30243563Creixell P, Pandey JP, Palmeri A, Bhattacharyya M, Creixell M, Ranganathan R, Pincus D, Yaffe MBCell systemsCatalytic Domain; Evolution, Molecular; Protein KinasesAllosteric Regulation; Allosteric Site; Humans; Mutation; Neoplasms; Substrate SpecificityHierarchical Organization Endows the Kinase Domain with Regulatory Plasticity. Cell Syst. 2018 10 24; 7(4):371-383.e4.Cell Syst2018-09-19T00:00:002018Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity.prns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD000495Concepts & Ideas14230.984851Allosteric SiteD000494Physiology41680.96611Allosteric RegulationRamaRanganathanxWNnDKAbGPjRkHR2QFPt+2z5/syyp7BaZQ==Rama Ranganathan41.7886000000000087.598699999999993563Ranganathan, RamaProfessorBiochemistry and Molecular BiologyMolecular Genetics and Cell BiologyDavidPincusx2tnCLQGOfnamXNnYUHhvWD+6g==David Pincus41.7886000000000087.598699999999993739Pincus, DavidAssistant ProfessorAuthorship 1231876Authorship 12318870.1704920.1704922authors10.259has subject areaD009154Physiology70239520.442648MutationD011494Chemicals & Drugs1122090.895876Protein KinasesD006801Living Beings2262862810.130052HumansD019143Phenomena1868130.635601Evolution, MolecularD020134Concepts & IdeasGenes & Molecular Sequences681560.949937Catalytic DomainD013379Concepts & Ideas1463470.916565Substrate Specificityhttp://ranganathanlab.org/Ranganathan LabD009369Disorders55628890.33847NeoplasmsUniversity of Chicagohttps://pincuslab.uchicago.edu/Pincus Labtrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professor