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Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS.
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Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS.
Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS. FASEB J. 2009 Mar; 23(3):783-94.
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PubMed
subject areas
Aminoimidazole Carboxamide
Cells, Cultured
Cellular Senescence
Cytosol
Fibroblasts
Gene Expression Regulation
Humans
Hyperoxia
Lung
Mitochondria
Nuclear Proteins
Polycomb Repressive Complex 1
Proto-Oncogene Proteins
Reactive Oxygen Species
Repressor Proteins
Retinoblastoma Protein
Ribonucleotides
Telomerase
Tumor Suppressor Protein p53