15857837Kouadio JL, Horn JR, Pal G, Kossiakoff AAThe Journal of biological chemistryBinding Sites; Human Growth Hormone; Receptors, SomatotropinAlanine; Allosteric Regulation; Amino Acid Sequence; Dimerization; Entropy; Gene Library; Humans; Kinetics; Molecular Sequence Data; Mutagenesis; Protein Structure, Tertiary; ThermodynamicsShotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface. J Biol Chem. 2005 Jul 08; 280(27):25524-32.J Biol Chem2005-04-26T00:00:002005Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface.prns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD000409Chemicals & Drugs53850.95928AlanineD000595Genes & Molecular Sequences43920620.7368Amino Acid SequenceD000494Physiology41680.96611Allosteric RegulationD001665Chemicals & Drugs32910980.797809Binding SitesBiochemistry and Molecular BiologyD008969Concepts & IdeasGenes & Molecular Sequences56030290.690324Molecular Sequence DataD011986Chemicals & Drugs4180.987355Receptors, SomatotropinAuthorship 269864D006801Living Beings2262862810.130052HumansD013816Occupations953080.906268ThermodynamicsD015723Chemicals & DrugsGenes & Molecular Sequences901300.960191Gene LibraryD016296Physiology1201990.949604Mutagenesis0.2694090.2694091authors10.2515has subject areaD017434Concepts & Ideas2687360.844002Protein Structure, TertiaryD019382Chemicals & Drugs18540.968196Human Growth HormoneD019277Concepts & IdeasOccupations26380.977307EntropyD019281Phenomena891430.967264Dimerizationhttp://kosslab.uchicago.eduKosslabhttp://recombinant-antibodies.orgRecombinant Antibody NetworkD007700Concepts & Ideas37115130.801669KineticsUniversity of ChicagoAnthonyKossiakoff1mlmGLIcGOf5hHlsaUXv9Gq0+s+oAnthony Kossiakoff41.78927490000000-87.601250000000001188Kossiakoff, AnthonyProfessortrue1ProfessorProfessor