AngelaLagerAngela Lager41.7886000000000087.598699999999993711Lager, AngelaCytogeneticsMolecular GeneticsChromosome AnalysisFluorescence In Situ Hybridization (FISH)Chromosomal MicroarrayMDr. Lager’s research and clinical interests are focused on using clinical cytogenetic and molecular genetic modalities for the investigation and discovery of neoplasm-associated genetic abnormalities. She’s interested in employing sophisticated clinical laboratory diagnostics toward discovery of novel disease markers, and using these markers for patient prognosis and treatment stratification.Assistant Professorplugins:TwitterTwitterprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:middleNamemiddle name or initialvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonLindsayAlpert22NlG6QHDb35k2lgLlPt+2z5/syyp7BaZQ==Lindsay Alpert41.7886000000000087.598699999999993450Alpert, LindsayAssociate ProfessorJenniferBennettJennifer Bennett41.7886000000000087.598699999999993688Bennett, JenniferAssociate ProfessorChicago60637IL0.7829030.015524494research areas0.4919530.046590532coauthor of9.997941.6011660similar to1116selected publicationsAuthorship 11318312Authorship 1159332Authorship 1176103Authorship 1234477Authorship 123331123584611Najm FJ, Lager AM, Zaremba A, Wyatt K, Caprariello AV, Factor DC, Karl RT, Maeda T, Miller RH, Tesar PJNature biotechnologyTranscription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Nat Biotechnol. 2013 May; 31(5):426-33.Nat Biotechnol2013-04-14T00:00:002013Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.30311390Zastrow DB, Baudet H, Shen W, Thomas A, Si Y, Weaver MA, Lager AM, Liu J, Mangels R, Dwight SS, Wright MW, Dobrowolski SF, Eilbeck K, Enns GM, Feigenbaum A, Lichter-Konecki U, Lyon E, Pasquali M, Watson M, Blau N, Steiner RD, Craigen WJ, Mao R, ClinGen Inborn Errors of Metabolism Working GroupHuman mutationUnique aspects of sequence variant interpretation for inborn errors of metabolism (IEM): The ClinGen IEM Working Group and the Phenylalanine Hydroxylase Gene. Hum Mutat. 2018 11; 39(11):1569-1580.Hum Mutat2018-11-01T00:00:002018Unique aspects of sequence variant interpretation for inborn errors of metabolism (IEM): The ClinGen IEM Working Group and the Phenylalanine Hydroxylase Gene.23773267Zechel JL, Doerner SK, Lager A, Tesar PJ, Heaney JD, Nadeau JHBMC geneticsContrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis. BMC Genet. 2013 Jun 17; 14:54.BMC Genet2013-06-17T00:00:002013Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis.30213958Lager AM, Corradin OG, Cregg JM, Elitt MS, Shick HE, Clayton BLL, Allan KC, Olsen HE, Madhavan M, Tesar PJNature communicationsRapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells. Nat Commun. 2018 09 13; 9(1):3708.Nat Commun2018-09-13T00:00:002018Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells.30146490Elitt MS, Shick HE, Madhavan M, Allan KC, Clayton BLL, Weng C, Miller TE, Factor DC, Barbar L, Nawash BS, Nevin ZS, Lager AM, Li Y, Jin F, Adams DJ, Tesar PJStem cell reportsChemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease. Stem Cell Reports. 2018 09 11; 11(3):711-726.Stem Cell Reports2018-08-23T00:00:002018Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease.AndrewKoh1mlmA4F1GuTQkntjbwjr93A=Andrew Koh41.7886000000000087.598699999999993756Koh, AndrewAssistant Professor05/2015Case Western Reserve UniversityCleveland, OHCase Western Reserve University, GeneticsPhDGenetics06/2017University of Wisconsin-MadisonMadison, WIUniversity of Wisconsin-Madison, Clinical Cytogenetics and GenomicsFellowshipClinical Cytogenetics and Genomics06/2018University of Wisconsin-MadisonMadison, WIUniversity of Wisconsin-Madison, Clinical Molecular Genetics and GenomicsFellowshipClinical Molecular Genetics and GenomicsD007753ObjectsOrganizations38430.963882LaboratoriesAuthorship 1407801532913980Burkard ME, Deming DA, Parsons BM, Kenny PA, Schuh MR, Leal T, Uboha N, Lang JM, Thompson MA, Warren R, Bauman J, Mably MS, Laffin J, Paschal CR, Lager AM, Lee K, Matkowskyj KA, Buehler DG, Rehrauer WM, Kolesar JJCO precision oncologyImplementation and Clinical Utility of an Integrated Academic-Community Regional Molecular Tumor Board. JCO Precis Oncol. 2017; 1.JCO Precis Oncol2017-07-05T00:00:002017Implementation and Clinical Utility of an Integrated Academic-Community Regional Molecular Tumor Board.Authorship 141480333048355Setia N, Wang CX, Lager A, Maron S, Shroff S, Arndt N, Peterson B, Kupfer SS, Ma C, Misdraji J, Catenacci D, Hart JCancerMorphologic and molecular analysis of early-onset gastric cancer. Cancer. 2020 01 01; 127(1):103-114.Cancer2020-01-01T00:00:002020Morphologic and molecular analysis of early-onset gastric cancer.33049052Carll T, Patel A, Derman B, Hyjek E, Lager A, Wanjari P, Segal J, Odenike O, Fidai S, Arber DBlood advancesDiagnosis and treatment of mixed phenotype (T-myeloid/lymphoid) acute leukemia with novel ETV6-FGFR2 rearrangement. Blood Adv. 2020 10 13; 4(19):4924-4928.Blood Adv2020-10-13T00:00:002020Diagnosis and treatment of mixed phenotype (T-myeloid/lymphoid) acute leukemia with novel ETV6-FGFR2 rearrangement.Medicine-Hematology and OncologyD009836Anatomy291230.931365OligodendrogliaElizabethKertowidjojoElizabeth Kertowidjojo41.7886000000000087.598699999999994044Kertowidjojo, ElizabethAssistant ProfessorAuthorship 1497761034516829Scribano CM, Wan J, Esbona K, Tucker JB, Lasek A, Zhou AS, Zasadil LM, Molini R, Fitzgerald J, Lager AM, Laffin JJ, Correia-Staudt K, Wisinski KB, Tevaarwerk AJ, O'Regan R, McGregor SM, Fowler AM, Chappell RJ, Bugni TS, Burkard ME, Weaver BAScience translational medicineChromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel. Sci Transl Med. 2021 Sep 08; 13(610):eabd4811.Sci Transl Med2021-09-08T00:00:002021Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel.Authorship 1501255Authorship 150246734625620Gutiontov SI, Turchan WT, Spurr LF, Rouhani SJ, Chervin CS, Steinhardt G, Lager AM, Wanjari P, Malik R, Connell PP, Chmura SJ, Juloori A, Hoffman PC, Ferguson MK, Donington JS, Patel JD, Vokes EE, Weichselbaum RR, Bestvina CM, Segal JP, Pitroda SPScientific reportsCDKN2A loss-of-function predicts immunotherapy resistance in non-small cell lung cancer. Sci Rep. 2021 10 08; 11(1):20059.Sci Rep2021-10-08T00:00:002021CDKN2A loss-of-function predicts immunotherapy resistance in non-small cell lung cancer.Authorship 153340935171727Kaumeyer B, Fidai S, Sukhanova M, Yap KL, Segal J, Raca G, Stock W, McNeer J, Lager AM, Gurbuxani SLeukemia & lymphomaMUC4 expression by immunohistochemistry is a specific marker for BCR-ABL1+ and BCR-ABL1-like B-lymphoblastic leukemia. Leuk Lymphoma. 2022 06; 63(6):1436-1444.Leuk Lymphoma2022-02-16T00:00:002022MUC4 expression by immunohistochemistry is a specific marker for BCR-ABL1+ and BCR-ABL1-like B-lymphoblastic leukemia.Authorship 155386335719104Symes E, Wang P, Lager AM, Bishop MR, Aqil B, Venkataraman GLeukemia & lymphomaTP53/PLCG2-mutated diffuse large B-cell lymphoma richter transformation (DLBCL-RT) of CLL with unusual CD2 and PD-1 expression. Leuk Lymphoma. 2022 11; 63(11):2735-2738.Leuk Lymphoma2022-06-18T00:00:002022TP53/PLCG2-mutated diffuse large B-cell lymphoma richter transformation (DLBCL-RT) of CLL with unusual CD2 and PD-1 expression.D039904Anatomy26310.972815Pluripotent Stem CellsVishnu AmaramSamara Simha Subhash ChandraVishnu Amaram Samara Simha Subhash Chandra41.7886000000000087.598699999999994214Samara Simha Subhash Chandra, Vishnu AmaramAssistant ProfessorD054198Disorders723690.731498Precursor Cell Lymphoblastic Leukemia-LymphomaD019070Concepts & Ideas1182730.887941Cell Lineagehttps://cgh.uchicago.edu/page/leadershipGlobal Healthhttps://www.uchicagomedicine.org/find-a-physician/physician/olufunmilayo-i-olopadeUChicago Medicinehttps://drewkohlab.org/Koh Labhttps://cancerbio.uchicago.edu/program/faculty/olufunmilayo-olopadeCancer Biologyhttps://www.uchicagomedicine.org/conditions-services/cancer/cancer-risk-preventionCancer Risk and Preventionhttps://imagebank.hematology.org/ASH Image Bankhttps://cytogenetics-sites.uchicago.edu/page/cancer-cytogenetics-laboratoryThe University of Chicago Cancer Cytogenetics Laboratory@gvencut1Authorship 163176437139596Stubbins RJ, Asom AS, Wang P, Lager AM, Gary A, Godley LAHaematologicaGermline loss-of-function BRCA1 and BRCA2 mutations and risk of de novo hematopoietic malignancies. Haematologica. 2024 Jan 01; 109(1):351-356.Haematologica2024-01-01T00:00:002024Germline loss-of-function BRCA1 and BRCA2 mutations and risk of de novo hematopoietic malignancies.CanerSayginCaner Saygin41.7886000000000087.598699999999994321Saygin, CanerAssistant ProfessorMedicinePathologyUniversity of ChicagoLucyGodley22VmD60QeczMknJtY0fp/Cv/+94=Lucy Godley41.78927490000000-87.601250000000001017Godley, LucyProfessorRichard A.LarsonRichard A. Larson41.78927490000000-87.601250000000001169Larson, Richard A.Professor37614113Rohrer CT, Lager AM, Brooks EG, Horner VLJournal of forensic sciencesPostmortem genetic testing in sudden unexplained death: A public health laboratory experience. J Forensic Sci. 2023 Nov; 68(6):2065-2075.J Forensic Sci2023-08-23T00:00:002023Postmortem genetic testing in sudden unexplained death: A public health laboratory experience.Authorship 1661162WendyStockwHF9BKIeOfnamXNnYUHhvWD+6g==Wendy Stock41.78927490000000-87.601250000000001502Stock, WendyProfessorRaviSalgiaRavi Salgia41.78927490000000-87.601250000000001937Salgia, RaviEmeritus/Emerita, ProfessorOlufunmilayoOlopade321vBIF1GuTQkntjbwjr93A=Olufunmilayo Olopade41.78927490000000-87.601250000000001960Olopade, OlufunmilayoProfessorSandeepGurbuxaniSandeep Gurbuxani41.78927490000000-87.601250000000002442Gurbuxani, SandeepProfessorYusukeNakamuraYusuke Nakamura41.78927490000000-87.60125000000000582Nakamura, YusukeEmeritus/Emerita, Professor38039510Johnston H, Youshanlouei HR, Osei C, Patel AA, DuVall A, Wang P, Wanjari P, Segal J, Venkataraman G, Cheng JX, Gurbuxani S, Lager A, Fitzpatrick C, Thirman M, Nawas M, Liu H, Drazer M, Odenike O, Larson R, Stock W, Saygin CBlood advancesSocioeconomic determinants of the biology and outcomes of acute lymphoblastic leukemia in adults. Blood Adv. 2024 01 09; 8(1):164-171.Blood Adv2024-01-09T00:00:002024Socioeconomic determinants of the biology and outcomes of acute lymphoblastic leukemia in adults.Authorship 1685391238150184Saygin C, Zhang P, Stauber J, Aldoss I, Sperling AS, Weeks LD, Luskin MR, Knepper TC, Wanjari P, Wang P, Lager AM, Fitzpatrick C, Segal JP, Gharghabi M, Gurbuxani S, Venkataraman G, Cheng JX, Eisfelder BJ, Bohorquez O, Patel AA, Umesh Nagalakshmi S, Jayaram S, Odenike OM, Larson RA, Godley LA, Arber DA, Gibson CJ, Munshi NC, Marcucci G, Ebert BL, Greally JM, Steidl U, Lapalombella R, Shah BD, Stock WBlood cancer discoveryAcute lymphoblastic leukemia with myeloid mutations is a high-risk disease associated with clonal hematopoiesis. Blood Cancer Discov. 2023 Dec 27.Blood Cancer Discov2023-12-27T00:00:002023Acute lymphoblastic leukemia with myeloid mutations is a high-risk disease associated with clonal hematopoiesis.Authorship 16921411https://voices.uchicago.edu/sayginlab/Saygin Labtrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessor1010GirishVenkataraman0HRsBaoUDczMknJtY0fp/Cv/+94=Girish Venkataraman0.000000000000000.000000000000002713Venkataraman, GirishProfessor