23086477Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, Pillai VB, Ravindra PV, Gupta M, Jeevanandam V, Cunningham JM, Deng CX, Lombard DB, Mostoslavsky R, Gupta MPNature medicineCardiomegaly; Heart Failure; JNK Mitogen-Activated Protein Kinases; Oncogene Protein v-akt; SirtuinsAcetylation; Animals; Chromatin; DNA-Binding Proteins; Histone Demethylases; Insulin-Like Growth Factor I; Mice; Mice, Transgenic; Promoter Regions, Genetic; Signal TransductionThe sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nat Med. 2012 Nov; 18(11):1643-50.Nat Med2012-10-21T00:00:002012The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.prns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD000107Phenomena751210.967753AcetylationD000818Living Beings1457265180.249646AnimalsD004268Chemicals & Drugs35612080.630119DNA-Binding ProteinsD006332Disorders361110.942608CardiomegalyD006333Disorders18711960.4939Heart FailureD007334Chemicals & Drugs611140.931804Insulin-Like Growth Factor ID008822Living Beings37515370.738477Mice, TransgenicAuthorship 4974010Authorship 4973911Authorship 497384Authorship 4974190.1131570.1131574authors10.2515has subject areaD051058Chemicals & Drugs18210.987917Oncogene Protein v-aktD011401Chemicals & Drugs3239370.765551Promoter Regions, GeneticD051379Living Beings980113130.368427MiceD056466Chemicals & Drugs21300.981246Histone DemethylasesD037761Chemicals & Drugs22450.960053SirtuinsD048031Chemicals & Drugs681130.947683JNK Mitogen-Activated Protein KinasesD002843AnatomyChemicals & DrugsPhysiology1613780.79677Chromatinhttp://maheshguptalaboratory.weebly.comMahesh Gupta LaboratoryD015398Physiology69932330.460071Signal TransductionPediatricsSurgeryUniversity of ChicagoJohnCunninghamJohn Cunningham41.78927490000000-87.601250000000001145Cunningham, JohnProfessorValluvanJeevanandamValluvan Jeevanandam41.78927490000000-87.601250000000002130Jeevanandam, ValluvanProfessorMahesh P.GuptaMahesh P. Gupta41.78927490000000-87.601250000000002244Gupta, Mahesh P.ProfessorGene H.KimGene H. Kim41.78927490000000-87.60125000000000921Kim, Gene H.Associate Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorMedicine-CardiologySurgery-Cardiac