BrandonFaubertBrandon Faubert41.7886000000000087.598699999999994090Faubert, BrandonCancer MetabolismStable Isotope TracingIn Vivo MetabolismThe primary research interest of the Faubert laboratory is investigating how metabolic reprogramming – alterations of metabolic flux in malignant cells – supports cancer cell survival and growth. We have extensive experience in measuring metabolism in vitro and in vivo, including measuring tumor metabolism intra-operatively in patients. The laboratory utilizes a series of mass spectrometry platforms to provide comprehensive views of metabolic pathways in biological systems. We use a variety of methods to assess metabolism, including isotope tracing (13C, 2H, etc.), metabolomics and metabolic flux to dissect the metabolic programs that underlie these malignant phenotypes. We complement these approaches with molecular imaging techniques to monitor metabolic states of tumor metabolism in vivo, in order to understand the breadth of metabolic diversity in cancer. Emerging work from the lab explores the metabolic alterations that occur during the metastatic cascade, and the tumor metabolism that results unique microenvironments.Assistant Professorplugins:TwitterTwitterprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational Trainingvivo:freetextKeywordkeywordsvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:orcidIdORCID idvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonObstetrics and GynecologyRadiation and Cellular OncologyD004734Physiology1402710.84244Energy MetabolismJingChenJing Chen41.7886000000000087.598699999999993958Chen, Jing0000-0002-5376-9062ProfessorMedicine-Hematology and OncologyObstetrics and Gynecology-Gynecologic OncologyTabraizMohammedTabraiz Mohammed41.7886000000000087.598699999999993996Mohammed, TabraizClinical AssociateMarina ChiaraGarassinoMarina Chiara Garassino41.7886000000000087.598699999999994025Garassino, Marina ChiaraProfessorChicago60637IL1.463840.0148098280research areas0.4622840.061011710coauthor of72.95486.3569160similar to1148selected publicationsAuthorship 14912310Authorship 14913010Authorship 1491326Authorship 1491426Authorship 1491444Authorship 1491021Authorship 14911611Authorship 1491351Authorship 1491361Authorship 1491612Authorship 1491843Authorship 1491972Authorship 14920410Authorship 1492056Authorship 1492086Authorship 1492342Authorship 14923813Authorship 1492491Authorship 1492513Authorship 1492004Authorship 1492141Authorship 1492335Authorship 1492694Authorship 14929012Authorship 1492581Authorship 14928022Authorship 1493184Authorship 14933610Authorship 14934018Authorship 1491154Authorship 14922417Authorship 1492256Authorship 149236231267018Faubert B, DeBerardinis RJ, Minna JDCell researchAIF: an acquired metabolic liability in lung cancer. Cell Res. 2019 08; 29(8):607-608.Cell Res2019-08-01T00:00:002019AIF: an acquired metabolic liability in lung cancer.33257855Kim J, Lee HM, Cai F, Ko B, Yang C, Lieu EL, Muhammad N, Rhyne S, Li K, Haloul M, Gu W, Faubert B, Kaushik AK, Cai L, Kasiri S, Marriam U, Nham K, Girard L, Wang H, Sun X, Kim J, Minna JD, Unsal-Kacmaz K, DeBerardinis RJNature metabolismThe hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer. Nat Metab. 2020 12; 2(12):1401-1412.Nat Metab2020-11-30T00:00:002020The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer.30728499Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, Van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TGP, Fendt SMNatureEvidence for an alternative fatty acid desaturation pathway increasing cancer plasticity. Nature. 2019 02; 566(7744):403-406.Nature2019-02-06T00:00:002019Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.25874445Fu A, Robitaille K, Faubert B, Reeks C, Dai XQ, Hardy AB, Sankar KS, Ogrel S, Al-Dirbashi OY, Rocheleau JV, Wheeler MB, MacDonald PE, Jones R, Screaton RADiabetologiaLKB1 couples glucose metabolism to insulin secretion in mice. Diabetologia. 2015 Jul; 58(7):1513-22.Diabetologia2015-04-16T00:00:002015LKB1 couples glucose metabolism to insulin secretion in mice.24304688McGuirk S, Gravel SP, Deblois G, Papadopoli DJ, Faubert B, Wegner A, Hiller K, Avizonis D, Akavia UD, Jones RG, Giguère V, St-Pierre JCancer & metabolismPGC-1a supports glutamine metabolism in breast cancer. Cancer Metab. 2013 Dec 05; 1(1):22.Cancer Metab2013-12-05T00:00:002013PGC-1a supports glutamine metabolism in breast cancer.28978464Rabinovitch RC, Samborska B, Faubert B, Ma EH, Gravel SP, Andrzejewski S, Raissi TC, Pause A, St-Pierre J, Jones RGCell reportsAMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species. Cell Rep. 2017 Oct 03; 21(1):1-9.Cell Rep2017-10-03T00:00:002017AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species.31564558Chen PH, Cai L, Huffman K, Yang C, Kim J, Faubert B, Boroughs L, Ko B, Sudderth J, McMillan EA, Girard L, Chen D, Peyton M, Shields MD, Yao B, Shames DS, Kim HS, Timmons B, Sekine I, Britt R, Weber S, Byers LA, Heymach JV, Chen J, White MA, Minna JD, Xiao G, DeBerardinis RJMolecular cellMetabolic Diversity in Human Non-Small Cell Lung Cancer Cells. Mol Cell. 2019 12 05; 76(5):838-851.e5.Mol Cell2019-09-26T00:00:002019Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.26603296Bott AJ, Peng IC, Fan Y, Faubert B, Zhao L, Li J, Neidler S, Sun Y, Jaber N, Krokowski D, Lu W, Pan JA, Powers S, Rabinowitz J, Hatzoglou M, Murphy DJ, Jones R, Wu S, Girnun G, Zong WXCell metabolismOncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation. Cell Metab. 2015 Dec 01; 22(6):1068-77.Cell Metab2015-10-23T00:00:002015Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation.31747582Ma EH, Verway MJ, Johnson RM, Roy DG, Steadman M, Hayes S, Williams KS, Sheldon RD, Samborska B, Kosinski PA, Kim H, Griss T, Faubert B, Condotta SA, Krawczyk CM, DeBerardinis RJ, Stewart KM, Richer MJ, Chubukov V, Roddy TP, Jones RGImmunityMetabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells. Immunity. 2019 11 19; 51(5):856-870.e5.Immunity2019-10-10T00:00:002019Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells.24486219Faubert B, Vincent EE, Poffenberger MC, Jones RGCancer lettersThe AMP-activated protein kinase (AMPK) and cancer: many faces of a metabolic regulator. Cancer Lett. 2015 Jan 28; 356(2 Pt A):165-70.Cancer Lett2014-01-28T00:00:002014The AMP-activated protein kinase (AMPK) and cancer: many faces of a metabolic regulator.31811141Luengo A, Abbott KL, Davidson SM, Hosios AM, Faubert B, Chan SH, Freinkman E, Zacharias LG, Mathews TP, Clish CB, DeBerardinis RJ, Lewis CA, Vander Heiden MGNature communicationsReactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer. Nat Commun. 2019 12 06; 10(1):5604.Nat Commun2019-12-06T00:00:002019Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer.26455923Pereira S, Park E, Moore J, Faubert B, Breen DM, Oprescu AI, Nahle A, Kwan D, Giacca A, Tsiani EApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolismeResveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo. Appl Physiol Nutr Metab. 2015 Nov; 40(11):1129-36.Appl Physiol Nutr Metab2015-07-10T00:00:002015Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo.28985563Faubert B, Li KY, Cai L, Hensley CT, Kim J, Zacharias LG, Yang C, Do QN, Doucette S, Burguete D, Li H, Huet G, Yuan Q, Wigal T, Butt Y, Ni M, Torrealba J, Oliver D, Lenkinski RE, Malloy CR, Wachsmann JW, Young JD, Kernstine K, DeBerardinis RJCellLactate Metabolism in Human Lung Tumors. 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Cell. 2013 Jun 06; 153(6):1239-51.Cell2013-06-06T00:00:002013Posttranscriptional control of T cell effector function by aerobic glycolysis.31042466Ni M, Solmonson A, Pan C, Yang C, Li D, Notzon A, Cai L, Guevara G, Zacharias LG, Faubert B, Vu HS, Jiang L, Ko B, Morales NM, Pei J, Vale G, Rakheja D, Grishin NV, McDonald JG, Gotway GK, McNutt MC, Pascual JM, DeBerardinis RJCell reportsFunctional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans. 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Nature. 2019 May; 569(7756):E4.Nature2019-05-01T00:00:002019Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.28538732Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, Peña CG, Heymach JV, Wauters E, Vansteenkiste J, Castrillon DH, Chen BPC, Wistuba I, Lambrechts D, Xu J, Minna JD, DeBerardinis RJNatureCPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature. 2017 06 01; 546(7656):168-172.Nature2017-05-24T00:00:002017CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.26625127Griss T, Vincent EE, Egnatchik R, Chen J, Ma EH, Faubert B, Viollet B, DeBerardinis RJ, Jones RGPLoS biologyMetformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis. 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Mol Cell. 2022 06 02; 82(11):1992-2005.e9.Mol Cell2022-04-12T00:00:002022Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation.Authorship 1541172Authorship 1542837Authorship 1542211135388219Solmonson A, Faubert B, Gu W, Rao A, Cowdin MA, Menendez-Montes I, Kelekar S, Rogers TJ, Pan C, Guevara G, Tarangelo A, Zacharias LG, Martin-Sandoval MS, Do D, Pachnis P, Dumesnil D, Mathews TP, Tasdogan A, Pham A, Cai L, Zhao Z, Ni M, Cleaver O, Sadek HA, Morrison SJ, DeBerardinis RJNatureCompartmentalized metabolism supports midgestation mammalian development. Nature. 2022 04; 604(7905):349-353.Nature2022-04-06T00:00:002022Compartmentalized metabolism supports midgestation mammalian development.35429459Zhang R, Chen D, Fan H, Wu R, Tu J, Zhang FQ, Wang M, Zheng H, Qu CK, Elf SE, Faubert B, He YY, Bissonnette MB, Gao X, DeBerardinis RJ, Chen JCell chemical biologyCellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells. Cell Chem Biol. 2022 07 21; 29(7):1200-1208.e6.Cell Chem Biol2022-04-15T00:00:002022Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells.SimonSchwoererxHFqA7YaHP7cg1pxY07n8GT98IW47aA=Simon Schwoerer41.7886000000000087.598699999999994247Schwoerer, SimonAssistant ProfessorD053858Physiology60780.943281Metabolic Networks and PathwaysD055372Chemicals & Drugs43640.948835AMP-Activated Protein KinasesAuthorship 1583386Authorship 1585063Authorship 1593261335981545Kaymak I, Luda KM, Duimstra LR, Ma EH, Longo J, Dahabieh MS, Faubert B, Oswald BM, Watson MJ, Kitchen-Goosen SM, DeCamp LM, Compton SE, Fu Z, DeBerardinis RJ, Williams KS, Sheldon RD, Jones RGCell metabolismCarbon source availability drives nutrient utilization in CD8+ T cells. Cell Metab. 2022 09 06; 34(9):1298-1311.e6.Cell Metab2022-08-17T00:00:002022Carbon source availability drives nutrient utilization in CD8+ T cells.36044570Pachnis P, Wu Z, Faubert B, Tasdogan A, Gu W, Shelton S, Solmonson A, Rao AD, Kaushik AK, Rogers TJ, Ubellacker JM, LaVigne CA, Yang C, Ko B, Ramesh V, Sudderth J, Zacharias LG, Martin-Sandoval MS, Do D, Mathews TP, Zhao Z, Mishra P, Morrison SJ, DeBerardinis RJScience advancesIn vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors. Sci Adv. 2022 09 02; 8(35):eabn9550.Sci Adv2022-08-31T00:00:002022In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors.36525494Kaushik AK, Tarangelo A, Boroughs LK, Ragavan M, Zhang Y, Wu CY, Li X, Ahumada K, Chiang JC, Tcheuyap VT, Saatchi F, Do QN, Yong C, Rosales T, Stevens C, Rao AD, Faubert B, Pachnis P, Zacharias LG, Vu H, Cai F, Mathews TP, Genovese G, Slusher BS, Kapur P, Sun X, Merritt M, Brugarolas J, DeBerardinis RJScience advancesIn vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Sci Adv. 2022 12 16; 8(50):eabp8293.Sci Adv2022-12-16T00:00:002022In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma.https://obgyn.uchicago.edu/page/section-gynecologic-oncologyGynecologic Oncology Section - Univ. of Chicagohttps://obgyn.uchicago.edu/Univ. of Chicago OB&GYNhttp://obg.bsd.uchicago.edu/FacultyResearch/lengyellab.htmOvarian Cancer Laboratory in Chicagohttps://www.uchicagomedicine.org/find-a-physician/physician/ernst-lengyelClinical Profilehttps://sites.google.com/view/jingchen-lab-uchicago/homeChen Labhttps://www.uchicagomedicine.org/conditions-services/obgyn/specialtyOB&GYN Clinical Patient information@schwoerersimonD005947Chemicals & Drugs2176370.784337GlucoseD009369Disorders55628890.33847Neoplasms2015McGill UniversityMontrealMcGill University, PhysiologyPhDPhysiology2021UT SouthwesternDallasUT Southwestern, Cancer MetabolismPostdocCancer MetabolismJamesDolezalJames Dolezal41.7886000000000087.598699999999994332Dolezal, JamesInstructorAuthorship 163523637214913Wu Z, Bezwada D, Harris RC, Pan C, Nguyen PT, Faubert B, Cai L, Cai F, Vu HS, Chen H, Sandoval MM, Do D, Gu W, Zhang Y, Ko B, Brooks B, Kelekar S, Zhang Y, Zacharias LG, Oaxaca KC, Mathews TP, Garcia-Bermudez J, Ni M, DeBerardinis RJbioRxiv : the preprint server for biologyElectron transport chain inhibition increases cellular dependence on purine transport and salvage. bioRxiv. 2023 May 11.bioRxiv2023-05-11T00:00:002023Electron transport chain inhibition increases cellular dependence on purine transport and salvage.MedicineUniversity of Chicagohttps://schwoererlab.uchicago.edu/Schworer LabJosephFransesJoseph Franses41.7886000000000087.598699999999994435Franses, JosephAssistant Professor37653041Mukherjee A, Bezwada D, Greco F, Zandbergen M, Shen T, Chiang CY, Tasdemir M, Fahrmann J, Grapov D, La Frano MR, Vu HS, Faubert B, Newman JW, McDonnell LA, Nezi L, Fiehn O, DeBerardinis RJ, Lengyel ENature metabolismAdipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis. Nat Metab. 2023 09; 5(9):1563-1577.Nat Metab2023-08-31T00:00:002023Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis.Authorship 16593012WendyStockwHF9BKIeOfnamXNnYUHhvWD+6g==Wendy Stock41.78927490000000-87.601250000000001502Stock, WendyProfessorEverett E.VokesEverett E. Vokes41.78927490000000-87.601250000000001920Vokes, Everett E.ProfessorRaviSalgiaRavi Salgia41.78927490000000-87.601250000000001937Salgia, RaviEmeritus/Emerita, ProfessorErnst RobertLengyel0m5sBaYMHOD5hHlsaUXv9Gq0+s+oErnst Robert Lengyel41.78927490000000-87.601250000000001942Lengyel, Ernst RobertProfessorRalph R.WeichselbaumxXB+DqgWEf/5hHlsaUXv9Gq0+s+oRalph R. Weichselbaum41.78927490000000-87.601250000000002521Weichselbaum, Ralph R.ProfessorOlatoyosiOdenikew21tDq8cEun5hHlsaUXv9Gq0+s+oOlatoyosi Odenike41.78927490000000-87.60125000000000399Odenike, OlatoyosiProfessorYusukeNakamuraYusuke Nakamura41.78927490000000-87.60125000000000582Nakamura, YusukeEmeritus/Emerita, ProfessorAuthorship 167715237907620Bartman CR, Faubert B, Rabinowitz JD, DeBerardinis RJNature reviews. CancerMetabolic pathway analysis using stable isotopes in patients with cancer. Nat Rev Cancer. 2023 Dec; 23(12):863-878.Nat Rev Cancer2023-10-31T00:00:002023Metabolic pathway analysis using stable isotopes in patients with cancer.37993715Fan H, Xia S, Xiang J, Li Y, Ross MO, Lim SA, Yang F, Tu J, Xie L, Dougherty U, Zhang FQ, Zheng Z, Zhang R, Wu R, Dong L, Su R, Chen X, Althaus T, Riedell PA, Jonker PB, Muir A, Lesinski GB, Rafiq S, Dhodapkar MV, Stock W, Odenike O, Patel AA, Opferman J, Tsuji T, Matsuzaki J, Shah H, Faubert B, Elf SE, Layden B, Bissonnette BM, He YY, Kline J, Mao H, Odunsi K, Gao X, Chi H, He C, Chen JNatureTrans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity. Nature. 2023 Nov; 623(7989):1034-1043.Nature2023-11-22T00:00:002023Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity.Authorship 16834332Authorship 168355238011656Miller JW, Faubert BM, Mathews TP, Waters JK, DeBerardinis RJ, Kernstine KHEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic SurgeryMetabolic signatures of thymomas: potential biomarkers and treatment targets. Eur J Cardiothorac Surg. 2024 Feb 01; 65(2).Eur J Cardiothorac Surg2024-02-01T00:00:002024Metabolic signatures of thymomas: potential biomarkers and treatment targets.38438799Feng Q, Bennett Z, Grichuk A, Pantoja R, Huang T, Faubert B, Huang G, Chen M, DeBerardinis RJ, Sumer BD, Gao JNature biomedical engineeringSeverely polarized extracellular acidity around tumour cells. Nat Biomed Eng. 2024 Mar 04.Nat Biomed Eng2024-03-04T00:00:002024Severely polarized extracellular acidity around tumour cells.Authorship 1708406true1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1InstructorInstructortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Clinical AssociateClinical Associatetrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1InstructorInstructortrue1ProfessorProfessortrue1ProfessorProfessor1010AbirMukherjeeAbir Mukherjee0.000000000000000.000000000000002809Mukherjee, AbirInstructor