D006935DisordersC23.888.852.54427430.980331Hypercapniaplugins:FeaturedVideosFeatured Videosprns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAnesthesia and Critical Care30185650Shigemura M, Lecuona E, Angulo M, Homma T, Rodríguez DA, Gonzalez-Gonzalez FJ, Welch LC, Amarelle L, Kim SJ, Kaminski N, Budinger GRS, Solway J, Sznajder JIScience translational medicineHypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling. Sci Transl Med. 2018 09 05; 10(457).Sci Transl Med2018-09-05T00:00:002018Hypercapnia increases airway smooth muscle contractility via caspase-7-mediated miR-133a-RhoA signaling.0.7155220.0017574827research area of0.8986670.0071709874subject area forGokhan M.Mutlu0G98H611OfnamXNnYUHhvWD+6g==Gokhan M. Mutlu0.000000000000000.000000000000002890Mutlu, Gokhan M.ProfessorMedicine-Pulmonary and Critical Care18188452Vadász I, Dada LA, Briva A, Trejo HE, Welch LC, Chen J, Tóth PT, Lecuona E, Witters LA, Schumacker PT, Chandel NS, Seeger W, Sznajder JIThe Journal of clinical investigationAMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis. J Clin Invest. 2008 Feb; 118(2):752-62.J Clin Invest2008-02-01T00:00:002008AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.19567489Kaw R, Hernandez AV, Walker E, Aboussouan L, Mokhlesi BChestDeterminants of hypercapnia in obese patients with obstructive sleep apnea: a systematic review and metaanalysis of cohort studies. Chest. 2009 Sep; 136(3):787-796.Chest2009-06-30T00:00:002009Determinants of hypercapnia in obese patients with obstructive sleep apnea: a systematic review and metaanalysis of cohort studies.20048031Mokhlesi B, Saager L, Kaw RCleveland Clinic journal of medicineQ: Should we routinely screen for hypercapnia in sleep apnea patients before elective noncardiac surgery? Cleve Clin J Med. 2010 Jan; 77(1):60-1.Cleve Clin J Med2010-01-01T00:00:002010Q: Should we routinely screen for hypercapnia in sleep apnea patients before elective noncardiac surgery?KristinTrelaKristin Trela41.7886000000000087.598699999999994238Trela, KristinAssistant Professor36094451Ryan BJ, Seeley AD, Pitsas DM, Mayer TA, Caldwell AR, Ceaser TG, Luippold AJ, Charkoudian N, Salgado RMAmerican journal of physiology. Regulatory, integrative and comparative physiologyInfluence of graded hypercapnia on endurance exercise performance in healthy humans. Am J Physiol Regul Integr Comp Physiol. 2022 11 01; 323(5):R638-R647.Am J Physiol Regul Integr Comp Physiol2022-09-12T00:00:002022Influence of graded hypercapnia on endurance exercise performance in healthy humans.https://mutlulab.uchicago.edu/Mutlu Labhttps://integrativephysiology.uchicago.edu/Institute for Integrative Physiology and Center for Systems Biology of Oxygen SensingMedicineUniversity of ChicagoJohn P.Kress3Wl7DrIGOfnamXNnYUHhvWD+6g==John P. Kress41.78927490000000-87.601250000000001303Kress, John P.ProfessorMarkChaneyMark Chaney41.78927490000000-87.601250000000001546Chaney, MarkProfessorNanduri R.Prabhakar2WNnD7QHEMzMknJtY0fp/Cv/+94=Nanduri R. Prabhakar41.78927490000000-87.601250000000001680Prabhakar, Nanduri R.Professortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorMedicine-Emergency Medicine