23041932McLaughlin RN, Poelwijk FJ, Raman A, Gosal WS, Ranganathan RNatureAdaptation, Physiological; Amino Acid Substitution; Mutant Proteins; PDZ Domains; ProteinsAmino Acid Sequence; Binding Sites; Evolution, Molecular; Ligands; Models, Molecular; Molecular Sequence Data; MutationThe spatial architecture of protein function and adaptation. Nature. 2012 Nov 01; 491(7422):138-42.Nature2012-10-07T00:00:002012The spatial architecture of protein function and adaptation.prns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD000222Physiology1603060.815144Adaptation, PhysiologicalD000595Genes & Molecular Sequences43920620.7368Amino Acid SequenceD001665Chemicals & Drugs32910980.797809Binding SitesRamaRanganathanxWNnDKAbGPjRkHR2QFPt+2z5/syyp7BaZQ==Rama Ranganathan41.7886000000000087.598699999999993563Ranganathan, RamaProfessorBiochemistry and Molecular BiologyAuthorship 11785950.4515130.1128782authors10.2512has subject areaD008958Concepts & Ideas24512840.706947Models, MolecularD008969Concepts & IdeasGenes & Molecular Sequences56030290.690324Molecular Sequence DataD009154Physiology70239520.442648MutationD008024Chemicals & Drugs2034330.884647LigandsD011506Chemicals & Drugs3127770.656392ProteinsArjunRaman1nBoBqAbOfnamXNnYUHhvWD+6g==Arjun Raman41.7886000000000087.598699999999993966Raman, ArjunAssistant ProfessorAuthorship 1405223D019143Phenomena1868130.635601Evolution, MolecularD019943PhysiologyProcedures1723390.894074Amino Acid SubstitutionD050505Chemicals & Drugs68940.957819Mutant ProteinsD054731Concepts & Ideas10140.987633PDZ Domainshttp://ranganathanlab.org/Ranganathan LabPathologyUniversity of Chicagotrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professor