10):3004-8. PMID: 11693339.
      Citations: 17     Fields:    Translation:HumansPHPublic Health
    145. Roy HK, Karoski WJ, Ratashak A, Smyrk TC. Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation. Br J Cancer. 2001 May 18; 84(10):1412-6. PMID: 11355956; PMCID: PMC2363636.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    146. Roy HK, Karolski WJ, Ratashak A. Distal bowel selectivity in the chemoprevention of experimental colon carcinogenesis by the non-steroidal anti-inflammatory drug nabumetone. Int J Cancer. 2001 May 15; 92(4):609-15. PMID: 11304699.
      Citations: 10     Fields:    Translation:AnimalsCells
    147. Roy HK, DiBaise JK, Black J, Karolski WJ, Ratashak A, Ansari S. Polyethylene glycol induces apoptosis in HT-29 cells: potential mechanism for chemoprevention of colon cancer. FEBS Lett. 2001 May 11; 496(2-3):143-6. PMID: 11356199.
      Citations: 10     Fields:    Translation:HumansCells
    148. Becker HD, Min B, Jacobi C, Raczniak G, Pelaschier J, Roy H, Klein S, Kern D, Söll D. The heterotrimeric Thermus thermophilus Asp-tRNA(Asn) amidotransferase can also generate Gln-tRNA(Gln). FEBS Lett. 2000 Jul 07; 476(3):140-4. PMID: 10913601.
      Citations: 17     Fields:    Translation:Cells
    149. Smith SR, de Jonge L, Zachwieja JJ, Roy H, Nguyen T, Rood J, Windhauser M, Volaufova J, Bray GA. Concurrent physical activity increases fat oxidation during the shift to a high-fat diet. Am J Clin Nutr. 2000 Jul; 72(1):131-8. PMID: 10871571.
      Citations: 21     Fields:    Translation:HumansCellsCTClinical Trials
    150. Smith SR, de Jonge L, Zachwieja JJ, Roy H, Nguyen T, Rood JC, Windhauser MM, Bray GA. Fat and carbohydrate balances during adaptation to a high-fat. Am J Clin Nutr. 2000 Feb; 71(2):450-7. PMID: 10648257.
      Citations: 30     Fields:    Translation:HumansCellsCTClinical Trials
    151. Roy HK. Colon cancer after gynecological cancer: guilt by association? Am J Gastroenterol. 1999 Dec; 94(12):3405. PMID: 10606294.
      Citations: 1     Fields:    Translation:Humans
    152. Khare S, Bolt MJ, Wali RK, Skarosi SF, Roy HK, Niedziela S, Scaglione-Sewell B, Aquino B, Abraham C, Sitrin MD, Brasitus TA, Bissonnette M. 1,25 dihydroxyvitamin D3 stimulates phospholipase C-gamma in rat colonocytes: role of c-Src in PLC-gamma activation. J Clin Invest. 1997 Apr 15; 99(8):1831-41. PMID: 9109427; PMCID: PMC508007.
      Citations: 11     Fields:    Translation:AnimalsCells
    153. Wali RK, Frawley BP, Hartmann S, Roy HK, Khare S, Scaglione-Sewell BA, Earnest DL, Sitrin MD, Brasitus TA, Bissonnette M. Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: potential roles of protein kinase C-alpha, -beta II, and -zeta. Cancer Res. 1995 Nov 15; 55(22):5257-64. PMID: 7585585.
      Citations: 13     Fields:    Translation:Animals
    154. Roy HK, Bissonnette M, Frawley BP, Wali RK, Niedziela SM, Earnest D, Brasitus TA. Selective preservation of protein kinase C-zeta in the chemoprevention of azoxymethane-induced colonic tumors by piroxicam. FEBS Lett. 1995 Jun 12; 366(2-3):143-5. PMID: 7789532.
      Citations: 1     Fields:    Translation:AnimalsCells
    155. Bissonnette M, Wali RK, Hartmann SC, Niedziela SM, Roy HK, Tien XY, Sitrin MD, Brasitus TA. 1,25-Dihydroxyvitamin D3 and 12-O-tetradecanoyl phorbol 13-acetate cause differential activation of Ca(2+)-dependent and Ca(2+)-independent isoforms of protein kinase C in rat colonocytes. J Clin Invest. 1995 May; 95(5):2215-21. PMID: 7738187; PMCID: PMC295833.
      Citations: 3     Fields:    Translation:AnimalsCells
    156. Wali RK, Bissonnette M, Jiang K, Niedziela SM, Khare S, Roy HK, Sitrin MD, Brasitus TA. 1,25-Dihydroxyvitamin D3 stimulates the phosphorylation of two acidic membrane proteins of 42,000 and 48,000 daltons in rat colonocytes: an effect modulated by vitamin D status. J Cell Physiol. 1995 Feb; 162(2):172-80. PMID: 7822428.
      Citations:    Fields:    Translation:AnimalsCells
    157. Earnest DL, Holubec H, Wali RK, Jolley CS, Bissonette M, Bhattacharyya AK, Roy H, Khare S, Brasitus TA. Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid. Cancer Res. 1994 Oct 01; 54(19):5071-4. PMID: 7923119.
      Citations: 47     Fields:    Translation:Animals
    158. Bissonnette M, Tien XY, Niedziela SM, Hartmann SC, Frawley BP, Roy HK, Sitrin MD, Perlman RL, Brasitus TA. 1,25(OH)2 vitamin D3 activates PKC-alpha in Caco-2 cells: a mechanism to limit secosteroid-induced rise in [Ca2+]i. Am J Physiol. 1994 Sep; 267(3 Pt 1):G465-75. PMID: 7943245.
      Citations: 8     Fields:    Translation:HumansCells
    159. Hubbs AE, Roy H. Assembly of in vitro synthesized large subunits into ribulose-bisphosphate carboxylase/oxygenase. Formation and discharge of an L8-like species. J Biol Chem. 1993 Jun 25; 268(18):13519-25. PMID: 8514785.
      Citations: 4     Fields:    Translation:AnimalsCells
    160. Roy H. Cigarette smoking and risk of cataracts. JAMA. 1993 Feb 10; 269(6):748. PMID: 8423655.
      Citations:    Fields:    Translation:Humans
    161. Bloom MV, Milos P, Roy H. Light-dependent assembly of ribulose-1,5-bisphosphate carboxylase. Proc Natl Acad Sci U S A. 1983 Feb; 80(4):1013-7. PMID: 16593277; PMCID: PMC393518.
      Citations: 32     Fields:    
    162. Roy H, Moudrianakis EN. Synthesis and discharge of the coupling factor.adenosine diphosphate complex in spinach chloroplast lamellae. Proc Natl Acad Sci U S A. 1971 Nov; 68(11):2720-4. PMID: 16591953; PMCID: PMC389509.
      Citations: 6     Fields:    
    163. Roy H, Moudrianakis EN. Interactions between ADP and the coupling factor of photophosphorylation. Proc Natl Acad Sci U S A. 1971 Feb; 68(2):464-8. PMID: 5277102; PMCID: PMC388961.
      Citations: 10     Fields:    Translation:Cells
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