D007652Chemicals & DrugsD08.811.520.224.600670.993298Oxo-Acid-Lyasesprns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:orcidIdORCID idPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson26145173Kang HB, Fan J, Lin R, Elf S, Ji Q, Zhao L, Jin L, Seo JH, Shan C, Arbiser JL, Cohen C, Brat D, Miziorko HM, Kim E, Abdel-Wahab O, Merghoub T, Fröhling S, Scholl C, Tamayo P, Barbie DA, Zhou L, Pollack BP, Fisher K, Kudchadkar RR, Lawson DH, Sica G, Rossi M, Lonial S, Khoury HJ, Khuri FR, Lee BH, Boggon TJ, He C, Kang S, Chen JMolecular cellMetabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling. Mol Cell. 2015 Aug 06; 59(3):345-358.Mol Cell2015-07-02T00:00:002015Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.JingChenJing Chen41.7886000000000087.598699999999993958Chen, Jing0000-0002-5376-9062Professor0.4950960.003190566research area of0.5456610.01284846subject area for15155874Field B, Cardon G, Traka M, Botterman J, Vancanneyt G, Mithen RPlant physiologyGlucosinolate and amino acid biosynthesis in Arabidopsis. Plant Physiol. 2004 Jun; 135(2):828-39.Plant Physiol2004-05-21T00:00:002004Glucosinolate and amino acid biosynthesis in Arabidopsis.Medicine-Hematology and OncologyChuanHe1Gp8Cq8dHMzMknJtY0fp/Cv/+94=Chuan He0.000000000000000.000000000000003123He, ChuanProfessorhttp://he-group.uchicago.eduMy Lab Sitehttps://sites.google.com/view/jingchen-lab-uchicago/homeChen LabChemistryHuman GeneticsMedicineUniversity of ChicagoNancy JeanCox2WFmE4EXCuiXhHlsaUXv9Gq0+s+oNancy Jean Cox41.78927490000000-87.601250000000001011Cox, Nancy JeanEmeritus/EmeritaScottSmemoScott Smemo41.78927490000000-87.601250000000001332Smemo, ScottPostdoctoral FellowNoboruSakabeNoboru Sakabe41.78927490000000-87.601250000000001788Sakabe, Noborutrue1true1ProfessorProfessortrue1Postdoctoral FellowPostdoctoral Fellowtrue1Emeritus/EmeritaEmeritus/Emeritatrue1ProfessorProfessor18775698Jia G, Yang CG, Yang S, Jian X, Yi C, Zhou Z, He CFEBS lettersOxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett. 2008 Oct 15; 582(23-24):3313-9.FEBS Lett2008-09-05T00:00:002008Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.24646999Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MANatureObesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 2014 Mar 20; 507(7492):371-5.Nature2014-03-12T00:00:002014Obesity-associated variants within FTO form long-range functional connections with IRX3.24834807Zheng G, Cox T, Tribbey L, Wang GZ, Iacoban P, Booher ME, Gabriel GJ, Zhou L, Bae N, Rowles J, He C, Olsen MJACS chemical neuroscienceSynthesis of a FTO inhibitor with anticonvulsant activity. ACS Chem Neurosci. 2014 Aug 20; 5(8):658-65.ACS Chem Neurosci2014-06-05T00:00:002014Synthesis of a FTO inhibitor with anticonvulsant activity.