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Matthew Churpek

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Pulmonary/Critical Care
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    Dr. Churpek is a Pulmonary and Critical Care physician with a PhD in Epidemiology whose research interests include developing clinical prediction models for patients who experience clinical deterioration in the hospital. His research aims to decrease preventable hospital death by identifying patients on the hospital wards who are at high risk of cardiac arrest or intensive care unit transfer early enough to improve their outcomes. Dr. Churpek is interested in the use of techniques such as survival analysis, machine learning, and simulation studies to improve the care of hospitalized patients, and he is supported by a K08 grant (K08HL121080) and R01 grant (R01GM123193).


    Collapse Biography 
    Collapse awards and honors
    2012ATS annual meeting Travel Award, American Thoracic Society
    2012CHEST- Young Investigator Award, CHEST
    2014ASCI Young Physician-Scientist Award, ASCI
    2014AHA Young Investigator Award, American Heart Association

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bhavani SV, Verhoef PA, Churpek MM. Reply to: Fever in Sepsis: Still a Hot Topic. Am J Respir Crit Care Med. 2019 Mar 25. PMID: 30908923.
      View in: PubMed
    2. Eguia E, Cobb AN, Baker MS, Joyce C, Gilbert E, Gonzalez R, Afshar M, Churpek MM. Risk factors for infection and evaluation of Sepsis-3 in patients with trauma. Am J Surg. 2019 Mar 08. PMID: 30885453.
      View in: PubMed
    3. Bhavani SV, Carey KA, Gilbert ER, Afshar M, Verhoef PA, Churpek MM. Identifying Novel Sepsis Subphenotypes Using Temperature Trajectories. Am J Respir Crit Care Med. 2019 Feb 21. PMID: 30789749.
      View in: PubMed
    4. Adegunsoye A, Oldham JM, Bellam SK, Montner S, Churpek MM, Noth I, Vij R, Strek ME, Chung JH. CT Honeycombing Identifies a Progressive Fibrotic Phenotype with Increased Mortality Across Diverse Interstitial Lung Diseases. Ann Am Thorac Soc. 2019 Jan 17. PMID: 30653927.
      View in: PubMed
    5. Afshar M, Joyce C, Oakey A, Formanek P, Yang P, Churpek MM, Cooper RS, Zelisko S, Price R, Dligach D. A Computable Phenotype for Acute Respiratory Distress Syndrome Using Natural Language Processing and Machine Learning. AMIA Annu Symp Proc. 2018; 2018:157-165. PMID: 30815053.
      View in: PubMed
    6. Han X, Edelson DP, Churpek MM. Response. Chest. 2018 Dec; 154(6):1462. PMID: 30526977.
      View in: PubMed
    7. Shappell C, Edelson DP, Churpek MM. The authors reply. Crit Care Med. 2018 Dec; 46(12):e1230. PMID: 30444831.
      View in: PubMed
    8. Mayampurath A, Ward C, Fahrenbach J, LaFond C, Howell M, Churpek MM. Association Between Room Location and Adverse Outcomes in Hospitalized Patients. HERD. 2018 Oct 31; 1937586718806702. PMID: 30380918.
      View in: PubMed
    9. Wolfe KS, Patel BK, MacKenzie EL, Giovanni SP, Pohlman AS, Churpek MM, Hall JB, Kress JP. Impact of Vasoactive Medications on ICU-Acquired Weakness in Mechanically Ventilated Patients. Chest. 2018 Oct; 154(4):781-787. PMID: 30217640.
      View in: PubMed
    10. Parker WF, Anderson AS, Huang ES, Garrity ER, Churpek MM. Reply: Does Overtreatment of Heart Transplantation Candidates Exist? J Am Coll Cardiol. 2018 Aug 07; 72(6):703-704. PMID: 30072009.
      View in: PubMed
    11. Shappell C, Snyder A, Edelson DP, Churpek MM. Predictors of In-Hospital Mortality After Rapid Response Team Calls in a 274 Hospital Nationwide Sample. Crit Care Med. 2018 Jul; 46(7):1041-1048. PMID: 29293147.
      View in: PubMed
    12. Rojas JC, Carey KA, Edelson DP, Venable LR, Howell MD, Churpek MM. Predicting Intensive Care Unit Readmission with Machine Learning Using Electronic Health Record Data. Ann Am Thorac Soc. 2018 Jul; 15(7):846-853. PMID: 29787309.
      View in: PubMed
    13. Koyner JL, Carey KA, Edelson DP, Churpek MM. The Development of a Machine Learning Inpatient Acute Kidney Injury Prediction Model. Crit Care Med. 2018 Jul; 46(7):1070-1077. PMID: 29596073.
      View in: PubMed
    14. Blagev DP, Collingridge DS, Rea S, Press VG, Churpek MM, Carey K, Mularski RA, Zeng S, Arjomandi M. Stability of Frequency of Severe Chronic Obstructive Pulmonary Disease Exacerbations and Health Care Utilization in Clinical Populations. Chronic Obstr Pulm Dis. 2018 Jun 20; 5(3):208-220. PMID: 30584584.
      View in: PubMed
    15. Adegunsoye A, Oldham JM, Bellam SK, Chung JH, Chung PA, Biblowitz KM, Montner S, Lee C, Hsu S, Husain AN, Vij R, Mutlu G, Noth I, Churpek MM, Strek ME. African-American race and mortality in interstitial lung disease: a multicentre propensity-matched analysis. Eur Respir J. 2018 06; 51(6). PMID: 29724923.
      View in: PubMed
    16. Blagev DP, Collingridge DS, Rea S, Horne BD, Press VG, Churpek MM, Carey KA, Mularski RA, Zeng S, Arjomandi M. The Laboratory-Based Intermountain Validated Exacerbation (LIVE) Score Identifies Chronic Obstructive Pulmonary Disease Patients at High Mortality Risk. Front Med (Lausanne). 2018; 5:173. PMID: 29942803.
      View in: PubMed
    17. Han X, Edelson DP, Snyder A, Pettit N, Sokol S, Barc C, Howell MD, Churpek MM. Implications of Centers for Medicare & Medicaid Services Severe Sepsis and Septic Shock Early Management Bundle and Initial Lactate Measurement on the Management of Sepsis. Chest. 2018 Aug; 154(2):302-308. PMID: 29804795.
      View in: PubMed
    18. Sanchez-Pinto LN, Venable LR, Fahrenbach J, Churpek MM. Comparison of variable selection methods for clinical predictive modeling. Int J Med Inform. 2018 08; 116:10-17. PMID: 29887230.
      View in: PubMed
    19. Lyons PG, Edelson DP, Churpek MM. Rapid response systems. Resuscitation. 2018 07; 128:191-197. PMID: 29777740.
      View in: PubMed
    20. Hirai T, Tate S, Dryer K, Jones D, Rosenberg J, Nathan S, Shah AP, Carey K, Churpek M, Edelson D, Friant J, Paul J, Blair JEA. Electronic cardiac arrest triage score best predicts mortality after intervention in patients with massive and submassive pulmonary embolism. Catheter Cardiovasc Interv. 2018 Aug 01; 92(2):366-371. PMID: 29745451.
      View in: PubMed
    21. Sanchez-Pinto LN, Luo Y, Churpek MM. Big Data and Data Science in Critical Care. Chest. 2018 Nov; 154(5):1239-1248. PMID: 29752973.
      View in: PubMed
    22. Parker WF, Anderson AS, Hedeker D, Huang ES, Garrity ER, Siegler M, Churpek MM. Geographic Variation in the Treatment of U.S. Adult Heart Transplant Candidates. J Am Coll Cardiol. 2018 Apr 24; 71(16):1715-1725. PMID: 29666020.
      View in: PubMed
    23. Churpek MM, Snyder A, Twu NM, Edelson DP. Accuracy Comparisons between Manual and Automated Respiratory Rate for Detecting Clinical Deterioration in Ward Patients. J Hosp Med. 2018 07 01; 13(7):486-487. PMID: 29394299.
      View in: PubMed
    24. Bartkowiak B, Snyder AM, Benjamin A, Schneider A, Twu NM, Churpek MM, Roggin KK, Edelson DP. Validating the Electronic Cardiac Arrest Risk Triage (eCART) Score for Risk Stratification of Surgical Inpatients in the Postoperative Setting: Retrospective Cohort Study. Ann Surg. 2018 Jan 12. PMID: 29334564.
      View in: PubMed
    25. Parker WF, Garrity ER, Fedson S, Churpek MM. Trends in the Use of Inotropes to List Adult Heart Transplant Candidates at Status 1A. Circ Heart Fail. 2017 Dec; 10(12). PMID: 29246896.
      View in: PubMed
    26. Green M, Lander H, Snyder A, Hudson P, Churpek M, Edelson D. Comparison of the Between the Flags calling criteria to the MEWS, NEWS and the electronic Cardiac Arrest Risk Triage (eCART) score for the identification of deteriorating ward patients. Resuscitation. 2018 02; 123:86-91. PMID: 29169912.
      View in: PubMed
    27. Churpek MM, Snyder A, Sokol S, Pettit NN, Edelson DP. Investigating the Impact of Different Suspicion of Infection Criteria on the Accuracy of Quick Sepsis-Related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores. Crit Care Med. 2017 Nov; 45(11):1805-1812. PMID: 28737573.
      View in: PubMed
    28. Churpek MM, Edelson DP, Lee JY, Carey K, Snyder A. Association Between Survival and Time of Day for Rapid Response Team Calls in a National Registry. Crit Care Med. 2017 10; 45(10):1677-1682. PMID: 28742548.
      View in: PubMed
    29. Adegunsoye A, Oldham JM, Chung JH, Montner SM, Lee C, Witt LJ, Stahlbaum D, Bermea RS, Chen LW, Hsu S, Husain AN, Noth I, Vij R, Strek ME, Churpek M. Phenotypic Clusters Predict Outcomes in a Longitudinal Interstitial Lung Disease Cohort. Chest. 2018 Feb; 153(2):349-360. PMID: 28964798.
      View in: PubMed
    30. Adegunsoye A, Oldham JM, Fernández Pérez ER, Hamblin M, Patel N, Tener M, Bhanot D, Robinson L, Bullick S, Chen L, Hsu S, Churpek M, Hedeker D, Montner S, Chung JH, Husain AN, Noth I, Strek ME, Vij R. Outcomes of immunosuppressive therapy in chronic hypersensitivity pneumonitis. ERJ Open Res. 2017 Jul; 3(3). PMID: 28845429.
      View in: PubMed
    31. O'Hanlon CE, Cooper JM, Lee SM, John P, Churpek M, Chin MH, Huang ES. Life Expectancy Predictions for Older Diabetic Patients as Estimated by Physicians and a Prognostic Model. MDM Policy Pract. 2017 Jan-Jun; 2(1):2381468317713718. PMID: 30288423.
      View in: PubMed
    32. Lyons PG, Snyder A, Sokol S, Edelson DP, Mokhlesi B, Churpek MM. Association Between Opioid and Benzodiazepine Use and Clinical Deterioration in Ward Patients. J Hosp Med. 2017 06; 12(6):428-434. PMID: 28574532.
      View in: PubMed
    33. Parker WF, Garrity ER, Fedson S, Churpek MM. Potential impact of a shock requirement on adult heart allocation. J Heart Lung Transplant. 2017 Sep; 36(9):1013-1016. PMID: 28579114.
      View in: PubMed
    34. Edelson DP, Churpek MM. Web Exclusives. Annals for Hospitalists Inpatient Notes - Predicting Codes-A Future With Fewer In-Hospital Cardiac Arrests. Ann Intern Med. 2017 05 16; 166(10):HO2-HO3. PMID: 28505657.
      View in: PubMed
    35. Churpek MM, Snyder A, Han X, Sokol S, Pettit N, Howell MD, Edelson DP. Quick Sepsis-related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores for Detecting Clinical Deterioration in Infected Patients outside the Intensive Care Unit. Am J Respir Crit Care Med. 2017 04 01; 195(7):906-911. PMID: 27649072.
      View in: PubMed
    36. Bhattacharjee P, Churpek MM, Snyder A, Howell MD, Edelson DP. Detecting Sepsis: Are Two Opinions Better Than One? J Hosp Med. 2017 04; 12(4):256-258. PMID: 28411298.
      View in: PubMed
    37. Volchenboum SL, Mayampurath A, Göksu-Gürsoy G, Edelson DP, Howell MD, Churpek MM. Association Between In-Hospital Critical Illness Events and Outcomes in Patients on the Same Ward. JAMA. 2016 12 27; 316(24):2674-2675. PMID: 28027358.
      View in: PubMed
    38. Churpek MM, Edelson DP. Moving Beyond Single-Parameter Early Warning Scores for Rapid Response System Activation. Crit Care Med. 2016 12; 44(12):2283-2285. PMID: 27858814.
      View in: PubMed
    39. Adegunsoye A, Hrusch CL, Bonham CA, Jaffery MR, Blaine KM, Sullivan M, Churpek MM, Strek ME, Noth I, Sperling AI. Skewed Lung CCR4 to CCR6 CD4+ T Cell Ratio in Idiopathic Pulmonary Fibrosis Is Associated with Pulmonary Function. Front Immunol. 2016; 7:516. PMID: 27933058.
      View in: PubMed
    40. Perman SM, Stanton E, Soar J, Berg RA, Donnino MW, Mikkelsen ME, Edelson DP, Churpek MM, Yang L, Merchant RM. Location of In-Hospital Cardiac Arrest in the United States-Variability in Event Rate and Outcomes. J Am Heart Assoc. 2016 09 29; 5(10). PMID: 27688235.
      View in: PubMed
    41. Kipnis P, Turk BJ, Wulf DA, LaGuardia JC, Liu V, Churpek MM, Romero-Brufau S, Escobar GJ. Development and validation of an electronic medical record-based alert score for detection of inpatient deterioration outside the ICU. J Biomed Inform. 2016 12; 64:10-19. PMID: 27658885.
      View in: PubMed
    42. Koyner JL, Adhikari R, Edelson DP, Churpek MM. Development of a Multicenter Ward-Based AKI Prediction Model. Clin J Am Soc Nephrol. 2016 11 07; 11(11):1935-1943. PMID: 27633727.
      View in: PubMed
    43. Greenberg JA, David MZ, Churpek MM, Pitrak DL, Hall JB, Kress JP. Sequential Organ Failure Assessment Score Modified for Recent Infection in Patients With Hematologic Malignant Tumors and Severe Sepsis. Am J Crit Care. 2016 09; 25(5):409-17. PMID: 27587420.
      View in: PubMed
    44. Kang MA, Churpek MM, Zadravecz FJ, Adhikari R, Twu NM, Edelson DP. Real-Time Risk Prediction on the Wards: A Feasibility Study. Crit Care Med. 2016 08; 44(8):1468-73. PMID: 27075140.
      View in: PubMed
    45. Bhattacharjee P, Edelson DP, Churpek MM. Identifying Patients With Sepsis on the Hospital Wards. Chest. 2017 04; 151(4):898-907. PMID: 27374948.
      View in: PubMed
    46. Churpek MM, Wendlandt B, Zadravecz FJ, Adhikari R, Winslow C, Edelson DP. Association between intensive care unit transfer delay and hospital mortality: A multicenter investigation. J Hosp Med. 2016 11; 11(11):757-762. PMID: 27352032.
      View in: PubMed
    47. Churpek MM, Adhikari R, Edelson DP. The value of vital sign trends for detecting clinical deterioration on the wards. Resuscitation. 2016 May; 102:1-5. PMID: 26898412.
      View in: PubMed
    48. Hamilton DE, Press VG, Twu NM, Yuen TC, Azu CN, Churpek MM, Edelson DP. Testing the functional assessment of mentation: A mobile application based assessment of mental status. J Hosp Med. 2016 07; 11(7):463-6. PMID: 26882263.
      View in: PubMed
    49. Churpek MM, Yuen TC, Winslow C, Meltzer DO, Kattan MW, Edelson DP. Multicenter Comparison of Machine Learning Methods and Conventional Regression for Predicting Clinical Deterioration on the Wards. Crit Care Med. 2016 Feb; 44(2):368-74. PMID: 26771782.
      View in: PubMed
    50. Churpek JE, Marquez R, Neistadt B, Claussen K, Lee MK, Churpek MM, Huo D, Weiner H, Bannerjee M, Godley LA, Le Beau MM, Pritchard CC, Walsh T, King MC, Olopade OI, Larson RA. Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia. Cancer. 2016 Jan 15; 122(2):304-11. PMID: 26641009.
      View in: PubMed
    51. Lyons PG, Zadravecz FJ, Edelson DP, Mokhlesi B, Churpek MM. In response to "Obstructive sleep apnea and adverse outcomes in surgical and nonsurgical patients on the wards". J Hosp Med. 2016 Feb; 11(2):157. PMID: 26606686.
      View in: PubMed
    52. Churpek MM, Zadravecz FJ, Winslow C, Howell MD, Edelson DP. Incidence and Prognostic Value of the Systemic Inflammatory Response Syndrome and Organ Dysfunctions in Ward Patients. Am J Respir Crit Care Med. 2015 Oct 15; 192(8):958-64. PMID: 26158402.
      View in: PubMed
    53. Shah T, Churpek MM, Coca Perraillon M, Konetzka RT. Response. Chest. 2015 Oct; 148(4):e134-e135. PMID: 26437829.
      View in: PubMed
    54. Zadravecz FJ, Tien L, Robertson-Dick BJ, Yuen TC, Twu NM, Churpek MM, Edelson DP. Comparison of mental-status scales for predicting mortality on the general wards. J Hosp Med. 2015 Oct; 10(10):658-63. PMID: 26374471.
      View in: PubMed
    55. Lyons PG, Zadravecz FJ, Edelson DP, Mokhlesi B, Churpek MM. Obstructive sleep apnea and adverse outcomes in surgical and nonsurgical patients on the wards. J Hosp Med. 2015 Sep; 10(9):592-8. PMID: 26073058.
      View in: PubMed
    56. Shah T, Churpek MM, Coca Perraillon M, Konetzka RT. Understanding why patients with COPD get readmitted: a large national study to delineate the Medicare population for the readmissions penalty expansion. Chest. 2015 May; 147(5):1219-1226. PMID: 25539483.
      View in: PubMed
    57. Churpek MM, Yuen TC, Winslow C, Hall J, Edelson DP. Differences in vital signs between elderly and nonelderly patients prior to ward cardiac arrest. Crit Care Med. 2015 Apr; 43(4):816-22. PMID: 25559439.
      View in: PubMed
    58. Churpek MM, Edelson DP. In search of the optimal rapid response system bundle. J Hosp Med. 2015 Jun; 10(6):411. PMID: 25772513.
      View in: PubMed
    59. Patel AR, Zadravecz FJ, Young RS, Williams MV, Churpek MM, Edelson DP. The value of clinical judgment in the detection of clinical deterioration. JAMA Intern Med. 2015 Mar; 175(3):456-8. PMID: 25558851.
      View in: PubMed
    60. Razi RR, Churpek MM, Yuen TC, Peek ME, Fisher T, Edelson DP. Racial disparities in outcomes following PEA and asystole in-hospital cardiac arrests. Resuscitation. 2015 Feb; 87:69-74. PMID: 25497394.
      View in: PubMed
    61. Churpek JE, Walsh T, Zheng Y, Moton Z, Thornton AM, Lee MK, Casadei S, Watts A, Neistadt B, Churpek MM, Huo D, Zvosec C, Liu F, Niu Q, Marquez R, Zhang J, Fackenthal J, King MC, Olopade OI. Inherited predisposition to breast cancer among African American women. Breast Cancer Res Treat. 2015 Jan; 149(1):31-9. PMID: 25428789.
      View in: PubMed
    62. Churpek MM, Yuen TC, Winslow C, Robicsek AA, Meltzer DO, Gibbons RD, Edelson DP. Multicenter development and validation of a risk stratification tool for ward patients. Am J Respir Crit Care Med. 2014 Sep 15; 190(6):649-55. PMID: 25089847.
      View in: PubMed
    63. Town JA, Churpek MM, Yuen TC, Huber MT, Kress JP, Edelson DP. Relationship between ICU bed availability, ICU readmission, and cardiac arrest in the general wards. Crit Care Med. 2014 Sep; 42(9):2037-41. PMID: 24776607.
      View in: PubMed
    64. Churpek MM, Yuen TC, Park SY, Gibbons R, Edelson DP. Using electronic health record data to develop and validate a prediction model for adverse outcomes in the wards*. Crit Care Med. 2014 Apr; 42(4):841-8. PMID: 24247472.
      View in: PubMed
    65. Yoder JC, Yuen TC, Churpek MM, Arora VM, Edelson DP. A prospective study of nighttime vital sign monitoring frequency and risk of clinical deterioration. JAMA Intern Med. 2013 Sep 09; 173(16):1554-5. PMID: 23817602.
      View in: PubMed
    66. Churpek MM, Yuen TC, Edelson DP. Risk stratification of hospitalized patients on the wards. Chest. 2013 Jun; 143(6):1758-1765. PMID: 23732586.
      View in: PubMed
    67. Churpek MM, Yuen TC, Edelson DP. Predicting clinical deterioration in the hospital: the impact of outcome selection. Resuscitation. 2013 May; 84(5):564-8. PMID: 23022075.
      View in: PubMed
    68. Edelson DP, Churpek MM. Sifting through the heterogeneity of the Rapid Response System literature. Resuscitation. 2012 Dec; 83(12):1419-20. PMID: 23000360.
      View in: PubMed
    69. Churpek MM, Yuen TC, Park SY, Meltzer DO, Hall JB, Edelson DP. Derivation of a cardiac arrest prediction model using ward vital signs*. Crit Care Med. 2012 Jul; 40(7):2102-8. PMID: 22584764.
      View in: PubMed
    70. Churpek MM, Hall JB. Measuring and rewarding quality in the ICU: the yardstick is not as straight as we wish. Am J Respir Crit Care Med. 2012 Jan 01; 185(1):3-4. PMID: 22210782.
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    71. Churpek MM, Yuen TC, Huber MT, Park SY, Hall JB, Edelson DP. Predicting cardiac arrest on the wards: a nested case-control study. Chest. 2012 May; 141(5):1170-1176. PMID: 22052772.
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    72. Patterson K, McShane PJ, Churpek MM, Verhoef PA. Recommended Reading from the University of Chicago Pulmonary and Critical Care Fellows: John F. McConville, M.D., Program Director. Am J Respir Crit Care Med. 2010 12 01; 182(11):1453-1454. PMID: 21757426.
      View in: PubMed
    73. El-Meanawy MA, Schelling JR, Pozuelo F, Churpek MM, Ficker EK, Iyengar S, Sedor JR. Use of serial analysis of gene expression to generate kidney expression libraries. Am J Physiol Renal Physiol. 2000 Aug; 279(2):F383-92. PMID: 10919859.
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