32132200Du X, Carvalho-de-Souza JL, Wei C, Carrasquel-Ursulaez W, Lorenzo Y, Gonzalez N, Kubota T, Staisch J, Hain T, Petrossian N, Xu M, Latorre R, Bezanilla F, Gomez CMProceedings of the National Academy of Sciences of the United States of AmericaCerebellum; Chlorzoxazone; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Mitochondria; Spinocerebellar DegenerationsAdolescent; Animals; Animals, Newborn; Cell Line; Dependovirus; Disease Models, Animal; DNA Mutational Analysis; Exome Sequencing; Female; Gene Knockdown Techniques; Genetic Vectors; Humans; Loss of Function Mutation; Mice; Oocytes; Rats; Recombinant Proteins; Transfection; XenopusLoss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxia. Proc Natl Acad Sci U S A. 2020 03 17; 117(11):6023-6034.Proc Natl Acad Sci U S A2020-03-04T00:00:002020Loss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxia.prns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD000229Living Beings30330.990243DependovirusD000293Living Beings111389680.40057AdolescentD000818Living Beings1457265180.249646AnimalsD000831Living Beings1905090.880181Animals, NewbornD002753Chemicals & Drugs550.993941ChlorzoxazoneD002531Anatomy842470.85133CerebellumD005822Chemicals & DrugsLiving Beings1784380.86851Genetic VectorsD004252Procedures2265260.864607DNA Mutational AnalysisBiochemistry and Molecular BiologyD009865Anatomy682200.911776OocytesD005260Physiology1992444050.191184FemaleAuthorship 1361639Authorship 13616410Authorship 13616510.7542710.1885683authors10.2523has subject areaD014981Living Beings511250.966831XenopusD006801Living Beings2262862810.130064HumansD008928AnatomyPhysiology2095350.748762MitochondriaD051379Living Beings980113130.368427MiceD011994Chemicals & Drugs36610140.836817Recombinant ProteinsD013132Disorders8180.983312Spinocerebellar DegenerationsD051381Living Beings61539840.616124RatsD051037Chemicals & Drugs680.992741Large-Conductance Calcium-Activated Potassium Channel alpha SubunitsD014162PhysiologyProcedures2878950.851325TransfectionD055785Procedures1412340.920362Gene Knockdown TechniquesD002460Anatomy54024660.697119Cell LineD00007365836420.961864Loss of Function Mutationhttp://nerve.bsd.uchicago.eduExcitability, Molecular Basishttp://nerve.bsd.uchicago.edu/FBLab SiteD004195Disorders59222270.60194Disease Models, AnimalNeurologyUniversity of ChicagoChristopher M.Gomez1GVmBqQPOeLchGhrbEnp6iv47M/z/LZWeXp7ceLFF3NDChristopher M. Gomez41.78927490000000-87.601250000000001095Gomez, Christopher M.ProfessorXiaofeiDuXiaofei Du41.78927490000000-87.601250000000002352Du, XiaofeiResearch Associate ProfessorFranciscoBezanillaFrancisco Bezanilla41.78927490000000-87.60125000000000987Bezanilla, FranciscoProfessortrue1ProfessorProfessortrue1Research Associate ProfessorResearch Associate Professortrue1ProfessorProfessor