D012259Chemicals & DrugsD08.811.277.352.355.350.715D08.811.277.352.700.350.71513240.981411Ribonuclease, Pancreaticplugins:FeaturedVideosFeatured Videosprns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonBiochemistry and Molecular BiologyMolecular Genetics and Cell Biology28911780Harris ME, York DM, Piccirilli JA, Anderson VEMethods in enzymologyKinetic Isotope Effect Analysis of RNA 2'-O-Transphosphorylation. Methods Enzymol. 2017; 596:433-457.Methods Enzymol2017-09-05T00:00:002017Kinetic Isotope Effect Analysis of RNA 2'-O-Transphosphorylation.0.8054790.01351913research area of0.8207360.013775121subject area forhttp://sosnick.uchicago.edu/Sosnick lab websitehttp://www.hcleelab.orgLee Lab WebsiteBiochem/Mol BioUniversity of ChicagoStephenKentStephen Kent41.78927490000000-87.601250000000001539Kent, StephenProfessorJoseph A.Piccirilli3XJgCKIcC+X5hHlsaUXv9Gq0+s+oJoseph A. Piccirilli41.78927490000000-87.60125000000000190Piccirilli, Joseph A.ProfessorMarcParisienMarc Parisien41.78927490000000-87.601250000000002511Parisien, MarcPostdoctoral FellowTobin R.Sosnickw3B6BLIbEO/5hHlsaUXv9Gq0+s+oTobin R. Sosnick41.78927490000000-87.60125000000000744Sosnick, Tobin R.Professor33986289Lee HH, Wang YN, Yang WH, Xia W, Wei Y, Chan LC, Wang YH, Jiang Z, Xu S, Yao J, Qiu Y, Hsu YH, Hwang WL, Yan M, Cha JH, Hsu JL, Shen J, Ye Y, Wu X, Hou MF, Tseng LM, Wang SC, Pan MR, Yang CH, Wang YL, Yamaguchi H, Pang D, Hortobagyi GN, Yu D, Hung MCNature communicationsHuman ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nat Commun. 2021 05 13; 12(1):2788.Nat Commun2021-05-13T00:00:002021Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation.true1Postdoctoral FellowPostdoctoral Fellowtrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professor25936517Harris ME, Piccirilli JA, York DMBiochimica et biophysica actaIntegration of kinetic isotope effect analyses to elucidate ribonuclease mechanism. Biochim Biophys Acta. 2015 Nov; 1854(11):1801-8.Biochim Biophys Acta2015-04-30T00:00:002015Integration of kinetic isotope effect analyses to elucidate ribonuclease mechanism.25812974Chen H, Piccirilli JA, Harris ME, York DMBiochimica et biophysica actaEffect of Zn2+ binding and enzyme active site on the transition state for RNA 2'-O-transphosphorylation interpreted through kinetic isotope effects. Biochim Biophys Acta. 2015 Nov; 1854(11):1795-800.Biochim Biophys Acta2015-03-23T00:00:002015Effect of Zn2+ binding and enzyme active site on the transition state for RNA 2'-O-transphosphorylation interpreted through kinetic isotope effects.Heng-ChiLeeHeng-Chi Lee0.000000000000000.000000000000003275Lee, Heng-ChiAssociate Professor27714155Boerema DJ, Tereshko VA, Zhang J, Kent SBOrganic & biomolecular chemistryChemical synthesis and enzymatic properties of RNase A analogues designed to enhance second-step catalytic activity. Org Biomol Chem. 2016 Sep 21; 14(37):8804-8814.Org Biomol Chem2016-09-21T00:00:002016Chemical synthesis and enzymatic properties of RNase A analogues designed to enhance second-step catalytic activity.