Wei-Jen Tang to Humans
This is a "connection" page, showing publications Wei-Jen Tang has written about Humans.
Connection Strength
0.376
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Reinvestigating the synthesis and efficacy of small benzimidazole derivatives as presequence protease enhancers. Eur J Med Chem. 2019 Dec 15; 184:111746.
Score: 0.020
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Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin. Biochemistry. 2019 07 09; 58(27):2996-3004.
Score: 0.020
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Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife. 2018 03 29; 7.
Score: 0.018
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Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3. Proc Natl Acad Sci U S A. 2016 May 03; 113(18):5000-5.
Score: 0.016
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Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus. Trends Endocrinol Metab. 2016 Jan; 27(1):24-34.
Score: 0.015
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Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme. J Mol Biol. 2015 Mar 27; 427(6 Pt B):1345-1358.
Score: 0.015
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Molecular basis of substrate recognition and degradation by human presequence protease. Structure. 2014 Jul 08; 22(7):996-1007.
Score: 0.014
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Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):13827-32.
Score: 0.013
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Ubiquitin is a novel substrate for human insulin-degrading enzyme. J Mol Biol. 2011 Feb 25; 406(3):454-66.
Score: 0.011
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Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response. J Biol Chem. 2011 Feb 11; 286(6):4670-9.
Score: 0.011
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Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme. EMBO J. 2010 Dec 01; 29(23):3952-66.
Score: 0.011
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The role of anthrolysin O in gut epithelial barrier disruption during Bacillus anthracis infection. Biochem Biophys Res Commun. 2010 Apr 02; 394(2):254-9.
Score: 0.010
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Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme. J Mol Biol. 2010 Jan 15; 395(2):430-43.
Score: 0.010
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Protective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation. J Biol Chem. 2009 Dec 04; 284(49):34005-18.
Score: 0.010
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The adenylyl cyclase activity of anthrax edema factor. Mol Aspects Med. 2009 Dec; 30(6):423-30.
Score: 0.010
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Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme. J Biol Chem. 2009 May 22; 284(21):14177-88.
Score: 0.010
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Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis. J Biol Chem. 2009 May 22; 284(21):14645-56.
Score: 0.010
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Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme. Biochemistry. 2008 Dec 02; 47(48):12822-34.
Score: 0.010
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Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin. Cell Mol Life Sci. 2008 Aug; 65(16):2574-85.
Score: 0.009
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A 1.3-A structure of zinc-bound N-terminal domain of calmodulin elucidates potential early ion-binding step. J Mol Biol. 2007 Nov 23; 374(2):517-27.
Score: 0.009
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Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem. 2007 Aug 31; 282(35):25453-63.
Score: 0.009
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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature. 2006 Oct 19; 443(7113):870-4.
Score: 0.008
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The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition. Biochem Biophys Res Commun. 2006 May 19; 343(4):1032-7.
Score: 0.008
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A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. Biochemistry. 2004 Dec 14; 43(49):15463-71.
Score: 0.007
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Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. Nature. 2002 Jan 24; 415(6870):396-402.
Score: 0.006
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Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase. Methods Enzymol. 2002; 345:231-41.
Score: 0.006
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The regulation of type 7 adenylyl cyclase by its C1b region and Escherichia coli peptidylprolyl isomerase, SlyD. J Biol Chem. 2001 Mar 16; 276(11):8500-6.
Score: 0.005
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Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening. Eur J Med Chem. 2019 Oct 01; 179:557-566.
Score: 0.005
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Class III adenylyl cyclases: regulation and underlying mechanisms. Adv Second Messenger Phosphoprotein Res. 1998; 32:137-51.
Score: 0.004
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Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination. J Mol Biol. 2018 02 02; 430(3):337-347.
Score: 0.004
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Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL. Oncotarget. 2016 Oct 18; 7(42):68833-68841.
Score: 0.004
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In vivo epidermal migration requires focal adhesion targeting of ACF7. Nat Commun. 2016 05 24; 7:11692.
Score: 0.004
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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. Nat Commun. 2015 Sep 23; 6:8250.
Score: 0.004
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Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme. Eur J Med Chem. 2015 Jan 27; 90:547-67.
Score: 0.004
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Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-ß hydrolysis. Eur J Med Chem. 2014 May 22; 79:184-93.
Score: 0.003
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Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification. Biochemistry. 2013 Jun 18; 52(24):4184-92.
Score: 0.003
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Regulation of mammalian adenylyl cyclases by G-protein alpha and beta gamma subunits. Cold Spring Harb Symp Quant Biol. 1992; 57:135-44.
Score: 0.003
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Expression and characterization of calmodulin-activated (type I) adenylylcyclase. J Biol Chem. 1991 May 05; 266(13):8595-603.
Score: 0.003
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Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. PLoS One. 2010 May 07; 5(5):e10504.
Score: 0.003
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The case for developing consensus standards for research in microbial pathogenesis: Bacillus anthracis toxins as an example. Infect Immun. 2009 Oct; 77(10):4182-6.
Score: 0.002
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Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'. Nat Chem Biol. 2008 Dec; 4(12):742-50.
Score: 0.002
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Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines. Biol Chem. 2008 Nov; 389(11):1441-5.
Score: 0.002
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Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues. Int J Mol Med. 2008 Oct; 22(4):421-31.
Score: 0.002
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Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently. J Biol Chem. 2008 Aug 29; 283(35):23836-45.
Score: 0.002
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Modular total chemical synthesis of a human immunodeficiency virus type 1 protease. J Am Chem Soc. 2007 Sep 19; 129(37):11480-90.
Score: 0.002
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Insights from atomic-resolution X-ray structures of chemically synthesized HIV-1 protease in complex with inhibitors. J Mol Biol. 2007 Oct 26; 373(3):573-86.
Score: 0.002
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The amino terminus of varicella-zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor. J Virol. 2007 Aug; 81(16):8525-32.
Score: 0.002
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Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1. J Biol Chem. 2007 Jul 06; 282(27):19781-7.
Score: 0.002
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Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction. Front Biosci. 2007 May 01; 12:4670-5.
Score: 0.002
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Anthrax edema factor potency depends on mode of cell entry. Biochem Biophys Res Commun. 2005 Sep 30; 335(3):850-7.
Score: 0.002
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Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities. Mol Cell. 2005 Aug 05; 19(3):321-32.
Score: 0.002
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Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling. J Exp Med. 2005 Feb 07; 201(3):325-31.
Score: 0.002
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Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor. Nat Biotechnol. 2004 Jun; 22(6):717-23.
Score: 0.002
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Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2. Nat Cell Biol. 2004 Feb; 6(2):146-53.
Score: 0.002