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Joon Seok Park

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Hematology and Oncology
AddressChicago IL 60637
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    Collapse Overview 
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    Dr. Park’s research group investigates how commensal microbes residing in the intestine influence systemic immunity, with a particular focus on cancer immunity. Recent studies, including those from Dr. Park’s lab, suggest that the gut microbiome plays a critical role in modulating responses to cancer immunotherapy. The lab is particularly interested in the signaling and metabolic mechanisms that mediate long-range communication between gut microbes and the immune system within the tumor microenvironment (TME).

    To explore these mechanisms, Dr. Park’s team examines how gut microbes regulate key immune components within the TME, the complex ecosystem that surrounds cancer cells. Their publications and preliminary findings indicate that gut commensals significantly shape the immune landscape in tumors, although the precise molecular and cellular processes remain poorly understood. By integrating gnotobiotic mouse models with a strong foundation in fundamental immunology, Dr. Park’s lab aims to uncover how commensal microbes and their metabolites modulate anti-tumor immunity in the context of cancer immunotherapy.

    One major direction of Dr. Park’s research focuses on dissecting the signaling pathways through which specific gut microbes influence immune cells in the TME. The lab aims to identify signaling receptors and mediators that translate microbial cues into changes in tumor-infiltrating immune cells, such as the PD-L2/RGMb modulation reported in their previous work. Additionally, the lab investigates how these pathways affect T cell responses and explores whether commensal-dependent immune mechanisms also play a role in other disease settings, such as chronic viral infections.

    A second research direction explores how the gut microbiome shapes the metabolomic landscape of the TME. Commensal microbes produce a diverse array of immunomodulatory molecules, including surface structures and extracellular metabolites, that can influence the differentiation and function of immune cells. While bacterial metabolites are known to circulate systemically and regulate anti-tumor responses, their presence and function within the TME remain largely unexplored. Dr. Park’s group is working to fill this gap by examining microbial metabolites—particularly lipids and glycerol derivatives—and their immunological effects in tumors. Using metabolomic approaches, the lab identifies and characterizes these metabolites with the long-term goal of engineering bacteria to produce therapeutic molecules that enhance anti-tumor immunity. The team is also developing delivery strategies to target these bacterial products to the TME.

    Together, Dr. Park’s research aims to deepen our understanding of the interplay between the gut microbiome and cancer immunity and to inform the development of innovative microbial-based therapies.
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    Collapse Biography 
    Collapse education and training
    Harvard Medical School, Boston, MAInstructor2024Immunology and Microbiome
    Harvard Medical School, Boston, MAPostdoctoral Fellowship2023Immunology and Microbiome
    The Rockefeller University, New York, NYPostdoctoral Associate2017Immunology
    Cornell University, New York, NYPh.D.2016Immunology
    Yonsei University, Seoul, KoreaB.S.2009Biochemistry

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Georgiev P, Han S, Huang AY, Nguyen TH, Drijvers JM, Creasey H, Pereira JA, Yao CH, Park JS, Conway TS, Fung ME, Liang D, Peluso M, Joshi S, Rowe JH, Miller BC, Freeman GJ, Sharpe AH, Haigis MC, Ringel AE. Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity. Cancer Immunol Res. 2024 Nov 04; 12(11):1525-1541. PMID: 39186561; PMCID: PMC11532741.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    2. Rowe JH, Elia I, Shahid O, Gaudiano EF, Sifnugel NE, Johnson S, Reynolds AG, Fung ME, Joshi S, LaFleur MW, Park JS, Pauken KE, Rabinowitz JD, Freeman GJ, Haigis MC, Sharpe AH. Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade. Cancer Discov. 2023 12 12; 13(12):2566-2583. PMID: 37728660; PMCID: PMC10843486.
      Citations: 15     Fields:    Translation:HumansCells
    3. Kurmi K, Liang D, van de Ven R, Georgiev P, Gassaway BM, Han S, Notarangelo G, Harris IS, Yao CH, Park JS, Hu SH, Peng J, Drijvers JM, Boswell S, Sokolov A, Dougan SK, Sorger PK, Gygi SP, Sharpe AH, Haigis MC. Metabolic modulation of mitochondrial mass during CD4+ T cell activation. Cell Chem Biol. 2023 09 21; 30(9):1064-1075.e8. PMID: 37716347; PMCID: PMC10604707.
      Citations: 5     Fields:    Translation:AnimalsCells
    4. Park JS, Gazzaniga FS, Kasper DL, Sharpe AH. Microbiota-dependent regulation of costimulatory and coinhibitory pathways via innate immune sensors and implications for immunotherapy. Exp Mol Med. 2023 09; 55(9):1913-1921. PMID: 37696895; PMCID: PMC10545783.
      Citations: 6     Fields:    
    5. Park JS, Gazzaniga FS, Wu M, Luthens AK, Gillis J, Zheng W, LaFleur MW, Johnson SB, Morad G, Park EM, Zhou Y, Watowich SS, Wargo JA, Freeman GJ, Kasper DL, Sharpe AH. Publisher Correction: Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature. 2023 Jun; 618(7966):E27. PMID: 37264079; PMCID: PMC12025598.
      Citations: 2     Fields:    
    6. Park JS, Gazzaniga FS, Wu M, Luthens AK, Gillis J, Zheng W, LaFleur MW, Johnson SB, Morad G, Park EM, Zhou Y, Watowich SS, Wargo JA, Freeman GJ, Kasper DL, Sharpe AH. Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature. 2023 05; 617(7960):377-385. PMID: 37138075; PMCID: PMC10219577.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    7. Yao CH, Park JS, Kurmi K, Hu SH, Notarangelo G, Crowley J, Jacobson H, Hui S, Sharpe AH, Haigis MC. Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis. Mol Cell. 2023 04 20; 83(8):1340-1349.e7. PMID: 37084714; PMCID: PMC10131091.
      Citations: 7     Fields:    Translation:HumansCells
    8. Lee HJ, Park JS, Yoo HJ, Lee HM, Lee BC, Kim JH. The Selenoprotein MsrB1 Instructs Dendritic Cells to Induce T-Helper 1 Immune Responses. Antioxidants (Basel). 2020 Oct 20; 9(10). PMID: 33092166; PMCID: PMC7589095.
      Citations: 10     
    9. Park JS, Kim JH. Role of non-classical T cells in skin immunity. Mol Immunol. 2018 11; 103:286-292. PMID: 30343117.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Ryu S, Park JS, Kim HY, Kim JH. Lipid-Reactive T Cells in Immunological Disorders of the Lung. Front Immunol. 2018; 9:2205. PMID: 30319649; PMCID: PMC6168663.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    11. Dobenecker MW, Park JS, Marcello J, McCabe MT, Gregory R, Knight SD, Rioja I, Bassil AK, Prinjha RK, Tarakhovsky A. Signaling function of PRC2 is essential for TCR-driven T cell responses. J Exp Med. 2018 04 02; 215(4):1101-1113. PMID: 29523590; PMCID: PMC5881460.
      Citations: 28     Fields:    Translation:AnimalsCells
    12. Park HJ, Park JS, Jeong YH, Son J, Ban YH, Lee BH, Chen L, Chang J, Chung DH, Choi I, Ha SJ. Correction: PD-1 Upregulated on Regulatory T Cells during Chronic Virus Infection Enhances the Suppression of CD8+ T Cell Immune Response via the Interaction with PD-L1 Expressed on CD8+ T Cells. J Immunol. 2015 Dec 15; 195(12):5841-2. PMID: 26637664.
      Citations: 11     Fields:    
    13. Park HJ, Park JS, Jeong YH, Son J, Ban YH, Lee BH, Chen L, Chang J, Chung DH, Choi I, Ha SJ. PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells. J Immunol. 2015 Jun 15; 194(12):5801-11. PMID: 25934860.
      Citations: 107     Fields:    Translation:AnimalsCells
    14. Zamarin D, Holmgaard RB, Subudhi SK, Park JS, Mansour M, Palese P, Merghoub T, Wolchok JD, Allison JP. Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy. Sci Transl Med. 2014 Mar 05; 6(226):226ra32. PMID: 24598590; PMCID: PMC4106918.
      Citations: 374     Fields:    Translation:AnimalsCells
    15. Corse E, Gottschalk RA, Park JS, Sepulveda MA, Loke P, Sullivan TJ, Johnson LK, Allison JP. Cutting edge: chronic inflammatory liver disease in mice expressing a CD28-specific ligand. J Immunol. 2013 Jan 15; 190(2):526-30. PMID: 23248264; PMCID: PMC4964790.
      Citations: 2     Fields:    Translation:AnimalsCells
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