LuisBarreiroLuis Barreiro41.7886000000000087.598699999999993670Barreiro, LuisFunctional Genomics, Population Genetics, Natural Selection, Innate Immunity, Population VariationOur lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.Professorplugins:FeaturedVideosFeatured Videosplugins:TwitterTwitterprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson28386004Bouziat R, Hinterleitner R, Brown JJ, Stencel-Baerenwald JE, Ikizler M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, Iskarpatyoti JA, Costes LM, Lawrence I, Palanski BA, Varma M, Zurenski MA, Khomandiak S, McAllister N, Aravamudhan P, Boehme KW, Hu F, Samsom JN, Reinecker HC, Kupfer SS, Guandalini S, Semrad CE, Abadie V, Khosla C, Barreiro LB, Xavier RJ, Ng A, Dermody TS, Jabri BScience (New York, N.Y.)Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science. 2017 04 07; 356(6333):44-50.Science2017-04-07T00:00:002017Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease.XuanyaoLiuXuanyao Liu41.7886000000000087.598699999999993540Liu, XuanyaoAssistant ProfessorChicago60637IL3.501380.00956677545research areas1.532420.029748331coauthor of157.03619.828160similar to11141selected publicationsAuthorship 1077908Medicine-GastroenterologyMedicine-Genetic MedicineMedicine-Infectious DiseasesMicrobiology29769727Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N, Bouziat R, Buscarlet M, Ringus DL, Wang Y, Li Y, Dinh V, Kim SM, McDonald BD, Zurenski MA, Musch MW, Furtado GC, Lira SA, Baier G, Chang EB, Eren AM, Weber CR, Busque L, Godley LA, Verdú EF, Barreiro LB, Jabri BNatureMicrobial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature. 2018 05; 557(7706):580-584.Nature2018-05-16T00:00:002018Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.Authorship 1098962703/2003Lusófona UniversityLisbonLusófona University, Biotechnological EngineeringMasterBiotechnological Engineering03/2008University of Paris VIIParisUniversity of Paris VII, Population GeneticsPhDPopulation Genetics02/2011University of ChicagoChicagoUniversity of Chicago, Functional GenomicsPost-docFunctional GenomicsAuthorship 1100291Authorship 1100332Authorship 11032115Authorship 1104644Authorship 1104724Authorship 1106315Authorship 1107501Authorship 11075919Authorship 11128511Authorship 11143013Authorship 1116533Authorship 1116813Authorship 1117096Authorship 11172016Authorship 1117841Authorship 11184910Authorship 11193115Authorship 11202512Authorship 1121222Authorship 1121656Authorship 1124203Authorship 1135634Authorship 11376710Authorship 11410212Authorship 1141801Authorship 1141953Authorship 11426111Authorship 1143768Authorship 1152172Authorship 1155963Authorship 11566017Authorship 1157213Authorship 1160383Authorship 1164959Authorship 1165978Authorship 1170768Authorship 11714410Authorship 11732128Authorship 1173702Authorship 1174831Authorship 1175541Authorship 1176356Authorship 1176483Authorship 11765710Authorship 1177251Authorship 1177632Authorship 1183212Authorship 11836910Authorship 1191662Authorship 1196371Authorship 1196572Authorship 1196721Authorship 1199222Authorship 11992820Authorship 12007710Authorship 1202223Authorship 1208806Authorship 12104920Authorship 1215551Authorship 1217662Authorship 12194311Authorship 1222123Authorship 1222406Authorship 1222691Authorship 1224382Authorship 1226033Authorship 1235921Authorship 1239391Authorship 1239506Authorship 1239641Authorship 1240564Authorship 1243054Authorship 1243504Authorship 12438718Authorship 12443510Authorship 1249293Authorship 1250247Authorship 125058118440271Boga JA, de Oña M, Fernández-Verdugo A, González D, Morilla A, Arias M, Barreiro L, Hidalgo F, Melón SJournal of clinical virology : the official publication of the Pan American Society for Clinical VirologyMolecular identification of two genotypes of mumps virus causing two regional outbreaks in Asturias, Spain. J Clin Virol. 2008 Aug; 42(4):425-8.J Clin Virol2008-04-28T00:00:002008Molecular identification of two genotypes of mumps virus causing two regional outbreaks in Asturias, Spain.21448974Manry J, Laval G, Patin E, Fornarino S, Tichit M, Bouchier C, Barreiro LB, Quintana-Murci LHuman mutationEvolutionary genetics evidence of an essential, nonredundant role of the IFN-? pathway in protective immunity. Hum Mutat. 2011 Jun; 32(6):633-42.Hum Mutat2011-03-29T00:00:002011Evolutionary genetics evidence of an essential, nonredundant role of the IFN-? pathway in protective immunity.27856275Cortes M, Cao M, Liu HL, Burns P, Moore C, Fecteau G, Desrochers A, Barreiro LB, Antel JP, Frasch MGJournal of neuroscience methodsRNAseq profiling of primary microglia and astrocyte cultures in near-term ovine fetus: A glial in vivo-in vitro multi-hit paradigm in large mammalian brain. J Neurosci Methods. 2017 01 30; 276:23-32.J Neurosci Methods2016-11-14T00:00:002016RNAseq profiling of primary microglia and astrocyte cultures in near-term ovine fetus: A glial in vivo-in vitro multi-hit paradigm in large mammalian brain.22162829Manry J, Laval G, Patin E, Fornarino S, Itan Y, Fumagalli M, Sironi M, Tichit M, Bouchier C, Casanova JL, Barreiro LB, Quintana-Murci LThe Journal of experimental medicineEvolutionary genetic dissection of human interferons. J Exp Med. 2011 Dec 19; 208(13):2747-59.J Exp Med2011-12-12T00:00:002011Evolutionary genetic dissection of human interferons.26769983Snyder-Mackler N, Kohn JN, Barreiro LB, Johnson ZP, Wilson ME, Tung JAnimal behaviourSocial status drives social relationships in groups of unrelated female rhesus macaques. Anim Behav. 2016 Jan 01; 111:307-317.Anim Behav2016-01-01T00:00:002016Social status drives social relationships in groups of unrelated female rhesus macaques.18082570Ben-Ali M, Barreiro LB, Chabbou A, Haltiti R, Braham E, Neyrolles O, Dellagi K, Gicquel B, Quintana-Murci L, Barbouche MRHuman immunologyPromoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients. Hum Immunol. 2007 Nov; 68(11):908-12.Hum Immunol2007-10-05T00:00:002007Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients.19360089Patin E, Laval G, Barreiro LB, Salas A, Semino O, Santachiara-Benerecetti S, Kidd KK, Kidd JR, Van der Veen L, Hombert JM, Gessain A, Froment A, Bahuchet S, Heyer E, Quintana-Murci LPLoS geneticsInferring the demographic history of African farmers and pygmy hunter-gatherers using a multilocus resequencing data set. PLoS Genet. 2009 Apr; 5(4):e1000448.PLoS Genet2009-04-10T00:00:002009Inferring the demographic history of African farmers and pygmy hunter-gatherers using a multilocus resequencing data set.29328912Kaufmann E, Sanz J, Dunn JL, Khan N, Mendonça LE, Pacis A, Tzelepis F, Pernet E, Dumaine A, Grenier JC, Mailhot-Léonard F, Ahmed E, Belle J, Besla R, Mazer B, King IL, Nijnik A, Robbins CS, Barreiro LB, Divangahi MCellBCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis. Cell. 2018 01 11; 172(1-2):176-190.e19.Cell2018-01-11T00:00:002018BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis.28923540Tung J, Barreiro LBCurrent opinion in genetics & developmentThe contribution of admixture to primate evolution. Curr Opin Genet Dev. 2017 Dec; 47:61-68.Curr Opin Genet Dev2017-09-15T00:00:002017The contribution of admixture to primate evolution.16252244Barreiro LB, Patin E, Neyrolles O, Cann HM, Gicquel B, Quintana-Murci LAmerican journal of human geneticsThe heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region. Am J Hum Genet. 2005 Nov; 77(5):869-86.Am J Hum Genet2005-09-29T00:00:002005The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region.16991095Barreiro LB, Quintana-Murci LThe Journal of infectious diseasesDC-SIGNR neck-region polymorphisms and HIV-1 susceptibility: From population stratification to a possible advantage of the 7/5 heterozygous genotype. J Infect Dis. 2006 Oct 15; 194(8):1184-5; author reply 1185-7.J Infect Dis2006-10-15T00:00:002006DC-SIGNR neck-region polymorphisms and HIV-1 susceptibility: From population stratification to a possible advantage of the 7/5 heterozygous genotype.27001747Langlais D, Barreiro LB, Gros PThe Journal of experimental medicineThe macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation. J Exp Med. 2016 Apr 04; 213(4):585-603.J Exp Med2016-03-21T00:00:002016The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.17030567Rosas-Magallanes V, Stadthagen-Gomez G, Rauzier J, Barreiro LB, Tailleux L, Boudou F, Griffin R, Nigou J, Jackson M, Gicquel B, Neyrolles OInfection and immunitySignature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages. Infect Immun. 2007 Jan; 75(1):504-7.Infect Immun2006-10-09T00:00:002006Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages.27604870Bouttier M, Laperriere D, Memari B, Mangiapane J, Fiore A, Mitchell E, Verway M, Behr MA, Sladek R, Barreiro LB, Mader S, White JHNucleic acids researchAlu repeats as transcriptional regulatory platforms in macrophage responses to M. tuberculosis infection. Nucleic Acids Res. 2016 12 15; 44(22):10571-10587.Nucleic Acids Res2016-09-06T00:00:002016Alu repeats as transcriptional regulatory platforms in macrophage responses to M. tuberculosis infection.28473590Patin E, Lopez M, Grollemund R, Verdu P, Harmant C, Quach H, Laval G, Perry GH, Barreiro LB, Froment A, Heyer E, Massougbodji A, Fortes-Lima C, Migot-Nabias F, Bellis G, Dugoujon JM, Pereira JB, Fernandes V, Pereira L, Van der Veen L, Mouguiama-Daouda P, Bustamante CD, Hombert JM, Quintana-Murci LScience (New York, N.Y.)Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America. Science. 2017 05 05; 356(6337):543-546.Science2017-05-05T00:00:002017Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America.18246066Barreiro LB, Laval G, Quach H, Patin E, Quintana-Murci LNature geneticsNatural selection has driven population differentiation in modern humans. Nat Genet. 2008 Mar; 40(3):340-5.Nat Genet2008-02-03T00:00:002008Natural selection has driven population differentiation in modern humans.19657388Ravel C, Chantot-Bastaraud S, Chalmey C, Barreiro L, Aknin-Seifer I, Pfeffer J, Berthaut I, Mathieu EE, Mandelbaum J, Siffroi JP, McElreavey K, Bashamboo APloS oneLack of association between genetic polymorphisms in enzymes associated with folate metabolism and unexplained reduced sperm counts. PLoS One. 2009 Aug 06; 4(8):e6540.PLoS One2009-08-06T00:00:002009Lack of association between genetic polymorphisms in enzymes associated with folate metabolism and unexplained reduced sperm counts.19953080Barreiro LB, Quintana-Murci LNature reviews. GeneticsFrom evolutionary genetics to human immunology: how selection shapes host defence genes. Nat Rev Genet. 2010 Jan; 11(1):17-30.Nat Rev Genet2009-12-01T00:00:002009From evolutionary genetics to human immunology: how selection shapes host defence genes.29531345Lopez M, Kousathanas A, Quach H, Harmant C, Mouguiama-Daouda P, Hombert JM, Froment A, Perry GH, Barreiro LB, Verdu P, Patin E, Quintana-Murci LNature ecology & evolutionThe demographic history and mutational load of African hunter-gatherers and farmers. Nat Ecol Evol. 2018 04; 2(4):721-730.Nat Ecol Evol2018-03-12T00:00:002018The demographic history and mutational load of African hunter-gatherers and farmers.21618349Ben-Ali M, Corre B, Manry J, Barreiro LB, Quach H, Boniotto M, Pellegrini S, Quintana-Murci LHuman mutationFunctional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family. Hum Mutat. 2011 Jun; 32(6):643-52.Hum Mutat2011-06-01T00:00:002011Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family.25533784Mandl JN, Ahmed R, Barreiro LB, Daszak P, Epstein JH, Virgin HW, Feinberg MBCellReservoir host immune responses to emerging zoonotic viruses. Cell. 2015 Jan 15; 160(1-2):20-35.Cell2014-12-18T00:00:002014Reservoir host immune responses to emerging zoonotic viruses.16698431Barreiro LB, Quach H, Krahenbuhl J, Khaliq S, Mohyuddin A, Mehdi SQ, Gicquel B, Neyrolles O, Quintana-Murci LHuman immunologyDC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population. Hum Immunol. 2006 Jan-Feb; 67(1-2):102-7.Hum Immunol2006-04-05T00:00:002006DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population.26300730Cao M, Cortes M, Moore CS, Leong SY, Durosier LD, Burns P, Fecteau G, Desrochers A, Auer RN, Barreiro LB, Antel JP, Frasch MGFrontiers in cellular neuroscienceFetal microglial phenotype in vitro carries memory of prior in vivo exposure to inflammation. Front Cell Neurosci. 2015; 9:294.Front Cell Neurosci2015-08-04T00:00:002015Fetal microglial phenotype in vitro carries memory of prior in vivo exposure to inflammation.29924972Randolph HE, Barreiro LBImmunityHoly Immune Tolerance, Batman! Immunity. 2018 06 19; 48(6):1074-1076.Immunity2018-06-19T00:00:002018Holy Immune Tolerance, Batman!21175682Quintana-Murci L, Barreiro LBAnnals of the New York Academy of SciencesThe role played by natural selection on Mendelian traits in humans. Ann N Y Acad Sci. 2010 Dec; 1214:1-17.Ann N Y Acad Sci2010-12-01T00:00:002010The role played by natural selection on Mendelian traits in humans.24604822Dubois-Colas N, Petit-Jentreau L, Barreiro LB, Durand S, Soubigou G, Lecointe C, Klibi J, Rezaï K, Lokiec F, Coppée JY, Gicquel B, Tailleux LThe Journal of infectious diseasesExtracellular adenosine triphosphate affects the response of human macrophages infected with Mycobacterium tuberculosis. J Infect Dis. 2014 Sep 01; 210(5):824-33.J Infect Dis2014-03-05T00:00:002014Extracellular adenosine triphosphate affects the response of human macrophages infected with Mycobacterium tuberculosis.20421973Laval G, Patin E, Barreiro LB, Quintana-Murci LPloS oneFormulating a historical and demographic model of recent human evolution based on resequencing data from noncoding regions. PLoS One. 2010 Apr 22; 5(4):e10284.PLoS One2010-04-22T00:00:002010Formulating a historical and demographic model of recent human evolution based on resequencing data from noncoding regions.25458997Brinkworth JF, Barreiro LBCurrent opinion in immunologyThe contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease. Curr Opin Immunol. 2014 Dec; 31:66-78.Curr Opin Immunol2014-10-22T00:00:002014The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease.25774601Tung J, Barreiro LB, Burns MB, Grenier JC, Lynch J, Grieneisen LE, Altmann J, Alberts SC, Blekhman R, Archie EAeLifeSocial networks predict gut microbiome composition in wild baboons. Elife. 2015 Mar 16; 4.Elife2015-03-16T00:00:002015Social networks predict gut microbiome composition in wild baboons.17872438Zhang SY, Jouanguy E, Ugolini S, Smahi A, Elain G, Romero P, Segal D, Sancho-Shimizu V, Lorenzo L, Puel A, Picard C, Chapgier A, Plancoulaine S, Titeux M, Cognet C, von Bernuth H, Ku CL, Casrouge A, Zhang XX, Barreiro L, Leonard J, Hamilton C, Lebon P, Héron B, Vallée L, Quintana-Murci L, Hovnanian A, Rozenberg F, Vivier E, Geissmann F, Tardieu M, Abel L, Casanova JLScience (New York, N.Y.)TLR3 deficiency in patients with herpes simplex encephalitis. Science. 2007 Sep 14; 317(5844):1522-7.Science2007-09-14T00:00:002007TLR3 deficiency in patients with herpes simplex encephalitis.22915823Goyette G, Boulais J, Carruthers NJ, Landry CR, Jutras I, Duclos S, Dermine JF, Michnick SW, LaBoissière S, Lajoie G, Barreiro L, Thibault P, Desjardins MMolecular & cellular proteomics : MCPProteomic characterization of phagosomal membrane microdomains during phagolysosome biogenesis and evolution. Mol Cell Proteomics. 2012 Nov; 11(11):1365-77.Mol Cell Proteomics2012-08-20T00:00:002012Proteomic characterization of phagosomal membrane microdomains during phagolysosome biogenesis and evolution.25240536Barreiro LB, Quintana-Murci LCurrent opinion in immunologyEditorial Overview: immunogenetics and transplantation: bringing evolution and genomics to human immunology. Curr Opin Immunol. 2014 Oct; 30:v-vii.Curr Opin Immunol2014-09-17T00:00:002014Editorial Overview: immunogenetics and transplantation: bringing evolution and genomics to human immunology.23874223Orlova M, Cobat A, Huong NT, Ba NN, Van Thuc N, Spencer J, Nédélec Y, Barreiro L, Thai VH, Abel L, Alcaïs A, Schurr EPLoS geneticsGene set signature of reversal reaction type I in leprosy patients. PLoS Genet. 2013; 9(7):e1003624.PLoS Genet2013-07-11T00:00:002013Gene set signature of reversal reaction type I in leprosy patients.24694833Fagny M, Patin E, Enard D, Barreiro LB, Quintana-Murci L, Laval GMolecular biology and evolutionExploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets. Mol Biol Evol. 2014 Jul; 31(7):1850-68.Mol Biol Evol2014-04-01T00:00:002014Exploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets.19609346Barreiro LB, Ben-Ali M, Quach H, Laval G, Patin E, Pickrell JK, Bouchier C, Tichit M, Neyrolles O, Gicquel B, Kidd JR, Kidd KK, Alcaïs A, Ragimbeau J, Pellegrini S, Abel L, Casanova JL, Quintana-Murci LPLoS geneticsEvolutionary dynamics of human Toll-like receptors and their different contributions to host defense. PLoS Genet. 2009 Jul; 5(7):e1000562.PLoS Genet2009-07-17T00:00:002009Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense.29960896Sanz J, Randolph HE, Barreiro LBCurrent opinion in genetics & developmentGenetic and evolutionary determinants of human population variation in immune responses. Curr Opin Genet Dev. 2018 12; 53:28-35.Curr Opin Genet Dev2018-06-28T00:00:002018Genetic and evolutionary determinants of human population variation in immune responses.27528013Blekhman R, Tang K, Archie EA, Barreiro LB, Johnson ZP, Wilson ME, Kohn J, Yuan ML, Gesquiere L, Grieneisen LE, Tung JScientific reportsCommon methods for fecal sample storage in field studies yield consistent signatures of individual identity in microbiome sequencing data. Sci Rep. 2016 08 16; 6:31519.Sci Rep2016-08-16T00:00:002016Common methods for fecal sample storage in field studies yield consistent signatures of individual identity in microbiome sequencing data.24981784Pacis A, Nédélec Y, Barreiro LBCurrent opinion in immunologyWhen genetics meets epigenetics: deciphering the mechanisms controlling inter-individual variation in immune responses to infection. Curr Opin Immunol. 2014 Aug; 29:119-26.Curr Opin Immunol2014-06-28T00:00:002014When genetics meets epigenetics: deciphering the mechanisms controlling inter-individual variation in immune responses to infection.27690314Pai AA, Baharian G, Pagé Sabourin A, Brinkworth JF, Nédélec Y, Foley JW, Grenier JC, Siddle KJ, Dumaine A, Yotova V, Johnson ZP, Lanford RE, Burge CB, Barreiro LBPLoS geneticsWidespread Shortening of 3' Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection. PLoS Genet. 2016 Sep; 12(9):e1006338.PLoS Genet2016-09-30T00:00:002016Widespread Shortening of 3' Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection.27709125Richards AL, Burns MB, Alazizi A, Barreiro LB, Pique-Regi R, Blekhman R, Luca FmSystemsGenetic and transcriptional analysis of human host response to healthy gut microbiota. mSystems. 2016 Jul-Aug; 1(4).mSystems2016-08-30T00:00:002016Genetic and transcriptional analysis of human host response to healthy gut microbiota.18510454Zhang J, Zhang X, Fu J, Bi Z, Arheart KL, Barreiro LB, Quintana-Murci L, Pahwa S, Liu HThe Journal of infectious diseasesProtective role of DC-SIGN (CD209) neck-region alleles with <5 repeat units in HIV-1 transmission. J Infect Dis. 2008 Jul 01; 198(1):68-71.J Infect Dis2008-07-01T00:00:002008Protective role of DC-SIGN (CD209) neck-region alleles with <5 repeat units in HIV-1 transmission.26334641Gross JA, Pacis A, Chen GG, Barreiro LB, Ernst C, Turecki GBMC genomicsCharacterizing 5-hydroxymethylcytosine in human prefrontal cortex at single base resolution. BMC Genomics. 2015 Sep 03; 16:672.BMC Genomics2015-09-03T00:00:002015Characterizing 5-hydroxymethylcytosine in human prefrontal cortex at single base resolution.23415668Grant AV, El Baghdadi J, Sabri A, El Azbaoui S, Alaoui-Tahiri K, Abderrahmani Rhorfi I, Gharbaoui Y, Abid A, Benkirane M, Raharimanga V, Richard V, Orlova M, Boland A, Migaud M, Okada S, Nolan DK, Bustamante J, Barreiro LB, Schurr E, Boisson-Dupuis S, Rasolofo V, Casanova JL, Abel LAmerican journal of human geneticsAge-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region. Am J Hum Genet. 2013 Mar 07; 92(3):407-14.Am J Hum Genet2013-02-14T00:00:002013Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region.24482540Siddle KJ, Deschamps M, Tailleux L, Nédélec Y, Pothlichet J, Lugo-Villarino G, Libri V, Gicquel B, Neyrolles O, Laval G, Patin E, Barreiro LB, Quintana-Murci LGenome researchA genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection. Genome Res. 2014 May; 24(5):850-9.Genome Res2014-01-30T00:00:002014A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection.17321900Barreiro LB, Neyrolles O, Babb CL, van Helden PD, Gicquel B, Hoal EG, Quintana-Murci LHuman immunologyLength variation of DC-SIGN and L-SIGN neck-region has no impact on tuberculosis susceptibility. Hum Immunol. 2007 Feb; 68(2):106-12.Hum Immunol2006-12-04T00:00:002006Length variation of DC-SIGN and L-SIGN neck-region has no impact on tuberculosis susceptibility.25562320Tzelepis F, Verway M, Daoud J, Gillard J, Hassani-Ardakani K, Dunn J, Downey J, Gentile ME, Jaworska J, Sanchez AM, Nédélec Y, Vali H, Tabrizian M, Kristof AS, King IL, Barreiro LB, Divangahi MThe Journal of clinical investigationAnnexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection. J Clin Invest. 2015 Feb; 125(2):752-68.J Clin Invest2014-12-22T00:00:002014Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection.28878260Cortes M, Cao M, Liu HL, Moore CS, Durosier LD, Burns P, Fecteau G, Desrochers A, Barreiro LB, Antel JP, Frasch MGScientific reportsa7 nicotinic acetylcholine receptor signaling modulates the inflammatory phenotype of fetal brain microglia: first evidence of interference by iron homeostasis. Sci Rep. 2017 09 06; 7(1):10645.Sci Rep2017-09-06T00:00:002017a7 nicotinic acetylcholine receptor signaling modulates the inflammatory phenotype of fetal brain microglia: first evidence of interference by iron homeostasis.27885030Snyder-Mackler N, Sanz J, Kohn JN, Brinkworth JF, Morrow S, Shaver AO, Grenier JC, Pique-Regi R, Johnson ZP, Wilson ME, Barreiro LB, Tung JScience (New York, N.Y.)Social status alters immune regulation and response to infection in macaques. Science. 2016 11 25; 354(6315):1041-1045.Science2016-11-25T00:00:002016Social status alters immune regulation and response to infection in macaques.27768889Nédélec Y, Sanz J, Baharian G, Szpiech ZA, Pacis A, Dumaine A, Grenier JC, Freiman A, Sams AJ, Hebert S, Pagé Sabourin A, Luca F, Blekhman R, Hernandez RD, Pique-Regi R, Tung J, Yotova V, Barreiro LBCellGenetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens. 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Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1204-9.Proc Natl Acad Sci U S A2012-01-10T00:00:002012Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.Authorship 151215734822289Randolph HE, Fiege JK, Thielen BK, Mickelson CK, Shiratori M, Barroso-Batista J, Langlois RA, Barreiro LBScience (New York, N.Y.)Genetic ancestry effects on the response to viral infection are pervasive but cell type specific. 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Series B, Biological sciencesAgonism and grooming behaviour explain social status effects on physiology and gene regulation in rhesus macaques. Philos Trans R Soc Lond B Biol Sci. 2022 02 28; 377(1845):20210132.Philos Trans R Soc Lond B Biol Sci2022-01-10T00:00:002022Agonism and grooming behaviour explain social status effects on physiology and gene regulation in rhesus macaques.Authorship 152272835058614Kaufmann E, Landekic M, Downey J, Chronopoulos J, Teimouri Nezhad S, Tran K, Vinh DC, Barreiro LB, Divangahi MNature immunologyLack of evidence for intergenerational inheritance of immune resistance to infections. Nat Immunol. 2022 02; 23(2):203-207.Nat Immunol2022-01-20T00:00:002022Lack of evidence for intergenerational inheritance of immune resistance to infections.Authorship 152394635068060Trigodet F, Lolans K, Fogarty E, Shaiber A, Morrison HG, Barreiro L, Jabri B, Eren AMMolecular ecology resourcesHigh molecular weight DNA extraction strategies for long-read sequencing of complex metagenomes. Mol Ecol Resour. 2022 Jul; 22(5):1786-1802.Mol Ecol Resour2022-02-07T00:00:002022High molecular weight DNA extraction strategies for long-read sequencing of complex metagenomes.AdaWeinstockAda Weinstock41.7886000000000087.598699999999994155Weinstock, AdaAssistant ProfessorAuthorship 1551631535654895Björk JR, Dasari MR, Roche K, Grieneisen L, Gould TJ, Grenier JC, Yotova V, Gottel N, Jansen D, Gesquiere LR, Gordon JB, Learn NH, Wango TL, Mututua RS, Kinyua Warutere J, Siodi L, Mukherjee S, Barreiro LB, Alberts SC, Gilbert JA, Tung J, Blekhman R, Archie EANature ecology & evolutionSynchrony and idiosyncrasy in the gut microbiome of wild baboons. Nat Ecol Evol. 2022 07; 6(7):955-964.Nat Ecol Evol2022-06-02T00:00:002022Synchrony and idiosyncrasy in the gut microbiome of wild baboons.Authorship 155402735732121Downey J, Randolph HE, Pernet E, Tran KA, Khader SA, King IL, Barreiro LB, Divangahi MCell reportsMitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus. Cell Rep. 2022 06 21; 39(12):110974.Cell Rep2022-06-21T00:00:002022Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus.RanBlekhmanRan Blekhman41.7886000000000087.598699999999994200Blekhman, RanAssociate ProfessorShabaanaKhaderShabaana Khader41.7886000000000087.598699999999994229Khader, ShabaanaProfessorAuthorship 15871628Authorship 15923424Authorship 15984512Authorship 1591461935987350Labrosse R, Boufaied I, Bourdin B, Gona S, Randolph HE, Logan BR, Bourbonnais S, Berthe C, Chan W, Buckley RH, Parrott RE, Cuvelier GDE, Kapoor N, Chandra S, Dávila Saldaña BJ, Eissa H, Goldman FD, Heimall J, O'Reilly R, Chaudhury S, Kolb EA, Shenoy S, Griffith LM, Pulsipher M, Kohn DB, Notarangelo LD, Pai SY, Cowan MJ, Dvorak CC, Haddad É, Puck JM, Barreiro LB, Decaluwe HThe Journal of allergy and clinical immunologyAberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation. J Allergy Clin Immunol. 2023 01; 151(1):260-271.J Allergy Clin Immunol2022-08-17T00:00:002022Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation.36630917Earley ZM, Lisicka W, Sifakis JJ, Aguirre-Gamboa R, Kowalczyk A, Barlow JT, Shaw DG, Discepolo V, Tan IL, Gona S, Ernest JD, Matzinger P, Barreiro LB, Morgun A, Bendelac A, Ismagilov RF, Shulzhenko N, Riesenfeld SJ, Jabri BImmunityGATA4 controls regionalization of tissue immunity and commensal-driven immunopathology. Immunity. 2023 01 10; 56(1):43-57.e10.Immunity2023-01-10T00:00:002023GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology.36599368Pernet E, Sun S, Sarden N, Gona S, Nguyen A, Khan N, Mawhinney M, Tran KA, Chronopoulos J, Amberkar D, Sadeghi M, Grant A, Wali S, Prevel R, Ding J, Martin JG, Thanabalasuriar A, Yipp BG, Barreiro LB, Divangahi MNatureNeonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE. Nature. 2023 02; 614(7948):530-538.Nature2023-01-04T00:00:002023Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE.36261521Klunk J, Vilgalys TP, Demeure CE, Cheng X, Shiratori M, Madej J, Beau R, Elli D, Patino MI, Redfern R, DeWitte SN, Gamble JA, Boldsen JL, Carmichael A, Varlik N, Eaton K, Grenier JC, Golding GB, Devault A, Rouillard JM, Yotova V, Sindeaux R, Ye CJ, Bikaran M, Dumaine A, Brinkworth JF, Missiakas D, Rouleau GA, Steinrücken M, Pizarro-Cerdá J, Poinar HN, Barreiro LBNatureEvolution of immune genes is associated with the Black Death. Nature. 2022 Nov; 611(7935):312-319.Nature2022-10-19T00:00:002022Evolution of immune genes is associated with the Black Death.Authorship 1609121236776396Mendonca LE, Pernet E, Khan N, Sanz J, Kaufmann E, Downey J, Grant A, Orlova M, Schurr E, Krawczyk C, Jones RG, Barreiro LB, Divangahi MFrontiers in immunologyHuman alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection. Front Immunol. 2022; 13:1044592.Front Immunol2023-01-26T00:00:002023Human alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection.http://luis-barreirolab.orgBarreiro Labhttps://pamerlab.uchicago.eduPamer Lab websitehttps://wlab.bioWeinstein Lab at UChicagohttp://dfi.uchicago.eduDuchossois Family Institutehttp://networks-liulab.org/Liu Lab Network websitehttps://sites.google.com/view/andywdahl/homeSubtype Lab Sitehttps://scholar.google.com/citations?user=luKT8JwAAAAJ&hl=enGoogle Scholarhttp://blekhmanlab.orgBlekhman Lab Websitehttps://voices.uchicago.edu/liulab/Xuanyao Liu's Lab@LB_Barreiroblekhman@xuanyaoliu24935923Orbelyan GA, Tang F, Sally B, Solus J, Meresse B, Ciszewski C, Grenier JC, Barreiro LB, Lanier LL, Jabri BJournal of immunology (Baltimore, Md. : 1950)Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12. J Immunol. 2014 Jul 15; 193(2):610-6.J Immunol2014-06-16T00:00:002014Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12.2017-09-14NIHTUNG, JENNY2012-09-01Stress and the Genome: Testing the Impact of Social Effects on Gene RegulationR01GM1025622022-05-31NIHTUNG, JENNY2017-09-15Stress and the Genome: Testing the Impact of Social Effects on Gene RegulationR01AG0572352024-05-31NIHBARREIRO, LUIS BRUNO2019-09-01Characterizing the impact of Yersinia Pestis to the phenotypic evolution of the human immune systemR01GM134376Co-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorD007113Physiology1664050.76086Immunity, InnateD014376Disorders391080.876943TuberculosisAuthorship 1629232Authorship 16306132Authorship 1632003Authorship 161990337094265Demeure CE, Poinar H, Barreiro L, Pizarro-Cerdá JMedecine sciences : M/S[The Black Death, natural selection and susceptibility to auto-immune disorders]. Med Sci (Paris). 2023 04; 39(4):331-333.Med Sci (Paris)2023-04-24T00:00:002023[The Black Death, natural selection and susceptibility to auto-immune disorders].37158607Roche KE, Bjork JR, Dasari MR, Grieneisen L, Jansen D, Gould TJ, Gesquiere LR, Barreiro LB, Alberts SC, Blekhman R, Gilbert JA, Tung J, Mukherjee S, Archie EAeLifeUniversal gut microbial relationships in the gut microbiome of wild baboons. Elife. 2023 05 09; 12.Elife2023-05-09T00:00:002023Universal gut microbial relationships in the gut microbiome of wild baboons.36999024Sun S, Aguirre-Gamboa R, Barreiro LBFrontiers in immunologyTransmission of stimulus-induced epigenetic changes through cell division is coupled to continuous transcription factor activity. Front Immunol. 2023; 14:1129577.Front Immunol2023-03-14T00:00:002023Transmission of stimulus-induced epigenetic changes through cell division is coupled to continuous transcription factor activity.37066254Vilgalys TP, Klunk J, Demeure CE, Cheng X, Shiratori M, Madej J, Beau R, Elli D, Patino MI, Redfern R, DeWitte SN, Gamble JA, Boldsen JL, Carmichael A, Varlik N, Eaton K, Grenier JC, Golding GB, Devault A, Rouillard JM, Yotova V, Sindeaux R, Ye CJ, Bikaran M, Dumaine A, Brinkworth JF, Missiakas D, Rouleau GA, Steinrücken M, Pizarro-Cerdá J, Poinar HN, Barreiro LBbioRxiv : the preprint server for biologyReply to Barton et al: signatures of natural selection during the Black Death. bioRxiv. 2023 Apr 07.bioRxiv2023-04-07T00:00:002023Reply to Barton et al: signatures of natural selection during the Black Death.Authorship 1635438Authorship 1637643Authorship 16382627Authorship 1642551337228750Groza C, Chen X, Pacis A, Simon MM, Pramatarova A, Aracena KA, Pastinen T, Barreiro LB, Bourque GCell genomicsGenome graphs detect human polymorphisms in active epigenomic state during influenza infection. Cell Genom. 2023 May 10; 3(5):100294.Cell Genom2023-04-07T00:00:002023Genome graphs detect human polymorphisms in active epigenomic state during influenza infection.37228757Chen X, Pacis A, Aracena KA, Gona S, Kwan T, Groza C, Lin YL, Sindeaux R, Yotova V, Pramatarova A, Simon MM, Pastinen T, Barreiro LB, Bourque GCell genomicsTransposable elements are associated with the variable response to influenza infection. Cell Genom. 2023 May 10; 3(5):100292.Cell Genom2023-04-07T00:00:002023Transposable elements are associated with the variable response to influenza infection.37293015Johnston RA, Aracena KA, Barreiro LB, Lea AJ, Tung JbioRxiv : the preprint server for biologyDNA methylation-environment interactions in the human genome. bioRxiv. 2023 Dec 15.bioRxiv2023-12-15T00:00:002023DNA methylation-environment interactions in the human genome.37322120Shaw DG, Aguirre-Gamboa R, Vieira MC, Gona S, DiNardi N, Wang A, Dumaine A, Gelderloos-Arends J, Earley ZM, Meckel KR, Ciszewski C, Castillo A, Monroe K, Torres J, Shah SC, Colombel JF, Itzkowitz S, Newberry R, Cohen RD, Rubin DT, Quince C, Cobey S, Jonkers IH, Weber CR, Pekow J, Wilson PC, Barreiro LB, Jabri BNature medicineAntigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis. Nat Med. 2023 Jun; 29(6):1520-1529.Nat Med2023-06-15T00:00:002023Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis.Human GeneticsMedicinePathologyUniversity of ChicagoNancy JeanCox2WFmE4EXCuiXhHlsaUXv9Gq0+s+oNancy Jean Cox41.78927490000000-87.601250000000001011Cox, Nancy JeanEmeritus/EmeritaYuvalSimonsYuval Simons41.7886000000000087.598699999999994425Simons, YuvalAssistant ProfessorJonathanPritchardJonathan K. Pritchard41.78927490000000-87.601250000000001284Pritchard, JonathanPROFESSOR37577719Lougheed DR, Liu H, Aracena KA, Grégoire R, Pacis A, Pastinen T, Barreiro LB, Joly Y, Bujold D, Bourque GbioRxiv : the preprint server for biologyEpiVar Browser: advanced exploration of epigenomics data under controlled access. bioRxiv. 2023 Aug 05.bioRxiv2023-08-05T00:00:002023EpiVar Browser: advanced exploration of epigenomics data under controlled access.Authorship 166038737749209Barreiro LBNature reviews. GeneticsThe evolutionary tale of lactase persistence in humans. Nat Rev Genet. 2024 Jan; 25(1):7.Nat Rev Genet2024-01-01T00:00:002024The evolutionary tale of lactase persistence in humans.37754680Bobba S, Howard NC, Das S, Ahmed M, Khan N, Marchante I, Barreiro LB, Sanz J, Divangahi M, Khader SAInfection and immunityMycobacterium tuberculosis infection drives differential responses in the bone marrow hematopoietic stem and progenitor cells. Infect Immun. 2023 10 17; 91(10):e0020123.Infect Immun2023-09-27T00:00:002023Mycobacterium tuberculosis infection drives differential responses in the bone marrow hematopoietic stem and progenitor cells.Authorship 1666341Authorship 1666527BanaJabriBana Jabri41.78927490000000-87.601250000000002278Jabri, BanaProfessorAlexander V.Chervonsky1mFhDrMDFuL5k2lgLlPt+2z5/syyp7BaZQ==Alexander V. Chervonsky41.78927490000000-87.601250000000002315Chervonsky, Alexander V.ProfessorYusukeNakamuraYusuke Nakamura41.78927490000000-87.60125000000000582Nakamura, YusukeEmeritus/Emerita, ProfessorYoavGiladYoav Gilad41.78927490000000-87.60125000000000747Gilad, YoavProfessorhttps://weinstocklab.owlstown.netWeinstock labTwitter AWeinstockAuthorship 16875819Authorship 169011938077046Sun SJ, Aguirre-Gamboa R, de Bree LCJ, Sanz J, Dumaine A, Joosten LAB, Divangahi M, Netea MG, Barreiro LBbioRxiv : the preprint server for biologyBCG vaccination impacts the epigenetic landscape of progenitor cells in human bone marrow. bioRxiv. 2023 Nov 28.bioRxiv2023-11-28T00:00:002023BCG vaccination impacts the epigenetic landscape of progenitor cells in human bone marrow.38076828Gregory DJ, Han F, Li P, Gritsenko M, Kyle J, Riley FE, Chavez D, Yotova V, Sindeaux RHM, Hawash MBF, Xu F, Hung LY, Hayden DL, Tompkins RG, Lanford RE, Kobzik L, Hellman J, Jacobs JM, Barreiro LB, Xiao W, Warren HSmedRxiv : the preprint server for health sciencesMulti-Omic blood analysis reveals differences in innate inflammatory sensitivity between species. medRxiv. 2023 Nov 30.medRxiv2023-11-30T00:00:002023Multi-Omic blood analysis reveals differences in innate inflammatory sensitivity between species.Authorship 1691541438150367Song AT, Sindeaux RHM, Li Y, Affia H, Agnihotri T, Leclerc S, van Vliet PP, Colas M, Guimond JV, Patey N, Feulner L, Joyal JS, Haddad E, Barreiro L, Andelfinger GCell reportsDevelopmental role of macrophages modeled in human pluripotent stem cell-derived intestinal tissue. Cell Rep. 2024 01 23; 43(1):113616.Cell Rep2023-12-26T00:00:002023Developmental role of macrophages modeled in human pluripotent stem cell-derived intestinal tissue.Authorship 1692801138181740Sarkar A, McInroy CJA, Harty S, Raulo A, Ibata NGO, Valles-Colomer M, Johnson KV, Brito IL, Henrich J, Archie EA, Barreiro LB, Gazzaniga FS, Finlay BB, Koonin EV, Carmody RN, Moeller AHCellMicrobial transmission in the social microbiome and host health and disease. Cell. 2024 01 04; 187(1):17-43.Cell2024-01-04T00:00:002024Microbial transmission in the social microbiome and host health and disease.Authorship 1706933Authorship 1707162338424460Aracena KA, Lin YL, Luo K, Pacis A, Gona S, Mu Z, Yotova V, Sindeaux R, Pramatarova A, Simon MM, Chen X, Groza C, Lougheed D, Gregoire R, Brownlee D, Boye C, Pique-Regi R, Li Y, He X, Bujold D, Pastinen T, Bourque G, Barreiro LBNature geneticsEpigenetic variation impacts individual differences in the transcriptional response to influenza infection. Nat Genet. 2024 Mar; 56(3):408-419.Nat Genet2024-02-29T00:00:002024Epigenetic variation impacts individual differences in the transcriptional response to influenza infection.38407202Johnston RA, Aracena KA, Barreiro LB, Lea AJ, Tung JeLifeDNA methylation-environment interactions in the human genome. Elife. 2024 Feb 26; 12.Elife2024-02-26T00:00:002024DNA methylation-environment interactions in the human genome.38449289Lougheed DR, Liu H, Aracena KA, Grégoire R, Pacis A, Pastinen T, Barreiro LB, Joly Y, Bujold D, Bourque GBioinformatics (Oxford, England)EpiVar browser: advanced exploration of epigenomics data under controlled access. Bioinformatics. 2024 Mar 06.Bioinformatics2024-03-06T00:00:002024EpiVar browser: advanced exploration of epigenomics data under controlled access.Authorship 1707667Authorship 1709191038479480Bulut O, Kilic G, Debisarun PA, Röring RJ, Sun S, Kolkman M, van Rijssen E, Ten Oever J, Koenen H, Barreiro L, Domínguez-Andrés J, Netea MGImmunology lettersAlendronate modulates cytokine responses in healthy young individuals after BCG vaccination. Immunol Lett. 2024 Mar 11; 267:106851.Immunol Lett2024-03-11T00:00:002024Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination.true1PROFESSORPROFESSORtrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1Emeritus/EmeritaEmeritus/Emeritatrue1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessor23851028Quach H, Wilson D, Laval G, Patin E, Manry J, Guibert J, Barreiro LB, Nerrienet E, Verschoor E, Gessain A, Przeworski M, Quintana-Murci LHuman molecular geneticsDifferent selective pressures shape the evolution of Toll-like receptors in human and African great ape populations. Hum Mol Genet. 2013 Dec 01; 22(23):4829-40.Hum Mol Genet2013-07-12T00:00:002013Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations.25136101Perry GH, Foll M, Grenier JC, Patin E, Nédélec Y, Pacis A, Barakatt M, Gravel S, Zhou X, Nsobya SL, Excoffier L, Quintana-Murci L, Dominy NJ, Barreiro LBProceedings of the National Academy of Sciences of the United States of AmericaAdaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers. Proc Natl Acad Sci U S A. 2014 09 02; 111(35):E3596-603.Proc Natl Acad Sci U S A2014-08-18T00:00:002014Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers.24495941Patin E, Siddle KJ, Laval G, Quach H, Harmant C, Becker N, Froment A, Régnault B, Lemée L, Gravel S, Hombert JM, Van der Veen L, Dominy NJ, Perry GH, Barreiro LB, Verdu P, Heyer E, Quintana-Murci LNature communicationsThe impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists. Nat Commun. 2014; 5:3163.Nat Commun2014-01-01T00:00:002014The impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists.24618913Davenport ER, Mizrahi-Man O, Michelini K, Barreiro LB, Ober C, Gilad YPloS oneSeasonal variation in human gut microbiome composition. PLoS One. 2014; 9(3):e90731.PLoS One2014-03-11T00:00:002014Seasonal variation in human gut microbiome composition.101026528553Davenport ER, Cusanovich DA, Michelini K, Barreiro LB, Ober C, Gilad YPloS oneGenome-Wide Association Studies of the Human Gut Microbiota. PLoS One. 2015; 10(11):e0140301.PLoS One2015-11-03T00:00:002015Genome-Wide Association Studies of the Human Gut Microbiota.26586179Blischak JD, Tailleux L, Mitrano A, Barreiro LB, Gilad YScientific reportsMycobacterial infection induces a specific human innate immune response. Sci Rep. 2015 Nov 20; 5:16882.Sci Rep2015-11-20T00:00:002015Mycobacterial infection induces a specific human innate immune response.26392366Pacis A, Tailleux L, Morin AM, Lambourne J, MacIsaac JL, Yotova V, Dumaine A, Danckaert A, Luca F, Grenier JC, Hansen KD, Gicquel B, Yu M, Pai A, He C, Tung J, Pastinen T, Kobor MS, Pique-Regi R, Gilad Y, Barreiro LBGenome researchBacterial infection remodels the DNA methylation landscape of human dendritic cells. Genome Res. 2015 Dec; 25(12):1801-11.Genome Res2015-09-21T00:00:002015Bacterial infection remodels the DNA methylation landscape of human dendritic cells.26616214Fagny M, Patin E, MacIsaac JL, Rotival M, Flutre T, Jones MJ, Siddle KJ, Quach H, Harmant C, McEwen LM, Froment A, Heyer E, Gessain A, Betsem E, Mouguiama-Daouda P, Hombert JM, Perry GH, Barreiro LB, Kobor MS, Quintana-Murci LNature communicationsThe epigenomic landscape of African rainforest hunter-gatherers and farmers. Nat Commun. 2015 Nov 30; 6:10047.Nat Commun2015-11-30T00:00:002015The epigenomic landscape of African rainforest hunter-gatherers and farmers.