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Zhen Gooi

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentSurgery-Otolaryngology-Head and Neck
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Zhen Gooi, MD, specializes in the care of patients with benign and malignant head and neck tumors. Within the field of head and neck surgery, his clinical interests are microvascular (free flap) reconstruction of the head and neck, and transoral robotic surgery, a minimally invasive treatment approach for selected head and neck tumors that avoids the need for traditional neck, jaw and throat incisions.

    Dr. Gooi is the author of numerous peer-reviewed articles and educational videos related to head and neck cancer and reconstruction. He has presented at numerous international conferences and serves as an invited reviewer for the journal Head and Neck.

    Collapse Biography 
    Collapse education and training
    Johns Hopkins HospitalFellowship
    Johns Hopkins HospitalResidency
    Johns Hopkins HospitalInternship
    King's College London School of MedicineMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Scott-Wittenborn N, D'Souza G, Aygun N, Tewari SR, Azadi J, Vosler P, Gooi Z, Mehta V, Mydlarz W, Nance M, Mlot S, Patel MR, Tan M, Miles BA, Troy T, Fakhry C. Feasibility of clinical evaluation of individuals with increased risk for HPV-associated oropharynx cancer. Head Neck. 2023 Jan; 45(1):95-102. PMID: 36200696; PMCID: PMC10215989.
      Citations:    Fields:    Translation:HumansCells
    2. Ginat DT, Juloori A, Vivar OI, Farber LA, Gooi Z, Rosenberg AJ. Imaging Features of Intratumoral Injection of NBTXR3 for Head and Neck Squamous Cell Carcinoma Lymph Node Metastases. Diagnostics (Basel). 2022 Sep 05; 12(9). PMID: 36140557; PMCID: PMC9498208.
    3. Rosenberg AJ, Agrawal N, Pearson AT, Gooi Z, Blair E, Portugal L, Cursio JF, Juloori A, Chin J, Rouse K, Villaflor VM, Seiwert TY, Izumchenko E, Lingen MW, Haraf DJ, Vokes EE. Phase I study of nab-paclitaxel-based induction followed by nab-paclitaxel-based concurrent chemotherapy and re-irradiation in previously treated head and neck squamous cell carcinoma. Br J Cancer. 2022 11; 127(8):1497-1506. PMID: 35945244; PMCID: PMC9553920.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    4. Hara JH, Gutiontov SI, Uddin S, Rosenberg AJ, Pearson AT, Gooi Z, Blair EA, Agrawal N, Vokes EE, Ginat DT, Haraf DJ, Juloori A. Characterizing Lymph Node Burden With Elective Unilateral Neck Irradiation in Human Papillomavirus-Positive Tonsil Squamous Cell Carcinoma: Defining the Upper Limits. Cureus. 2022 Jul; 14(7):e27521. PMID: 36060366; PMCID: PMC9424785.
    5. Uddin S, Singh A, Mishra V, Agrawal N, Gooi Z, Izumchenko E. Molecular drivers of oral cavity squamous cell carcinoma in non-smoking and non-drinking patients: what do we know so far? Oncol Rev. 2022 Feb 22; 16(1):549. PMID: 35340886; PMCID: PMC8941340.
      Citations: 4     
    6. Rosenberg AJ, Izumchenko E, Pearson A, Gooi Z, Blair E, Karrison T, Juloori A, Ginat D, Cipriani N, Lingen M, Sloane H, Edelstein DL, Keyser K, Fredebohm J, Holtrup F, Jones FS, Haraf D, Agrawal N, Vokes EE. Prospective study evaluating dynamic changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer treated with induction chemotherapy and response-adaptive treatment. BMC Cancer. 2022 Jan 03; 22(1):17. PMID: 34980038; PMCID: PMC8722316.
      Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
    7. Hara J, Rosenberg AJ, Pearson A, Gooi Z, Baird BJ, Blair EA, Agrawal N, Vokes EE, Haraf DJ, Juloori A. Organ Preservation With Definitive Chemoradiotherapy for T4 Laryngeal Squamous Cell Carcinoma. Int J Radiat Oncol Biol Phys. 2021 Nov 01; 111(3S):e363. PMID: 34701276.
    8. Rosenberg AJ, Agrawal N, Pearson A, Gooi Z, Blair E, Cursio J, Juloori A, Ginat D, Howard A, Chin J, Kochanny S, Foster C, Cipriani N, Lingen M, Izumchenko E, Seiwert TY, Haraf D, Vokes EE. Risk and response adapted de-intensified treatment for HPV-associated oropharyngeal cancer: Optima paradigm expanded experience. Oral Oncol. 2021 11; 122:105566. PMID: 34662771; PMCID: PMC9295443.
      Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
    9. Howard A, Agrawal N, Gooi Z. Lip and Oral Cavity Squamous Cell Carcinoma. Hematol Oncol Clin North Am. 2021 10; 35(5):895-911. PMID: 34274176.
      Citations: 4     Fields:    Translation:Humans
    10. Dahm J, Nwaudo D, Gooi Z, Lee M, El Dafrawy M. Migration of an Anterior Cervical Discectomy and Fusion Screw into the Constrictor Muscle of the Hypopharynx: A Case Report. JBJS Case Connect. 2021 05 19; 11(2). PMID: 34010178.
      Citations:    Fields:    Translation:Humans
    11. Foster CC, Seiwert TY, MacCracken E, Blair EA, Agrawal N, Melotek JM, Portugal L, Brisson RJ, Gooi Z, Spiotto MT, Vokes EE, Haraf DJ. Dose and Volume De-Escalation for Human Papillomavirus-Positive Oropharyngeal Cancer is Associated with Favorable Posttreatment Functional Outcomes. Int J Radiat Oncol Biol Phys. 2020 07 15; 107(4):662-671. PMID: 32311416.
      Citations: 10     Fields:    Translation:HumansCellsCTClinical Trials
    12. Gooi Z, Vokes EE. Prolonging Life, but at What Price? JAMA Otolaryngol Head Neck Surg. 2019 12 01; 145(12):1103-1104. PMID: 31600372.
      Citations: 1     Fields:    Translation:Humans
    13. Seiwert TY, Foster CC, Blair EA, Karrison TG, Agrawal N, Melotek JM, Portugal L, Brisson RJ, Dekker A, Kochanny S, Gooi Z, Lingen MW, Villaflor VM, Ginat DT, Haraf DJ, Vokes EE. OPTIMA: a phase II dose and volume de-escalation trial for human papillomavirus-positive oropharyngeal cancer. Ann Oncol. 2019 10 01; 30(10):1673. PMID: 31168601.
      Citations: 11     Fields:    
    14. Gooi Z, Agrawal N. Tonsil Cancer. N Engl J Med. 2019 Jul 25; 381(4):e8. PMID: 31340096.
      Citations:    Fields:    Translation:Humans
    15. Seiwert TY, Foster CC, Blair EA, Karrison TG, Agrawal N, Melotek JM, Portugal L, Brisson RJ, Dekker A, Kochanny S, Gooi Z, Lingen MW, Villaflor VM, Ginat DT, Haraf DJ, Vokes EE. OPTIMA: a phase II dose and volume de-escalation trial for human papillomavirus-positive oropharyngeal cancer. Ann Oncol. 2019 02 01; 30(2):297-302. PMID: 30481287.
      Citations: 49     Fields:    Translation:HumansCellsCTClinical Trials
    16. Rettig EM, Gooi Z, Bardin R, Bogale M, Rooper L, Acha E, Koch WM. Oral Human Papillomavirus Infection and Head and Neck Squamous Cell Carcinoma in Rural Northwest Cameroon. OTO Open. 2019 Jan-Mar; 3(1):2473974X18818415. PMID: 31236529; PMCID: PMC6572919.
      Citations: 5     
    17. Yan K, Agrawal N, Gooi Z. Head and Neck Masses. Med Clin North Am. 2018 Nov; 102(6):1013-1025. PMID: 30342605.
      Citations: 11     Fields:    Translation:Humans
    18. Ginat D, Schulte J, Gooi Z, Cipriani N. High-Grade Conventional Osteosarcoma of the Mandible Associated With P53 Germline Mutation. J Craniofac Surg. 2018 May; 29(3):738-740. PMID: 29420387.
      Citations: 3     Fields:    Translation:Humans
    19. Foster CC, Melotek JM, Brisson RJ, Seiwert TY, Cohen EEW, Stenson KM, Blair EA, Portugal L, Gooi Z, Agrawal N, Vokes EE, Haraf DJ. Definitive chemoradiation for locally-advanced oral cavity cancer: A 20-year experience. Oral Oncol. 2018 05; 80:16-22. PMID: 29706184.
      Citations: 13     Fields:    Translation:Humans
    20. Yesensky JA, Hasina R, Wroblewski KE, Bellairs J, Gooi Z, Saloura V, Cipriani NA, Vokes EE, Portugal LG, Seiwert TY, Blair ED, Agrawal N. Role of dental hardware in oral cavity squamous cell carcinoma in the low-risk nonsmoker nondrinker population. Head Neck. 2018 04; 40(4):784-792. PMID: 29356169.
      Citations: 3     Fields:    Translation:Humans
    21. Gooi Z. Why Actionable Statements Are Needed for Measurement Development. Otolaryngol Head Neck Surg. 2018 03; 158(3):407-408. PMID: 29205087.
      Citations:    Fields:    Translation:Humans
    22. Yesensky J, Agrawal N, Bayan S, Blair E, Portugal L, Chan J, Goldenberg D, Gooi Z. AHNS Series - Do you know your guidelines? Principles of treatment for glottic cancer: A review of the National Comprehensive Cancer Network guidelines. Head Neck. 2017 09; 39(9):1729-1732. PMID: 28653453.
      Citations: 2     Fields:    Translation:Humans
    23. Feng AL, Razavi CR, Lakshminarayanan P, Ashai Z, Olds K, Balicki M, Gooi Z, Day AT, Taylor RH, Richmon JD. The robotic ENT microsurgery system: A novel robotic platform for microvascular surgery. Laryngoscope. 2017 11; 127(11):2495-2500. PMID: 28581249.
      Citations: 4     Fields:    Translation:HumansAnimals
    24. Chan JY, Gooi Z, Mydlarz WK, Agrawal N. Risk of thyroid malignancy following an index head and neck squamous cell carcinoma: A population-based study. Ear Nose Throat J. 2016 Dec; 95(12):E7-E11. PMID: 27929600.
      Citations: 1     Fields:    Translation:Humans
    25. Gooi Z, Richmon J, Agrawal N, Blair E, Portugal L, Vokes E, Seiwert T, de Souza J, Saloura V, Haraf D, Goldenberg D, Chan J. AHNS Series - Do you know your guidelines? Principles of treatment for nasopharyngeal cancer: A review of the National Comprehensive Cancer Network guidelines. Head Neck. 2017 02; 39(2):201-205. PMID: 27898198.
      Citations: 5     Fields:    Translation:Humans
    26. Ooi ASH, Butz DR, Gooi Z, Chang DW. Modification of the Radial Forearm Fasciocutaneous Flap in Partial Pharyngolaryngeal Reconstruction to Minimize Fistula Formation. Plast Reconstr Surg. 2016 Nov; 138(5):903e-907e. PMID: 27783007.
      Citations: 1     Fields:    Translation:Humans
    27. Chan JY, Gooi Z, Wong EW, Ng SK, Tong MC, Vlantis AC. Low-grade myofibroblastic sarcoma: A population-based study. Laryngoscope. 2017 01; 127(1):116-121. PMID: 27377169.
      Citations: 17     Fields:    Translation:Humans
    28. Gooi Z, Fakhry C, Goldenberg D, Richmon J, Kiess AP, Education Committee of the American Head and Neck Society (AHNS). AHNS Series: Do you know your guidelines?Principles of radiation therapy for head and neck cancer: A review of the National Comprehensive Cancer Network guidelines. Head Neck. 2016 07; 38(7):987-92. PMID: 27015108.
      Citations: 9     Fields:    Translation:Humans
    29. Gooi Z, Chan JY, Fakhry C. The epidemiology of the human papillomavirus related to oropharyngeal head and neck cancer. Laryngoscope. 2016 Apr; 126(4):894-900. PMID: 26845348.
      Citations: 48     Fields:    Translation:HumansCells
    30. Contrera KJ, Aygun N, Ward BK, Gooi Z, Richmon JD. Internal jugular vein duplication and fenestration: Case series and literature review. Laryngoscope. 2016 07; 126(7):1585-8. PMID: 26498831; PMCID: PMC5405004.
      Citations: 9     Fields:    Translation:Humans
    31. Noureldine SI, Gooi Z, Tufano RP. Minimally invasive parathyroid surgery. Gland Surg. 2015 Oct; 4(5):410-9. PMID: 26425454; PMCID: PMC4561661.
      Citations: 25     
    32. Chan JY, Gooi Z, Mydlarz WK, Agrawal N. Risk of second primary malignancy after nasopharyngeal carcinoma in the United States: A population-based study. Head Neck. 2016 04; 38 Suppl 1:E1130-6. PMID: 26314805.
      Citations: 5     Fields:    Translation:Humans
    33. Pang J, Mydlarz WK, Gooi Z, Waters KM, Bishop J, Sciubba JJ, Kim YJ, Fakhry C. Follicular dendritic cell sarcoma of the head and neck: Case report, literature review, and pooled analysis of 97 cases. Head Neck. 2016 04; 38 Suppl 1:E2241-9. PMID: 25917851; PMCID: PMC4696909.
      Citations: 24     Fields:    Translation:Humans
    34. Gooi Z, Ishman SL, Bock JM, Blumin JH, Akst LM. Changing Patterns in Reflux Care: 10-Year Comparison of ABEA Members. Ann Otol Rhinol Laryngol. 2015 Dec; 124(12):940-6. PMID: 26091843.
      Citations: 6     Fields:    Translation:Humans
    35. Li R, Faden DL, Fakhry C, Langelier C, Jiao Y, Wang Y, Wilkerson MD, Pedamallu CS, Old M, Lang J, Loyo M, Ahn SM, Tan M, Gooi Z, Chan J, Richmon J, Wood LD, Hruban RH, Bishop J, Westra WH, Chung CH, Califano J, Gourin CG, Bettegowda C, Meyerson M, Papadopoulos N, Kinzler KW, Vogelstein B, DeRisi JL, Koch WM, Agrawal N. Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke. Head Neck. 2015 Nov; 37(11):1642-9. PMID: 24954188; PMCID: PMC4272912.
      Citations: 38     Fields:    Translation:Humans
    36. Gooi Z, Gourin CG, Boahene KD, Byrne PJ, Richmon JD. Temporal trends in head and neck cancer surgery reconstruction. Head Neck. 2015 Oct; 37(10):1509-17. PMID: 24890759.
      Citations: 3     Fields:    Translation:Humans
    37. Gooi Z, Ward BK, Mener DJ, Ozgursoy OB, Pai SI. A staged thyroidectomy approach for gastric bypass patients. Laryngoscope. 2015 Apr; 125(4):1028-30. PMID: 25043176.
      Citations: 2     Fields:    Translation:Humans
    38. Gooi Z, Mydlarz WK, Tunkel DE, Eisele DW. Submandibular venous malformation phleboliths mimicking sialolithiasis in children. Laryngoscope. 2014 Dec; 124(12):2826-8. PMID: 24986521.
      Citations: 3     Fields:    Translation:Humans
    39. Gooi Z, Ishman SL, Bock JM, Blumin JH, Akst LM. Laryngopharyngeal reflux: paradigms for evaluation, diagnosis, and treatment. Ann Otol Rhinol Laryngol. 2014 Oct; 123(10):677-85. PMID: 24789800.
      Citations: 4     Fields:    Translation:Humans
    40. Smith DF, Maleki Z, Coughlan D, Gooi Z, Akpeng B, Ogawa T, Bishop JA, Frick KD, Agrawal N, Gourin CG, Ha PK, Koch WM, Richmon JD, Westra WH, Pai SI. Human papillomavirus status of head and neck cancer as determined in cytologic specimens using the hybrid-capture 2 assay. Oral Oncol. 2014 Jun; 50(6):600-4. PMID: 24630260; PMCID: PMC4318229.
      Citations: 6     Fields:    Translation:HumansCells
    41. Gooi Z, Richmon J. Long-term oral intake through a salivary bypass tube with chronic pharyngocutaneous fistula. Am J Otolaryngol. 2012 Nov-Dec; 33(6):762-3. PMID: 22673096.
      Citations: 2     Fields:    Translation:Humans
    42. Gooi Z, Lee R, Wong KK, Tam PKh. The use of splenic artery embolisation as a bridge to safe laparoscopic splenectomy in a patient with resistant immune thrombocytopenic purpura. J Paediatr Child Health. 2009 Dec; 45(12):767-9. PMID: 20416004.
      Citations: 1     Fields:    Translation:Humans
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