SimonSchwoererxHFqA7YaHP7cg1pxY07n8GT98IW47aA=Simon Schwoerer41.7886000000000087.598699999999994247Schwoerer, SimonThe Schwörer Lab is interested in understanding how cellular metabolism regulates regenerative responses in health and disease.
We are specifically interested in:
- how metabolism controls the plasticity and functions of fibroblasts and stem cells
- how metabolic rewiring in fibroblasts contributes to fibrotic disease and tumor progression
- how alterations in nutrient availability impact cell fate and function and can lead to therapeutic vulnerabilities in the tumor microenvironment.
Cancer-associated fibroblasts (CAFs) are part of the tumor microenvironment and can support tumor progression via various mechanisms. The Schwörer Lab is interested in the metabolic control of CAF function in desmoplastic tumors such as pancreatic and breast cancer. Specifically, our research aims to understand how nutrient availability and utilization regulate CAF activation, heterogeneity, and function within tumors. Ultimately, we aim to identify tumor-specific metabolic vulnerabilities in CAFs that could be targeted in combination with chemo- and immunotherapy to improve patient outcomes.Assistant Professorplugins:TwitterTwitterprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor Receiptvivo:degreeEarneddegree earnedDepartmentvivo:educationalTrainingeducation and trainingEducational TrainingGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:orcidIdORCID idvivo:overviewoverviewvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes toURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonD003094Chemicals & Drugs1322680.871987CollagenRadiation and Cellular OncologyAnuNeerukondaAnu Neerukonda41.7886000000000087.598699999999993797Neerukonda, AnuClinical AssociateAriRosenbergAri Rosenberg41.7886000000000087.598699999999993839Rosenberg, AriAssistant ProfessorJingChenJing Chen41.7886000000000087.598699999999993958Chen, Jing0000-0002-5376-9062ProfessorGokhan M.Mutlu0G98H611OfnamXNnYUHhvWD+6g==Gokhan M. Mutlu0.000000000000000.000000000000002890Mutlu, Gokhan M.ProfessorMedicine-Hematology and OncologyTabraizMohammedTabraiz Mohammed41.7886000000000087.598699999999993996Mohammed, TabraizClinical AssociateD008928AnatomyPhysiology2095350.748762MitochondriaD011392Chemicals & Drugs42570.968344ProlineJessicaGarciaJessica Garcia41.7886000000000087.598699999999994183Garcia, JessicaClinical Associate1.706020.026180989research areas0.03761240.03761241coauthor of21.15473.6430160similar to118selected publications09/2022Memorial Sloan Kettering Cancer CenterNew YorkMemorial Sloan Kettering Cancer Center, Postdoctoral Fellow03/2017Friedrich Schiller UniversityJena Friedrich Schiller University, PhD04/2013Ulm UniversityUlmUlm University, MSc09/2011Ulm UniversityUlmUlm University, BScNational Cancer Institute20252021K99/R00 Pathway to Independence AwardGerry Metastasis and Tumor Ecosystems Center20222020Postdoctoral Innovation AwardHuman Frontier Science Foundation20212018Postdoctoral FellowshipGerman Academic Exchange Service2017Travel AwardUlm University20112008Student scholarshipAuthorship 1575287Authorship 1575298Authorship 1575306Authorship 1575313Authorship 1575328Authorship 15753311Authorship 157534926277064Rinkenauer AC, Press AT, Raasch M, Pietsch C, Schweizer S, Schwörer S, Rudolph KL, Mosig A, Bauer M, Traeger A, Schubert USJournal of controlled release : official journal of the Controlled Release SocietyComparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo. J Control Release. 2015 Oct 28; 216:158-68.J Control Release2015-08-12T00:00:002015Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo.33888598Zhu J, Schwörer S, Berisa M, Kyung YJ, Ryu KW, Yi J, Jiang X, Cross JR, Thompson CBScience (New York, N.Y.)Mitochondrial NADP(H) generation is essential for proline biosynthesis. Science. 2021 05 28; 372(6545):968-972.Science2021-04-22T00:00:002021Mitochondrial NADP(H) generation is essential for proline biosynthesis.34764457Schwörer S, Pavlova NN, Cimino FV, King B, Cai X, Sizemore GM, Thompson CBNature metabolismFibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment. Nat Metab. 2021 11; 3(11):1484-1499.Nat Metab2021-11-11T00:00:002021Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment.32134147Schwörer S, Berisa M, Violante S, Qin W, Zhu J, Hendrickson RC, Cross JR, Thompson CBThe EMBO journalProline biosynthesis is a vent for TGFß-induced mitochondrial redox stress. EMBO J. 2020 04 15; 39(8):e103334.EMBO J2020-03-05T00:00:002020Proline biosynthesis is a vent for TGFß-induced mitochondrial redox stress.31607565Zhu J, Berisa M, Schwörer S, Qin W, Cross JR, Thompson CBCell metabolismTranssulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation. Cell Metab. 2019 11 05; 30(5):865-876.e5.Cell Metab2019-10-10T00:00:002019Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation.30773467Schwörer S, Vardhana SA, Thompson CBCell metabolismCancer Metabolism Drives a Stromal Regenerative Response. Cell Metab. 2019 03 05; 29(3):576-591.Cell Metab2019-02-14T00:00:002019Cancer Metabolism Drives a Stromal Regenerative Response.D059016Phenomena1404150.763796Tumor MicroenvironmentD00007264520360.953494Cancer-Associated Fibroblastshttps://mutlulab.uchicago.edu/Mutlu Labhttps://sites.google.com/view/jingchen-lab-uchicago/homeChen Lab@schwoerersimonMedicinePathologyUniversity of Chicagohttps://schwoererlab.uchicago.edu/Schworer LabAGA Foundation2023Augustyn Award in Digestive CancerCancer Research Foundation20242023Young Investigator AwardAuthorship 1652651American Society for Matrix Biology2023Founders Award36912618Schwörer S, Cimino FV, Ros M, Tsanov KM, Ng C, Lowe SW, Carmona-Fontaine C, Thompson CBCancer researchHypoxia Potentiates the Inflammatory Fibroblast Phenotype Promoted by Pancreatic Cancer Cell-Derived Cytokines. Cancer Res. 2023 05 15; 83(10):1596-1610.Cancer Res2023-05-15T00:00:002023Hypoxia Potentiates the Inflammatory Fibroblast Phenotype Promoted by Pancreatic Cancer Cell-Derived Cytokines.KayMedinaKay L. Medina41.78927490000000-87.601250000000001568Medina, KayRaviSalgiaRavi Salgia41.78927490000000-87.601250000000001937Salgia, RaviEmeritus/Emerita, ProfessorRalph R.WeichselbaumxXB+DqgWEf/5hHlsaUXv9Gq0+s+oRalph R. Weichselbaum41.78927490000000-87.601250000000002521Weichselbaum, Ralph R.ProfessorThomas F.GajewskiThomas F. Gajewski41.78927490000000-87.60125000000000355Gajewski, Thomas F.ProfessorYusukeNakamuraYusuke Nakamura41.78927490000000-87.60125000000000582Nakamura, YusukeEmeritus/Emerita, Professortrue1true1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1Emeritus/Emerita, ProfessorEmeritus/Emerita, Professortrue1ProfessorProfessortrue1Clinical AssociateClinical Associatetrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant Professortrue1Clinical AssociateClinical Associatetrue1ProfessorProfessortrue1Clinical AssociateClinical Associatetrue1ProfessorProfessortrue1ProfessorProfessor27919074Schwörer S, Becker F, Feller C, Baig AH, Köber U, Henze H, Kraus JM, Xin B, Lechel A, Lipka DB, Varghese CS, Schmidt M, Rohs R, Aebersold R, Medina KL, Kestler HA, Neri F, von Maltzahn J, Tümpel S, Rudolph KLNatureEpigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals. Nature. 2016 12 15; 540(7633):428-432.Nature2016-11-30T00:00:002016Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.