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Vladimir Liarski

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Rheumatology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    I am currently an Assistant Professor in Rheumatology in the Physician Scholar Track with a strong background in Immunology who is immensely interested in human translational research as it applies to systemic lupus erythematous (SLE) and the idiopathic inflammatory myopathy (IIM) group of disorders. My main research focus is the role of inflammation and the study of its’ organization, cellular make-up, and presence of cognate versus non-cognate immune interactions by means of computerized, objective, and high-throughput techniques based on image analysis of multichannel immunofluorescently-labeled images of human tissue, acquired with confocal laser scanning microscopy.
    Having been interested in basic and translational research since college, I have acquired a good foundation of research techniques and have had hands-on training in key aspects of data acquisition and analysis under multiple excellent mentors. Besides the standard medical basic science curriculum, I have participated in independent study, culminating in an AAI Advanced Immunology Course to establish a solid foundation of knowledge in this area. I have also completed the Optical Microscopy and Imaging in the Biomedical Sciences course offered at the Marine Biological Laboratory at Woods Hole to further my knowledge of optical image acquisition and analysis. In addition, I have completed advanced graduate courses in Immunology and Image Analysis at the University of Chicago.


    Collapse Biography 
    Collapse awards and honors
    2013Best Abstract Award , American College of Rheumatology Research Workshop, Dallas, TX
    2012Best Abstract Award , 6th Annual National Young Rheumatology Investigator Forum at the Congress of Clinical Rheumatology
    2006MD degree with Honors in Research in Pathology, NYU School of Medicine

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Liarski VM, Sibley A, van Panhuys N, Ai J, Chang A, Kennedy D, Merolle M, Germain RN, Giger ML, Clark MR. Quantifying in situ adaptive immune cell cognate interactions in humans. Nat Immunol. 2019 04; 20(4):503-513. PMID: 30778242.
      View in: PubMed
    2. Narang N, Lang RM, Liarski VM, Jeevanandam V, Hofmann Bowman MA. Aortic Valve Replacement for Moderate Aortic Stenosis with Severe Calcification and Left Ventricualr Dysfunction-A Case Report and Review of the Literature. Front Cardiovasc Med. 2017; 4:14. PMID: 28396860.
      View in: PubMed
    3. Ko K, Wang J, Perper S, Jiang Y, Yanez D, Kaverina N, Ai J, Liarski VM, Chang A, Peng Y, Lan L, Westmoreland S, Olson L, Giger ML, Chun Wang L, Clark MR. Bcl-2 as a Therapeutic Target in Human Tubulointerstitial Inflammation. Arthritis Rheumatol. 2016 11; 68(11):2740-2751. PMID: 27159593.
      View in: PubMed
    4. Trotter K, Clark MR, Liarski VM. Overview of pathophysiology and treatment of human lupus nephritis. Curr Opin Rheumatol. 2016 09; 28(5):460-7. PMID: 27341623.
      View in: PubMed
    5. Bermea RS, Sharma N, Cohen K, Liarski VM. Use of Eculizumab in Atypical Hemolytic Uremic Syndrome, Complicating Systemic Lupus Erythematosus. J Clin Rheumatol. 2016 Sep; 22(6):320-3. PMID: 27556240.
      View in: PubMed
    6. Henault J, Riggs JM, Karnell JL, Liarski VM, Li J, Shirinian L, Xu L, Casey KA, Smith MA, Khatry DB, Izhak L, Clarke L, Herbst R, Ettinger R, Petri M, Clark MR, Mustelin T, Kolbeck R, Sanjuan MA. Self-reactive IgE exacerbates interferon responses associated with autoimmunity. Nat Immunol. 2016 Feb; 17(2):196-203. PMID: 26692173.
      View in: PubMed
    7. Kinloch AJ, Chang A, Ko K, Henry Dunand CJ, Henderson S, Maienschein-Cline M, Kaverina N, Rovin BH, Salgado Ferrer M, Wolfgeher D, Liarski V, Haddon DJ, Utz PJ, Wilson PC, Clark MR. Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritis. Arthritis Rheumatol. 2014 Dec; 66(12):3359-70. PMID: 25306868.
      View in: PubMed
    8. Liarski VM, Kaverina N, Chang A, Brandt D, Yanez D, Talasnik L, Carlesso G, Herbst R, Utset TO, Labno C, Peng Y, Jiang Y, Giger ML, Clark MR. Cell distance mapping identifies functional T follicular helper cells in inflamed human renal tissue. Sci Transl Med. 2014 Apr 02; 6(230):230ra46. PMID: 24695686.
      View in: PubMed
    9. Hamel KM, Liarski VM, Clark MR. Germinal center B-cells. Autoimmunity. 2012 Aug; 45(5):333-47. PMID: 22390182.
      View in: PubMed
    10. Peng Y, Jiang Y, Liarski V, Kaverina N, Clark MR, Giger ML. Computer image analysis of cell-cell interactions in human renal tissue by using multi-channel immunoflourescent confocal microscopy. Proc of SPIE. 2012; 8125:1-7.
    11. Singh K, Deshpande P, Pryshchep S, Colmegna I, Liarski V, Weyand CM, Goronzy JJ. ERK-dependent T cell receptor threshold calibration in rheumatoid arthritis. J Immunol. 2009 Dec 15; 183(12):8258-67. PMID: 20007589.
      View in: PubMed
    12. Lecanda J, Parekh TV, Gama P, Lin K, Liarski V, Uretsky S, Mittal K, Gold LI. Transforming growth factor-beta, estrogen, and progesterone converge on the regulation of p27Kip1 in the normal and malignant endometrium. Cancer Res. 2007 Feb 01; 67(3):1007-18. PMID: 17283133.
      View in: PubMed
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