D000103Chemicals & DrugsD08.811.464.257.050D08.811.641.2496240.986249Acetyl-CoA Carboxylaseplugins:TwitterTwitterprns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonMichaelCharltonMichael Charlton0.000000000000000.000000000000003423Charlton, MichaelProfessor1.988890.03314076research area of0.6748870.059705925subject area forMolecular Genetics and Cell BiologyMedicine-Gastroenterology29772612Jang S, Gornicki P, Marjanovic J, Bass E, P Iurcotta T, Rodriguez P, Austin J, Haselkorn RFEBS lettersActivity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor. FEBS Lett. 2018 06; 592(12):2048-2058.FEBS Lett2018-06-08T00:00:002018Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor.30059671Loomba R, Kayali Z, Noureddin M, Ruane P, Lawitz EJ, Bennett M, Wang L, Harting E, Tarrant JM, McColgan BJ, Chung C, Ray AS, Subramanian GM, Myers RP, Middleton MS, Lai M, Charlton M, Harrison SAGastroenterologyGS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2018 11; 155(5):1463-1473.e6.Gastroenterology2018-07-27T00:00:002018GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease.JothamAustinJotham Austin0.000000000000000.000000000000002979Austin, JothamResearch Associate ProfessorOphthalmology and Visual Science20439761Marjanovic J, Chalupska D, Patenode C, Coster A, Arnold E, Ye A, Anesi G, Lu Y, Okun I, Tkachenko S, Haselkorn R, Gornicki PProceedings of the National Academy of Sciences of the United States of AmericaRecombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity. Proc Natl Acad Sci U S A. 2010 May 18; 107(20):9093-8.Proc Natl Acad Sci U S A2010-05-03T00:00:002010Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity.https://ophthalmology.uchicago.edu/Department of OphthalmologyUChicagoOVS MedicineMol Gen/Cell BioUniversity of ChicagoRobertHaselkornRobert Haselkorn41.78927490000000-87.601250000000001490Haselkorn, RobertProfessor EmeritusRimaMcLeodxW9qB6QaHczbgn4qdUXm+mb7+MTz7LFLRima McLeod41.78927490000000-87.601250000000002187McLeod, RimaProfessorYusukeNakamuraYusuke Nakamura41.78927490000000-87.60125000000000582Nakamura, YusukeEmeritus/Emerita, Professortrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1ProfessorProfessortrue1Professor EmeritusProfessor Emeritustrue1Research Associate ProfessorResearch Associate Professortrue1ProfessorProfessor20168990Maeda S, Kobayashi MA, Araki S, Babazono T, Freedman BI, Bostrom MA, Cooke JN, Toyoda M, Umezono T, Tarnow L, Hansen T, Gaede P, Jorsal A, Ng DP, Ikeda M, Yanagimoto T, Tsunoda T, Unoki H, Kawai K, Imanishi M, Suzuki D, Shin HD, Park KS, Kashiwagi A, Iwamoto Y, Kaku K, Kawamori R, Parving HH, Bowden DW, Pedersen O, Nakamura YPLoS geneticsA single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. PLoS Genet. 2010 Feb 12; 6(2):e1000842.PLoS Genet2010-02-12T00:00:002010A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes.23301879Jang S, Marjanovic J, Gornicki PThe New phytologistResistance to herbicides caused by single amino acid mutations in acetyl-CoA carboxylase in resistant populations of grassy weeds. New Phytol. 2013 Mar; 197(4):1110-1116.New Phytol2013-01-10T00:00:002013Resistance to herbicides caused by single amino acid mutations in acetyl-CoA carboxylase in resistant populations of grassy weeds.