32848143Lee TH, Yeh CF, Lee YT, Shih YC, Chen YT, Hung CT, You MY, Wu PC, Shentu TP, Huang RT, Lin YS, Wu YF, Lin SJ, Lu FL, Tsao PN, Lin TH, Lo SC, Tseng YS, Wu WL, Chen CN, Wu CC, Lin SL, Sperling AI, Guzy RD, Fang Y, Yang KCNature communicationsIdiopathic Pulmonary Fibrosis; Protein Disulfide-Isomerases; Pulmonary Fibrosis; Receptor, Transforming Growth Factor-beta Type I; Thioredoxins; Transforming Growth Factor beta1Animals; Bleomycin; Disease Models, Animal; Endoplasmic Reticulum Stress; Gene Deletion; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Folding; Protein Stability; Signal Transduction; Up-RegulationFibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFß signaling through TGFBR1 stabilization. Nat Commun. 2020 08 26; 11(1):4254.Nat Commun2020-08-26T00:00:002020Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFß signaling through TGFBR1 stabilization.plugins:FeaturedPresentationsFeatured Presentationsplugins:FeaturedVideosFeatured Videosprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD000818Living Beings1457265180.249624AnimalsD001761Chemicals & Drugs43980.961888BleomycinD008810Living Beings55730870.60566Mice, Inbred C57BLD013879Chemicals & Drugs12130.991639ThioredoxinsD006801Living Beings2262862810.130052HumansAuthorship 140267Authorship 140266230.3899450.1949722authors10.2519has subject areaD008297Physiology1931408600.201617MaleD015854Physiology3257100.800467Up-RegulationMedicine-Pulmonary and Critical CareD017353Physiology1973280.888117Gene DeletionD018345Living Beings43819180.695188Mice, KnockoutD017510Physiology902800.84624Protein FoldingD059865Disorders42830.944017Endoplasmic Reticulum StressD019704Chemicals & Drugs8180.991903Protein Disulfide-IsomerasesD051379Living Beings980113130.368397MiceD053773Chemicals & Drugs56870.948516Transforming Growth Factor beta1D054990Disorders391640.825391Idiopathic Pulmonary FibrosisD055550Concepts & Ideas76990.964685Protein Stabilityhttps://biomedsciences.uchicago.edu/page/anne-i-sperling-phdUChicago BioD004195Disorders59222270.601904Disease Models, AnimalD011658Disorders471230.87189Pulmonary FibrosisD015398Physiology69932330.460036Signal TransductionUniversity of ChicagoAnne I.SperlingAnne I. Sperling41.78927490000000-87.601250000000001999Sperling, Anne I.Professortrue1ProfessorProfessor