D004722Chemicals & DrugsD08.811.277.352.355.350D08.811.277.352.700.35026920.920028Endoribonucleasesplugins:TwitterTwitterprns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:mediaLinksmedia linksprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson3.222640.0048384926research area of0.95820.021036273subject area forBiochemistry and Molecular BiologyScottOakesScott Oakes41.7886000000000087.598699999999993838Oakes, ScottProfessor33564093Kim Y, Wower J, Maltseva N, Chang C, Jedrzejczak R, Wilamowski M, Kang S, Nicolaescu V, Randall G, Michalska K, Joachimiak ACommunications biologyTipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. Commun Biol. 2021 02 09; 4(1):193.Commun Biol2021-02-09T00:00:002021Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2.CassandraHayne1GpoEq8QOfnamXNnYUHhvWD+6g==Cassandra Hayne41.7886000000000087.598699999999994272Hayne, CassandraAssistant Professor33504779Pillon MC, Frazier MN, Dillard LB, Williams JG, Kocaman S, Krahn JM, Perera L, Hayne CK, Gordon J, Stewart ZD, Sobhany M, Deterding LJ, Hsu AL, Dandey VP, Borgnia MJ, Stanley RENature communicationsCryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics. Nat Commun. 2021 01 27; 12(1):636.Nat Commun2021-01-27T00:00:002021Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics.32476018Hayne CK, Schmidt CA, Haque MI, Matera AG, Stanley RENucleic acids researchReconstitution of the human tRNA splicing endonuclease complex: insight into the regulation of pre-tRNA cleavage. Nucleic Acids Res. 2020 08 20; 48(14):7609-7622.Nucleic Acids Res2020-08-20T00:00:002020Reconstitution of the human tRNA splicing endonuclease complex: insight into the regulation of pre-tRNA cleavage.http://pathology.uchicago.eduUChicago Dept of Pathologyhttp://www.oakeslab.uchicago.eduOakes Lab Websitehttps://openwetware.org/wiki/Pan_LabPan Lab sitehttps://haynelab.com/Lab Websitehttp://www.optikira.comOptiKiraTheHayneLabArgonne National LaboratoryApril 2023https://biologicalsciences.uchicago.edu/news/features/cassandra-hayne-profileBSD FeatureMay 2023https://www.nature.com/articles/s41594-023-00995-9NSMB News & Views37231153Hayne CK, Butay KJU, Stewart ZD, Krahn JM, Perera L, Williams JG, Petrovitch RM, Deterding LJ, Matera AG, Borgnia MJ, Stanley RENature structural & molecular biologyStructural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex. Nat Struct Mol Biol. 2023 06; 30(6):824-833.Nat Struct Mol Biol2023-05-25T00:00:002023Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex.PathologyUniversity of ChicagoTaoPanw2NmG6AbOfnamXNnYUHhvWD+6g==Tao Pan41.78927490000000-87.601250000000001308Pan, TaoProfessor37544645Hayne CK, Sekulovski S, Hurtig JE, Stanley RE, Trowitzsch S, van Hoof AThe Journal of biological chemistryNew insights into RNA processing by the eukaryotic tRNA splicing endonuclease. J Biol Chem. 2023 09; 299(9):105138.J Biol Chem2023-08-05T00:00:002023New insights into RNA processing by the eukaryotic tRNA splicing endonuclease.Joseph A.Piccirilli3XJgCKIcC+X5hHlsaUXv9Gq0+s+oJoseph A. Piccirilli41.78927490000000-87.60125000000000190Piccirilli, Joseph A.ProfessorAndrzejJoachimiakAndrzej Joachimiak41.78927490000000-87.60125000000000603Joachimiak, Andrzejtrue1true1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessor