16141422Rikitake Y, Kim HH, Huang Z, Seto M, Yano K, Asano T, Moskowitz MA, Liao JKStrokeEnzyme Inhibitors; Protein Serine-Threonine Kinases; Stroke1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Analysis of Variance; Animals; Antihypertensive Agents; Aorta; Blotting, Northern; Blotting, Western; Brain Ischemia; Cattle; Cell Line; Cells, Cultured; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Humans; Hypoxia; Infarction, Middle Cerebral Artery; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pyridines; Regional Blood Flow; rho-Associated Kinases; RNA, Messenger; Time Factors; Umbilical Veins; Up-RegulationInhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke. 2005 Oct; 36(10):2251-7.Stroke2005-09-01T00:00:002005Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.prns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD000818Living Beings1457265180.249624AnimalsD000860DisordersPhenomena1726380.668837HypoxiaD001011Anatomy1102800.873639AortaD000959Chemicals & Drugs905210.70252Antihypertensive AgentsD000704Concepts & Ideas4099120.83234Analysis of VarianceD002560Physiology722120.873367Cerebrovascular CirculationD002417Living Beings1753740.939904CattleD004730Anatomy1354350.823162Endothelium, VascularD004791Chemicals & Drugs2686320.779731Enzyme InhibitorsD004305Concepts & Ideas52019580.724084Dose-Response Relationship, DrugD008810Living Beings55730870.60566Mice, Inbred C57BLD009569Chemicals & Drugs1152770.872656Nitric OxideD011725Chemicals & Drugs1533090.839039PyridinesD012039Physiology1041970.948231Regional Blood FlowD006801Living Beings2262862810.130052HumansD013997Concepts & Ideas118351980.519628Time FactorsAuthorship 278208D014471Anatomy25460.991782Umbilical VeinsD015854Physiology3257100.800467Up-Regulation0.2760340.2760341authors10.2535has subject areaD020244Disorders16350.962795Infarction, Middle Cerebral ArteryD018696Chemicals & DrugsPhysiology49940.93101Neuroprotective AgentsD051379Living Beings980113130.368397MiceD012333Chemicals & Drugs51619750.640012RNA, MessengerD015153PhenomenaProcedures3187810.86116Blotting, WesternD015536Physiology2565040.86254Down-RegulationD015152PhenomenaProcedures1232560.965038Blotting, NorthernD020521Disorders1609590.510301StrokeD019001Chemicals & Drugs531250.947608Nitric Oxide SynthaseD047908Chemicals & Drugs1833780.829617Intracellular Signaling Peptides and ProteinsD052250Chemicals & Drugs36880.960794Nitric Oxide Synthase Type IIID054460Chemicals & Drugs401590.883845rho-Associated KinasesD000577Chemicals & Drugs41600.972929AmidesD002460Anatomy54024660.697085Cell LineD002478Anatomy60328100.667881Cells, CulturedD002545Disorders813970.698294Brain IschemiaD019307Chemicals & Drugs11360.9790811-(5-Isoquinolinesulfonyl)-2-MethylpiperazineMedicineUniversity of ChicagoJamesLiaoJames Liao41.78927490000000-87.60125000000000382Liao, JamesProfessortrue1ProfessorProfessor