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The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.
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The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. Elife. 2018 11 29; 7.
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PubMed
subject areas
Breast Neoplasms
Drug Resistance, Neoplasm
Estrogen Receptor alpha
Female
Humans
Indoles
Ligands
MCF-7 Cells
Mutant Proteins
Mutation
Piperazines
Protein Binding
Protein Domains
Protein Structure, Secondary
Pyridines
Raloxifene Hydrochloride
Selective Estrogen Receptor Modulators
Structure-Activity Relationship
Tamoxifen
authors with profiles
Geoffrey Greene