22383528Qin J, Berdyshev E, Poirer C, Schwartz NB, Dawson GThe Journal of biological chemistryCeramides; Glucuronosyltransferase; Hyaluronic Acid; Proto-Oncogene Proteins c-akt; Sphingomyelin PhosphodiesteraseAnimals; Brain; Enzyme Activation; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Glycosaminoglycans; Hyaluronan Synthases; Membrane Microdomains; Mice; Osteogenesis Imperfecta; Phosphorylation; Signal Transduction; Sphingolipids; TOR Serine-Threonine Kinases; Up-RegulationNeutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt. J Biol Chem. 2012 Apr 20; 287(17):13620-32.J Biol Chem2012-03-01T00:00:002012Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt.prns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:hasSubjectAreaMajorTopicListhas major subject area listprns:hasSubjectAreaMinorTopicListhas minor subject area listprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed Identifiervivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:hasSubjectAreahas subject areavivo:hrJobTitleHR job titleInformation Resourcevivo:informationResourceInAuthorshipauthorsvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD002518Chemicals & Drugs18350.980623CeramidesD000818Living Beings1457265180.249646AnimalsD001921Anatomy49222110.472384BrainD005347Anatomy2447290.786045FibroblastsD004789Physiology2436920.874749Enzyme ActivationD010013Disorders440.998975Osteogenesis ImperfectaD006025Chemicals & Drugs22470.975372GlycosaminoglycansD013108Chemicals & Drugs11210.992422Sphingomyelin PhosphodiesteraseD010766Phenomena34811010.802883PhosphorylationAuthorship 47783Authorship 477824D015854Physiology3257100.800494Up-Regulation0.2164840.1082423authors10.2521has subject areaD020869Procedures44213810.644641Gene Expression ProfilingD051379Living Beings980113130.368427MiceD058570Chemicals & Drugs991820.885161TOR Serine-Threonine KinasesD013107Chemicals & Drugs13200.982873SphingolipidsD015971Physiology1432110.891492Gene Expression Regulation, EnzymologicD000076002380.99933Hyaluronan SynthasesD006820Chemicals & Drugs35490.962833Hyaluronic AcidD014453Chemicals & Drugs561840.884177GlucuronosyltransferaseD015398Physiology69932330.460071Signal TransductionD021962Anatomy39540.964883Membrane MicrodomainsD051057Chemicals & Drugs1483210.870541Proto-Oncogene Proteins c-aktPediatricsUniversity of ChicagoNancy B.SchwartzNancy B. Schwartz41.78927490000000-87.601250000000001432Schwartz, Nancy B.Professortrue1ProfessorProfessorAuthorship 59765