17353442Kajimoto H, Hashimoto K, Bonnet SN, Haromy A, Harry G, Moudgil R, Nakanishi T, Rebeyka I, Thébaud B, Michelakis ED, Archer SLCirculationDuctus Arteriosus; Oxygen; Protein Serine-Threonine Kinases; Reactive Oxygen Species; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Enzyme Activation; Enzyme Induction; Feedback, Physiological; Female; Fetal Heart; Gestational Age; Humans; Hydrogen Peroxide; Hypoplastic Left Heart Syndrome; Infant, Newborn; Intracellular Signaling Peptides and Proteins; Male; Mitochondria, Heart; Nifedipine; Organ Culture Techniques; Oxidation-Reduction; Partial Pressure; Phenylephrine; Pyridines; Rabbits; rho-Associated Kinases; Superoxides; VasoconstrictionOxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction. Circulation. 2007 Apr 03; 115(13):1777-88.Circulation2007-03-12T00:00:002007Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.prns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD000818Living Beings1457265180.249624AnimalsD000831Living Beings1905090.880163Animals, NewbornD007231Living Beings50923690.641593Infant, NewbornD004789Physiology2436920.87473Enzyme ActivationD005318Anatomy9130.990473Fetal HeartD009543Chemicals & Drugs20280.993688NifedipineD004373Anatomy6260.974539Ductus ArteriosusD006861Chemicals & Drugs791570.932127Hydrogen PeroxideD004790Physiology58880.982142Enzyme InductionD010656Chemicals & Drugs22350.992466PhenylephrineD009924Procedures771340.963061Organ Culture TechniquesD010084Phenomena1543730.90754Oxidation-ReductionD010313Phenomena31500.990924Partial PressureAuthorship 3167610D008929Anatomy24500.964717Mitochondria, HeartD010100Chemicals & Drugs2287250.682362OxygenD005260Physiology1992444050.191167FemaleD011725Chemicals & Drugs1533090.839039PyridinesD011817Living Beings2286360.897344RabbitsD006801Living Beings2262862810.130052HumansD013481Chemicals & Drugs46730.965361SuperoxidesD014661DisordersPhysiology27930.959751VasoconstrictionD008297Physiology1931408600.201617MaleD020743Chemicals & Drugs330.998681rhoB GTP-Binding Protein0.07670230.07670231authors10.2535has subject areaD020013Physiology821290.921977Calcium SignalingD025461Phenomena43620.952483Feedback, PhysiologicalD017382Chemicals & Drugs1474800.796023Reactive Oxygen SpeciesD020742Chemicals & Drugs41830.941129rhoA GTP-Binding ProteinD018636Disorders15720.924996Hypoplastic Left Heart SyndromeD047908Chemicals & Drugs1833780.829617Intracellular Signaling Peptides and ProteinsD054460Chemicals & Drugs401590.883845rho-Associated KinasesD000577Chemicals & Drugs41600.972929AmidesD002121Chemicals & Drugs722030.912284Calcium Channel BlockersD005865Physiology1133100.90231Gestational AgeD019307Chemicals & Drugs11360.9790811-(5-Isoquinolinesulfonyl)-2-MethylpiperazineD020746Chemicals & Drugs27390.979857Calcium Channels, L-TypeMedicineUniversity of ChicagoStephenArcherStephen Archer41.78927490000000-87.601250000000002615Archer, StephenProfessortrue1ProfessorProfessor