SebastianFicaSebastian Fica0.000000000000000.000000000000002974Fica, SebastianPost Doctoral Scholarprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonBiochemistry and Molecular BiologyMolecular Genetics and Cell BiologyRadiation and Cellular OncologyD005091Chemicals & Drugs1984500.856712ExonsAuthorship 1128812Authorship 117780128981077Fica SM, Nagai KNature structural & molecular biologyCryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine. Nat Struct Mol Biol. 2017 Oct 05; 24(10):791-799.Nat Struct Mol Biol2017-10-05T00:00:002017Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine.29146871Wilkinson ME, Fica SM, Galej WP, Norman CM, Newman AJ, Nagai KScience (New York, N.Y.)Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection. Science. 2017 12 08; 358(6368):1283-1288.Science2017-11-16T00:00:002017Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.Authorship 127081130705154Fica SM, Oubridge C, Wilkinson ME, Newman AJ, Nagai KScience (New York, N.Y.)A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation. Science. 2019 02 15; 363(6428):710-714.Science2019-01-31T00:00:002019A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.D012326Physiology661420.886968RNA SplicingAuthorship 139401132717639Fica SMCurrent opinion in structural biologyCryo-EM snapshots of the human spliceosome reveal structural adaptions for splicing regulation. Curr Opin Struct Biol. 2020 12; 65:139-148.Curr Opin Struct Biol2020-07-24T00:00:002020Cryo-EM snapshots of the human spliceosome reveal structural adaptions for splicing regulation.Chicago60637ILCaitlinCastroCaitlin Castro0.000000000000000.000000000000002931Castro, CaitlinFellowRongShenRong Shen0.000000000000000.000000000000002936Shen, RongPost Doctoral Scholar4.228540.0088465962research areas0.6531260.1216424coauthor of53.56661.7910460similar to1115selected publicationsSunhwanJoSunhwan Jo0.000000000000000.000000000000003046Jo, SunhwanPost Doctoral ScholarD020285Procedures30900.917902Cryoelectron MicroscopyAuthorship 144743633674615Strittmatter LM, Capitanchik C, Newman AJ, Hallegger M, Norman CM, Fica SM, Oubridge C, Luscombe NM, Ule J, Nagai KNature communicationspsiCLIP reveals dynamic RNA binding by DEAH-box helicases before and after exon ligation. Nat Commun. 2021 03 05; 12(1):1488.Nat Commun2021-03-05T00:00:002021psiCLIP reveals dynamic RNA binding by DEAH-box helicases before and after exon ligation.Authorship 144843233705709Wilkinson ME, Fica SM, Galej WP, Nagai KMolecular cellStructural basis for conformational equilibrium of the catalytic spliceosome. Mol Cell. 2021 04 01; 81(7):1439-1452.e9.Mol Cell2021-03-10T00:00:002021Structural basis for conformational equilibrium of the catalytic spliceosome.D017381Anatomy11450.951969SpliceosomesD012441Living Beings1204340.770546Saccharomyces cerevisiaeAuthorship 160174636409063Parker MT, Soanes BK, Kusakina J, Larrieu A, Knop K, Joy N, Breidenbach F, Sherwood AV, Barton GJ, Fica SM, Davies BH, Simpson GGeLifem6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5' splice site. Elife. 2022 Nov 21; 11.Elife2022-11-21T00:00:002022m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5' splice site.ChuanHe1Gp8Cq8dHMzMknJtY0fp/Cv/+94=Chuan He0.000000000000000.000000000000003123He, ChuanProfessorhttp://bishoplab.bsd.uchicago.edu/Bishop Lab Websitehttp://he-group.uchicago.eduMy Lab Sitehttp://glicklab.bsd.uchicago.edu/Glick Labhttps://staley.uchicago.eduStaley Lab WebsiteBiochem/Mol BioChemistryUniversity of ChicagoJonathan P.Staley3XF9Cq0QeczMknJtY0fp/Cv/+94=Jonathan P. Staley41.78927490000000-87.601250000000001221Staley, Jonathan P.ProfessorPrakashKoodathingalPrakash Koodathingal41.78927490000000-87.601250000000001441Koodathingal, PrakashAuthorship 166964237787376Parker MT, Fica SM, Barton GJ, Simpson GGeLifeInter-species association mapping links splice site evolution to METTL16 and SNRNP27K. Elife. 2023 10 03; 12.Elife2023-10-03T00:00:002023Inter-species association mapping links splice site evolution to METTL16 and SNRNP27K.Joseph A.Piccirilli3XJgCKIcC+X5hHlsaUXv9Gq0+s+oJoseph A. Piccirilli41.78927490000000-87.60125000000000190Piccirilli, Joseph A.ProfessorBenjaminGlickBenjamin Glick41.78927490000000-87.601250000000001957Glick, BenjaminProfessorDouglas K.Bishop02BgGKkaCczbgn4qdUXm+mb7+MTz7LFLDouglas K. Bishop41.78927490000000-87.601250000000002358Bishop, Douglas K.ProfessorNan-ShengLiNan-Sheng Li41.78927490000000-87.60125000000000351Li, Nan-ShengAuthorship 168872338123540Aupic J, BoriĊĦek J, Fica SM, Galej WP, Magistrato ANature communicationsMonovalent metal ion binding promotes the first transesterification reaction in the spliceosome. Nat Commun. 2023 Dec 20; 14(1):8482.Nat Commun2023-12-20T00:00:002023Monovalent metal ion binding promotes the first transesterification reaction in the spliceosome.true1true1true1Post Doctoral ScholarPost Doctoral Scholartrue1Post Doctoral ScholarPost Doctoral Scholartrue1Postdoctoral ScholarPostdoctoral Scholartrue1FellowFellowtrue1Postdoctoral ScholarPostdoctoral Scholartrue1Post Doctoral ScholarPost Doctoral Scholartrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 669221Authorship 757521Authorship 73894424196718Fica SM, Tuttle N, Novak T, Li NS, Lu J, Koodathingal P, Dai Q, Staley JP, Piccirilli JANatureRNA catalyses nuclear pre-mRNA splicing. Nature. 2013 Nov 14; 503(7475):229-34.Nature2013-11-06T00:00:002013RNA catalyses nuclear pre-mRNA splicing.24747940Fica SM, Mefford MA, Piccirilli JA, Staley JPNature structural & molecular biologyEvidence for a group II intron-like catalytic triplex in the spliceosome. Nat Struct Mol Biol. 2014 May; 21(5):464-471.Nat Struct Mol Biol2014-04-20T00:00:002014Evidence for a group II intron-like catalytic triplex in the spliceosome.1010Authorship 86840326803803Nguyen TH, Galej WP, Fica SM, Lin PC, Newman AJ, Nagai KCurrent opinion in structural biologyCryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast. Curr Opin Struct Biol. 2016 Feb; 36:48-57.Curr Opin Struct Biol2016-01-21T00:00:002016CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast.ArmandoHernandezArmando Hernandez0.000000000000000.000000000000002727Hernandez, ArmandoPostdoctoral ScholarRaymondHulseRaymond Hulse0.000000000000000.000000000000002740Hulse, RaymondPostdoctoral Scholar23686287Schellenberg MJ, Wu T, Ritchie DB, Fica S, Staley JP, Atta KA, LaPointe P, MacMillan AMNature structural & molecular biologyA conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat Struct Mol Biol. 2013 Jun; 20(6):728-34.Nat Struct Mol Biol2013-05-19T00:00:002013A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.Authorship 98169327459055Galej WP, Wilkinson ME, Fica SM, Oubridge C, Newman AJ, Nagai KNatureCryo-EM structure of the spliceosome immediately after branching. Nature. 2016 09 08; 537(7619):197-201.Nature2016-07-26T00:00:002016Cryo-EM structure of the spliceosome immediately after branching.Authorship 99275128076345Fica SM, Oubridge C, Galej WP, Wilkinson ME, Bai XC, Newman AJ, Nagai KNatureStructure of a spliceosome remodelled for exon ligation. Nature. 2017 02 16; 542(7641):377-380.Nature2017-01-11T00:00:002017Structure of a spliceosome remodelled for exon ligation.