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Last Name
Institution

Robert Guzy

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Pulmonary and Critical Care
AddressChicago IL 60637
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tyker A, Ventura IB, Lee CT, Strykowski R, Garcia N, Guzy R, Jablonski R, Vij R, Strek ME, Chung JH, Adegunsoye A. High-titer rheumatoid factor seropositivity predicts mediastinal lymphadenopathy and mortality in rheumatoid arthritis-related interstitial lung disease. Sci Rep. 2021 11 24; 11(1):22821. PMID: 34819525.
      View in: PubMed
    2. Wu D, Lee TH, Huang RT, D Guzy R, Schoettler N, Adegunsoye A, Mueller J, Husain A, I Sperling A, Mutlu GM, Fang Y. SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy. Am J Respir Cell Mol Biol. 2021 08; 65(2):222-226. PMID: 33971111.
      View in: PubMed
    3. Guzy R, Redente EF. Kindlin for the Fire: Targeting Proline Synthesis to Extinguish Matrix Production in Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2021 07; 65(1):4-5. PMID: 33844940.
      View in: PubMed
    4. McMullen P, Pytel P, Snyder A, Smith H, Vickery J, Brainer J, Guzy R, Wu D, Schoettler N, Adegunsoye A, Sperling A, Hart J, Alpert L, Chang A, Gurbuxani S, Krausz T, Husain AN, Mueller J. A series of COVID-19 autopsies with clinical and pathologic comparisons to both seasonal and pandemic influenza. J Pathol Clin Res. 2021 09; 7(5):459-470. PMID: 33960723.
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    5. Lee TH, Wu D, Guzy R, Schoettler N, Adegunsoye A, Mueller J, Hussein A, Sperling A, Mutlu GM, Fang Y. SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy. bioRxiv. 2021 Jan 18. PMID: 33469586.
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    6. Guzy R. Fibroblast Growth Factor Inhibitors in Lung Fibrosis: Friends or Foes? Am J Respir Cell Mol Biol. 2020 09; 63(3):273-274. PMID: 32369705.
      View in: PubMed
    7. Lee TH, Yeh CF, Lee YT, Shih YC, Chen YT, Hung CT, You MY, Wu PC, Shentu TP, Huang RT, Lin YS, Wu YF, Lin SJ, Lu FL, Tsao PN, Lin TH, Lo SC, Tseng YS, Wu WL, Chen CN, Wu CC, Lin SL, Sperling AI, Guzy RD, Fang Y, Yang KC. Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFß signaling through TGFBR1 stabilization. Nat Commun. 2020 08 26; 11(1):4254. PMID: 32848143.
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    8. El-Baz LMF, Shoukry NM, Hafez HS, Guzy RD, Salem ML. Fibroblast Growth Factor 2 Augments Transforming Growth Factor Beta 1 Induced Epithelial-mesenchymal Transition in Lung Cell Culture Model. Iran J Allergy Asthma Immunol. 2020 Aug 25; 19(4):348-361. PMID: 33463102.
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    9. Dorry SJ, Ansbro BO, Ornitz DM, Mutlu GM, Guzy RD. FGFR2 Is Required for AEC2 Homeostasis and Survival after Bleomycin-induced Lung Injury. Am J Respir Cell Mol Biol. 2020 05; 62(5):608-621. PMID: 31860803.
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    10. Reed EB, Ard S, La J, Park CY, Culligan L, Fredberg JJ, Smolyaninova LV, Orlov SN, Chen B, Guzy R, Mutlu GM, Dulin NO. Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling. Respir Res. 2019 Jul 29; 20(1):168. PMID: 31358001.
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    11. Hegab AE, Ozaki M, Kameyama N, Gao J, Kagawa S, Yasuda H, Soejima K, Yin Y, Guzy RD, Nakamura Y, Ornitz DM, Betsuyaku T. Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer-associated fibroblasts. J Pathol. 2019 10; 249(2):193-205. PMID: 31090071.
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    12. Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Mutlu GM, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV. Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 06 15; 199(12):1517-1536. PMID: 30554520.
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    13. Ard S, Reed EB, Smolyaninova LV, Orlov SN, Mutlu GM, Guzy RD, Dulin NO. Sustained Smad2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-ß. Am J Respir Cell Mol Biol. 2019 03; 60(3):367-369. PMID: 30821500.
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    14. Koo HY, El-Baz LM, House S, Cilvik SN, Dorry SJ, Shoukry NM, Salem ML, Hafez HS, Dulin NO, Ornitz DM, Guzy RD. Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation. J Pathol. 2018 09; 246(1):54-66. PMID: 29873400.
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    15. Hamanaka RB, Nigdelioglu R, Meliton AY, Tian Y, Witt LJ, O'Leary E, Sun KA, Woods PS, Wu D, Ansbro B, Ard S, Rohde JM, Dulin NO, Guzy RD, Mutlu GM. Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018 05; 58(5):585-593. PMID: 29019702.
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    16. Qiao Y, Lipovsky C, Hicks S, Bhatnagar S, Li G, Khandekar A, Guzy R, Woo KV, Nichols CG, Efimov IR, Rentschler S. Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice. Circ Res. 2017 Aug 18; 121(5):549-563. PMID: 28674041.
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    17. Guzy RD, Li L, Smith C, Dorry SJ, Koo HY, Chen L, Ornitz DM. Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling. J Biol Chem. 2017 06 23; 292(25):10364-10378. PMID: 28487375.
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    18. Adegunsoye A, Strek ME, Garrity E, Guzy R, Bag R. Comprehensive Care of the Lung Transplant Patient. Chest. 2017 07; 152(1):150-164. PMID: 27729262.
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    19. Guzy RD, Stoilov I, Elton TJ, Mecham RP, Ornitz DM. Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin. Am J Respir Cell Mol Biol. 2015 Jan; 52(1):116-28. PMID: 24988442.
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    20. Kulkarni HS, Guzy RD, McEvoy C. YKL-40 in pediatric asthma, MUC5B promoter polymorphism in idiopathic pulmonary fibrosis, and esmolol in septic shock. Am J Respir Crit Care Med. 2014 May 01; 189(9):1138-40. PMID: 24787067.
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    21. Waypa GB, Marks JD, Guzy RD, Mungai PT, Schriewer JM, Dokic D, Ball MK, Schumacker PT. Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation. Am J Respir Crit Care Med. 2013 Feb 15; 187(4):424-32. PMID: 23328522.
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    22. Loor G, Kondapalli J, Iwase H, Chandel NS, Waypa GB, Guzy RD, Vanden Hoek TL, Schumacker PT. Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion. Biochim Biophys Acta. 2011 Jul; 1813(7):1382-94. PMID: 21185334.
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    23. Waypa GB, Marks JD, Guzy R, Mungai PT, Schriewer J, Dokic D, Schumacker PT. Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells. Circ Res. 2010 Feb 19; 106(3):526-35. PMID: 20019331.
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    24. Guzy RD, Sharma B, Bell E, Chandel NS, Schumacker PT. Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Mol Cell Biol. 2008 Jan; 28(2):718-31. PMID: 17967865.
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    25. Guzy RD, Mack MM, Schumacker PT. Mitochondrial complex III is required for hypoxia-induced ROS production and gene transcription in yeast. Antioxid Redox Signal. 2007 Sep; 9(9):1317-28. PMID: 17627464.
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    26. Iwase H, Robin E, Guzy RD, Mungai PT, Vanden Hoek TL, Chandel NS, Levraut J, Schumacker PT. Nitric oxide during ischemia attenuates oxidant stress and cell death during ischemia and reperfusion in cardiomyocytes. Free Radic Biol Med. 2007 Aug 15; 43(4):590-9. PMID: 17640569.
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    27. Robin E, Guzy RD, Loor G, Iwase H, Waypa GB, Marks JD, Hoek TL, Schumacker PT. Oxidant stress during simulated ischemia primes cardiomyocytes for cell death during reperfusion. J Biol Chem. 2007 Jun 29; 282(26):19133-43. PMID: 17488710.
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    28. Waypa GB, Guzy R, Mungai PT, Mack MM, Marks JD, Roe MW, Schumacker PT. Increases in mitochondrial reactive oxygen species trigger hypoxia-induced calcium responses in pulmonary artery smooth muscle cells. Circ Res. 2006 Oct 27; 99(9):970-8. PMID: 17008601.
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    29. Guzy RD, Schumacker PT. Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia. Exp Physiol. 2006 Sep; 91(5):807-19. PMID: 16857720.
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    30. Guzy RD, Hoyos B, Robin E, Chen H, Liu L, Mansfield KD, Simon MC, Hammerling U, Schumacker PT. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab. 2005 Jun; 1(6):401-8. PMID: 16054089.
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    31. Mansfield KD, Guzy RD, Pan Y, Young RM, Cash TP, Schumacker PT, Simon MC. Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab. 2005 Jun; 1(6):393-9. PMID: 16054088.
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    32. Ziarek S, Sawaryn T, Guzy R, Binkiewicz J, Cieslik Z, Janicka J. [Management of acute hemorrhagic-necrotic pancreatitis]. Wiad Lek. 1987 Aug 01; 40(15):1024-30. PMID: 3433772.
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    33. Ziarek S, Sawaryn T, Guzy R, Dabek J, Binkiewicz J, Romaniuk J, Filipczyk W. [Autologous transplantation of splenic tissue to the muscles of the abdominal wall]. Przegl Lek. 1986; 43(4):375-8. PMID: 2944157.
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    34. Ziarek S, Sawaryn T, Guzy R, Binkiewicz J, Dabek J, Araia P. [Treatment of desmoid tumors]. Zentralbl Chir. 1983; 108(16):1046-50. PMID: 6637214.
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    35. Czyzewski K, Dzielicki J, Zurek K, Szlachta E, Guzy R, Hordynski A, Bargiel J. [Complications following tracheostomy in patients suffering from severe chest injuries and the possibilities of avoiding them]. Pol Tyg Lek. 1979 Feb 19; 34(8):289-92. PMID: 441040.
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    36. Czyzewski K, Pudelski J, Dzielicki J, Guzy R. [Respiratory disorders as a consequence of thoracic injuries]. Pol Przegl Chir. 1979 Jan; 51(1):1-6. PMID: 461237.
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    37. Czyzewski K, Romanski A, Zurek K, Dzielicki J, Guzy R, Fatyga M, Okuljar Z. [Thoracic injuries in children]. Pol Tyg Lek. 1978 Apr 24; 33(17):679-81. PMID: 662764.
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