JueqiChenJueqi Chen41.7886000000000087.598699999999993822Chen, JueqiInnate ImmunityMicrobiologyInflammationFluorescence MicroscopyBiochemistryInflammasomes are multi-protein complexes that are responsible for the induction of proinflammatory cytokines and inflammatory cell death. They are unique in innate immune signaling because they can be triggered by a plethora of diverse signals from both pathogens and environmental danger. The research in our lab focuses on dissecting the molecular mechanisms of inflammasome pathways and studying how their dysfunction leads to defective host defense against various pathogenic microorganisms, as well as the impact on autoimmune diseases, neurodegeneration and metabolic syndromes.
Our lab utilizes diverse and complementary approaches, including biochemical assays, confocal fluorescence imaging, CRISPR knockout/rescue and animal models. Our recent study has uncovered the unexpected role of trans-Golgi network dispersion in inflammasome activation, and we are currently interested in studying how pathogens are able to evade or hijack these cellular signals to counter the host defense. We believe that these studies will unveil potential therapeutic targets for infectious diseases and many other human health problems.Assistant Professorprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonRadiation and Cellular OncologyMedicine-GastroenterologyMicrobiologyAaronEsser-KahnAaron Esser-Kahn41.7886000000000087.598699999999993755Esser-Kahn, AaronProfessorChicago60637IL0.792510.011477463research areas4.971440.83399560similar to116selected publications06/2019UT Southwestern Medical CenterDallas, TXUT Southwestern Medical Center, Immunology & MicrobiologyPostdoctoral ResearcherImmunology & Microbiology12/2014UT Southwestern Medical CenterDallas, TXUT Southwestern Medical Center, Biomedical SciencePh.D.Biomedical Science06/2009Zhejiang UniversityHangzhou, ChinaZhejiang University, BiotechnologyB.S.BiotechnologyAuthorship 1317791Authorship 1317803Authorship 1317812Authorship 1317822Authorship 1317831Authorship 131784223312890Chen J, Chen ZJCurrent opinion in immunologyRegulation of NF-?B by ubiquitination. Curr Opin Immunol. 2013 Feb; 25(1):4-12.Curr Opin Immunol2013-01-08T00:00:002013Regulation of NF-?B by ubiquitination.24630723Cai X, Chen J, Xu H, Liu S, Jiang QX, Halfmann R, Chen ZJCellPrion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation. Cell. 2014 Mar 13; 156(6):1207-1222.Cell2014-03-13T00:00:002014Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation.30487600Chen J, Chen ZJNaturePtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation. Nature. 2018 12; 564(7734):71-76.Nature2018-11-28T00:00:002018PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation.30200854Tan X, Sun L, Chen J, Chen ZJAnnual review of microbiologyDetection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids. Annu Rev Microbiol. 2018 Sep 08; 72:447-478.Annu Rev Microbiol2018-09-08T00:00:002018Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids.23951545Liu S, Chen J, Cai X, Wu J, Chen X, Wu YT, Sun L, Chen ZJeLifeMAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades. Elife. 2013 Aug 14; 2:e00785.Elife2013-08-14T00:00:002013MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades.22099304Skaug B, Chen J, Du F, He J, Ma A, Chen ZJMolecular cellDirect, noncatalytic mechanism of IKK inhibition by A20. Mol Cell. 2011 Nov 18; 44(4):559-71.Mol Cell2011-11-18T00:00:002011Direct, noncatalytic mechanism of IKK inhibition by A20.MarkMimeeMark Mimee41.7886000000000087.598699999999993860Mimee, MarkAssistant ProfessorPritzker Institute for Molecular EngineeringD018129Chemicals & Drugs14150.991171Phosphatidylinositol PhosphatesLaurieComstockLaurie Comstock41.7886000000000087.598699999999994086Comstock, LaurieProfessorD058847Chemicals & Drugs19230.97173InflammasomesD021601Anatomy8120.989232trans-Golgi NetworkShabaanaKhaderShabaana Khader41.7886000000000087.598699999999994229Khader, ShabaanaProfessorD00007119917220.981182NLR Family, Pyrin Domain-Containing 3 Proteinhttps://voices.uchicago.edu/mimeelab/Lab Websitehttps://voices.uchicago.edu/jueqi/research/Jueqi Chen LabMohammedKaplanMohammed Kaplan41.7886000000000087.598699999999994369Kaplan, MohammedAssistant ProfessorD054875Phenomena50670.963033UbiquitinationPathologyUniversity of ChicagoEugene B.Chang0mBqA6AbHszMknJtY0fp/Cv/+94=Eugene B. Chang41.78927490000000-87.601250000000001255Chang, Eugene B.ProfessorGuidoFranzosoGuido Franzoso41.78927490000000-87.601250000000001334Franzoso, GuidoErinGreenErin Green41.7886000000000087.598699999999994456Green, ErinAssistant ProfessorRalph R.WeichselbaumxXB+DqgWEf/5hHlsaUXv9Gq0+s+oRalph R. Weichselbaum41.78927490000000-87.601250000000002521Weichselbaum, Ralph R.ProfessorThomas F.GajewskiThomas F. Gajewski41.78927490000000-87.60125000000000355Gajewski, Thomas F.Professortrue1true1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessor1010