NicolasChevrier2WFhDrcHEOnLsW9naE/t8mL1sc65/A==Nicolas Chevrier41.7886000000000087.598699999999993754Chevrier, NicolasOur research aims to uncover the grammar – or general rules – governing how successful immune responses work to stop an infection or remove diseased cells while keeping the host healthy at the end of the process. We emphasize a multiscale approach that parallels the organization of the immune system across the body from molecules and cells to tissues to the whole organism. By creating new tools and approaches, we study how interactions occur between immunological components across these scales to uncover fundamental concepts in immunology and beyond. We pursue this goal in the hope that it will contribute knowledge to the longstanding question of how to manipulate the immune system at will.Assistant Professorplugins:TwitterTwitterprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational Trainingvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:orcidIdORCID idvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonJeffreyHubbell3Wp8CaMQFeD5hHlsaUXv9Gq0+s+oJeffrey Hubbell41.7886000000000087.598699999999993473Hubbell, JeffreyBarry L. MacLean ProfessorMelodySwartzMelody Swartz41.7886000000000087.598699999999993497Swartz, MelodyProfessorD003713Anatomy1054240.763412Dendritic CellsMedicine-Infectious DiseasesMicrobiology22078882Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H, Carr SA, Regev A, Amit I, Hacohen NCellSystematic discovery of TLR signaling components delineates viral-sensing circuits. Cell. 2011 Nov 11; 147(4):853-67.Cell2011-11-11T00:00:002011Systematic discovery of TLR signaling components delineates viral-sensing circuits.Chicago60637IL1.146940.0149988145research areas0.476990.1059863coauthor of14.58432.785460similar to1121selected publicationsAaronEsser-KahnAaron Esser-Kahn41.7886000000000087.598699999999993755Esser-Kahn, AaronProfessorAuthorship 1257185Authorship 1257199Authorship 1257241Authorship 1257059Authorship 1257093Authorship 1256972Authorship 1257143Authorship 1257151Authorship 12572613Authorship 1256875Authorship 1257175Authorship 1257237Authorship 12569315Authorship 1257025Authorship 125720927695002Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AHNature immunologySuppression by TFR cells leads to durable and selective inhibition of B cell effector function. Nat Immunol. 2016 Dec; 17(12):1436-1446.Nat Immunol2016-10-03T00:00:002016Suppression by TFR cells leads to durable and selective inhibition of B cell effector function.22940246Garber M, Yosef N, Goren A, Raychowdhury R, Thielke A, Guttman M, Robinson J, Minie B, Chevrier N, Itzhaki Z, Blecher-Gonen R, Bornstein C, Amann-Zalcenstein D, Weiner A, Friedrich D, Meldrim J, Ram O, Cheng C, Gnirke A, Fisher S, Friedman N, Wong B, Bernstein BE, Nusbaum C, Hacohen N, Regev A, Amit IMolecular cellA high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Mol Cell. 2012 Sep 14; 47(5):810-22.Mol Cell2012-08-30T00:00:002012A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals.22386268Moseman EA, Iannacone M, Bosurgi L, Tonti E, Chevrier N, Tumanov A, Fu YX, Hacohen N, von Andrian UHImmunityB cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity. 2012 Mar 23; 36(3):415-26.Immunity2012-03-01T00:00:002012B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity.26824662Mostafavi S, Yoshida H, Moodley D, LeBoité H, Rothamel K, Raj T, Ye CJ, Chevrier N, Zhang SY, Feng T, Lee M, Casanova JL, Clark JD, Hegen M, Telliez JB, Hacohen N, De Jager PL, Regev A, Mathis D, Benoist C, Immunological Genome Project ConsortiumCellParsing the Interferon Transcriptional Network and Its Disease Associations. Cell. 2016 Jan 28; 164(3):564-78.Cell2016-01-28T00:00:002016Parsing the Interferon Transcriptional Network and Its Disease Associations.21467299Guia S, Jaeger BN, Piatek S, Mailfert S, Trombik T, Fenis A, Chevrier N, Walzer T, Kerdiles YM, Marguet D, Vivier E, Ugolini SScience signalingConfinement of activating receptors at the plasma membrane controls natural killer cell tolerance. Sci Signal. 2011 Apr 05; 4(167):ra21.Sci Signal2011-04-05T00:00:002011Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance.23303808Salcedo SP, Chevrier N, Lacerda TL, Ben Amara A, Gerart S, Gorvel VA, de Chastellier C, Blasco JM, Mege JL, Gorvel JPThe Journal of infectious diseasesPathogenic brucellae replicate in human trophoblasts. J Infect Dis. 2013 Apr; 207(7):1075-83.J Infect Dis2013-01-09T00:00:002013Pathogenic brucellae replicate in human trophoblasts.23190424Shalek AK, Gaublomme JT, Wang L, Yosef N, Chevrier N, Andersen MS, Robinson JT, Pochet N, Neuberg D, Gertner RS, Amit I, Brown JR, Hacohen N, Regev A, Wu CJ, Park HNano lettersNanowire-mediated delivery enables functional interrogation of primary immune cells: application to the analysis of chronic lymphocytic leukemia. Nano Lett. 2012 Dec 12; 12(12):6498-504.Nano Lett2012-12-03T00:00:002012Nanowire-mediated delivery enables functional interrogation of primary immune cells: application to the analysis of chronic lymphocytic leukemia.25745177Jovanovic M, Rooney MS, Mertins P, Przybylski D, Chevrier N, Satija R, Rodriguez EH, Fields AP, Schwartz S, Raychowdhury R, Mumbach MR, Eisenhaure T, Rabani M, Gennert D, Lu D, Delorey T, Weissman JS, Carr SA, Hacohen N, Regev AScience (New York, N.Y.)Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens. Science. 2015 Mar 06; 347(6226):1259038.Science2015-02-12T00:00:002015Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens.23503680Gat-Viks I, Chevrier N, Wilentzik R, Eisenhaure T, Raychowdhury R, Steuerman Y, Shalek AK, Hacohen N, Amit I, Regev ANature biotechnologyDeciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli. Nat Biotechnol. 2013 Apr; 31(4):342-9.Nat Biotechnol2013-03-17T00:00:002013Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli.16829963Uematsu S, Jang MH, Chevrier N, Guo Z, Kumagai Y, Yamamoto M, Kato H, Sougawa N, Matsui H, Kuwata H, Hemmi H, Coban C, Kawai T, Ishii KJ, Takeuchi O, Miyasaka M, Takeda K, Akira SNature immunologyDetection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol. 2006 Aug; 7(8):868-74.Nat Immunol2006-07-09T00:00:002006Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.24120862Tonti E, Jiménez de Oya N, Galliverti G, Moseman EA, Di Lucia P, Amabile A, Sammicheli S, De Giovanni M, Sironi L, Chevrier N, Sitia G, Gennari L, Guidotti LG, von Andrian UH, Iannacone MCell reportsBisphosphonates target B cells to enhance humoral immune responses. Cell Rep. 2013 Oct 31; 5(2):323-30.Cell Rep2013-10-10T00:00:002013Bisphosphonates target B cells to enhance humoral immune responses.28658630Mertins P, Przybylski D, Yosef N, Qiao J, Clauser K, Raychowdhury R, Eisenhaure TM, Maritzen T, Haucke V, Satoh T, Akira S, Carr SA, Regev A, Hacohen N, Chevrier NCell reportsAn Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling. Cell Rep. 2017 06 27; 19(13):2853-2866.Cell Rep2017-06-27T00:00:002017An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling.28942919Kadoki M, Patil A, Thaiss CC, Brooks DJ, Pandey S, Deep D, Alvarez D, von Andrian UH, Wagers AJ, Nakai K, Mikkelsen TS, Soumillon M, Chevrier NCellOrganism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues. Cell. 2017 Oct 05; 171(2):398-413.e21.Cell2017-09-21T00:00:002017Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues.19729616Amit I, Garber M, Chevrier N, Leite AP, Donner Y, Eisenhaure T, Guttman M, Grenier JK, Li W, Zuk O, Schubert LA, Birditt B, Shay T, Goren A, Zhang X, Smith Z, Deering R, McDonald RC, Cabili M, Bernstein BE, Rinn JL, Meissner A, Root DE, Hacohen N, Regev AScience (New York, N.Y.)Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science. 2009 Oct 09; 326(5950):257-63.Science2009-09-03T00:00:002009Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses.06/2012Harvard Medical SchoolBoston, USAHarvard Medical School, ImmunologyPh.D.Immunology06/2007Université de la MéditerranéeMarseille, FranceUniversité de la Méditerranée, Biochemistry, ImmunologyM.S.Biochemistry, Immunology06/2005Université de BourgogneDijon, FranceUniversité de Bourgogne, BiochemistryB.S.BiochemistryEricPamerEric Pamer41.7886000000000087.598699999999993819Pamer, EricProfessorPritzker Institute for Molecular EngineeringSamanthaRiesenfeldxHBgDrIQF+rcnX5EdUXm+mb7+MTz7LFLSamantha Riesenfeld41.7886000000000087.598699999999993903Riesenfeld, SamanthaAssistant ProfessorAuthorship 135897632076350Pandey S, Takahama M, Gruenbaum A, Zewde M, Cheronis K, Chevrier NNature protocolsA whole-tissue RNA-seq toolkit for organism-wide studies of gene expression with PME-seq. Nat Protoc. 2020 04; 15(4):1459-1483.Nat Protoc2020-02-19T00:00:002020A whole-tissue RNA-seq toolkit for organism-wide studies of gene expression with PME-seq.Authorship 137991132490290Chevrier NCurrent opinion in systems biologyDecoding the Body Language of Immunity: Tackling the Immune System at the Organism Level. Curr Opin Syst Biol. 2019 Dec; 18:19-26.Curr Opin Syst Biol2019-11-06T00:00:002019Decoding the Body Language of Immunity: Tackling the Immune System at the Organism Level.D007370Chemicals & Drugs701750.916489Interferon Type IAuthorship 141829433113356Pandey S, Gruenbaum A, Kanashova T, Mertins P, Cluzel P, Chevrier NCell systemsPairwise Stimulations of Pathogen-Sensing Pathways Predict Immune Responses to Multi-adjuvant Combinations. Cell Syst. 2020 11 18; 11(5):495-508.e10.Cell Syst2020-10-27T00:00:002020Pairwise Stimulations of Pathogen-Sensing Pathways Predict Immune Responses to Multi-adjuvant Combinations.HuanhuanChen3W1wCKQWEenXsW9naE/t8mL1sc65/A==Huanhuan Chen41.7886000000000087.598699999999993993Chen, HuanhuanAssistant ProfessorD018805Disorders1193040.748378SepsisAuthorship 151075434795271Bessa-Neto D, Beliu G, Kuhlemann A, Pecoraro V, Doose S, Retailleau N, Chevrier N, Perrais D, Sauer M, Choquet DNature communicationsBioorthogonal labeling of transmembrane proteins with non-canonical amino acids unveils masked epitopes in live neurons. Nat Commun. 2021 11 18; 12(1):6715.Nat Commun2021-11-18T00:00:002021Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids unveils masked epitopes in live neurons.ShabaanaKhaderShabaana Khader41.7886000000000087.598699999999994229Khader, ShabaanaProfessorD051193Chemicals & Drugs49920.925481Toll-Like ReceptorsAuthorship 1610021736778287Takahama M, Patil A, Johnson K, Cipurko D, Miki Y, Taketomi Y, Carbonetto P, Plaster M, Richey G, Pandey S, Cheronis K, Ueda T, Gruenbaum A, Dudek SM, Stephens M, Murakami M, Chevrier NbioRxiv : the preprint server for biologyOrganism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation. bioRxiv. 2023 Feb 02.bioRxiv2023-02-02T00:00:002023Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation.https://pamerlab.uchicago.eduPamer Lab websitehttps://pme.uchicago.edu/faculty/samantha-riesenfeldWebsitehttp://stephenslab.uchicago.edu/lab websitehttp://dfi.uchicago.eduDuchossois Family Institutehttps://github.com/stephenslabgithub pagehttps://pme.uchicago.edu/faculty/samantha-riesenfeldRiesenfeld Websitehttp://www.chevrierlab.orgChevrier Labmstephens999D016207Chemicals & Drugs3167750.734015CytokinesMatthewStephensMatthew Stephens0.000000000000000.000000000000003155Stephens, MatthewProfessorBen May DepartmentHuman GeneticsMedicinePathologyUniversity of ChicagoPeter S.CarbonettoPeter S. Carbonetto41.78927490000000-87.601250000000001504Carbonetto, Peter S.0000-0003-1144-6780Research Assistant ProfessorRichardJonesRichard B. Jones41.78927490000000-87.601250000000002031Jones, RichardAssistant ProfessorThomas F.GajewskiThomas F. Gajewski41.78927490000000-87.60125000000000355Gajewski, Thomas F.ProfessorAnita S.Chong1mFhBK8SOfnamXNnYUHhvWD+6g==Anita S. Chong41.78927490000000-87.60125000000000535Chong, Anita S.ProfessorYusukeNakamuraYusuke Nakamura41.78927490000000-87.60125000000000582Nakamura, YusukeEmeritus/Emerita, Professor38191855Takahama M, Patil A, Richey G, Cipurko D, Johnson K, Carbonetto P, Plaster M, Pandey S, Cheronis K, Ueda T, Gruenbaum A, Kawamoto T, Stephens M, Chevrier NNature immunologyA pairwise cytokine code explains the organism-wide response to sepsis. Nat Immunol. 2024 Feb; 25(2):226-239.Nat Immunol2024-01-08T00:00:002024A pairwise cytokine code explains the organism-wide response to sepsis.Authorship 16946614https://pcarbo.github.io/personal websitehttps://github.com/pcarbo/GitHubhttp://www.linkedin.com/pub/peter-carbonetto/59/8ab/7aLinkedInhttp://scholar.google.com/citations?user=ghacqrQAAAAJGoogle Scholarhttps://stephenslab.uchicago.eduStephens lab websitetrue1Assistant ProfessorAssistant Professortrue1Research Assistant ProfessorResearch Assistant Professortrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Barry L. MacLean ProfessorBarry L. MacLean Professortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessorSurgery-TransplantStatistics