D055551Chemicals & DrugsD12.776.580.216.270.62524330.983366HSP27 Heat-Shock Proteinsplugins:FeaturedVideosFeatured Videosplugins:TwitterTwitterprns:emailEncryptedemail addressprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonValerieAbadieValerie Abadie41.7886000000000087.598699999999993673Abadie, ValerieResearch Associate ProfessorMedicine-GastroenterologyObstetrics and Gynecology-Maternal Fetal Medicine26082332Do K, Speranza G, Chang LC, Polley EC, Bishop R, Zhu W, Trepel JB, Lee S, Lee MJ, Kinders RJ, Phillips L, Collins J, Lyons J, Jeong W, Antony R, Chen AP, Neckers L, Doroshow JH, Kummar SInvestigational new drugsPhase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors. Invest New Drugs. 2015 Aug; 33(4):921-30.Invest New Drugs2015-06-18T00:00:002015Phase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors.21512157Iwashita Y, Sakiyama T, Musch MW, Ropeleski MJ, Tsubouchi H, Chang EBAmerican journal of physiology. Gastrointestinal and liver physiologyPolyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response. Am J Physiol Gastrointest Liver Physiol. 2011 Jul; 301(1):G181-7.Am J Physiol Gastrointest Liver Physiol2011-04-21T00:00:002011Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response.1.196780.016023224research area of0.5085650.048798624subject area forSaroshRanaSarosh Rana0.000000000000000.000000000000003121Rana, SaroshProfessorhttp://obg.bsd.uchicago.edu/FacultyResearch/Ranalab/index.htmlRana Preeclampsia lab@saroshranaOBMedicineUniversity of ChicagoEugene B.Chang0mBqA6AbHszMknJtY0fp/Cv/+94=Eugene B. Chang41.78927490000000-87.601250000000001255Chang, Eugene B.ProfessorPeiliChenPeili Chen41.78927490000000-87.60125000000000157Chen, PeiliRESEARCH ASSOCIATE (ASSISTANT PROFESSOR)YusukeNakamuraYusuke Nakamura41.78927490000000-87.60125000000000582Nakamura, YusukeEmeritus/Emerita, Professortrue1RESEARCH ASSOCIATE (ASSISTANT PROFESSOR)RESEARCH ASSOCIATE (ASSISTANT PROFESSOR)true1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1ProfessorProfessortrue1Research Associate ProfessorResearch Associate Professortrue1ProfessorProfessor24585183Lin J, Deng Z, Tanikawa C, Shuin T, Miki T, Matsuda K, Nakamura YInternational journal of oncologyDownregulation of the tumor suppressor HSPB7, involved in the p53 pathway, in renal cell carcinoma by hypermethylation. Int J Oncol. 2014 May; 44(5):1490-8.Int J Oncol2014-02-27T00:00:002014Downregulation of the tumor suppressor HSPB7, involved in the p53 pathway, in renal cell carcinoma by hypermethylation.24970393Rana S, Rajakumar A, Geahchan C, Salahuddin S, Cerdeira AS, Burke SD, George EM, Granger JP, Karumanchi SAFASEB journal : official publication of the Federation of American Societies for Experimental BiologyOuabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1a pathway. FASEB J. 2014 Oct; 28(10):4324-34.FASEB J2014-06-26T00:00:002014Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1a pathway.21131586Chang E, Heo KS, Woo CH, Lee H, Le NT, Thomas TN, Fujiwara K, Abe JBloodMK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation. Blood. 2011 Feb 24; 117(8):2527-37.Blood2010-12-03T00:00:002010MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation.