33964209Cui C, Chakraborty K, Tang XA, Zhou G, Schoenfelt KQ, Becker KM, Hoffman A, Chang YF, Blank A, Reardon CA, Kenny HA, Vaisar T, Lengyel E, Greene G, Becker LCellCarcinogenesis; Leukocyte Elastase; NeoplasmsAllosteric Regulation; Animals; CD8-Positive T-Lymphocytes; Cell Death; Cell Line, Tumor; Cell Proliferation; Eosinophil Cationic Protein; fas Receptor; Histones; Humans; Mice; Neutrophils; Pancreatic Elastase; Protease Inhibitors; Protein Domains; Protein Isoforms; Proteolysis; Secretory Leukocyte Peptidase Inhibitor; SwineNeutrophil elastase selectively kills cancer cells and attenuates tumorigenesis. Cell. 2021 06 10; 184(12):3163-3177.e21.Cell2021-05-07T00:00:002021Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis.prns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD000494Physiology41680.96611Allosteric RegulationD000818Living Beings1457265180.249624AnimalsObstetrics and GynecologyD010196Chemicals & Drugs13150.992049Pancreatic ElastaseD009504Anatomy1603060.870674NeutrophilsD011480Chemicals & Drugs51720.962356Protease InhibitorsD013552Living Beings1975540.876017SwineD006657Chemicals & Drugs1523090.838801HistonesD006801Living Beings2262862810.130052HumansBen May Department of Cancer ResearchObstetrics and Gynecology-Gynecologic OncologyAuthorship 14642011Authorship 14641714Authorship 14641813Authorship 146419150.8184030.2046014authors10.2522has subject areaD018414Anatomy1605560.744835CD8-Positive T-LymphocytesD049109Physiology43515710.639735Cell ProliferationD051379Living Beings980113130.368397MiceD059748Physiology731000.942264ProteolysisD016923Physiology1342560.90447Cell DeathD019272Chemicals & Drugs880.990491Leukocyte ElastaseD045744Anatomy46824210.643233Cell Line, TumorD000072417811280.939629Protein DomainsD063646Disorders1111940.849113Carcinogenesishttps://obgyn.uchicago.edu/page/section-gynecologic-oncologyGynecologic Oncology Section - Univ. of Chicagohttps://benmay.uchicago.eduBen May Department web sitehttps://obgyn.uchicago.edu/Univ. of Chicago OB&GYNhttp://obg.bsd.uchicago.edu/FacultyResearch/lengyellab.htmOvarian Cancer Laboratory in Chicagohttps://www.uchicagomedicine.org/find-a-physician/physician/ernst-lengyelClinical Profilehttps://www.uchicago-ccbandme.org/current-ccb-mentorsCCB recruitment sitehttps://www.thebeckerlaboratory.com/My Lab Sitehttps://www.uchicagomedicine.org/conditions-services/obgyn/specialtyOB&GYN Clinical Patient informationD009369Disorders55628890.33847NeoplasmsD019014Chemicals & Drugs44750.96079fas ReceptorD020033Chemicals & Drugs1812690.909625Protein IsoformsD047150Chemicals & Drugs440.998215Eosinophil Cationic ProteinD053481Chemicals & Drugs550.99812Secretory Leukocyte Peptidase InhibitorUniversity of ChicagoErnst RobertLengyel0m5sBaYMHOD5hHlsaUXv9Gq0+s+oErnst Robert Lengyel41.78927490000000-87.601250000000001942Lengyel, Ernst RobertProfessorLevBecker22d/CYF1GuTQkntjbwjr93A=Lev Becker41.78927490000000-87.601250000000002508Becker, LevAssociate ProfessorHilaryKennyHilary Kenny41.78927490000000-87.601250000000002548Kenny, HilaryResearch Associate ProfessorGeoffreyGreene0GV7DqQbHMzMknJtY0fp/Cv/+94=Geoffrey Greene41.78927490000000-87.60125000000000901Greene, GeoffreyProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Research Associate ProfessorResearch Associate Professortrue1ProfessorProfessor