RomualdGirardRomuald Girard41.7886000000000087.598699999999993817Girard, RomualdResearch Assistant Professorplugins:TwitterTwitterprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:orcidIdORCID idvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson27494817Girard R, Fam MD, Zeineddine HA, Tan H, Mikati AG, Shi C, Jesselson M, Shenkar R, Wu M, Cao Y, Hobson N, Larsson HBW, Christoforidis GA, Awad IAJournal of neurosurgeryVascular permeability and iron deposition biomarkers in longitudinal follow-up of cerebral cavernous malformations. J Neurosurg. 2017 Jul; 127(1):102-110.J Neurosurg2016-08-05T00:00:002016Vascular permeability and iron deposition biomarkers in longitudinal follow-up of cerebral cavernous malformations.28402516Fam MD, Hanley D, Stadnik A, Zeineddine HA, Girard R, Jesselson M, Cao Y, Money L, McBee N, Bistran-Hall AJ, Mould WA, Lane K, Camarata PJ, Zuccarello M, Awad IANeurosurgerySurgical Performance in Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation Phase III Clinical Trial. Neurosurgery. 2017 Nov 01; 81(5):860-866.Neurosurgery2017-11-01T00:00:002017Surgical Performance in Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation Phase III Clinical Trial.28489816Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Võsa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn MLNatureEndothelial TLR4 and the microbiome drive cerebral cavernous malformations. Nature. 2017 05 18; 545(7654):305-310.Nature2017-05-10T00:00:002017Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.MatthewKaufman2mN9H6oUDOrUkHREdUXm+mb7+MTz7LFLMatthew Kaufman41.7886000000000087.598699999999993591Kaufman, MatthewAssistant ProfessorD002543Disorders723250.776648Cerebral HemorrhageMartinHermanMartin Herman41.7886000000000087.598699999999993692Herman, MartinAssistant ProfessorOrganismal Biology and AnatomyParamitaDasParamita Das41.7886000000000087.598699999999993736Das, ParamitaAssistant ProfessorSurgery-General Surgery28970240Lopez-Ramirez MA, Fonseca G, Zeineddine HA, Girard R, Moore T, Pham A, Cao Y, Shenkar R, de Kreuk BJ, Lagarrigue F, Lawler J, Glass CK, Awad IA, Ginsberg MHThe Journal of experimental medicineThrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations. J Exp Med. 2017 Nov 06; 214(11):3331-3346.J Exp Med2017-09-28T00:00:002017Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations.28791783Zeineddine HA, Girard R, Cao Y, Hobson N, Fam MD, Stadnik A, Tan H, Shen J, Chaudagar K, Shenkar R, Thompson RE, McBee N, Hanley D, Carroll T, Christoforidis GA, Awad IAJournal of magnetic resonance imaging : JMRIQuantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations with recent hemorrhage. J Magn Reson Imaging. 2018 04; 47(4):1133-1138.J Magn Reson Imaging2017-08-09T00:00:002017Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations with recent hemorrhage.29946133Zeineddine HA, Girard R, Saadat L, Shen L, Lightle R, Moore T, Cao Y, Hobson N, Shenkar R, Avner K, Chaudager K, Koskimäki J, Polster SP, Fam MD, Shi C, Lopez-Ramirez MA, Tang AT, Gallione C, Kahn ML, Ginsberg M, Marchuk DA, Awad IALaboratory investigation; a journal of technical methods and pathologyPhenotypic characterization of murine models of cerebral cavernous malformations. Lab Invest. 2019 03; 99(3):319-330.Lab Invest2018-06-26T00:00:002018Phenotypic characterization of murine models of cerebral cavernous malformations.30442679Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Koskimäki J, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MHBloodCerebral cavernous malformations form an anticoagulant vascular domain in humans and mice. Blood. 2019 01 17; 133(3):193-204.Blood2018-11-15T00:00:002018Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice.29660039Polster SP, Cao Y, Carroll T, Flemming K, Girard R, Hanley D, Hobson N, Kim H, Koenig J, Koskimäki J, Lane K, Majersik JJ, McBee N, Morrison L, Shenkar R, Stadnik A, Thompson RE, Zabramski J, Zeineddine HA, Awad IANeurosurgeryTrial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH). Neurosurgery. 2019 04 01; 84(4):954-964.Neurosurgery2019-04-01T00:00:002019Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH).29294116Fam MD, Stadnik A, Zeineddine HA, Girard R, Mayo S, Dlugash R, McBee N, Lane K, Mould WA, Ziai W, Hanley D, Awad IANeurosurgerySymptomatic Hemorrhagic Complications in Clot Lysis: Evaluation of Accelerated Resolution of Intraventricular Hemorrhage Phase III Clinical Trial (CLEAR III): A Posthoc Root-Cause Analysis. Neurosurgery. 2018 12 01; 83(6):1260-1268.Neurosurgery2018-12-01T00:00:002018Symptomatic Hemorrhagic Complications in Clot Lysis: Evaluation of Accelerated Resolution of Intraventricular Hemorrhage Phase III Clinical Trial (CLEAR III): A Posthoc Root-Cause Analysis.28819935Girard R, Zeineddine HA, Fam MD, Mayampurath A, Cao Y, Shi C, Shenkar R, Polster SP, Jesselson M, Duggan R, Mikati AG, Christoforidis G, Andrade J, Whitehead KJ, Li DY, Awad IATranslational stroke researchPlasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations. Transl Stroke Res. 2018 02; 9(1):34-43.Transl Stroke Res2017-08-17T00:00:002017Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations.30476251Polster SP, Stadnik A, Akers AL, Cao Y, Christoforidis GA, Fam MD, Flemming KD, Girard R, Hobson N, Koenig JI, Koskimäki J, Lane K, Liao JK, Lee C, Lyne SB, McBee N, Morrison L, Piedad K, Shenkar R, Sorrentino M, Thompson RE, Whitehead KJ, Zeineddine HA, Hanley DF, Awad IANeurosurgeryAtorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial. Neurosurgery. 2019 12 01; 85(6):843-853.Neurosurgery2019-12-01T00:00:002019Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial.29720384Girard R, Zeineddine HA, Koskimäki J, Fam MD, Cao Y, Shi C, Moore T, Lightle R, Stadnik A, Chaudagar K, Polster S, Shenkar R, Duggan R, Leclerc D, Whitehead KJ, Li DY, Awad IACirculation researchPlasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth. Circ Res. 2018 06 08; 122(12):1716-1721.Circ Res2018-05-02T00:00:002018Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth.ShyamPrabhakaranShyam Prabhakaran41.7886000000000087.598699999999993768Prabhakaran, ShyamProfessor30744543Shenkar R, Peiper A, Pardo H, Moore T, Lightle R, Girard R, Hobson N, Polster SP, Koskimäki J, Zhang D, Lyne SB, Cao Y, Chaudagar K, Saadat L, Gallione C, Pytel P, Liao JK, Marchuk D, Awad IAStrokeRho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease. Stroke. 2019 03; 50(3):738-744.Stroke2019-03-01T00:00:002019Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.30728328Koskimäki J, Girard R, Li Y, Saadat L, Zeineddine HA, Lightle R, Moore T, Lyne S, Avner K, Shenkar R, Cao Y, Shi C, Polster SP, Zhang D, Carrión-Penagos J, Romanos S, Fonseca G, Lopez-Ramirez MA, Chapman EM, Popiel E, Tang AT, Akers A, Faber P, Andrade J, Ginsberg M, Derry WB, Kahn ML, Marchuk DA, Awad IAJCI insightComprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes. JCI Insight. 2019 Feb 07; 4(3).JCI Insight2019-02-07T00:00:002019Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes.30891610Awad IA, Polster SP, Carrión-Penagos J, Thompson RE, Cao Y, Stadnik A, Money PL, Fam MD, Koskimäki J, Girard R, Lane K, McBee N, Ziai W, Hao Y, Dodd R, Carlson AP, Camarata PJ, Caron JL, Harrigan MR, Gregson BA, Mendelow AD, Zuccarello M, Hanley DF, MISTIE III Trial InvestigatorsNeurosurgerySurgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure. Neurosurgery. 2019 06 01; 84(6):1157-1168.Neurosurgery2019-06-01T00:00:002019Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure.30996251Chapman EM, Lant B, Ohashi Y, Yu B, Schertzberg M, Go C, Dogra D, Koskimäki J, Girard R, Li Y, Fraser AG, Awad IA, Abdelilah-Seyfried S, Gingras AC, Derry WBNature communicationsA conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis. Nat Commun. 2019 04 17; 10(1):1791.Nat Commun2019-04-17T00:00:002019A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis.31217347Lyne SB, Girard R, Koskimäki J, Zeineddine HA, Zhang D, Cao Y, Li Y, Stadnik A, Moore T, Lightle R, Shi C, Shenkar R, Carrión-Penagos J, Polster SP, Romanos S, Akers A, Lopez-Ramirez M, Whitehead KJ, Kahn ML, Ginsberg MH, Marchuk DA, Awad IAJCI insightBiomarkers of cavernous angioma with symptomatic hemorrhage. JCI Insight. 2019 06 20; 4(12).JCI Insight2019-06-20T00:00:002019Biomarkers of cavernous angioma with symptomatic hemorrhage.D006392Disorders23690.934544Hemangioma, CavernousChicago60637IL7.813860.00228292288research areas9.142540.033775414coauthor of245.7629.2330360similar to1170selected publicationsAuthorship 1312604Authorship 1313044Authorship 1311094Authorship 1312154Authorship 1311141Authorship 1309671Authorship 1309738Authorship 1309544Authorship 1309852Authorship 1311353Authorship 1313661Authorship 1310755Authorship 1314071Authorship 1314101Authorship 13147210Authorship 1315315Authorship 1315517Authorship 1315462Authorship 1315764Authorship 1316218Authorship 1315994Authorship 1315612Authorship 1317626Authorship 1317001Authorship 1317593Authorship 1317054Authorship 1317561Authorship 1317738485931Lloyd JS, Mendenhall RC, De Florio GP, Girard RAArchives of otolaryngology (Chicago, Ill. : 1960)A study of the practice of otorhinolaryngology in the United States. Initial findings. Arch Otolaryngol. 1979 Oct; 105(10):610-20.Arch Otolaryngol1979-10-01T00:00:001979A study of the practice of otorhinolaryngology in the United States. Initial findings.28378784Ligneul R, Girard R, Dreher JCScientific reportsSocial brains and divides: the interplay between social dominance orientation and the neural sensitivity to hierarchical ranks. Sci Rep. 2017 04 05; 7:45920.Sci Rep2017-04-05T00:00:002017Social brains and divides: the interplay between social dominance orientation and the neural sensitivity to hierarchical ranks.7207795Mendenhall RC, Watts C, Radecki SE, Girard RANeurosurgeryNeurosurgery in the United States: a log-diary study. Neurosurgery. 1981 Feb; 8(2):267-76.Neurosurgery1981-02-01T00:00:001981Neurosurgery in the United States: a log-diary study.7069471Watts C, Mendenhall RC, Radecki SE, Girard RAJournal of neurosurgeryNeurosurgical manpower: the physician's viewpoint. J Neurosurg. 1982 May; 56(5):609-14.J Neurosurg1982-05-01T00:00:001982Neurosurgical manpower: the physician's viewpoint.30639489Heino I, Frantzén J, Rinne J, Girard R, Cao Y, Sajanti A, Katila AJ, Posti JP, Takala RSK, Tenovuo O, Koskimäki JWorld neurosurgeryRisk Factors for Recurrent Hematoma After Surgery for Acute Traumatic Subdural Hematoma. World Neurosurg. 2019 Apr; 124:e563-e571.World Neurosurg2019-01-10T00:00:002019Risk Factors for Recurrent Hematoma After Surgery for Acute Traumatic Subdural Hematoma.Authorship 13240812Authorship 1324882531446620McKerracher L, Shenkar R, Abbinanti M, Cao Y, Peiper A, Liao JK, Lightle R, Moore T, Hobson N, Gallione C, Ruschel J, Koskimäki J, Girard R, Rosen K, Marchuk DA, Awad IATranslational stroke researchA Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease. Transl Stroke Res. 2020 06; 11(3):365-376.Transl Stroke Res2019-08-24T00:00:002019A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.31426861Koskimäki J, Zhang D, Li Y, Saadat L, Moore T, Lightle R, Polster SP, Carrión-Penagos J, Lyne SB, Zeineddine HA, Shi C, Shenkar R, Romanos S, Avner K, Srinath A, Shen L, Detter MR, Snellings D, Cao Y, Lopez-Ramirez MA, Fonseca G, Tang AT, Faber P, Andrade J, Ginsberg M, Kahn ML, Marchuk DA, Girard R, Awad IAActa neuropathologica communicationsTranscriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations. Acta Neuropathol Commun. 2019 08 19; 7(1):132.Acta Neuropathol Commun2019-08-19T00:00:002019Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations.Authorship 1328251131515878Hobson N, Polster SP, Cao Y, Flemming K, Shu Y, Huston J, Gerrard CY, Selwyn R, Mabray M, Zafar A, Girard R, Carrión-Penagos J, Chen YF, Parrish T, Zhou XJ, Koenig JI, Shenkar R, Stadnik A, Koskimäki J, Dimov A, Turley D, Carroll T, Awad IAJournal of magnetic resonance imaging : JMRIPhantom validation of quantitative susceptibility and dynamic contrast-enhanced permeability MR sequences across instruments and sites. J Magn Reson Imaging. 2020 04; 51(4):1192-1199.J Magn Reson Imaging2019-09-12T00:00:002019Phantom validation of quantitative susceptibility and dynamic contrast-enhanced permeability MR sequences across instruments and sites.Authorship 1345421731776290Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Rödel CJ, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Schwaninger M, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn MLScience translational medicineDistinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation. Sci Transl Med. 2019 11 27; 11(520).Sci Transl Med2019-11-27T00:00:002019Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.Authorship 135188231917316Koskimäki J, Zhang D, Carrión-Penagos J, Girard R, Piedad K, Polster SP, Lyne S, Stadnik A, Awad IAWorld neurosurgerySymptomatic Brain Hemorrhages from Cavernous Angioma After Botulinum Toxin Injections, a Role of TLR/MEKK3 Mechanism? Case Report and Review of the Literature. World Neurosurg. 2020 Apr; 136:7-11.World Neurosurg2020-01-07T00:00:002020Symptomatic Brain Hemorrhages from Cavernous Angioma After Botulinum Toxin Injections, a Role of TLR/MEKK3 Mechanism? Case Report and Review of the Literature.Authorship 135636332034809Srinath A, Romanos S, Lyne SB, Leporq B, Koskimäki J, Girard RJournal of magnetic resonance imaging : JMRIEditorial for "Ensemble Learning for Early-Response Prediction of Antidepressant Treatment in Major Depressive Disorder". J Magn Reson Imaging. 2020 07; 52(1):172-173.J Magn Reson Imaging2020-02-08T00:00:002020Editorial for "Ensemble Learning for Early-Response Prediction of Antidepressant Treatment in Major Depressive Disorder".Authorship 136595332244216Carrión-Penagos J, Zeineddine HA, Polster SP, Girard R, Lyne SB, Koskimäki J, Romanos S, Srinath A, Zhang D, Cao Y, Stadnik A, Piedad K, Shenkar R, Awad IAJournal of neurosurgerySubclinical imaging changes in cerebral cavernous angiomas during prospective surveillance. J Neurosurg. 2020 Apr 03; 134(3):1147-1154.J Neurosurg2020-04-03T00:00:002020Subclinical imaging changes in cerebral cavernous angiomas during prospective surveillance.Authorship 137238532362501Zhang D, Kinloch AJ, Srinath A, Shenkar R, Girard R, Lightle R, Moore T, Koskimäki J, Mohsin A, Carrión-Penagos J, Romanos S, Shen L, Clark MR, Shi C, Awad IAJournal of autoimmunityAntibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu. J Autoimmun. 2020 09; 113:102469.J Autoimmun2020-04-30T00:00:002020Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu.Authorship 137854732461638Polster SP, Sharma A, Tanes C, Tang AT, Mericko P, Cao Y, Carrión-Penagos J, Girard R, Koskimäki J, Zhang D, Stadnik A, Romanos SG, Lyne SB, Shenkar R, Yan K, Lee C, Akers A, Morrison L, Robinson M, Zafar A, Bittinger K, Kim H, Gilbert JA, Kahn ML, Shen L, Awad IANature communicationsPermissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma. Nat Commun. 2020 05 27; 11(1):2659.Nat Commun2020-05-27T00:00:002020Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma.Authorship 1383131632556941Koskimäki J, Polster SP, Li Y, Romanos S, Srinath A, Zhang D, Carrión-Penagos J, Lightle R, Moore T, Lyne SB, Stadnik A, Piedad K, Cao Y, Shenkar R, Dimov AV, Hobson N, Christoforidis GA, Carroll T, Girard R, Awad IAGeroScienceCommon transcriptome, plasma molecules, and imaging signatures in the aging brain and a Mendelian neurovascular disease, cerebral cavernous malformation. Geroscience. 2020 10; 42(5):1351-1363.Geroscience2020-06-17T00:00:002020Common transcriptome, plasma molecules, and imaging signatures in the aging brain and a Mendelian neurovascular disease, cerebral cavernous malformation.Authorship 1390701032648916Hong CC, Tang AT, Detter MR, Choi JP, Wang R, Yang X, Guerrero AA, Wittig CF, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Goddard LM, Ren AA, Leu NA, Sterling S, Yang J, Li L, Chen M, Mericko-Ishizuka P, Dow LE, Watanabe H, Schwaninger M, Min W, Marchuk DA, Zheng X, Awad IA, Kahn MLThe Journal of experimental medicineCerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. J Exp Med. 2020 10 05; 217(10).J Exp Med2020-10-05T00:00:002020Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.Authorship 1393081032710309Detter MR, Shenkar R, Benavides CR, Neilson CA, Moore T, Lightle R, Hobson N, Shen L, Cao Y, Girard R, Zhang D, Griffin E, Gallione CJ, Awad IA, Marchuk DAAngiogenesisNovel Murine Models of Cerebral Cavernous Malformations. Angiogenesis. 2020 11; 23(4):651-666.Angiogenesis2020-07-24T00:00:002020Novel Murine Models of Cerebral Cavernous Malformations.Authorship 140661132917932Sajanti A, Lyne SB, Girard R, Frantzén J, Rantamäki T, Heino I, Cao Y, Diniz C, Umemori J, Li Y, Takala R, Posti JP, Roine S, Koskimäki F, Rahi M, Rinne J, Castrén E, Koskimäki JScientific reportsA comprehensive p75 neurotrophin receptor gene network and pathway analyses identifying new target genes. Sci Rep. 2020 09 11; 10(1):14984.Sci Rep2020-09-11T00:00:002020A comprehensive p75 neurotrophin receptor gene network and pathway analyses identifying new target genes.D015415Concepts & Ideas59717090.619611BiomarkersAuthorship 142627733301422Li W, Shenkar R, Detter MR, Moore T, Benavides C, Lightle R, Girard R, Hobson N, Cao Y, Li Y, Griffin E, Gallione C, Zabramski JM, Ginsberg MH, Marchuk DA, Awad IAThe Journal of clinical investigationPropranolol inhibits cavernous vascular malformations by ß1 adrenergic receptor antagonism in animal models. J Clin Invest. 2021 02 01; 131(3).J Clin Invest2021-02-01T00:00:002021Propranolol inhibits cavernous vascular malformations by ß1 adrenergic receptor antagonism in animal models.Authorship 1434146Authorship 143464133469662Girard R, Li Y, Stadnik A, Shenkar R, Hobson N, Romanos S, Srinath A, Moore T, Lightle R, Shkoukani A, Akers A, Carroll T, Christoforidis GA, Koenig JI, Lee C, Piedad K, Greenberg SM, Kim H, Flemming KD, Ji Y, Awad IANeurosurgeryA Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH). Neurosurgery. 2021 02 16; 88(3):686-697.Neurosurgery2021-02-16T00:00:002021A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH).33475732Polster SP, Carrión-Penagos J, Lyne SB, Gregson BA, Cao Y, Thompson RE, Stadnik A, Girard R, Money PL, Lane K, McBee N, Ziai W, Mould WA, Iqbal A, Metcalfe S, Hao Y, Dodd R, Carlson AP, Camarata PJ, Caron JL, Harrigan MR, Zuccarello M, Mendelow AD, Hanley DF, Awad IANeurosurgeryIntracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials. Neurosurgery. 2021 04 15; 88(5):961-970.Neurosurgery2021-04-15T00:00:002021Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials.Radiology-Basic Sciences33910229Ren AA, Snellings DA, Su YS, Hong CC, Castro M, Tang AT, Detter MR, Hobson N, Girard R, Romanos S, Lightle R, Moore T, Shenkar R, Benavides C, Beaman MM, Müller-Fielitz H, Chen M, Mericko P, Yang J, Sung DC, Lawton MT, Ruppert JM, Schwaninger M, Körbelin J, Potente M, Awad IA, Marchuk DA, Kahn MLNaturePIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism. Nature. 2021 06; 594(7862):271-276.Nature2021-04-28T00:00:002021PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.Neurological SurgeryAuthorship 14673916Authorship 146809834039038Sone JY, Li Y, Hobson N, Romanos SG, Srinath A, Lyne SB, Shkoukani A, Carrión-Penagos J, Stadnik A, Piedad K, Lightle R, Moore T, Li Y, Bi D, Shenkar R, Carroll T, Ji Y, Girard R, Awad IAJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and MetabolismPerfusion and permeability as diagnostic biomarkers of cavernous angioma with symptomatic hemorrhage. J Cereb Blood Flow Metab. 2021 11; 41(11):2944-2956.J Cereb Blood Flow Metab2021-05-26T00:00:002021Perfusion and permeability as diagnostic biomarkers of cavernous angioma with symptomatic hemorrhage.34043589Lopez-Ramirez MA, Lai CC, Soliman SI, Hale P, Pham A, Estrada EJ, McCurdy S, Girard R, Verma R, Moore T, Lightle R, Hobson N, Shenkar R, Poulsen O, Haddad GG, Daneman R, Gongol B, Sun H, Lagarrigue F, Awad IA, Ginsberg MHThe Journal of clinical investigationAstrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation. J Clin Invest. 2021 07 01; 131(13).J Clin Invest2021-07-01T00:00:002021Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation.Authorship 147634534166073Snellings DA, Hong CC, Ren AA, Lopez-Ramirez MA, Girard R, Srinath A, Marchuk DA, Ginsberg MH, Awad IA, Kahn MLCirculation researchCerebral Cavernous Malformation: From Mechanism to Therapy. Circ Res. 2021 06 25; 129(1):195-215.Circ Res2021-06-24T00:00:002021Cerebral Cavernous Malformation: From Mechanism to Therapy.Authorship 1487749Authorship 149490334472454Ritala JF, Lyne SB, Sajanti A, Girard R, Koskimäki JNeural regeneration researchTowards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain. Neural Regen Res. 2022 Apr; 17(4):701-704.Neural Regen Res2022-04-01T00:00:002022Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain.Authorship 1497653Authorship 149747434520969Shkoukani A, Srinath A, Stadnik A, Girard R, Shenkar R, Sheline A, Dahlem K, Lee C, Flemming K, Awad IAJournal of stroke and cerebrovascular diseases : the official journal of National Stroke AssociationCOVID-19 in a Hemorrhagic Neurovascular Disease, Cerebral Cavernous Malformation. J Stroke Cerebrovasc Dis. 2021 Nov; 30(11):106101.J Stroke Cerebrovasc Dis2021-09-08T00:00:002021COVID-19 in a Hemorrhagic Neurovascular Disease, Cerebral Cavernous Malformation.718180Mendenhall RC, Ramsay DL, Girard RA, DeFlorio GP, Weary PE, Lloyd JSArchives of dermatologyA study of the practice of dermatology in the United States. Initial findings. Arch Dermatol. 1978 Oct; 114(10):1456-62.Arch Dermatol1978-10-01T00:00:001978A study of the practice of dermatology in the United States. Initial findings.Authorship 1499411634558140Sone JY, Hobson N, Srinath A, Romanos SG, Li Y, Carrión-Penagos J, Shkoukani A, Stadnik A, Piedad K, Lightle R, Moore T, DeBiasse D, Bi D, Shenkar R, Carroll T, Ji Y, Girard R, Awad IAJournal of magnetic resonance imaging : JMRIPerfusion and Permeability MRI Predicts Future Cavernous Angioma Hemorrhage and Growth. J Magn Reson Imaging. 2022 05; 55(5):1440-1449.J Magn Reson Imaging2021-09-24T00:00:002021Perfusion and Permeability MRI Predicts Future Cavernous Angioma Hemorrhage and Growth.Authorship 150184734596055Li W, Shenkar R, Detter MR, Moore T, Benavides C, Lightle R, Girard R, Hobson N, Cao Y, Li Y, Griffin E, Gallione C, Zabramski JM, Ginsberg MH, Marchuk DA, Awad IAThe Journal of clinical investigationPropranolol inhibits cavernous vascular malformations by ß1 adrenergic receptor antagonism in animal models. J Clin Invest. 2021 10 01; 131(19).J Clin Invest2021-10-01T00:00:002021Propranolol inhibits cavernous vascular malformations by ß1 adrenergic receptor antagonism in animal models.SeanPolsterSean Polster41.7886000000000087.598699999999994144Polster, Sean0000-0002-3229-5021Assistant ProfessorAuthorship 153834235355835Snellings DA, Girard R, Lightle R, Srinath A, Romanos S, Li Y, Chen C, Ren AA, Kahn ML, Awad IA, Marchuk DANature cardiovascular researchDevelopmental venous anomalies are a genetic primer for cerebral cavernous malformations. Nat Cardiovasc Res. 2022 Mar; 1:246-252.Nat Cardiovasc Res2022-03-14T00:00:002022Developmental venous anomalies are a genetic primer for cerebral cavernous malformations.D020786Disorders282230.784958Hemangioma, Cavernous, Central Nervous System35382850Shenkar R, Moore T, Benavides C, Lightle R, Detter MR, Hobson N, Girard R, DeBiasse D, Patrucco M, Gallione C, Zabramski JM, Marchuk DA, Awad IAJournal of translational medicinePropranolol as therapy for cerebral cavernous malformations: a cautionary note. J Transl Med. 2022 04 05; 20(1):160.J Transl Med2022-04-05T00:00:002022Propranolol as therapy for cerebral cavernous malformations: a cautionary note.Authorship 1540237Authorship 154209235420918Magid-Bernstein J, Girard R, Polster S, Srinath A, Romanos S, Awad IA, Sansing LHCirculation researchCerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions. Circ Res. 2022 04 15; 130(8):1204-1229.Circ Res2022-04-14T00:00:002022Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions.Authorship 154903835592432Hagan MJ, Shenkar R, Srinath A, Romanos SG, Stadnik A, Kahn ML, Marchuk DA, Girard R, Awad IAACS pharmacology & translational scienceRapamycin in Cerebral Cavernous Malformations: What Doses to Test in Mice and Humans. ACS Pharmacol Transl Sci. 2022 May 13; 5(5):266-277.ACS Pharmacol Transl Sci2022-04-25T00:00:002022Rapamycin in Cerebral Cavernous Malformations: What Doses to Test in Mice and Humans.Authorship 1553372735715588Romanos SG, Srinath A, Li Y, Xie B, Chen C, Li Y, Moore T, Bi D, Sone JY, Lightle R, Hobson N, Zhang D, Koskimäki J, Shen L, McCurdy S, Lai CC, Stadnik A, Piedad K, Carrión-Penagos J, Shkoukani A, Snellings D, Shenkar R, Sulakhe D, Ji Y, Lopez-Ramirez MA, Kahn ML, Marchuk DA, Ginsberg MH, Girard R, Awad IATranslational stroke researchCirculating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease. Transl Stroke Res. 2023 08; 14(4):513-529.Transl Stroke Res2022-06-17T00:00:002022Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease.EricThompsonEric Thompson41.7886000000000087.598699999999994283Thompson, EricProfessorAuthorship 1613343036869161Srinath A, Xie B, Li Y, Sone JY, Romanos S, Chen C, Sharma A, Polster S, Dorrestein PC, Weldon KC, DeBiasse D, Moore T, Lightle R, Koskimäki J, Zhang D, Stadnik A, Piedad K, Hagan M, Shkoukani A, Carrión-Penagos J, Bi D, Shen L, Shenkar R, Ji Y, Sidebottom A, Pamer E, Gilbert JA, Kahn ML, D'Souza M, Sulakhe D, Awad IA, Girard RCommunications medicinePlasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma. Commun Med (Lond). 2023 Mar 03; 3(1):35.Commun Med (Lond)2023-03-03T00:00:002023Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma.D001932Disorders2197630.646182Brain Neoplasmshttps://www.kaufmanlab.orgKaufman Labhttp://surgeryresearch.uchicago.edu/robert-shenkarRobert Shenkar, PhDmattAntimattAuthorship 1619292Authorship 1620681137052208Sone JY, Koskimäki J, Girard RJournal of magnetic resonance imaging : JMRIEditorial for "The Consistence of Dynamic-Contrast-Enhanced MRI and Filter-Exchange Imaging in Measuring Water Exchange Across the Blood-Brain Barrier in High-Grade Glioma". J Magn Reson Imaging. 2023 12; 58(6):1861-1862.J Magn Reson Imaging2023-04-13T00:00:002023Editorial for "The Consistence of Dynamic-Contrast-Enhanced MRI and Filter-Exchange Imaging in Measuring Water Exchange Across the Blood-Brain Barrier in High-Grade Glioma".37146402Hage S, Hagan M, Bi D, Stadnik A, Lee J, Romanos S, Srinath A, Shenkar R, Lee C, Horowitz PM, Girard R, Awad IAJournal of stroke and cerebrovascular diseases : the official journal of National Stroke AssociationImpact of socioeconomics and race on clinical follow-up and trial enrollment and adherence in cerebral cavernous malformation. J Stroke Cerebrovasc Dis. 2023 Jul; 32(7):107167.J Stroke Cerebrovasc Dis2023-05-03T00:00:002023Impact of socioeconomics and race on clinical follow-up and trial enrollment and adherence in cerebral cavernous malformation.Authorship 164147337333396Hage S, Kinkade S, Girard R, Flemming KD, Kim H, Torbey MT, Huang J, Huston J, Shu Y, Selwyn RG, Hart BL, Mabray MC, Feghali J, Sair HI, Narvid J, Lupo JM, Lee J, Stadnik A, Alcazar R, Shenkar R, Hobson N, DeBiasse D, Lane K, McBee N, Treine K, Ostapkovich N, Wang Y, Thompson RE, Mendoza-Puccini C, Koenig J, Carroll T, Hanley DF, Awad IAmedRxiv : the preprint server for health sciencesCavernous Angioma Symptomatic Hemorrhage (CASH) Trial Readiness II: Imaging Biomarkers and Trial Modeling. medRxiv. 2023 Jun 05.medRxiv2023-06-05T00:00:002023Cavernous Angioma Symptomatic Hemorrhage (CASH) Trial Readiness II: Imaging Biomarkers and Trial Modeling.NeurologyUniversity of Chicago37748978Zhang D, Kinloch AJ, Srinath A, Shenkar R, Girard R, Lightle R, Moore T, Koskimäki J, Mohsin A, Carrión-Penagos J, Romanos S, Shen L, Clark MR, Shi C, Awad IAJournal of autoimmunityCorrigendum to "Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu" [J. Autoimmun. 113 (2020) 102469]. J Autoimmun. 2023 Sep 23; 103116.J Autoimmun2023-09-23T00:00:002023Corrigendum to "Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu" [J. Autoimmun. 113 (2020) 102469].37759937Li Y, Srinath A, Alcazar-Felix RJ, Hage S, Bindal A, Lightle R, Shenkar R, Shi C, Girard R, Awad IABrain sciencesInflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation. Brain Sci. 2023 Sep 17; 13(9).Brain Sci2023-09-17T00:00:002023Inflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation.Authorship 1665985Authorship 1666599LarryGoldsteinLarry Goldstein41.78927490000000-87.601250000000001509Goldstein, LarryLeShenLe Shen41.78927490000000-87.60125000000000411Shen, LeResearch Associate ProfessorAuthorship 167727337919320Ressler AK, Snellings DA, Girard R, Gallione CJ, Lightle R, Allen AS, Awad IA, Marchuk DANature communicationsSingle-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations. Nat Commun. 2023 11 02; 14(1):7009.Nat Commun2023-11-02T00:00:002023Single-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations.IssamAwad3mN+CqU1DO/RmHllZ0mg9mHvIssam Awad41.78927490000000-87.60125000000000867Awad, IssamProfessorRobertShenkarRobert Shenkar41.78927490000000-87.60125000000000963Shenkar, RobertResearch Associate ProfessorAuthorship 1688445Authorship 1689736Authorship 168969338134265Hage S, Kinkade S, Girard R, Flemming KD, Kim H, Torbey MT, Huang J, Huston J, Shu Y, Selwyn RG, Hart BL, Mabray MC, Feghali J, Sair HI, Narvid J, Lupo JM, Lee J, Stadnik A, Alcazar-Felix RJ, Shenkar R, Hobson N, DeBiasse D, Lane K, McBee NA, Treine K, Ostapkovich N, Wang Y, Thompson RE, Koenig JI, Carroll T, Hanley DF, Awad IAStrokeTrial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part II: Biomarkers and Trial Modeling. Stroke. 2024 01; 55(1):31-39.Stroke2023-12-22T00:00:002023Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part II: Biomarkers and Trial Modeling.38134268Flemming KD, Kim H, Hage S, Mandrekar J, Kinkade S, Girard R, Torbey M, Huang J, Huston J, Shu Y, Lanzino G, Selwyn R, Hart B, Mabray M, Feghali J, Sair HI, Narvid J, Lupo JM, Lee J, Stadnik A, Alcazar-Felix RJ, Shenkar R, Lane K, McBee N, Treine K, Ostapkovich N, Wang Y, Thompson R, Koenig JI, Carroll T, Hanley D, Awad IStrokeTrial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part I: Event Rates and Clinical Outcome. Stroke. 2024 01; 55(1):22-30.Stroke2023-12-22T00:00:002023Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part I: Event Rates and Clinical Outcome.38105801Heino I, Sajanti A, Lyne SB, Frantzén J, Girard R, Cao Y, Ritala JF, Katila AJ, Takala RSK, Posti JP, Saarinen AJ, Hellström S, Laukka D, Saarenpää I, Rahi M, Tenovuo O, Rinne J, Koskimäki JBrain & spineOutcome and survival of surgically treated acute subdural hematomas and postcraniotomy hematomas - A retrospective cohort study. Brain Spine. 2023; 3:102714.Brain Spine2023-11-22T00:00:002023Outcome and survival of surgically treated acute subdural hematomas and postcraniotomy hematomas - A retrospective cohort study.38195510Li Y, Girard R, Srinath A, Cruz DV, Ciszewski C, Chen C, Lightle R, Romanos S, Sone JY, Moore T, DeBiasse D, Stadnik A, Lee JJ, Shenkar R, Koskimäki J, Lopez-Ramirez MA, Marchuk DA, Ginsberg MH, Kahn ML, Shi C, Awad IACell communication and signaling : CCSTranscriptomic signatures of individual cell types in cerebral cavernous malformation. Cell Commun Signal. 2024 01 09; 22(1):23.Cell Commun Signal2024-01-09T00:00:002024Transcriptomic signatures of individual cell types in cerebral cavernous malformation.Authorship 1693862Authorship 169623538255217Hellström S, Sajanti A, Srinath A, Bennett C, Girard R, Cao Y, Frantzén J, Koskimäki F, Falter J, Lyne SB, Rantamäki T, Takala R, Posti JP, Roine S, Puolitaival J, Jänkälä M, Kolehmainen S, Rahi M, Rinne J, Castrén E, Koskimäki JBiomedicinesBrain Plasticity Modulator p75 Neurotrophin Receptor in Human Urine after Different Acute Brain Injuries-A Prospective Cohort Study. Biomedicines. 2024 Jan 05; 12(1).Biomedicines2024-01-05T00:00:002024Brain Plasticity Modulator p75 Neurotrophin Receptor in Human Urine after Different Acute Brain Injuries-A Prospective Cohort Study.true1true1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Research Associate ProfessorResearch Associate Professortrue1ProfessorProfessortrue1Research Assistant ProfessorResearch Assistant Professortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Research Associate ProfessorResearch Associate Professor25966944Mikati AG, Khanna O, Zhang L, Girard R, Shenkar R, Guo X, Shah A, Larsson HB, Tan H, Li L, Wishnoff MS, Shi C, Christoforidis GA, Awad IAJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and MetabolismVascular permeability in cerebral cavernous malformations. J Cereb Blood Flow Metab. 2015 Oct; 35(10):1632-9.J Cereb Blood Flow Metab2015-05-13T00:00:002015Vascular permeability in cerebral cavernous malformations.TimothyCarrollTimothy Carroll0.000000000000000.000000000000003278Carroll, TimothyProfessor26861901Girard R, Khanna O, Shenkar R, Zhang L, Wu M, Jesselson M, Zeineddine HA, Gangal A, Fam MD, Gibson CC, Whitehead KJ, Li DY, Liao JK, Shi C, Awad IABiomarkers in medicinePeripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease. Biomark Med. 2016; 10(3):255-64.Biomark Med2016-02-09T00:00:002016Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease.27086141Shi C, Shenkar R, Zeineddine HA, Girard R, Fam MD, Austin C, Moore T, Lightle R, Zhang L, Wu M, Cao Y, Gunel M, Louvi A, Rorrer A, Gallione C, Marchuk DA, Awad IAJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune PharmacologyB-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models. J Neuroimmune Pharmacol. 2016 06; 11(2):369-77.J Neuroimmune Pharmacol2016-04-16T00:00:002016B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models.26965464Tan H, Zhang L, Mikati AG, Girard R, Khanna O, Fam MD, Liu T, Wang Y, Edelman RR, Christoforidis G, Awad IAAJNR. American journal of neuroradiologyQuantitative Susceptibility Mapping in Cerebral Cavernous Malformations: Clinical Correlations. AJNR Am J Neuroradiol. 2016 Jul; 37(7):1209-15.AJNR Am J Neuroradiol2016-03-10T00:00:002016Quantitative Susceptibility Mapping in Cerebral Cavernous Malformations: Clinical Correlations.27345427Girard R, Zeineddine HA, Orsbon C, Tan H, Moore T, Hobson N, Shenkar R, Lightle R, Shi C, Fam MD, Cao Y, Shen L, Neander AI, Rorrer A, Gallione C, Tang AT, Kahn ML, Marchuk DA, Luo ZX, Awad IAJournal of neuroscience methodsMicro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease. J Neurosci Methods. 2016 09 15; 271:14-24.J Neurosci Methods2016-06-23T00:00:002016Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease.27879448Shenkar R, Shi C, Austin C, Moore T, Lightle R, Cao Y, Zhang L, Wu M, Zeineddine HA, Girard R, McDonald DA, Rorrer A, Gallione C, Pytel P, Liao JK, Marchuk DA, Awad IAStrokeRhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations. Stroke. 2017 01; 48(1):187-194.Stroke2016-11-22T00:00:002016RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.